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The purpose of this study was to determine the brain regions associated with anosognosia in Alzheimer's disease (AD). Anosognosia for memory disturbance was assessed in 29 probable AD patients, based on the discrepancy between questionnaire scores of the patients and their caregivers. In I-123-IMP single photon emission computed tomography (SPECT), a significant association was found between anosognosia and decreased perfusion in the orbitofrontal cortex, using regression analysis. This result is consistent with the previous studies that have reported an association between frontal dysfunction and anosognosia, and further suggests that the orbitofrontal cortex specifically associates with anosognosia in AD within the frontal cortex.
LLM-integrated app systems extend the utility of Large Language Models (LLMs) with third-party apps that are invoked by a system LLM using interleaved planning and execution phases to answer user queries. These systems introduce new attack vectors where malicious apps can cause integrity violation of planning or execution, availability breakdown, or privacy compromise during execution. In this work, we identify new attacks impacting the integrity of planning, as well as the integrity and availability of execution in LLM-integrated apps, and demonstrate them against IsolateGPT, a recent solution designed to mitigate attacks from malicious apps. We propose Abstract-Concrete-Execute (ACE), a new secure architecture for LLM-integrated app systems that provides security guarantees for system planning and execution. Specifically, ACE decouples planning into two phases by first creating an abstract execution plan using only trusted information, and then mapping the abstract plan to a concrete plan using installed system apps. We verify that the plans generated by our system satisfy user-specified secure information flow constraints via static analysis on the structured plan output. During
Large language models (LLMs) extended as systems, such as ChatGPT, have begun supporting third-party applications. These LLM apps leverage the de facto natural language-based automated execution paradigm of LLMs: that is, apps and their interactions are defined in natural language, provided access to user data, and allowed to freely interact with each other and the system. These LLM app ecosystems resemble the settings of earlier computing platforms, where there was insufficient isolation between apps and the system. Because third-party apps may not be trustworthy, and exacerbated by the imprecision of natural language interfaces, the current designs pose security and privacy risks for users. In this paper, we evaluate whether these issues can be addressed through execution isolation and what that isolation might look like in the context of LLM-based systems, where there are arbitrary natural language-based interactions between system components, between LLM and apps, and between apps. To that end, we propose IsolateGPT, a design architecture that demonstrates the feasibility of execution isolation and provides a blueprint for implementing isolation, in LLM-based systems. We evalua
Melanoma detection is vital for early diagnosis and effective treatment. While deep learning models on dermoscopic images have shown promise, they require specialized equipment, limiting their use in broader clinical settings. This study introduces a multi-modal melanoma detection system using conventional photo images, making it more accessible and versatile. Our system integrates image data with tabular metadata, such as patient demographics and lesion characteristics, to improve detection accuracy. It employs a multi-modal neural network combining image and metadata processing and supports a two-step model for cases with or without metadata. A three-stage pipeline further refines predictions by boosting algorithms and enhancing performance. To address the challenges of a highly imbalanced dataset, specific techniques were implemented to ensure robust training. An ablation study evaluated recent vision architectures, boosting algorithms, and loss functions, achieving a peak Partial ROC AUC of 0.18068 (0.2 maximum) and top-15 retrieval sensitivity of 0.78371. Results demonstrate that integrating photo images with metadata in a structured, multi-stage pipeline yields significant pe
This work describes the participation of the MLLP-VRAIN research group in the shared task of the IWSLT 2026 Simultaneous Speech Translation track. Our submission utilizes the recently released Parakeet and Qwen 3.5 models to create a robust, cascaded solution for long-form SimulST through the use of adaptive "black-box" policies. We explore relaxations of these policies to achieve better quality-latency trade-offs. Compared to last year, we participate on all language directions. In addition to this, for the En$\rightarrow${De, It, Zh} directions we also participate in this year's new context track employing a combination of ASR word-boosting and a RAG mechanism of offline pre-translated exemplars to guide generation and enrich our system with domain-specific context. Finally, we provide a detailed latency analysis of our system. Compared to last year, results on the MCIF En$\rightarrow$De test set shows a substantial quality improvement of +5.82 XCOMET-XL. Our context track processing further improves performance by +1.03.
Efficient maintenance has always been essential for the successful application of engineering systems. However, the challenges to be overcome in the implementation of Industry 4.0 necessitate new paradigms of maintenance optimization. Machine learning techniques are becoming increasingly used in engineering and maintenance, with reinforcement learning being one of the most promising. In this paper, we propose a gamma degradation process together with a novel maintenance model in which repairs are increasingly imperfect, i.e., the beneficial effect of system repairs decreases as more repairs are performed, reflecting the degradational behavior of real-world systems. To generate maintenance policies for this system, we developed a reinforcement-learning-based agent using a Double Deep Q-Network architecture. This agent presents two important advantages: it works without a predefined preventive threshold, and it can operate in a continuous degradation state space. Our agent learns to behave in different scenarios, showing great flexibility. In addition, we performed an analysis of how changes in the main parameters of the environment affect the maintenance policy proposed by the agent
We introduce LLM x MapReduce-V3, a hierarchically modular agent system designed for long-form survey generation. Building on the prior work, LLM x MapReduce-V2, this version incorporates a multi-agent architecture where individual functional components, such as skeleton initialization, digest construction, and skeleton refinement, are implemented as independent model-context-protocol (MCP) servers. These atomic servers can be aggregated into higher-level servers, creating a hierarchically structured system. A high-level planner agent dynamically orchestrates the workflow by selecting appropriate modules based on their MCP tool descriptions and the execution history. This modular decomposition facilitates human-in-the-loop intervention, affording users greater control and customization over the research process. Through a multi-turn interaction, the system precisely captures the intended research perspectives to generate a comprehensive skeleton, which is then developed into an in-depth survey. Human evaluations demonstrate that our system surpasses representative baselines in both content depth and length, highlighting the strength of MCP-based modular planning.
The learning process for medical residents presents significant challenges, demanding both the ability to interpret complex case reports and the rapid acquisition of accurate medical knowledge from reliable sources. Residents typically study case reports and engage in discussions with peers and mentors, but finding relevant educational materials and evidence to support their learning from these cases is often time-consuming and challenging. To address this, we introduce MedTutor, a novel system designed to augment resident training by automatically generating evidence-based educational content and multiple-choice questions from clinical case reports. MedTutor leverages a Retrieval-Augmented Generation (RAG) pipeline that takes clinical case reports as input and produces targeted educational materials. The system's architecture features a hybrid retrieval mechanism that synergistically queries a local knowledge base of medical textbooks and academic literature (using PubMed, Semantic Scholar APIs) for the latest related research, ensuring the generated content is both foundationally sound and current. The retrieved evidence is filtered and ordered using a state-of-the-art reranking
The growing penetration of renewable and distributed generation is transforming power systems and challenging conventional protection schemes that rely on fixed settings and local measurements. Machine learning (ML) offers a data-driven alternative for centralized fault classification (FC) and fault localization (FL), enabling faster and more adaptive decision-making. However, practical deployment critically depends on robustness. Protection algorithms must remain reliable even when confronted with missing, noisy, or degraded sensor data. This work introduces a unified framework for systematically evaluating the robustness of ML models in power system protection. High-fidelity EMT simulations are used to model realistic degradation scenarios, including sensor outages, reduced sampling rates, and transient communication losses. The framework provides a consistent methodology for benchmarking models, quantifying the impact of limited observability, and identifying critical measurement channels required for resilient operation. Results show that FC remains highly stable under most degradation types but drops by about 13% under single-phase loss, while FL is more sensitive overall, wit
The re-energization of electrical distribution systems in a post-disaster scenario is of grave importance as most modern infrastructure systems rely heavily on the presence of electricity. This paper introduces a method to coordinate the field teams for the optimal energization of an electrical distribution system after an earthquake-induced blackout. The proposed method utilizes a Markov Decision Process (MDP) to create an optimal energization strategy, which aims to minimize the expected time to energize each distribution system component. The travel duration of each team and the possible outcomes of the energization attempts are considered in the state transitions. The failure probabilities of the system components are computed using the fragility curves of structures and the Peak Ground Acceleration (PGA) values which are encoded to the MDP model via transition probabilities. Furthermore, the proposed solution offers several methods to determine the non-optimal actions during the construction of the MDP and eliminate them in order to improve the run-time performance without sacrificing the optimality of the solution.
This paper presents CMU's submission to the IWSLT 2025 Simultaneous Speech Translation (SST) task for translating unsegmented English speech into Chinese and German text in a streaming manner. Our end-to-end speech-to-text system integrates a chunkwise causal Wav2Vec 2.0 speech encoder, an adapter, and the Qwen2.5-7B-Instruct as the decoder. We use a two-stage simultaneous training procedure on robust speech segments curated from LibriSpeech, CommonVoice, and VoxPopuli datasets, utilizing standard cross-entropy loss. Our model supports adjustable latency through a configurable latency multiplier. Experimental results demonstrate that our system achieves 44.3 BLEU for English-to-Chinese and 25.1 BLEU for English-to-German translations on the ACL60/60 development set, with computation-aware latencies of 2.7 seconds and 2.3 seconds, and theoretical latencies of 2.2 and 1.7 seconds, respectively.
This work describes the participation of the MLLP-VRAIN research group in the shared task of the IWSLT 2025 Simultaneous Speech Translation track. Our submission addresses the unique challenges of real-time translation of long-form speech by developing a modular cascade system that adapts strong pre-trained models to streaming scenarios. We combine Whisper Large-V3-Turbo for ASR with the multilingual NLLB-3.3B model for MT, implementing lightweight adaptation techniques rather than training new end-to-end models from scratch. Our approach employs document-level adaptation with prefix training to enhance the MT model's ability to handle incomplete inputs, while incorporating adaptive emission policies including a wait-$k$ strategy and RALCP for managing the translation stream. Specialized buffer management techniques and segmentation strategies ensure coherent translations across long audio sequences. Experimental results on the ACL60/60 dataset demonstrate that our system achieves a favorable balance between translation quality and latency, with a BLEU score of 31.96 and non-computational-aware StreamLAAL latency of 2.94 seconds. Our final model achieves a preliminary score on the
This paper presents causal block-diagram models to represent the equations of motion of multi-body systems in a very compact and simple closed form. Both the forward dynamics (from the forces and torques imposed at the various degrees-of-freedom to the motions of these degrees-of-freedom) or the inverse dynamics (from the motions imposed at the degrees-of-freedom to the resulting forces and torques) can be considered and described by a block diagram model. This work extends the Two-Input Two-Output Port (TITOP) theory by including all non-linear terms and uniform or gravitational acceleration fields. Connection among different blocks is possible through the definition of the motion vector. The model of a system composed of a floating base, rigid bodies, revolute and prismatic joints, working under gravity is developed to illustrate the methodology. The proposed model is validated by simulation and cross-checking with a model built using an alternative modeling tool on a scenario where the nonlinear terms are determining.
Existing language learning tools, even those powered by Large Language Models (LLMs), often lack support for polyglot learners to build linguistic connections across vocabularies in multiple languages, provide limited customization for individual learning paces or needs, and suffer from detrimental cognitive offloading. To address these limitations, we design Do-It-Yourself Multilingual Knowledge Graph (DIY-MKG), an open-source system that supports polyglot language learning. DIY-MKG allows the user to build personalized vocabulary knowledge graphs, which are constructed by selective expansion with related words suggested by an LLM. The system further enhances learning through rich annotation capabilities and an adaptive review module that leverages LLMs for dynamic, personalized quiz generation. In addition, DIY-MKG allows users to flag incorrect quiz questions, simultaneously increasing user engagement and providing a feedback loop for prompt refinement. Our evaluation of LLM-based components in DIY-MKG shows that vocabulary expansion is reliable and fair across multiple languages, and that the generated quizzes are highly accurate, validating the robustness of DIY-MKG.
The Controller Area Network (CAN) protocol, essential for automotive embedded systems, lacks inherent security features, making it vulnerable to cyber threats, especially with the rise of autonomous vehicles. Traditional security measures offer limited protection, such as payload encryption and message authentication. This paper presents a novel Intrusion Detection System (IDS) designed for the CAN environment, utilizing Hardware Performance Counters (HPCs) to detect anomalies indicative of cyber attacks. A RISC-V-based CAN receiver is simulated using the gem5 simulator, processing CAN frame payloads with AES-128 encryption as FreeRTOS tasks, which trigger distinct HPC responses. Key HPC features are optimized through data extraction and correlation analysis to enhance classification efficiency. Results indicate that this approach could significantly improve CAN security and address emerging challenges in automotive cybersecurity.
Serverless computing has redefined cloud application deployment by abstracting infrastructure and enabling on-demand, event-driven execution, thereby enhancing developer agility and scalability. However, maintaining consistent application performance in serverless environments remains a significant challenge. The dynamic and transient nature of serverless functions makes it difficult to distinguish between benign and anomalous behavior, which in turn undermines the effectiveness of traditional anomaly detection methods. These conventional approaches, designed for stateful and long-running services, struggle in serverless settings where executions are short-lived, functions are isolated, and observability is limited. In this first comprehensive vision paper on anomaly detection for serverless systems, we systematically explore the unique challenges posed by this paradigm, including the absence of persistent state, inconsistent monitoring granularity, and the difficulty of correlating behaviors across distributed functions. We further examine a range of threats that manifest as anomalies, from classical Denial-of-Service (DoS) attacks to serverless-specific threats such as Denial-of-
The rapid advancement in capabilities of large language models (LLMs) raises a pivotal question: How can LLMs accelerate scientific discovery? This work tackles the crucial first stage of research, generating novel hypotheses. While recent work on automated hypothesis generation focuses on multi-agent frameworks and extending test-time compute, none of the approaches effectively incorporate transparency and steerability through a synergistic Human-in-the-loop (HITL) approach. To address this gap, we introduce IRIS: Interactive Research Ideation System, an open-source platform designed for researchers to leverage LLM-assisted scientific ideation. IRIS incorporates innovative features to enhance ideation, including adaptive test-time compute expansion via Monte Carlo Tree Search (MCTS), fine-grained feedback mechanism, and query-based literature synthesis. Designed to empower researchers with greater control and insight throughout the ideation process. We additionally conduct a user study with researchers across diverse disciplines, validating the effectiveness of our system in enhancing ideation. We open-source our code at https://github.com/Anikethh/IRIS-Interactive-Research-Ideati
This article presents Teledrive, a telepresence robotic system with embodied AI features that empowers an operator to navigate the telerobot in any unknown remote place with minimal human intervention. We conceive Teledrive in the context of democratizing remote care-giving for elderly citizens as well as for isolated patients, affected by contagious diseases. In particular, this paper focuses on the problem of navigating to a rough target area (like bedroom or kitchen) rather than pre-specified point destinations. This ushers in a unique AreaGoal based navigation feature, which has not been explored in depth in the contemporary solutions. Further, we describe an edge computing-based software system built on a WebRTC-based communication framework to realize the aforementioned scheme through an easy-to-use speech-based human-robot interaction. Moreover, to enhance the ease of operation for the remote caregiver, we incorporate a person following feature, whereby a robot follows a person on the move in its premises as directed by the operator. Moreover, the system presented is loosely coupled with specific robot hardware, unlike the existing solutions. We have evaluated the efficacy o
Speaker anonymization is an effective privacy protection solution that conceals the speaker's identity while preserving the linguistic content and paralinguistic information of the original speech. To establish a fair benchmark and facilitate comparison of speaker anonymization systems, the VoicePrivacy Challenge (VPC) was held in 2020 and 2022, with a new edition planned for 2024. In this paper, we describe our proposed speaker anonymization system for VPC 2024. Our system employs a disentangled neural codec architecture and a serial disentanglement strategy to gradually disentangle the global speaker identity and time-variant linguistic content and paralinguistic information. We introduce multiple distillation methods to disentangle linguistic content, speaker identity, and emotion. These methods include semantic distillation, supervised speaker distillation, and frame-level emotion distillation. Based on these distillations, we anonymize the original speaker identity using a weighted sum of a set of candidate speaker identities and a randomly generated speaker identity. Our system achieves the best trade-off of privacy protection and emotion preservation in VPC 2024.
Scientific literature searches are often exploratory, whereby users are not yet familiar with a particular field or concept but are interested in learning more about it. However, existing systems for scientific literature search are typically tailored to keyword-based lookup searches, limiting the possibilities for exploration. We propose NLP-KG, a feature-rich system designed to support the exploration of research literature in unfamiliar natural language processing (NLP) fields. In addition to a semantic search, NLP-KG allows users to easily find survey papers that provide a quick introduction to a field of interest. Further, a Fields of Study hierarchy graph enables users to familiarize themselves with a field and its related areas. Finally, a chat interface allows users to ask questions about unfamiliar concepts or specific articles in NLP and obtain answers grounded in knowledge retrieved from scientific publications. Our system provides users with comprehensive exploration possibilities, supporting them in investigating the relationships between different fields, understanding unfamiliar concepts in NLP, and finding relevant research literature. Demo, video, and code are avai