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Under homeostatic conditions, murine dendritic cells (DCs) undergo a tolerogenic activation termed homeostatic maturation, preventing autoimmunity by inducing tolerance to innocuous antigens; whether this process occurs in humans is unknown. In this issue of Immunity, Lu et al. report that splenic human type 2 DCs undergo homeostatic maturation under thymic stromal lymphopoietin (TSLP) instruction.
Aviation history provides an apt metaphor for the state of Rasch measurement practice, and its potential future. Flying was initially widely believed to be nothing but a spectacular and dangerous fad. Few saw in it any potential for the huge industry that it is today. The current state of Rasch measurement practice is quite akin to daredevil barnstorming in that the field is focused on isolated demonstrations of disconnected technical effects. Only when the analogues of air traffic control, airports, support staff, training programs, textbooks, and partner industries (hotels, restaurants) are in place will Rasch measurement come into its own as the technical medium of a widespread industry. The point at which current practice tips into a new paradigm depends on the realization of operationally validated theory in a supportive social context. The paper closes with speculations on what crossing Rasch measurement's tipping point might entail.
Over the past 10 years, gamer profiles have been developed to understand the reason underlying players' intrinsic motivation. While the research undertaken has led to the creation of distinct models (e.g., BrainHex and Hexad typologies), there is a lack of studies on the prevalence of these profiles among a specific population and the association between the target population's profiles and their personality traits, gaming behavior, and sociodemographic characteristics. Thus, the present study aimed to (a) establish the gamer profiles of French undergraduate law students, (b) examine the relationships between the participants' profiles and their personality traits, gaming behavior, and sociodemographic characteristics, with a view to the development of serious games specifically intended for this population. In total, 753 French undergraduate students participated in the study, completing an online questionnaire. Data were analyzed using Latent Profile Analysis (LPA), chi-square, and ANOVA. The main findings show that among participants, the two most prevalent gamers' profiles are Mastermind (45%) and Seeker (22.7%); followed by three less represented archetypes: Conqueror (12.9%), Daredevil (9.7%), and Achiever (9.7%). These archetypes are associated with the participants' Big Five personality traits. Specifically, Daredevils, Masterminds, and Seekers have high mean scores on Extraversion (p < .001); Achievers and Seekers have high mean scores on Agreeableness (p < .001); Seekers and Achievers have high mean scores on Neuroticism (p < .001); and Seekers, Masterminds, and Achievers have high mean scores on Openness (p < .001). The unveiled profiles are also significantly associated with the participants' gaming behavior including their playing frequency (p < .001), game types (p = .031), and sociodemographic characteristics (p < .001). For example, Masterminds are more likely to be female than the other four profiles (p < .001), while Conquerors and Daredevils are more likely to have a low socio-economic status compared to those with intermediate and high socio-economic status (p = .49). These findings can be used to design serious/educational games tailored to the studied population.
'Operation Wild Dog' was the title given to an incredible escapade by two Army Dental Corps soldiers who decided to mount their own two-man raid on occupied France in 1942. In an attempt to forestall claims of desertion, they involved Prime Minister Winston Churchill and, when they ultimately faced a court martial, were lauded in the press for their daredevil exploits. Inspired by raids carried out by Special Services units on Norway, Italy and France, Sergeant Peter King, a regular soldier and dental clerk orderly, and Private Thomas Leslie Cuthbertson, a trainee dental mechanic, set about their unofficial raid, outlined below.
Sexual abuse in childhood can disable self-esteem, self-concept, relationships, and ability to trust. It can also leave psychological trauma that compromises a boy's confidence in adults. While some boys who willingly participate may adjust to sexual abuse, many others face complications, such as reduced quality of life, impaired social relationships, less than optimal daily functioning, and self-destructive behavior. These problems can respond to treatment if detected. In this paper, we examine the prevalence, characteristics, psychological consequences, treatment, and coping patterns of boys who have been sexually abused and their failure to disclose abuse unless asked during a therapeutic encounter. Nurses have a responsibility to detect the clues to sexual abuse, diagnose the psychological consequences, and advocate for protection and treatment. Computerized literature search of the Medline and PsychInfo literature and books on sexual abuse of boys. Psychological responses to abuse such as anxiety, denial, self-hypnosis, dissociation, and self-mutilation are common. Coping strategies may include being the angry avenger, the passive victim, rescuer, daredevil, or conformist. Sexual abuse may precipitate runaway behavior, chronic use of sick days, poor school or job performance, costly medical, emergency and or mental health visits. In worst cases, the boy may decide that life is not worth living and plan suicide. The nurse has a key role to play in screening, assessing, and treating sexual abuse children.
Introduction: There is a need to evaluate the influence of risk factors such as patency of foramen ovale (PFO) or "daredevil" psychological profile on contra-indication policy after a decompression sickness (DCS). Methods: By crossing information obtained from Belgian Hyperbaric Centers, DAN Emergency Hotline, the press, and Internet diving forums, it was possible to be accountable for the majority if not all DCS, which have occurred in Belgium from January 1993 to June 2013. From the available 594 records we excluded all cases with tentative diagnosis, medullary DCS or unreliability of reported dive profile, leaving 209 divers records with cerebral DCS for analysis. Demographics, dive parameters, and PFO grading were recorded. Twenty-three injured divers were tested using the Zuckerman's Sensation Seeking Scale V and compared to a matched group not involved in risky activities. Results: 41.2% of all injured came for iterative DCS. The average depth significantly increases with previous occurrences of DCS (1st DCS: 31.8 ± 7.9 mfw; 2nd DCS: 35.5 ± 9.8 mfw; 3rd DCS: 43.4 ± 6.1 mfw). There is also an increase of PFO prevalence among multiple injured divers (1st DCS: 66.4% 2nd & 3rd DCS: 100%) with a significant increase in PFO grade. Multiple-times injured significantly scored higher than control group on thrill and adventure seeking (TAS), experience seeking, boredom susceptibility and total score. Conclusion: There is an inability of injured diver to adopt conservative dive profile after a DCS. Further work is needed to ascertain whether selected personality characteristics or PFO should be taken into account in the clearance decision to resume diving.
Current theories of text processing say little about how authors' narrative choices, including the introduction of small mysteries, can affect readers' narrative experiences. Gerrig, Love, and McKoon (2009) provided evidence that 1 type of small mystery-a character introduced without information linking him or her to the story-affects readers' moment-by-moment processing. For that project, participants read stories that introduced characters by proper name alone (e.g., "Judy") or with information connecting the character to the rest of the story (e.g., "our principal Judy"). In an online recognition probe task, responses to the character's name 3 lines after his or her introduction were faster when the character had not been introduced with connecting information, suggesting that the character remained accessible awaiting resolution. In the 4 experiments in this article, we extend our theoretical analysis of small mysteries. In Experiments 1 and 2, we found evidence that trait information (e.g., "daredevil Judy") is not sufficient to connect a character to a text. In Experiments 3 and 4, we found evidence that the moment-by-moment processing effects of such small mysteries also affect readers' memory for the stories. We interpret the results in terms of Kintsch's (1988) construction-integration model of discourse processing.
In a new paper in the October 8(th) issue of Cell, Kuo and Krasnow (2015) report a previously undescribed mechanism for cell sorting and reveal a dynamic, daredevil behavior of epithelial cells.
A new study suggests AI chatbots may do more than spread misinformation — they can actively strengthen a user’s false beliefs。 Because conversational AI often validates and builds on what users say, it can make distorted memories, conspiracy theories, or delusions feel more believable and emotionally real。 Researchers warn that AI companions may be
Astronomers have unleashed a powerful new AI tool called RAVEN to comb through data from NASA’s TESS mission—and it’s paying off in a big way。 By analyzing millions of stars, the system has confirmed over 100 exoplanets, including 31 brand-new worlds, and identified thousands more promising candidates。 What makes this especially exciting is the dis
A bizarre planetary pairing 190 light-years away is challenging everything astronomers thought they knew about how worlds form。 A “lonely” hot Jupiter — typically found without nearby companions — is sharing its system with a smaller mini-Neptune tucked even closer to the star, a setup once thought nearly impossible
Astronomers have spotted something surprising in the far outer Solar System—a faint, short-lived atmosphere clinging to a tiny icy world that shouldn’t be able to hold one at all。 The object, called 2002 XV93, is far smaller than Pluto, yet observations during a rare stellar alignment revealed its presence through a subtle dimming of starlight。 Eve
For nearly 100 years, reinforced rubber has powered everything from car tires to airplanes, yet scientists never fully understood why adding tiny particles of carbon black made rubber so incredibly strong。 Now, researchers at the University of South Florida have finally cracked the mystery using massive computer simulations that took the equivalent
For decades, relaxor ferroelectrics have powered everything from medical ultrasounds to sonar systems, yet their inner atomic structure remained a mystery—until now。 Researchers have finally mapped their three-dimensional structure in unprecedented detail, uncovering hidden patterns in how electric charges are arranged at the nanoscale。 The breakth
Scientists may have found a powerful new way to hunt for alien life — not by searching for specific molecules, but by looking for hidden patterns in how those molecules are organized。 Researchers discovered that living systems leave behind a kind of chemical “fingerprint” in the statistical distribution of amino acids and fatty acids, one that cons
A team at the University of Hong Kong has developed a new “super steel” that can survive the harsh conditions needed to make green hydrogen from seawater。 The material uses an unexpected double-protection mechanism that resists corrosion far better than conventional stainless steel。 Even more impressive, it could replace costly titanium parts used