共找到 20 条结果
A newly identified protein may be one of the biggest obstacles holding CAR T-cell therapy back。 Researchers found that NFIL3 causes these engineered immune cells to become exhausted and lose their cancer-fighting power over time。 When NFIL3 was disabled, the cells remained stronger for longer and controlled tumors more effectively in animal models
Holding is one of the most commonly used real–time control strategies in transit operations. Given a transit network and its operations plan, the holding problem is to decide at a given time at a control station, which vehicle is to be held and for how long, such that the total passenger cost along the route is minimized over a time period. Previous research on the holding problem has always assumed no real–time information available. Such an assumption not only poses great difficulties in solving the problem, but also limits practical applications in a real–time, dynamic operations environment. In this paper we formulate the holding problem as a deterministic quadratic program in a rolling horizon scheme, and develop an efficient solution algorithm to solve it. Using headway data collected by an automated system, we tested the algorithm and evaluated the impact of the resulting holding policies. Important and interesting properties of the holding solution, obtained from both theoretical and computational analyses, are presented.
Previous studies report that cash holdings are more valuable for financially constrained firms than for unconstrained firms. We examine (i) why this is so and (ii) why some constrained firms appear to hold too little cash. Our results indicate that greater cash holdings are associated with higher levels of investment for constrained firms with high hedging needs and that the association between investment and value is stronger for constrained firms than for unconstrained firms. These findings imply that higher cash holdings allow constrained firms to undertake value-increasing projects that might otherwise be bypassed. We further find that some constrained firms exhibit low cash holdings because of persistently low cash flows. Overall, our findings support the view that greater cash holdings of constrained firms are a value-increasing response to costly external financing. The Author 2009. Published by Oxford University Press on behalf of The Society for Financial Studies. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org., Oxford University Press.
In many countries holders of patents must pay an annual renewal fee in order to keep their patents in force. This paper uses data on the proportion of patents renewed, and the renewal fees faced by, post World War II cohorts of patents in France, the United Kingdom, and Germany, in conjunction with a model of patent holders' renewal decisions, to estimate the returns earned from holding patents in these countries. Since patents are often applied for at a nearly stage in the innovation process, the model allows agents to be uncertain about the sequence of returns that will be earned if the patent is kept inforce. Formally, then, the paper presents and solves a discrete choice optimal stochastic control model, derives the implications of the model on aggregate behaviour, and then estimates the parameters of the model from aggregate data. The estimates enable a detailed description of the evolution of the distribution of returns earned from holding patents over their life spans,and calculations of both; the annual returns earned from holding the patents still in force (or the patent stocks) in the alternative countries, and the distribution of the discounted value of returns earned from holding the patents in a cohort.
ABSTRACT We examine the relation between institutional holdings and payout policy in U.S. public firms. We find that payout policy affects institutional holdings. Institutions avoid firms that do not pay dividends. However, among dividend‐paying firms they prefer firms that pay fewer dividends. Our evidence indicates that institutions prefer firms that repurchase shares, and regular repurchasers over nonregular repurchasers. Higher institutional holdings or a concentration of holdings do not cause firms to increase their dividends, their repurchases, or their total payout. Our results do not support models that predict that high dividends attract institutional clientele, or models that predict that institutions cause firms to increase payout.
ABSTRACT Agency theories predict that the value of corporate cash holdings is less in countries with poor investor protection because of the greater ability of controlling shareholders to extract private benefits from cash holdings in such countries. Using various specifications of the valuation regressions of Fama and French (1998) , we find that the relation between cash holdings and firm value is much weaker in countries with poor investor protection than in other countries. In further support of the importance of agency theories, the relation between dividends and firm value is weaker in countries with stronger investor protection.
Building on an inductive, qualitative study of independent workers—people not affiliated with an organization or established profession—this paper develops a theory about the management of precarious and personalized work identities. We find that in the absence of organizational or professional membership, workers experience stark emotional tensions encompassing both the anxiety and fulfillment of working in precarious and personal conditions. Lacking the holding environment provided by an organization, the workers we studied endeavored to create one for themselves through cultivating connections to routines, places, people, and a broader purpose. These personal holding environments helped them manage the broad range of emotions stirred up by their precarious working lives and focus on producing work that let them define, express, and develop their selves. Thus holding environments transformed workers’ precariousness into a tolerable and even generative predicament. By clarifying the process through which people manage emotions associated with precarious and personalized work identities, and thereby render their work identities viable and their selves vital, this paper advances theorizing on the emotional underpinnings of identity work and the systems psychodynamics of independent work.
Researchers discovered a way to reverse the direction of energy flow in turbulence, challenging a theory that has stood for more than 80 years。 The finding could open new possibilities for controlling ocean currents, improving medical technologies, and enhancing climate forecasting
NASA's James Webb Space Telescope has uncovered unusual chemistry in interstellar comet 3I/ATLAS, including the first direct detection of methane on a visitor from another star system。 The comet also contains exceptionally high levels of carbon dioxide, making it unlike most comets born in our solar system。 Scientists believe the methane was hidden
A decades-old mystery about Saturn has finally been solved thanks to the James Webb Space Telescope。 Scientists discovered that Saturn’s changing “rotation rate” was never caused by the planet speeding up or slowing down, but by powerful winds high in its atmosphere。 Webb’s unprecedented observations revealed that Saturn’s northern lights actively
Scientists at Lawrence Livermore National Laboratory recreated part of the intense chaos inside a nuclear fireball to better understand how radioactive fallout forms。 Their experiments revealed that the way vaporized materials cool can dramatically change the particles that eventually form, especially for volatile elements like cesium
A breakthrough lithium-extraction method could help solve one of clean energy’s dirtiest problems。 Researchers at Columbia Engineering have developed a fast new technique that pulls lithium directly from salty underground brines using a temperature-sensitive solvent, avoiding the giant evaporation ponds that can take years and drain precious water
Scientists have created a tiny chip that can generate, steer, and read light-based information all in one device, marking a major leap toward ultra-fast, energy-efficient computing。 The breakthrough uses atomically thin materials and nanoscale structures to control a unique quantum property of light called the “valley” degree of freedom, allowing i
With the case confirmed, it is the fly's first breach of the US-Mexico border
A mysterious particle from deep space has scientists buzzing after the most energetic neutrino ever detected slammed through the Mediterranean Sea。 Now, researchers think they may have identified the cosmic “culprits” behind it: blazars — supermassive black holes blasting jets of matter straight toward Earth
Astronomers have finally cracked the mystery behind a strange class of repeating cosmic signals that has baffled scientists for years。 Using Australia’s ASKAP radio telescope, researchers traced the bursts to a rare stellar duo in which a dense white dwarf is relentlessly siphoning material from a nearby red dwarf companion。 As the stolen matter sp
Scientists have uncovered a surprising new way to control superconductivity — the mysterious phenomenon where electricity flows with zero energy loss。 By pairing twisted layers of graphene with a synthetic diamond material, researchers were able to effectively switch superconductivity on and off by tweaking how electrons interact with their surroun