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The Alzheimer's Disease Neuroimaging Initiative (ADNI) provides a comprehensive multimodal neuroimaging resource for studying aging and Alzheimer's disease (AD). Since its second wave, ADNI has increasingly collected resting-state functional MRI (rs-fMRI), a valuable resource for discovering brain connectivity changes predictive of cognitive decline and AD. A major barrier to its use is the considerable variability in acquisition protocols and data quality, compounded by missing imaging sessions and inconsistencies in how functional scans temporally align with clinical assessments. As a result, many studies only utilize a small subset of the total rs-fMRI data, limiting statistical power, reproducibility, and the ability to study longitudinal functional brain changes at scale. Here, we describe a pipeline for ADNI rs-fMRI data that encompasses the download of necessary imaging and clinical data, temporally aligning the clinical and imaging data, preprocessing, and quality control. We integrate data curation and preprocessing across all ADNI sites and scanner types using a combination of open-source software (Clinica, fMRIPrep, and MRIQC) and bespoke tools. Quality metrics and repor

In this paper, we look into Signed Product Cordial Labeling for Splitting Graphs of Bull graph and Splitting graph of Star graph , Square of Path graph, Coronaand also for the graph obtained by joining two copies of Helm by a Path of arbitrary length.

This paper describes the final prototype of an assistive robot used for increasing engagement of older adults in the context of SHAPES project. It then highlights lessons learned from hands-on training during the first phases of the pilots at Clinica Humana and Can Granada residence in Mallorca (Spain).

Creatine is best known as a muscle-building supplement, but scientists are now investigating whether it could also help treat depression by boosting the brain's energy supply。 A new review examined five randomized clinical trials involving 238 participants and found mixed results。 Two studies, both involving women with major depressive disorder, re

Research in Sports Sciences is supported often by inferences based on the declaration of the value of the statistic statistically significant or nonsignificant on the bases of a P value derived from a null-hypothesis test. Taking into account that studies are manly conducted in sample, the use of null hypothesis testing only allows estimating the true values (population) of the statistics used. However, evidence has grown in many areas of knowledge that this approach often leads to confusion and misinterpretation. To overcome this limitation they have recently emerged recommendations to support the statistical analysis with approaches that make use of more intuitive interpretations and more practical, especially based on the magnitudes (certainty / uncertainty) of the true values found. With the intent to provide alternative solutions to methodological designs recurrently used in research in sports sciences, this paper will seek to i) briefly spell out some of the weaknesses associated with the null hypothesis tests based in the P value; ii) reflect on the implications of the use of practical/clinical significance as opposed to statistical significance; iii) submit proposals for us

Rehabilitation is a painful and tiring process involving series of exercises that patients must repeat over a long period. Unfortunately, patients often grow bored, frustrated, and lose motivation making rehabilitation less effective. In the recent years video games have been widely used to implement rehabilitation protocols so as to make the process more entertaining, engaging and to keep patients motivated. In this paper, we present an integrated framework we developed for the wrist rehabilitation of patients affected by Juvenile Idiopathic Arthritis (JIA) following a therapeutic protocol at the Clinica Pediatrica G. e D. De Marchi. The framework comprises four video games and a set modules that let the therapists tune and control the exercises the games implemented, record all the patients actions, replay and analyze the sessions. We present the result of a preliminary validation we performed with four poliarticular JIA patients at the clinic under the supervision of the therapists. Overall, we received good feedback both from the young patients, who enjoyed performing known rehabilitation exercises using video games, and therapists who were satisfied with the framework and its

Much of it comes from heavy-duty trucks and buses that burn diesel

Astronomers have finally cracked the mystery of the famous “Pink Planet,” a strange world 57 light-years away that has puzzled scientists for more than a decade。 Using the James Webb Space Telescope, researchers discovered that its atmosphere contains water vapor, methane, carbon dioxide, ammonia, and something never directly confirmed before in su

The global cobalt supply chain is more interconnected—and more vulnerable—than previously thought, with disruptions capable of triggering far-reaching cascades across multiple countries and industries。 Researchers warn that protecting battery supply chains will require system-wide coordination because critical bottlenecks can turn local shocks into

In this paper we present a delay induced model for hepatitis C virus incorporating the healthy and infected hepatocytes as well as infectious and noninfectious virions. The model is mathematically analyzed and characterized, both for the steady states and the dynamical behavior of the model. It is shown that time delay does not affect the local asymptotic stability of the uninfected steady state. However, it can destabilize the endemic equilibrium, leading to Hopf bifurcation to periodic solutions with realistic data sets. The model is also validated using 12 patient data obtained from the study, conducted at the University of Sao Paulo Hospital das clinicas.

Peptide drugs are popular, but FDA scientists warn they're untested, may be harmful

Researchers found that a Chinese sodium-ion battery performs far better than expected, with production quality and design features comparable to Tesla’s batteries。 If engineers can improve cold-weather charging and energy density, sodium could become a cheaper and more abundant alternative to lithium for EVs and large-scale energy storage

A colossal ancient collision may have left some of the Moon’s deepest secrets surprisingly close to future Artemis landing sites。 By recreating the impact that formed the giant South Pole-Aitken basin—the Moon’s largest and oldest crater—scientists found that a low-angle strike from a large, iron-cored object blasted material from deep inside the M

New Fire Stick OS helps Amazon block third-party homepage launchers, ad blockers

A new study suggests Earth may have been sending tiny hitchhikers to Venus for billions of years。 Researchers found that asteroid impacts could launch microbes into space, where some might survive the journey and end up suspended in Venus' clouds。 If future missions detect life there, there's a surprising chance it didn't originate on Venus at all—

What if consciousness isn’t limited to brains like ours。 Philosophers Eric Schwitzgebel and Jeremy Pober argue that consciousness could arise in many different forms of life, even in beings built from radically different materials than those found on Earth。 Drawing on the vastness of the universe and the likely existence of countless alien civiliza

Also, the science of poop's distinctive shape, boron buckyballs, and the secret to a soccer feint

Researchers have shown that ultracold atoms can be driven into a strange new quantum state called a fractional Fermi sea, where particles organize themselves in unexpected ways。 The discovery points to a new phase of matter that goes beyond established quantum theories and could expand the possibilities of quantum simulation

A clever nanoscale redesign may have solved one of superconductivity’s biggest problems。 Researchers in Sweden discovered that by subtly sculpting the surface beneath an ultrathin superconducting material, they could make it stay superconducting at higher temperatures and under much stronger magnetic fields