Objective. As proton arc therapy (PAT) approaches clinical implementation, optimizing treatment plans for this innovative delivery modality remains challenging, especially in addressing arc delivery time. Existing algorithms for minimizing delivery time are either optimal but computationally demanding or fast but at the expense of sacrificing many degrees of freedom. In this study, we introduce a flexible method for pre-selecting energy layers (EL) in PAT treatment planning before the actual robust spot weight optimization. Our EL pre-selection method employs metaheuristics to minimize a bi-objective function, considering a dynamic delivery time proxy and tumor geometrical coverage penalized as a function of selected organs-at-risk crossing. It is capable of parallelizing multiple instances of the problem. We evaluate the method using three different treatment sites, providing a comprehensive dosimetric analysis benchmarked against dynamic proton arc plans generated with early energy layer selection and spot assignment (ELSA) and IMPT plans in RayStation TPS. The algorithm efficiently generates Pareto-optimal EL pre-selections in approximately 5 minutes. Subsequent PAT treatment pl
A new sequence for single-voxel diffusion-weighted 1H MRS (DWS), named DW-SPECIAL, is proposed to improve the detection and subsequent estimation of the diffusion properties of strongly J-coupled metabolites. It combines the semi-adiabatic SPECIAL sequence with a stimulated echo (STE) diffusion block. Acquisitions with DW-SPECIAL and STE-LASER, the current gold-standard for rodent DWS experiments at high fields, were performed at 14.1T on phantoms and in vivo on the rat brain. The apparent diffusion coefficient and intra-stick diffusivity (Callaghan's model) were fitted and compared between the sequences for glutamate, glutamine (Gln), myo-inositol, taurine, total N-acetylaspartate, total choline, total creatine and the macromolecules. The shorter echo time achieved with DW-SPECIAL (18 ms against 33 ms with STE-LASER) substantially limited the metabolites' signal loss caused by J-evolution. In addition, DW-SPECIAL preserved the main advantages of STE-LASER: absence of cross-terms, diffusion time during a STE and limited sensitivity to B1 inhomogeneities. In vivo, compared to STE-LASER, DW-SPECIAL yielded the same spectral quality and reduced the Cramer Rao Lower Bounds (CRLB) for J
A rare meteorite has revealed evidence of a massive lost world that once orbited the young Sun before being destroyed in a catastrophic collision。 The discovery suggests some early planets formed from dramatically different materials than Earth and Mars, rewriting part of the solar system’s origin story
Scientists have uncovered a new explanation for what powers Yellowstone and other supervolcanoes。 Instead of a deep plume rising from near Earth’s core, a broad “mantle wind” may push hot rock beneath Yellowstone, generating magma closer to the surface。 This process helps create a massive underground magma network and may explain how supervolcanoes
Researchers have proposed that black holes stop evaporating at the last moment, leaving behind tiny remnants that preserve all the information they contain。 The same seven-dimensional geometry behind this idea could also help explain why elementary particles have mass
Two newly confirmed "super-puff" planets are so diffuse that they are less dense than cotton candy, despite being about the size of Jupiter。 Their rare orbital relationship and enormous, lightweight atmospheres could provide valuable clues about how some of the strangest planets in the galaxy come to exist
A new AI-powered framework could transform how astronomers measure the expansion of the Universe。 By analyzing images of Type Ia supernovae and modeling their environments in unprecedented detail, researchers can estimate cosmic distances with near-spectroscopic accuracy。 The technique is designed for the flood of data expected from the upcoming Ve
A strange gamma-ray glow at the center of the Milky Way has long sparked debate over whether it comes from hidden neutron stars or elusive dark matter。 By applying machine learning to more than a million simulated observations, researchers included photon energy data for the first time and reached a different conclusion than many earlier studies
Hubble has captured a spectacular view of LH 95, where about 2,500 young stars are still on their journey to becoming full-fledged stars。 Scientists discovered these growing stars can keep pulling in gas and dust for millions of years, extending an important stage of stellar development。 The region also contains multiple generations of stars living
The discovery underscores the increased effort being poured into Mac infostealers
An unusual gravitational wave signal has renewed hopes that primordial black holes, long considered purely theoretical, may finally be within reach of discovery。 If confirmed, they could solve one of astronomy's greatest mysteries by explaining the nature of dark matter
We analyse the model of Tuberculosis due to Blower (Nature Medecine 1(8) 815-821) from the point of view of symmetry and singularity analysis. From the study we provide a demonstration of the integrability of the model to present an explicit solution.
The EU went after Google for the practice of bundling its search engine and browser with Android
A colossal ancient collision may have left some of the Moon’s deepest secrets surprisingly close to future Artemis landing sites。 By recreating the impact that formed the giant South Pole-Aitken basin—the Moon’s largest and oldest crater—scientists found that a low-angle strike from a large, iron-cored object blasted material from deep inside the M
Astronomers may have witnessed one of the rarest and most dramatic cosmic events ever seen: a long-sought intermediate-mass black hole ripping apart a dense white dwarf star and devouring it。 The Einstein Probe space telescope caught the explosion in its earliest moments, revealing an unusual sequence of intense X-ray flashes unlike anything seen i
A new study suggests Earth may have been sending tiny hitchhikers to Venus for billions of years。 Researchers found that asteroid impacts could launch microbes into space, where some might survive the journey and end up suspended in Venus' clouds。 If future missions detect life there, there's a surprising chance it didn't originate on Venus at all—
Scientists have uncovered a surprising connection between quantum gravity and an exotic quantum state of matter that could explain why the universe isn’t expanding wildly fast。 The study suggests that the very shape of space-time may protect the cosmological constant from disruptive quantum effects