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This report documents the development and evaluation of domain-specific language models for neurology. Initially focused on building a bespoke model, the project adapted to rapid advances in open-source and commercial medical LLMs, shifting toward leveraging retrieval-augmented generation (RAG) and representational models for secure, local deployment. Key contributions include the creation of neurology-specific datasets (case reports, QA sets, textbook-derived data), tools for multi-word expression extraction, and graph-based analyses of medical terminology. The project also produced scripts and Docker containers for local hosting. Performance metrics and graph community results are reported, with future possible work open for multimodal models using open-source architectures like phi-4.

Abnormal head movements (AHMs) manifest across a broad spectrum of neurological disorders; however, the absence of a multi-condition resource integrating kinematic measurements, clinical severity scores, and patient demographics constitutes a persistent barrier to the development of AI-driven diagnostic tools. To address this gap, this study introduces NeuroPose-AHM, a knowledge-based dataset of neurologically induced AHMs constructed through a multi-LLM extraction framework applied to 1,430 peer-reviewed publications. The dataset contains 2,756 patient-group-level records spanning 57 neurological conditions, derived from 846 AHM-relevant papers. Inter-LLM reliability analysis confirms robust extraction performance, with study-level classification achieving strong agreement (kappa = 0.822). To demonstrate the dataset's analytical utility, a four-task framework is applied to cervical dystonia (CD), the condition most directly defined by pathological head movement. First, Task 1 performs multi-label AHM type classification (F1 = 0.856). Task 2 constructs the Head-Neck Severity Index (HNSI), a unified metric that normalizes heterogeneous clinical rating scales. The clinical relevance

Patients with rare neurological diseases report cognitive symptoms -"brain fog"- invisible to traditional tests. We propose continuous neurocognitive monitoring via smartphone speech analysis integrated with Relational Graph Transformer (RELGT) architectures. Proof-of-concept in phenylketonuria (PKU) shows speech-derived "Proficiency in Verbal Discourse" correlates with blood phenylalanine (p = -0.50, p < 0.005) but not standard cognitive tests (all |r| < 0.35). RELGT could overcome information bottlenecks in heterogeneous medical data (speech, labs, assessments), enabling predictive alerts weeks before decompensation. Key challenges: multi-disease validation, clinical workflow integration, equitable multilingual deployment. Success would transform episodic neurology into continuous personalized monitoring for millions globally.

Large language models (LLMs) have shown promise in medical domains, but their ability to handle specialized neurological reasoning requires systematic evaluation. We developed a comprehensive benchmark using 305 questions from Israeli Board Certification Exams in Neurology, classified along three complexity dimensions: factual knowledge depth, clinical concept integration, and reasoning complexity. We evaluated ten LLMs using base models, retrieval-augmented generation (RAG), and a novel multi-agent system. Results showed significant performance variation. OpenAI-o1 achieved the highest base performance (90.9% accuracy), while specialized medical models performed poorly (52.9% for Meditron-70B). RAG provided modest benefits but limited effectiveness on complex reasoning questions. In contrast, our multi-agent framework, decomposing neurological reasoning into specialized cognitive functions including question analysis, knowledge retrieval, answer synthesis, and validation, achieved dramatic improvements, especially for mid-range models. The LLaMA 3.3-70B-based agentic system reached 89.2% accuracy versus 69.5% for its base model, with substantial gains on level 3 complexity questio

While imaging-genetics holds great promise for unraveling the complex interplay between brain structure and genetic variation in neurological disorders, traditional methods are limited to simplistic linear models or to black-box techniques that lack interpretability. In this paper, we present NeuroPathX, an explainable deep learning framework that uses an early fusion strategy powered by cross-attention mechanisms to capture meaningful interactions between structural variations in the brain derived from MRI and established biological pathways derived from genetics data. To enhance interpretability and robustness, we introduce two loss functions over the attention matrix - a sparsity loss that focuses on the most salient interactions and a pathway similarity loss that enforces consistent representations across the cohort. We validate NeuroPathX on both autism spectrum disorder and Alzheimer's disease. Our results demonstrate that NeuroPathX outperforms competing baseline approaches and reveals biologically plausible associations linked to the disorder. These findings underscore the potential of NeuroPathX to advance our understanding of complex brain disorders. Code is available at

Accurate decoding of EEG signals requires comprehensive modeling of both temporal dynamics within individual channels and spatial dependencies across channels. While Transformer-based models utilizing channel-independence (CI) strategies have demonstrated strong performance in various time series tasks, they often overlook the inter-channel correlations that are critical in multivariate EEG signals. This omission can lead to information degradation and reduced prediction accuracy, particularly in complex tasks such as neurological outcome prediction. To address these challenges, we propose Biaxialformer, characterized by a meticulously engineered two-stage attention-based framework. This model independently captures both sequence-specific (temporal) and channel-specific (spatial) EEG information, promoting synergy and mutual reinforcement across channels without sacrificing CI. By employing joint learning of positional encodings, Biaxialformer preserves both temporal and spatial relationships in EEG data, mitigating the interchannel correlation forgetting problem common in traditional CI models. Additionally, a tokenization module with variable receptive fields balance the extracti

Neurological conditions affecting visual perception create profound experiential divides between affected individuals and their caregivers, families, and medical professionals. We present the Perceptual Reality Transformer, a comprehensive framework employing six distinct neural architectures to simulate eight neurological perception conditions with scientifically-grounded visual transformations. Our system learns mappings from natural images to condition-specific perceptual states, enabling others to experience approximations of simultanagnosia, prosopagnosia, ADHD attention deficits, visual agnosia, depression-related changes, anxiety tunnel vision, and Alzheimer's memory effects. Through systematic evaluation across ImageNet and CIFAR-10 datasets, we demonstrate that Vision Transformer architectures achieve optimal performance, outperforming traditional CNN and generative approaches. Our work establishes the first systematic benchmark for neurological perception simulation, contributes novel condition-specific perturbation functions grounded in clinical literature, and provides quantitative metrics for evaluating simulation fidelity. The framework has immediate applications in m

Psychological resilience, defined as the ability to rebound from adversity, is crucial for mental health. Compared with traditional resilience assessments through self-reported questionnaires, resilience assessments based on neurological data offer more objective results with biological markers, hence significantly enhancing credibility. This paper proposes a novel data-efficient model to address the scarcity of neurological data. We employ Neuro Kolmogorov-Arnold Networks as the structure of the prediction model. In the training stage, a new trait-informed multimodal representation algorithm with a smart chunk technique is proposed to learn the shared latent space with limited data. In the test stage, a new noise-informed inference algorithm is proposed to address the low signal-to-noise ratio of the neurological data. The proposed model not only shows impressive performance on both public datasets and self-constructed datasets but also provides some valuable psychological hypotheses for future research.

Voice-based health assessment offers unprecedented opportunities for scalable, non-invasive disease screening, yet existing approaches typically focus on single conditions and fail to leverage the rich, multi-faceted information embedded in speech. We present MARVEL (Multi-task Acoustic Representations for Voice-based Health Analysis), a privacy-conscious multitask learning framework that simultaneously detects nine distinct neurological, respiratory, and voice disorders using only derived acoustic features, eliminating the need for raw audio transmission. Our dual-branch architecture employs specialized encoders with task-specific heads sharing a common acoustic backbone, enabling effective cross-condition knowledge transfer. Evaluated on the large-scale Bridge2AI-Voice v2.0 dataset, MARVEL achieves an overall AUROC of 0.78, with exceptional performance on neurological disorders (AUROC = 0.89), particularly for Alzheimer's disease/mild cognitive impairment (AUROC = 0.97). Our framework consistently outperforms single-modal baselines by 5-19% and surpasses state-of-the-art self-supervised models on 7 of 9 tasks, while correlation analysis reveals that the learned representations ex

The Congress of Neurological Surgeons Self-Assessment for Neurological Surgeons (CNS-SANS) questions are widely used by neurosurgical residents to prepare for written board examinations. Recently, these questions have also served as benchmarks for evaluating large language models' (LLMs) neurosurgical knowledge. This study aims to assess the performance of state-of-the-art LLMs on neurosurgery board-like questions and to evaluate their robustness to the inclusion of distractor statements. A comprehensive evaluation was conducted using 28 large language models. These models were tested on 2,904 neurosurgery board examination questions derived from the CNS-SANS. Additionally, the study introduced a distraction framework to assess the fragility of these models. The framework incorporated simple, irrelevant distractor statements containing polysemous words with clinical meanings used in non-clinical contexts to determine the extent to which such distractions degrade model performance on standard medical benchmarks. 6 of the 28 tested LLMs achieved board-passing outcomes, with the top-performing models scoring over 15.7% above the passing threshold. When exposed to distractions, accurac

Large-scale models pre-trained on Electroencephalography (EEG) have shown promise in clinical applications such as neurological disorder detection. However, the practical deployment of EEG-based large-scale models faces critical challenges such as limited labeled EEG data and suboptimal performance in clinical scenarios. To address these issues, we propose NeuroDx-LM, a novel large-scale model specifically designed for detecting EEG-based neurological disorders. Our key contributions include (i) a Selective Temporal-Frequency Embedding mechanism that adaptively captures complex temporal and spectral patterns in EEG signals; and (ii) a Progressive Feature-Aware Training strategy that refines feature representation in a two-stage process. In the first stage, our model learns the fundamental discriminative features of EEG activities; in the second stage, the model further extracts more specialized fine-grained features for accurate diagnostic performance. We evaluated NeuroDx-LM on the CHB-MIT and Schizophrenia datasets, achieving state-of-the-art performance in EEG-based seizure and schizophrenia detection, respectively. These results demonstrate the great potential of EEG-based larg

Neurological diseases are the leading global cause of disability, yet most lack disease-modifying treatments. We present PROTON, a heterogeneous graph transformer that generates testable hypotheses across molecular, organoid, and clinical systems. To evaluate PROTON, we apply it to Parkinson's disease (PD), bipolar disorder (BD), and Alzheimer's disease (AD). In PD, PROTON linked genetic risk loci to genes essential for dopaminergic neuron survival and predicted pesticides toxic to patient-derived neurons, including the insecticide endosulfan, which ranked within the top 1.29% of predictions. In silico screens performed by PROTON reproduced six genome-wide $α$-synuclein experiments, including a split-ubiquitin yeast two-hybrid system (normalized enrichment score [NES] = 2.30, FDR-adjusted $p < 1 \times 10^{-4}$), an ascorbate peroxidase proximity labeling assay (NES = 2.16, FDR $< 1 \times 10^{-4}$), and a high-depth targeted exome sequencing study in 496 synucleinopathy patients (NES = 2.13, FDR $< 1 \times 10^{-4}$). In BD, PROTON predicted calcitriol as a candidate drug that reversed proteomic alterations observed in cortical organoids derived from BD patients. In AD, w

Neurological disorders pose major global health challenges, driving advances in brain signal analysis. Scalp electroencephalography (EEG) and intracranial EEG (iEEG) are widely used for diagnosis and monitoring. However, dataset heterogeneity and task variations hinder the development of robust deep learning solutions. This review systematically examines recent advances in deep learning approaches for EEG/iEEG-based neurological diagnostics, focusing on applications across 7 neurological conditions using 46 datasets. For each condition, we review representative methods and their quantitative results, integrating performance comparisons with analyses of data usage, model design, and task-specific adaptations, while highlighting the role of pre-trained multi-task models in achieving scalable, generalizable solutions. Finally, we propose a standardized benchmark to evaluate models across diverse datasets and improve reproducibility, emphasizing how recent innovations are transforming neurological diagnostics toward intelligent, adaptable healthcare systems.

Rule-based explanation methods offer rigorous and globally interpretable insights into neural network behavior. However, existing approaches are mostly limited to small fully connected networks and depend on costly layerwise rule extraction and substitution processes. These limitations hinder their generalization to more complex architectures such as Transformers. Moreover, existing methods produce shallow, decision-tree-like rules that fail to capture rich, high-level abstractions in complex domains like computer vision and natural language processing. To address these challenges, we propose NEUROLOGIC, a novel framework that extracts interpretable logical rules directly from deep neural networks. Unlike previous methods, NEUROLOGIC can construct logic rules over hidden predicates derived from neural representations at any chosen layer, in contrast to costly layerwise extraction and rewriting. This flexibility enables broader architectural compatibility and improved scalability. Furthermore, NEUROLOGIC supports richer logical constructs and can incorporate human prior knowledge to ground hidden predicates back to the input space, enhancing interpretability. We validate NEUROLOGIC

Pathologically altered iron levels, detected using iron-sensitive MRI techniques such as quantitative susceptibility mapping (QSM), are observed in neurological disorders such as multiple sclerosis (MS) and may play a crucial role in disease pathophysiology. However, brain iron changes occur slowly, even in neurological diseases, and can be influenced by physiological factors such as diet. Therefore, novel analysis methods are needed to improve sensitivity to disease-related iron changes as compared to conventional region-based analysis methods. This study introduces IRONMAP, Iron Network Mapping and Analysis Protocol, which is a novel network-based analysis method to evaluate over-time changes in magnetic susceptibility. With this novel methodology, we analyzed short-term (<1 year) longitudinal QSM data from a cohort of individuals with MS (pwMS) and healthy controls (HCs) and assessed disease-related network patterns, comparing the new approach to a conventional per-region rate-of-change method. IRONMAP analysis was able to detect over-time, MS-related brain iron abnormalities that were undetectable using the rate-of-change approach. IRONMAP was applicable on the per-subject l

Deep learning-based EEG classification is crucial for the automated detection of neurological disorders, improving diagnostic accuracy and enabling early intervention. However, the low signal-to-noise ratio of EEG signals limits model performance, making feature selection (FS) vital for optimizing representations learned by neural network encoders. Existing FS methods are seldom designed specifically for EEG diagnosis; many are architecture-dependent and lack interpretability, limiting their applicability. Moreover, most rely on single-iteration data, resulting in limited robustness to variability. To address these issues, we propose IEFS-GMB, an Information Entropy-based Feature Selection method guided by a Gradient Memory Bank. This approach constructs a dynamic memory bank storing historical gradients, computes feature importance via information entropy, and applies entropy-based weighting to select informative EEG features. Experiments on four public neurological disease datasets show that encoders enhanced with IEFS-GMB achieve accuracy improvements of 0.64% to 6.45% over baseline models. The method also outperforms four competing FS techniques and improves model interpretabil

Canine gait analysis using wearable inertial sensors is gaining attention in veterinary clinical settings, as it provides valuable insights into a range of mobility impairments. Neurological and orthopedic conditions cannot always be easily distinguished even by experienced clinicians. The current study explored and developed a deep learning approach using inertial sensor readings to assess whether neurological and orthopedic gait could facilitate gait analysis. Our investigation focused on optimizing both performance and generalizability in distinguishing between these gait abnormalities. Variations in sensor configurations, assessment protocols, and enhancements to deep learning model architectures were further suggested. Using a dataset of 29 dogs, our proposed approach achieved 96% accuracy in the multiclass classification task (healthy/orthopedic/neurological) and 82% accuracy in the binary classification task (healthy/non-healthy) when generalizing to unseen dogs. Our results demonstrate the potential of inertial-based deep learning models to serve as a practical and objective diagnostic and clinical aid to differentiate gait assessment in orthopedic and neurological conditio