共找到 20 条结果
Reliability coefficients often take the form of intraclass correlation coefficients. In this article, guidelines are given for choosing among six different forms of the intraclass correlation for reliability studies in which n target are rated by k judges. Relevant to the choice of the coefficient are the appropriate statistical model for the reliability and the application to be made of the reliability results. Confidence intervals for each of the forms are reviewed.
暂无摘要（点击查看原文获取完整内容）
暂无摘要（点击查看原文获取完整内容）
We present an efficient scheme for calculating the Kohn-Sham ground state of metallic systems using pseudopotentials and a plane-wave basis set. In the first part the application of Pulay's DIIS method (direct inversion in the iterative subspace) to the iterative diagonalization of large matrices will be discussed. Our approach is stable, reliable, and minimizes the number of order ${\mathit{N}}_{\mathrm{atoms}}^{3}$ operations. In the second part, we will discuss an efficient mixing scheme also based on Pulay's scheme. A special ``metric'' and a special ``preconditioning'' optimized for a plane-wave basis set will be introduced. Scaling of the method will be discussed in detail for non-self-consistent and self-consistent calculations. It will be shown that the number of iterations required to obtain a specific precision is almost independent of the system size. Altogether an order ${\mathit{N}}_{\mathrm{atoms}}^{2}$ scaling is found for systems containing up to 1000 electrons. If we take into account that the number of k points can be decreased linearly with the system size, the overall scaling can approach ${\mathit{N}}_{\mathrm{atoms}}$. We have implemented these algorithms within a powerful package called VASP (Vienna ab initio simulation package). The program and the techniques have been used successfully for a large number of different systems (liquid and amorphous semiconductors, liquid simple and transition metals, metallic and semiconducting surfaces, phonons in simple metals, transition metals, and semiconductors) and turned out to be very reliable. \textcopyright{} 1996 The American Physical Society.
A representation and interpretation of the area under a receiver operating characteristic (ROC) curve obtained by the "rating" method, or by mathematical predictions based on patient characteristics, is presented. It is shown that in such a setting the area represents the probability that a randomly chosen diseased subject is (correctly) rated or ranked with greater suspicion than a randomly chosen non-diseased subject. Moreover, this probability of a correct ranking is the same quantity that is estimated by the already well-studied nonparametric Wilcoxon statistic. These two relationships are exploited to (a) provide rapid closed-form expressions for the approximate magnitude of the sampling variability, i.e., standard error that one uses to accompany the area under a smoothed ROC curve, (b) guide in determining the size of the sample required to provide a sufficiently reliable estimate of this area, and (c) determine how large sample sizes should be to ensure that one can statistically detect differences in the accuracy of diagnostic techniques.
BACKGROUND: Most older adults prefer to age in place, and supporting older adults to remain in their own homes and communities is also favored by policy makers. Technology can play a role in staying independent, active and healthy. However, the use of technology varies considerably among older adults. Previous research indicates that current models of technology acceptance are missing essential predictors specific to community-dwelling older adults. Furthermore, in situ research within the specific context of aging in place is scarce, while this type of research is needed to better understand how and why community-dwelling older adults are using technology. OBJECTIVE: To explore which factors influence the level of use of various types of technology by older adults who are aging in place and to describe these factors in a comprehensive model. METHODS: A qualitative explorative field study was set up, involving home visits to 53 community-dwelling older adults, aged 68-95, living in the Netherlands. Purposive sampling was used to include participants with different health statuses, living arrangements, and levels of technology experience. During each home visit: (1) background information on the participants' chronic conditions, major life events, frailty, cognitive functioning, subjective health, ownership and use of technology was gathered, and (2) a semistructured interview was conducted regarding reasons for the level of use of technology. The study was designed to include various types of technology that could support activities of daily living, personal health or safety, mobility, communication, physical activity, personal development, and leisure activities. Thematic analysis was employed to analyze interview transcripts. RESULTS: The level of technology use in the context of aging in place is influenced by six major themes: challenges in the domain of independent living; behavioral options; personal thoughts on technology use; influence of the social network; influence of organizations, and the role of the physical environment. CONCLUSION: Older adults' perceptions and use of technology are embedded in their personal, social, and physical context. Awareness of these psychological and contextual factors is needed in order to facilitate aging in place through the use of technology. A conceptual model covering these factors is presented.
Unrivalled in the way it makes the teaching of statistics compelling and accessible to even the most anxious of students, the only statistics textbook you and your students will ever need just got better! Andy Field's comprehensive and bestselling Discovering Statistics Using SPSS 4th Edition takes students from introductory statistical concepts through very advanced concepts, incorporating SPSS throughout. The Fourth Edition focuses on providing essential content updates, better accessibility to key features, more instructor resources, and more content specific to select disciplines. It also incorporates powerful new digital developments on the textbook's companion website(visit sagepub.com for more information). WebAssign The Fourth Edition will be available on WebAssign, allowing instructors to produce and manage assignments with their studnets online using a grade book that allows them to track and monitor students' progress. Students receive unlimited practice using a combination of approximately 2000 multiple choice and algorithmic questions. WebAssign provided students with instant feedback and links directly to the accompanying eBook section where the concept was covered, allowing students to find the correct solution. SAGE MobileStudy SAGE MobileStudy allows students equipped with smartphones and tablets to access select material, such as Cramming Sam's Study Tips, anywhere they receive mobile service. With QR codes included throughout the text, it's easy for students to get right to the section they need to study, allowing them to continue their study from virtually anywhere, even when they are away from thier printed copy of the text. Click here to preview the MobileStudy site (available late spring 2013). Education and Sport Sciences instructor support materials with enhanced ones for Psychology, Business and Management and the Health sciences make the book even more relevant to a wider range of subjects across the social sciences and where statistics is taught to a cross-disciplinary audience. Major Updates to the 4th Edition Fully compatible with recent SPSS releases up to and including version 20.0 Exciting new characters, including statistical cult leader Oditi, who provides students access to interesting and helpful video clips to illustrate statistical and SPSS concepts, and Confusious, who helps students clarify confusing quantitative terminology New discipline specific support matierlas have been added for Education, Sports Sciences, Psychology, Business & Management, and Health Sciences, making the book even more relevant to a wider range of subjects across the Social, Behavioral, and Health Sciences is taught to an interdisciplinary audience. An enhanced Companion Website (available late spring 2013) offers a wealth of material that can be used in conjunction with the textbook, including: PowerPoints Testbanks Answers to the Smart Alex tasks at the end of each chapter Datafiles for testing problems in SPSS Flashcards of key concepts Self-assessment multiple-choice questions Online videos of key statistical and SPSS procedures
Maximum likelihood or restricted maximum likelihood (REML) estimates of the parameters in linear mixed-effects models can be determined using the lmer function in the lme4 package for R. As for most model-fitting functions in R, the model is described in an lmer call by a formula, in this case including both fixed- and random-effects terms. The formula and data together determine a numerical representation of the model from which the profiled deviance or the profiled REML criterion can be evaluated as a function of some of the model parameters. The appropriate criterion is optimized, using one of the constrained optimization functions in R, to provide the parameter estimates. We describe the structure of the model, the steps in evaluating the profiled deviance or REML criterion, and the structure of classes or types that represents such a model. Sufficient detail is included to allow specialization of these structures by users who wish to write functions to fit specialized linear mixed models, such as models incorporating pedigrees or smoothing splines, that are not easily expressible in the formula language used by lmer.
In this Section: 1. Brief Table of Contents 2. Full Table of Contents 1. BRIEF TABLE OF CONTENTS Chapter 1 Introduction Chapter 2 A Guide to Statistical Techniques: Using the Book Chapter 3 Review of Univariate and Bivariate Statistics Chapter 4 Cleaning Up Your Act: Screening Data Prior to Analysis Chapter 5 Multiple Regression Chapter 6 Analysis of Covariance Chapter 7 Multivariate Analysis of Variance and Covariance Chapter 8 Profile Analysis: The Multivariate Approach to Repeated Measures Chapter 9 Discriminant Analysis Chapter 10 Logistic Regression Chapter 11 Survival/Failure Analysis Chapter 12 Canonical Correlation Chapter 13 Principal Components and Factor Analysis Chapter 14 Structural Equation Modeling Chapter 15 Multilevel Linear Modeling Chapter 16 Multiway Frequency Analysis 2. FULL TABLE OF CONTENTS Chapter 1: Introduction Multivariate Statistics: Why? Some Useful Definitions Linear Combinations of Variables Number and Nature of Variables to Include Statistical Power Data Appropriate for Multivariate Statistics Organization of the Book Chapter 2: A Guide to Statistical Techniques: Using the Book Research Questions and Associated Techniques Some Further Comparisons A Decision Tree Technique Chapters Preliminary Check of the Data Chapter 3: Review of Univariate and Bivariate Statistics Hypothesis Testing Analysis of Variance Parameter Estimation Effect Size Bivariate Statistics: Correlation and Regression. Chi-Square Analysis Chapter 4: Cleaning Up Your Act: Screening Data Prior to Analysis Important Issues in Data Screening Complete Examples of Data Screening Chapter 5: Multiple Regression General Purpose and Description Kinds of Research Questions Limitations to Regression Analyses Fundamental Equations for Multiple Regression Major Types of Multiple Regression Some Important Issues. Complete Examples of Regression Analysis Comparison of Programs Chapter 6: Analysis of Covariance General Purpose and Description Kinds of Research Questions Limitations to Analysis of Covariance Fundamental Equations for Analysis of Covariance Some Important Issues Complete Example of Analysis of Covariance Comparison of Programs Chapter 7: Multivariate Analysis of Variance and Covariance General Purpose and Description Kinds of Research Questions Limitations to Multivariate Analysis of Variance and Covariance Fundamental Equations for Multivariate Analysis of Variance and Covariance Some Important Issues Complete Examples of Multivariate Analysis of Variance and Covariance Comparison of Programs Chapter 8: Profile Analysis: The Multivariate Approach to Repeated Measures General Purpose and Description Kinds of Research Questions Limitations to Profile Analysis Fundamental Equations for Profile Analysis Some Important Issues Complete Examples of Profile Analysis Comparison of Programs Chapter 9: Discriminant Analysis General Purpose and Description Kinds of Research Questions Limitations to Discriminant Analysis Fundamental Equations for Discriminant Analysis Types of Discriminant Analysis Some Important Issues Comparison of Programs Chapter 10: Logistic Regression General Purpose and Description Kinds of Research Questions Limitations to Logistic Regression Analysis Fundamental Equations for Logistic Regression Types of Logistic Regression Some Important Issues Complete Examples of Logistic Regression Comparison of Programs Chapter 11: Survival/Failure Analysis General Purpose and Description Kinds of Research Questions Limitations to Survival Analysis Fundamental Equations for Survival Analysis Types of Survival Analysis Some Important Issues Complete Example of Survival Analysis Comparison of Programs Chapter 12: Canonical Correlation General Purpose and Description Kinds of Research Questions Limitations Fundamental Equations for Canonical Correlation Some Important Issues Complete Example of Canonical Correlation Comparison of Programs Chapter 13: Principal Components and Factor Analysis General Purpose and Description Kinds of Research Questions Limitations Fundamental Equations for Factor Analysis Major Types of Factor Analysis Some Important Issues Complete Example of FA Comparison of Programs Chapter 14: Structural Equation Modeling General Purpose and Description Kinds of Research Questions Limitations to Structural Equation Modeling Fundamental Equations for Structural Equations Modeling Some Important Issues Complete Examples of Structural Equation Modeling Analysis. Comparison of Programs Chapter 15: Multilevel Linear Modeling General Purpose and Description Kinds of Research Questions Limitations to Multilevel Linear Modeling Fundamental Equations Types of MLM Some Important Issues Complete Example of MLM Comparison of Programs Chapter 16: Multiway Frequency Analysis General Purpose and Description Kinds of Research Questions Limitations to Multiway Frequency Analysis Fundamental Equations for Multiway Frequency Analysis Some Important Issues Complete Example of Multiway Frequency Analysis Comparison of Programs
暂无摘要（点击查看原文获取完整内容）
Valid measurement scales for predicting user acceptance of computers are in short supply. Most subjective measures used in practice are unvalidated, and their relationship to system usage is unknown. The present research develops and validates new scales for two specific variables, perceived usefulness and perceived ease of use, which are hypothesized to be fundamental determinants of user acceptance. Definitions for these two variables were used to develop scale items that were pretested for content validity and then tested for reliability and construct validity in two studies involving a total of 152 users and four application programs. The measures were refined and streamlined, resulting in two six-item scales with reliabilities of .98 for usefulness and .94 for ease of use. The scales exhibited high convergent, discriminant, and factorial validity. Perceived usefulness was significantly correlated with both self-reported current usage (r=.63, Study 1) and self-predicted future usage (r=.85, Study 2). Perceived ease of use was also significantly correlated with current usage (r=.45, Study 1) and future usage (r=.59, Study 2). In both studies, usefulness had a significantly greater correlation with usage behavior than did ease of use. Regression analyses suggest that perceived ease of use may actually be a causal antecedent to perceived usefulness, as opposed to a parallel, direct determinant of system usage. Implications are drawn for future research on user acceptance.
BACKGROUND: The number of prokaryotic genome sequences becoming available is growing steadily and is growing faster than our ability to accurately annotate them. DESCRIPTION: We describe a fully automated service for annotating bacterial and archaeal genomes. The service identifies protein-encoding, rRNA and tRNA genes, assigns functions to the genes, predicts which subsystems are represented in the genome, uses this information to reconstruct the metabolic network and makes the output easily downloadable for the user. In addition, the annotated genome can be browsed in an environment that supports comparative analysis with the annotated genomes maintained in the SEED environment. The service normally makes the annotated genome available within 12-24 hours of submission, but ultimately the quality of such a service will be judged in terms of accuracy, consistency, and completeness of the produced annotations. We summarize our attempts to address these issues and discuss plans for incrementally enhancing the service. CONCLUSION: By providing accurate, rapid annotation freely to the community we have created an important community resource. The service has now been utilized by over 120 external users annotating over 350 distinct genomes.
We report a major update of the MAFFT multiple sequence alignment program. This version has several new features, including options for adding unaligned sequences into an existing alignment, adjustment of direction in nucleotide alignment, constrained alignment and parallel processing, which were implemented after the previous major update. This report shows actual examples to explain how these features work, alone and in combination. Some examples incorrectly aligned by MAFFT are also shown to clarify its limitations. We discuss how to avoid misalignments, and our ongoing efforts to overcome such limitations.
The recently-developed statistical method known as the "bootstrap" can be used to place confidence intervals on phylogenies. It involves resampling points from one's own data, with replacement, to create a series of bootstrap samples of the same size as the original data. Each of these is analyzed, and the variation among the resulting estimates taken to indicate the size of the error involved in making estimates from the original data. In the case of phylogenies, it is argued that the proper method of resampling is to keep all of the original species while sampling characters with replacement, under the assumption that the characters have been independently drawn by the systematist and have evolved independently. Majority-rule consensus trees can be used to construct a phylogeny showing all of the inferred monophyletic groups that occurred in a majority of the bootstrap samples. If a group shows up 95% of the time or more, the evidence for it is taken to be statistically significant. Existing computer programs can be used to analyze different bootstrap samples by using weights on the characters, the weight of a character being how many times it was drawn in bootstrap sampling. When all characters are perfectly compatible, as envisioned by Hennig, bootstrap sampling becomes unnecessary; the bootstrap method would show significant evidence for a group if it is defined by three or more characters.
暂无摘要（点击查看原文获取完整内容）
暂无摘要（点击查看原文获取完整内容）
We present a new technique called “t-SNE” that visualizes high-dimensional data by giving each datapoint a location in a two or three-dimensional map. The technique is a variation of Stochastic Neighbor Embedding (Hinton and Roweis, 2002) that is much easier to optimize, and produces significantly better visualizations by reducing the tendency to crowd points together in the center of the map. t-SNE is better than existing techniques at creating a single map that reveals structure at many different scales. This is particularly important for high-dimensional data that lie on several different, but related, low-dimensional manifolds, such as images of objects from multiple classes seen from multiple viewpoints. For visualizing the structure of very large datasets, we show how t-SNE can use random walks on neighborhood graphs to allow the implicit structure of all of the data to influence the way in which a subset of the data is displayed. We illustrate the performance of t-SNE on a wide variety of datasets and compare it with many other non-parametric visualization techniques, including Sammon mapping, Isomap, and Locally Linear Embedding. The visualizations produced by t-SNE are significantly better than those produced by the other techniques on almost all of the datasets.
Abstract A method for estimating the cholesterol content of the serum low-density lipoprotein fraction (Sf0-20) is presented. The method involves measurements of fasting plasma total cholesterol, triglyceride, and high-density lipoprotein cholesterol concentrations, none of which requires the use of the preparative ultracentrifuge. Comparison of this suggested procedure with the more direct procedure, in which the ultracentrifuge is used, yielded correlation coefficients of .94 to .99, depending on the patient population compared.
This paper presents a new vision Transformer, called Swin Transformer, that capably serves as a general-purpose backbone for computer vision. Challenges in adapting Transformer from language to vision arise from differences between the two domains, such as large variations in the scale of visual entities and the high resolution of pixels in images compared to words in text. To address these differences, we propose a hierarchical Transformer whose representation is computed with Shifted windows. The shifted windowing scheme brings greater efficiency by limiting self-attention computation to non-overlapping local windows while also allowing for cross-window connection. This hierarchical architecture has the flexibility to model at various scales and has linear computational complexity with respect to image size. These qualities of Swin Transformer make it compatible with a broad range of vision tasks, including image classification (87.3 top-1 accuracy on ImageNet-1K) and dense prediction tasks such as object detection (58.7 box AP and 51.1 mask AP on COCO test-dev) and semantic segmentation (53.5 mIoU on ADE20K val). Its performance surpasses the previous state-of-the-art by a large margin of +2.7 box AP and +2.6 mask AP on COCO, and +3.2 mIoU on ADE20K, demonstrating the potential of Transformer-based models as vision backbones. The hierarchical design and the shifted window approach also prove beneficial for all-MLP architectures. The code and models are publicly available at https://github.com/microsoft/Swin-Transformer.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUse of Dinitrosalicylic Acid Reagent for Determination of Reducing SugarG. L. MillerCite this: Anal. Chem. 1959, 31, 3, 426–428Publication Date (Print):March 1, 1959Publication History Published online1 May 2002Published inissue 1 March 1959https://pubs.acs.org/doi/10.1021/ac60147a030https://doi.org/10.1021/ac60147a030research-articleACS PublicationsRequest reuse permissionsArticle Views45222Altmetric-Citations19440LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts