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The purpose of this study was to explore the effect of Chan-Chuang qigong on symptoms distress and psychological distress of breast cancer patients who underwent chemotherapy. A quasi-experimental design was adopted. Subjects were recruited from breast cancer outpatients receiving chemotherapy at an 1800-bed medical center in Taipei, Taiwan. Of these subjects, 35 were assigned to the control group and 32 to the experimental group in which Chan-Chuang qigong was administered. Assignment was not random. The instruments included a 21-item symptom distress scale and psychological distress with the symptom checklist-90-revised. Data of the symptoms and psychological distress were collected on the day before chemotherapy as baseline values, and also collected on days 8, 15 and 22 of chemotherapy. The results showed that the overall severity of symptom distress in the experimental group was significantly lower than the control group on day 22 (p < 0.05). The symptoms with significant improvement included pain, numbness, heartburn and dizziness (p < 0.05). With regard to psychological distress, the difference of overall severity between the two groups was not statistically significant (p > 0.05). However, the items of "unwillingness to live" (p < 0.05) and "hopelessness about the future" (p < 0.05) were significantly improved in the experimental group. In conclusion, Chan-Chuang qigong had the effect of attenuating the symptom distress and probably some part of the psychological distress of chemotherapy patients.

After surgery, breast cancer patients are offered adjuvant chemotherapy to avoid cancer cell spread. During chemotherapy process, neutrophils could fall relatively, and side effects could spike to the peak. Therefore, the medical care personnel should prevent the progression of the side effects. This study aimed to examine the effects of Chan-Chuang qi-gong therapy on complete blood counts in breast cancer patients treated with chemotherapy. This study used a quasi-experimental design. The experiment group (n = 32) received a 21-day Chan-Chuang qi-gong therapy, whereas the control group (n = 35) did not. White blood cells, platelet, and hemoglobin were measured on the day before chemotherapy and on days 8, 15, and 22 during chemotherapy. According to this study, there were significant differences in white blood cells (F = 115.76, P <.001), platelets (F = 25.29, P <.001), and hemoglobin (F = 15.39, P <.001) over the 3-week therapy between the experiment and control groups. Chan-Chuang qi-gong therapy may decrease leukopenia in breast cancer patients treated with chemotherapy. It is recommended conducting more studies on qi-gong and then introducing it in clinical nursing practice at an appropriate time to promote quality of nursing care and quality of patient life.

First published in 1889. This re-issues the second, revised edition of 1926. Chuang Tzu was to Lao Tzu, the author of Tao Te Ching, as Hui-neng, the sixth Patriarch of Zen Buddhism, was to Bodhidharma, and in some respects St.Paul to Jesus; he expanded the original teaching into a system and was thus the founder of Tao-ism. Whereas Lao Tzu was a contemporary of Confucius in the sixth century B.C, Chuang Tzu lived over two hundred years later. He was one of the greatest minds produced by China; philosopher, metaphysician, moralist and poet. It is impossible to understand the spiritual depth of the Tao Te Ching without the aid of Chuang Tzu.

Complex diseases are cascade process which are associate with functional abnormalities in multiple proteins and protein interaction networks. One drug one target has not been able to intervene well with disease. More and more evidences show that Chinese herb formula usually treats complex diseases in the form of multi-components and multi-targets. The key step to elucidate the action mechanism of traditional Chinese medicine (TCM) is to optimize the important components in the formula of TCM. At present, there are several models of formula Therapeutic Mechanisms of Lang Chuang Wan for SLE optimization based on network pharmacology has been proposed. Most of these models focus on the 2D/3D similarity of chemical structure of drug components, and ignore the construction of functional optimization space based on relationship between disease-causing genes and drug targets. How to select the key group of effective components (KGEC) from the formula of TCM based on the optimal space which link pathogenic genes and drug targets is a bottleneck problem in network pharmacology. To address this issue, we have designed a novel network pharmacological model, which takes Lang Chuang Wan (LCW) treatment of systemic lupus erythematosus (SLE) as the case. We used the weighted gene regulatory network and active components targets network to construct disease-targets-components network, after filtering through the network attribute degree, the optimization space and effective proteins were obtained. And then selected the KGEC use contribution index (CI) model based on a reversed strategy. The results show that the enriched pathways of effective proteins we selected can cover 96% of the disease-causing genes enriched pathways. After reverse analysis of effective proteins and optimization with CI index model, 82 KGEC were obtained, and 105 enriched pathways of the targets of 82 KGEC were consistent with enriched pathways of pathogenic genes (80.15%). These results indicate that the proposed model with good accuracy in screening the KGEC in the formula of TCM, which provides reference for the optimization and mechanism analysis of the formula in TCM.

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Quantum Computation and Quantum Information, by M.A. Nielsen and I.L. Chuang, Cambridge, Cambridge University Press, 2010, 708 pp., £45.00 (hardback), ISBN 978-1-107-00217-3. Scope: textbook. Level...

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A contemporary translation remaining faithful to the original collection of tales, poems and parables of Taoist philosophy. The collection covers a wide range of issues, from ambition to politics, and is accompanied by an introduction on the author and his place in Chinese thought and history.

1. Introduction2. Free and Easy Wandering3. Discussion on Making All Things Equal4. The Secret of Caring for Life5. In the World of Men6. The Sign of Virtue Complete7. The Great and Venerable Teacher8. Fit for Emperors and Kings9. Autumn Floods10. Supreme Happiness11. Mastering Life12. External Things

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From the methanol extract of the crude drug "She chuang zi" [Japanese name "Jyashoshi", the fruit of Cnidium monnieri CUSSON (Umbelliferae)], two new substances were obtained as the main constituents of the water soluble portion. From the results of spectral investigations, they were characterized as 3, 7-dimethyl-1, 2, 6, 7-tetrahydroxyoct-3(10)-ene (obtained as a mixture of two epimers) and 3-methyl-1, 2, 3, 4-tetrahydroxy-butane, respectively. It is interesting that such monoterpenoid and hemiterpenoid tetraols were obtained from the water soluble portion of an Umbelliferous crude drug which contained an abundance of essential oil and coumarin derivatives.

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&lt;div&gt;&lt;p&gt;In their comment, Chen and Chuang [&lt;a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1006916#pcbi.1006916.ref001" target="_blank"&gt;1&lt;/a&gt;] pointed out several weak points of our recent paper [&lt;a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1006916#pcbi.1006916.ref002" target="_blank"&gt;2&lt;/a&gt;]. Here we respond in detail to clarify the dataset we used in our work. We also discuss the three confounding factors they listed in their comment.&lt;/p&gt;&lt;/div&gt;

Fractionation with supercritical CO(2) is employed to divide ethanolic extract (E) of B. kaoi into four fractions (R, F1, F2 and F3). To assess the selectivity of the fractionation, extracts of the four fractions were characterized in terms of the hepatoprotective capacity and activity of antioxidant enzymes to against CCl(4)-induced damage. The in vitro study revealed that pretreatment with B. kaoi extract or its fractions, except F3, significantly protected primary hepatocytes against damage by CCl(4) (P<0.05). The R and F1 fractions had the highest saikosaponins content (175 and 200 mg/g dry weight, respectively) and most effectively protected the liver from damage by CCl(4). This study demonstrated that the oral pretreatment of B. kaoi (100 and 500 mg/kg), except F3, three days before a single dose of CCl(4) (CCl(4)/olive oil=1:1, 3 ml/kg, sc) was administered significantly lowered the serum levels of hepatic enzyme markers (AST and ALT) (P<0.05). A pathological examination showed that lesions, including ballooning degeneration, necrosis, hepatitis and portal triaditis were partially healed by treatment with B. kaoi extract and fractions. Oxidative stress induced by CCl(4) led to lipid peroxidation (MDA) and changes in the levels of the antioxidant enzymes in the liver. However, all the fractions, except F3, markedly suppressed lipid peroxidation and reversed the activities of the antioxidant enzymes to the normal levels.

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