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This study reports the foundations, strategies, and results of an institutional change experience based on the combination of participatory-action-research and new currents of collective mobilization and political participation. It aimed to achieve the institution's greater social commitment and a more participatory and transparent management. The process took place in a Spanish public university and was promoted and coordinated by a Work Group that emerged from grassroots university community. Collective diagnosis was performed through face-to-face strategies (global, sectorial, and faculty meetings) and virtual tools (web-blog, on-line surveys, shared documents). Collective action combined nonformal with formal institutional participation and applied hybrid activism, self-organization in horizontal structures and integrative conflict management. A sequential process of diagnosis, collective action, and negotiation was implemented. As a result, the university Governing Team, representatives from different sectors and members of the Work Group worked jointly to define several institutional actions that were thereafter launched. Those actions aimed to improve institutional participation and transparency, and greater institutional social commitment. The combination of participatory-action-research and new ways of collective action can be an excellent tool to draw institutions towards greater social engagement, thus contributing to sustainable social change. A model to guide institutional change is drafted.
Cancerogenesis is driven by mutations leading to aberrant functioning of a complex network of molecular interactions and simultaneously affecting multiple cellular functions. Therefore, the successful application of bioinformatics and systems biology methods for analysis of high-throughput data in cancer research heavily depends on availability of global and detailed reconstructions of signalling networks amenable for computational analysis. We present here the Atlas of Cancer Signalling Network (ACSN), an interactive and comprehensive map of molecular mechanisms implicated in cancer. The resource includes tools for map navigation, visualization and analysis of molecular data in the context of signalling network maps. Constructing and updating ACSN involves careful manual curation of molecular biology literature and participation of experts in the corresponding fields. The cancer-oriented content of ACSN is completely original and covers major mechanisms involved in cancer progression, including DNA repair, cell survival, apoptosis, cell cycle, EMT and cell motility. Cell signalling mechanisms are depicted in detail, together creating a seamless 'geographic-like' map of molecular interactions frequently deregulated in cancer. The map is browsable using NaviCell web interface using the Google Maps engine and semantic zooming principle. The associated web-blog provides a forum for commenting and curating the ACSN content. ACSN allows uploading heterogeneous omics data from users on top of the maps for visualization and performing functional analyses. We suggest several scenarios for ACSN application in cancer research, particularly for visualizing high-throughput data, starting from small interfering RNA-based screening results or mutation frequencies to innovative ways of exploring transcriptomes and phosphoproteomes. Integration and analysis of these data in the context of ACSN may help interpret their biological significance and formulate mechanistic hypotheses. ACSN may also support patient stratification, prediction of treatment response and resistance to cancer drugs, as well as design of novel treatment strategies.
"This is not COVID," and other reasons why risk to the public is currently low
Curiosity has detected a surprising variety of organic molecules on Mars, including compounds tied to the chemistry of life。 Some of these molecules may be billions of years old, preserved in ancient clay-rich rocks that once held water。 One standout find resembles building blocks of DNA, raising exciting questions about Mars’ past
Astronomers have unleashed a powerful new AI tool called RAVEN to comb through data from NASA’s TESS mission—and it’s paying off in a big way。 By analyzing millions of stars, the system has confirmed over 100 exoplanets, including 31 brand-new worlds, and identified thousands more promising candidates。 What makes this especially exciting is the dis
A team at the University of Hong Kong has developed a new “super steel” that can survive the harsh conditions needed to make green hydrogen from seawater。 The material uses an unexpected double-protection mechanism that resists corrosion far better than conventional stainless steel。 Even more impressive, it could replace costly titanium parts used
The plan isn't final and could change, but his ouster would be no surprise
Physicists are rethinking one of quantum mechanics’ biggest puzzles: how fuzzy possibilities become definite reality。 New research suggests that spontaneous “collapse” processes—possibly linked to gravity—could subtly blur time itself。 This wouldn’t affect clocks we use today, but it reveals a hidden limit to how precise time can ever be
Penn researchers have developed a smarter AI method for solving notoriously difficult inverse equations, which help scientists uncover hidden causes behind observable effects。 By introducing “mollifier layers” that smooth noisy data, they’ve made these calculations more stable and far less computationally demanding。 This could transform fields like
A group of undergraduate students pulled off something remarkable: they built their own dark matter detector and used it to probe one of physics’ biggest mysteries。 Working with limited resources but plenty of creativity, they designed a stripped-down experiment to hunt for axions — hypothetical particles that could make up dark matter
For decades, relaxor ferroelectrics have powered everything from medical ultrasounds to sonar systems, yet their inner atomic structure remained a mystery—until now。 Researchers have finally mapped their three-dimensional structure in unprecedented detail, uncovering hidden patterns in how electric charges are arranged at the nanoscale。 The breakth
A bizarre planetary pairing 190 light-years away is challenging everything astronomers thought they knew about how worlds form。 A “lonely” hot Jupiter — typically found without nearby companions — is sharing its system with a smaller mini-Neptune tucked even closer to the star, a setup once thought nearly impossible
A scorching, airless world just 48 light-years away is offering scientists a rare glimpse into the geology of distant planets。 Using the James Webb Space Telescope, researchers studied LHS 3844 b—a tidally locked “super-Earth” with a permanent dayside hot enough to melt metal—and discovered it’s a dark, barren rock with no atmosphere
Voyager 1 just powered down a nearly 50-year-old instrument to stay alive in deep space。 The spacecraft is running critically low on energy, forcing NASA to make careful sacrifices to keep its mission going。 Despite the shutdown, it continues to send back unique data from beyond our solar system
The Universe’s biggest black holes may not be born giants after all。 Scientists analyzing gravitational-wave signals from dozens of black hole collisions found evidence that the heaviest black holes are likely “cosmic recyclers” — formed through repeated smashups inside incredibly crowded star clusters。 These violent chain reactions appear to creat
Astronomers have spotted something surprising in the far outer Solar System—a faint, short-lived atmosphere clinging to a tiny icy world that shouldn’t be able to hold one at all。 The object, called 2002 XV93, is far smaller than Pluto, yet observations during a rare stellar alignment revealed its presence through a subtle dimming of starlight。 Eve
A powerful new electromagnetic thruster has taken a major step forward after a successful high-energy test at NASA’s Jet Propulsion Laboratory。 Fueled by lithium vapor and driven by intense magnetic forces, the experimental engine reached record-breaking power levels—far beyond anything currently used in space。 Glowing hotter than molten lava and f