) at 2,496 (771 PWS) independent loci with 807 (247 PWS) end points. Among these, fine-mapping implicated 148 (73 PWS) coding variants associated with 83 (42 PWS) end points. Moreover, 91 (47 PWS) had an allele frequency of <5% in non-Finnish European individuals, of which 62 (32 PWS) were enriched by more than twofold in Finland. These findings demonstrate the power of bottlenecked populations to find entry points into the biology of common diseases through low-frequency, high impact variants.
Instructure, which provides Canvas software to thousands of schools and universities around the world, did not say what it had given the hackers in exchange for the stolen data
Scientists may have uncovered a surprising secret behind why life exists at all。 A new study suggests that the Universe’s fundamental constants — the deep physical rules that govern everything from atoms to stars — appear to sit within an incredibly narrow “sweet spot” that allows liquids to flow properly inside living cells。 Even tiny shifts in th
Hubble has revealed a giant planet-forming disk unlike anything astronomers have seen before。 Nicknamed “Dracula’s Chivito,” the enormous structure appears turbulent and oddly lopsided, with towering filaments visible on only one side。 The disk contains enough material to potentially create multiple giant planets, making it a fascinating new labora
Astronomers using the James Webb Space Telescope have spotted something that shouldn’t exist—at least not so early in the universe。 A massive galaxy, formed less than 2 billion years after the Big Bang, appears to have no rotation at all, a trait usually seen only in much older, evolved galaxies。 This challenges current theories that young galaxies
A mysterious comet from beyond our solar system is giving astronomers a rare glimpse into alien worlds — and it may have formed in a place far colder and stranger than anything around our Sun。 The interstellar visitor, called 3I/ATLAS, contains an astonishingly high amount of “heavy water,” far exceeding anything seen in our own solar system
Physicists may have just cracked open a hidden side of the quantum world。 For decades, every known particle was thought to belong to one of two categories — bosons or fermions — but researchers have now shown that bizarre “in-between” particles called anyons could also exist in a one-dimensional system。 Even more exciting, these strange particles m
A bizarre planetary pairing 190 light-years away is challenging everything astronomers thought they knew about how worlds form。 A “lonely” hot Jupiter — typically found without nearby companions — is sharing its system with a smaller mini-Neptune tucked even closer to the star, a setup once thought nearly impossible
NASA’s Psyche spacecraft is about to pull off a dramatic close flyby of Mars, skimming just 2,800 miles above the planet to get a powerful gravitational boost on its journey to the mysterious metal-rich asteroid Psyche。 The maneuver will save propellant while giving mission scientists a rare chance to test and calibrate the spacecraft’s instruments
Scientists may have found a powerful new way to hunt for alien life — not by searching for specific molecules, but by looking for hidden patterns in how those molecules are organized。 Researchers discovered that living systems leave behind a kind of chemical “fingerprint” in the statistical distribution of amino acids and fatty acids, one that cons
A team at the University of Hong Kong has developed a new “super steel” that can survive the harsh conditions needed to make green hydrogen from seawater。 The material uses an unexpected double-protection mechanism that resists corrosion far better than conventional stainless steel。 Even more impressive, it could replace costly titanium parts used
Astronomers using NASA’s James Webb Space Telescope have created the clearest map yet of the universe’s “cosmic web” — the enormous hidden structure that connects galaxies across space。 By analyzing more than 164,000 galaxies through the massive COSMOS-Web survey, researchers were able to trace this vast network back to when the universe was just a
A scorching, airless world just 48 light-years away is offering scientists a rare glimpse into the geology of distant planets。 Using the James Webb Space Telescope, researchers studied LHS 3844 b—a tidally locked “super-Earth” with a permanent dayside hot enough to melt metal—and discovered it’s a dark, barren rock with no atmosphere
NASA’s Curiosity rover had an unexpectedly stubborn Mars souvenir after drilling into a rock nicknamed “Atacama” — the entire chunk ripped loose from the ground and stayed stuck to the rover’s drill。 Engineers watched as Curiosity shook, vibrated, tilted, and spun the drill over several days in an effort to free the rock, while cameras captured the