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Obtain estimated marginal means (EMMs) for many linear, generalized linear, and mixed models. Compute contrasts or linear functions of EMMs, trends, and comparisons of slopes. Plots and other displays. Least-squares means are discussed, and the term "estimated marginal means" is suggested, in Searle, Speed, and Milliken (1980) Population marginal means in the linear model: An alternative to least squares means, The American Statistician 34(4), 216-221 <<a href="https://doi.org/10.1080%2F00031305.1980.10483031" target="_top">doi:10.1080/00031305.1980.10483031</a>>.
A new study suggests spacecraft exhaust could quickly contaminate the moon's most scientifically valuable regions, potentially masking ancient clues about how life began on Earth。 Researchers say future lunar missions should consider new ways to reduce and monitor this pollution before it becomes widespread
This article presents global cancer statistics by world region for the year 2022 based on updated estimates from the International Agency for Research on Cancer (IARC). There were close to 20 million new cases of cancer in the year 2022 (including nonmelanoma skin cancers [NMSCs]) alongside 9.7 million deaths from cancer (including NMSC). The estimates suggest that approximately one in five men or women develop cancer in a lifetime, whereas around one in nine men and one in 12 women die from it. Lung cancer was the most frequently diagnosed cancer in 2022, responsible for almost 2.5 million new cases, or one in eight cancers worldwide (12.4% of all cancers globally), followed by cancers of the female breast (11.6%), colorectum (9.6%), prostate (7.3%), and stomach (4.9%). Lung cancer was also the leading cause of cancer death, with an estimated 1.8 million deaths (18.7%), followed by colorectal (9.3%), liver (7.8%), female breast (6.9%), and stomach (6.8%) cancers. Breast cancer and lung cancer were the most frequent cancers in women and men, respectively (both cases and deaths). Incidence rates (including NMSC) varied from four-fold to five-fold across world regions, from over 500 in Australia/New Zealand (507.9 per 100,000) to under 100 in Western Africa (97.1 per 100,000) among men, and from over 400 in Australia/New Zealand (410.5 per 100,000) to close to 100 in South-Central Asia (103.3 per 100,000) among women. The authors examine the geographic variability across 20 world regions for the 10 leading cancer types, discussing recent trends, the underlying determinants, and the prospects for global cancer prevention and control. With demographics-based predictions indicating that the number of new cases of cancer will reach 35 million by 2050, investments in prevention, including the targeting of key risk factors for cancer (including smoking, overweight and obesity, and infection), could avert millions of future cancer diagnoses and save many lives worldwide, bringing huge economic as well as societal dividends to countries over the forthcoming decades.
Scientists have rewritten the story of gallium after discovering that its unusual atomic bonds re-form at high temperatures, contradicting decades of accepted theory。 The finding changes how researchers explain why the metal melts so easily and behaves unlike almost any other metal。 Beyond solving a long-standing scientific mystery, the work could
Scientists have identified new clues that could help astronomers spot one of the most famous hypothetical alien megastructures: a Dyson sphere。 The study finds that red dwarfs and white dwarfs are the most promising stars to examine, since advanced civilizations could potentially build energy-harvesting swarms around them more easily。 These objects
Dark matter may be far more complicated than scientists once believed。 A new study suggests it could consist of at least two different kinds of particles that slowly separate over time, with heavier particles sinking toward the centers of galaxies and lighter ones drifting outward。 This simple idea could explain several puzzling cosmic observations
Researchers have achieved a major milestone by creating a long-sought two-dimensional quantum material and confirming its unusual conducting edge states。 The ability to control these states through strain could make the material a promising platform for future room-temperature quantum electronics
A team of mathematicians used whimsical "silly sprinklers" to solve a physics mystery that has puzzled scientists for decades。 Their experiments showed that the rotation of both normal and reverse sprinklers is driven by the momentum of flowing water, not by the outside water flow or other long-standing theories。 The results finally provide a clear
Physicists from Heinrich Heine University Düsseldorf (HHU) have examined a fundamental property of quantum mechanics in collaboration with the German Aerospace Center (DLR)。 In the scientific journal Physical Review Letters, they show that this theory does not necessarily need to be formulated with imaginary numbers – real numbers can in fact also
What if time doesn't actually exist until something changes。 Scientists at the University of Birmingham created a tiny "mini universe" using 24,000 ultracold atoms and showed that the flow of time can emerge naturally from changes inside a quantum system, without relying on any external clock
JWST has captured unusually detailed images of gas feeding the supermassive black hole at the center of NGC 4696。 A vast filament appears to funnel material into an 800-light-year-wide spinning disk, where gas races around at up to 600 kilometers per second。 The findings suggest black holes may recycle their own fuel by heating gas with jets and la
A planet with one side permanently roasting and the other frozen in endless darkness might still have a chance of supporting life。 Researchers found that heat inside a tidally locked exoplanet could circulate in a stable, continuous loop, helping moderate temperatures in certain regions。 Their laboratory model suggests these worlds may be more hosp
Scientists say new technologies have reopened the debate over whether Mars could someday be terraformed, turning a once impossible idea into a serious research topic。 Before anyone tries to reshape the Red Planet, though, researchers say we must understand the risks, including what might be lost if Mars already harbors its own forms of life
NASA's James Webb Space Telescope has revealed new details about the blistering lava planet 55 Cancri e, where temperatures are high enough to melt rock。 The data indicate the planet likely has a hydrogen-rich atmosphere shaped by gases escaping from its molten interior, with signs that volcanic outgassing may even create temporary clouds
Researchers discovered that electricity can dramatically reshape how heat flows through certain ceramic materials, increasing heat conduction by almost threefold in a preferred direction。 The unexpected result could lead to much more efficient cooling technologies and energy-saving devices