Malcolm Dole’s now famous paper that led to electrospray ionization was published in 1968.1 That was the year after I had left the faculty of mechanical engineering at Princeton to join the faculty of chemical engineering at Yale where I continued my ten-year affair with big leaks in vacuum systems. Those leaks had turned out to be very powerful and versatile research tools because they could produce molecular beams with much higher energies and intensities than could the effusive sources with which Otto Stern and his disciples had earned half a dozen Nobel prizes in physics. Moreover, the supersonic free jets issuing from these leaks introduced their component gases to nonequilibrium steady states having combinations of temperature and density not previously dreamt of, let alone encountered. Those supersonic free jets subsequently ushered in the era of electrospray ionization (ESI) in mass spectrometry (MS) and are thus responsible for my being here today. (Jets also powered my transport on this trip to Austin but those jets were neither supersonic nor free!) When I was told that I would have the honor of receiving the 2002 award from the ABRF, I realized that once again I was following in the footsteps of Csaba Horvath who received this award in 2001. Csaba had also preceded me by a year or two in becoming a chemical engineer at Yale. That sequence, together with subsequent events, lends credence to the notion that the loom of Fate might be weaving some preordained pattern! When I arrived at New Haven in 1967 Csaba was spending half his time in the medical school, working with Professor Seymour “Sandy” Lipsky on HPLC, then known as “high pressure liquid chromatography.” The success of their efforts changed the meaning of “P” from pressure to performance, an achievement honored by Csaba’s receiving this ABRF award last year. The subject of this year’s award—electrospray ionization—has become a hyphen of choice in the practice of LC-MS. Because detection follows separation in that practice, it seems entirely appropriate, and consistent with classic Presbyterian Predestination, that today’s award for an LC detection method should follow last year’s award for LC separation itself! Moreover, the notion of an intervention by Fate is given still more credence by the fact that, unbeknownst to the Award Committee, REVIEWS Journal of Biomolecular Techniques 13:101–118 © 2002 ABRF
We propose a new equilibrium enforcing method paired with a loss derived from the Wasserstein distance for training auto-encoder based Generative Adversarial Networks. This method balances the generator and discriminator during training. Additionally, it provides a new approximate convergence measure, fast and stable training and high visual quality. We also derive a way of controlling the trade-off between image diversity and visual quality. We focus on the image generation task, setting a new milestone in visual quality, even at higher resolutions. This is achieved while using a relatively simple model architecture and a standard training procedure.
Deep learning has demonstrated tremendous success in variety of application domains in the past few years. This new field of machine learning has been growing rapidly and applied in most of the application domains with some new modalities of applications, which helps to open new opportunity. There are different methods have been proposed on different category of learning approaches, which includes supervised, semi-supervised and un-supervised learning. The experimental results show state-of-the-art performance of deep learning over traditional machine learning approaches in the field of Image Processing, Computer Vision, Speech Recognition, Machine Translation, Art, Medical imaging, Medical information processing, Robotics and control, Bio-informatics, Natural Language Processing (NLP), Cyber security, and many more. This report presents a brief survey on development of DL approaches, including Deep Neural Network (DNN), Convolutional Neural Network (CNN), Recurrent Neural Network (RNN) including Long Short Term Memory (LSTM) and Gated Recurrent Units (GRU), Auto-Encoder (AE), Deep Belief Network (DBN), Generative Adversarial Network (GAN), and Deep Reinforcement Learning (DRL). In addition, we have included recent development of proposed advanced variant DL techniques based on the mentioned DL approaches. Furthermore, DL approaches have explored and evaluated in different application domains are also included in this survey. We have also comprised recently developed frameworks, SDKs, and benchmark datasets that are used for implementing and evaluating deep learning approaches. There are some surveys have published on Deep Learning in Neural Networks [1, 38] and a survey on RL [234]. However, those papers have not discussed the individual advanced techniques for training large scale deep learning models and the recently developed method of generative models [1].
Regions where 773 flashes began during 13 thunderstorms were located by calculating centroids of the sources of the first six or 10 VHF pulses that were emitted by each flash. Sources were located by measuring differences in the times at which their pulses arrived at five widely spaced receivers stationed on the ground. We found that the distribution of origin heights was bimodal with peaks at 5.3 and 9.2 km above mean sea level (amsl). Standard errors in the coordinates of flash origins were estimated to be 20–80 m in X and Y and 160–240 m in the height coordinate Z . There were 431 flashes in the lower group and 342 in the higher. Flashes in the lower group were more numerous in 10 storms; in three storms, high flashes were in the majority. There was evidence to suggest that this condition depended partly on the phase of the host thunderstorm. Recorded E field changes produced by 165 flashes whose paths we had mapped convinced us that the vast majority of the 773 flashes, including the 342 high flashes, had also been negative. Flash origins tended to cluster in regions that were a few kilometers or less in horizontal diameter. Densities of flash origins in these regions ranged from 1.25 to 25 km −3 . The origins of 658 flashes were mapped onto radar precipitation patterns of their host storms. We found that 66% of the flashes began within one picture element, approximately 270 m, of the contours for 20 dB Z ; 27% began inside these contours, and most of these began at edges of high‐reflectivity cores. The remaining 7% began outside the 20‐dB Z contours. Similar results (73%: 19%: 8%) were obtained for 276 high flashes that began at heights above 7.4 km amsl, but 195 ground flashes scored 54%: 36%: 9% and showed a greater tendency to begin inside the 20‐dB Z contours. The distribution of distances between origins and their nearest 20‐dB Z contours showed a marked peak near zero. We concluded that charge‐density in thunderclouds was affected by the presence of heavy precipitation and that 20‐dB Z surfaces enclosed regions that carried excess negative charge.
Research Article| July 01, 2005 Evidence from ophiolites, blueschists, and ultrahigh-pressure metamorphic terranes that the modern episode of subduction tectonics began in Neoproterozoic time Robert J. Stern Robert J. Stern 1University of Texas, Dallas, Geosciences Department, P.O. Box 830688, 2601 North Floyd Road, Richardson, Texas 75083-0688, USA Search for other works by this author on: GSW Google Scholar Author and Article Information Robert J. Stern 1University of Texas, Dallas, Geosciences Department, P.O. Box 830688, 2601 North Floyd Road, Richardson, Texas 75083-0688, USA Publisher: Geological Society of America Received: 16 Nov 2004 Revision Received: 31 Jan 2005 Accepted: 04 Feb 2005 First Online: 02 Mar 2017 Online ISSN: 1943-2682 Print ISSN: 0091-7613 Geological Society of America Geology (2005) 33 (7): 557–560. https://doi.org/10.1130/G21365.1 Article history Received: 16 Nov 2004 Revision Received: 31 Jan 2005 Accepted: 04 Feb 2005 First Online: 02 Mar 2017 Cite View This Citation Add to Citation Manager Share Icon Share Facebook Twitter LinkedIn Email Permissions Search Site Citation Robert J. Stern; Evidence from ophiolites, blueschists, and ultrahigh-pressure metamorphic terranes that the modern episode of subduction tectonics began in Neoproterozoic time. Geology 2005;; 33 (7): 557–560. doi: https://doi.org/10.1130/G21365.1 Download citation file: Ris (Zotero) Refmanager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentBy SocietyGeology Search Advanced Search Abstract Earth is the only known planet with subduction zones and plate tectonics, and this fact demonstrates that special conditions are required for this mode of planetary heat loss. Sinking of cold, dense lithosphere in subduction zones is the principal plate-driving force, so plate tectonics could not have begun until Earth cooled sufficiently to allow lithosphere to collapse into the underlying asthenosphere. Direct geologic evidence for when the modern episode of subduction tectonics began focuses on the first appearance of ophiolitic graveyards, blueschist facies metamorphic rocks, and ultrahigh-pressure metamorphic terranes. Ophiolites manifest two modes of lithospheric motion expected from subduction tectonics: seafloor spreading and obduction. High-pressure, low-temperature metamorphic blueschists and ultrahigh-pressure terranes indicate subduction and exhumation of oceanic and continental crust, respectively. These lines of evidence indicate that the modern style of subduction tectonics began in Neoproterozoic time. This revolution in the functioning of the solid Earth may have driven wild fluctuations in Earth's climate, described under the "snowball Earth" hypothesis. These conclusions may be controversial, but suggest fruitful avenues for research in geodynamics and paleoclimate. You do not have access to this content, please speak to your institutional administrator if you feel you should have access.
Using high-quality longitudinal data on 125,720 singleton live births in Matlab, Bangladesh, we assessed the effects of duration of intervals between pregnancy outcomes on infant and child mortality and how these effects vary over subperiods of infancy and childhood and by the type of outcome that began the interval. Controlling for other correlates of infant and child mortality, we find that shorter intervals are associated with higher mortality. Interval effects are greater if the interval began with a live birth than with another pregnancy outcome. In the first week of the child's life, the effects of short intervals are greater if the sibling born at the beginning of the interval died; after the first month, the effects are greater if that sibling was still alive. Many relationships found are consistent with the maternal depletion hypothesis, and some with sibling competition. Some appear to be due to correlated risks among births to the same mother.
How Language Began revolutionizes our understanding of the one tool that has allowed us to become the "lords of the planet." Mankind has a distinct advantage over other terrestrial species: we talk to one another. But how did we acquire the most advanced form of communication on Earth? Daniel L. Everett, a "bombshell" linguist and "instant folk hero" (Tom Wolfe, Harper's), provides in this sweeping history a comprehensive examination of the evolutionary story of language, from the earliest speaking attempts by hominids to the more than seven thousand languages that exist today. Although fossil hunters and linguists have brought us closer to unearthing the true origins of language, Daniel Everett's discoveries have upended the contemporary linguistic world, reverberating far beyond academic circles. While conducting field research in the Amazonian rainforest, Everett came across an age-old language nestled amongst a tribe of hunter-gatherers. Challenging long-standing principles in the field, Everett now builds on the theory that language was not intrinsic to our species. In order to truly understand its origins, a more interdisciplinary approach is needed-one that accounts as much for our propensity for culture as it does our biological makeup. Language began, Everett theorizes, with Homo Erectus, who catalyzed words through culturally invented symbols. Early humans, as their brains grew larger, incorporated gestures and voice intonations to communicate, all of which built on each other for 60,000 generations. Tracing crucial shifts and developments across the ages, Everett breaks down every component of speech, from harnessing control of more than a hundred respiratory muscles in the larynx and diaphragm, to mastering the use of the tongue. Moving on from biology to execution, Everett explores why elements such as grammar and storytelling are not nearly as critical to language as one might suspect. In the book's fi
This study extends findings on the effects of intensive applied behavior analytic treatment for children with autism who began treatment at a mean age of 5.5 years. The behavioral treatment group (n = 13, 8 boys) was compared to an eclectic treatment group (n = 12, 11 boys). Assignment to groups was made independently based on the availability of qualified supervisors. Both behavioral and eclectic treatment took place in public kindergartens and elementary schools for typically developing children. At a mean age of 8 years, 2 months, the behavioral treatment group showed larger increases in IQ and adaptive functioning than did the eclectic group. The behavioral treatment group also displayed fewer aberrant behaviors and social problems at follow-up. Results suggest that behavioral treatment was effective for children with autism in the study.
Accelerated losses of biodiversity are a hallmark of the current era. Large declines of population size have been widely observed and currently 22,176 species are threatened by extinction. The time at which a threatened species began rapid population decline (RPD) and the rate of RPD provide important clues about the driving forces of population decline and anticipated extinction time. However, these parameters remain unknown for the vast majority of threatened species. Here we analyzed the genetic diversity data of nuclear and mitochondrial loci of 2,764 vertebrate species and found that the mean genetic diversity is lower in threatened species than in related nonthreatened species. Our coalescence-based modeling suggests that in many threatened species the RPD began ∼123 y ago (a 95% confidence interval of 20-260 y). This estimated date coincides with widespread industrialization and a profound change in global living ecosystems over the past two centuries. On average the population size declined by ∼25% every 10 y in a threatened species, and the population size was reduced to ∼5% of its ancestral size. Moreover, the ancestral size of threatened species was, on average, ∼22% smaller than that of nonthreatened species. Because the time period of RPD is short, the cumulative effect of RPD on genetic diversity is still not strong, so that the smaller ancestral size of threatened species may be the major cause of their reduced genetic diversity; RPD explains 24.1-37.5% of the difference in genetic diversity between threatened and nonthreatened species.
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Human language is not the same as human speech. We use gestures and signs to communicate alongside, or instead of, speaking. Yet gestures and speech are processed in the same areas of the human brain, and the study of how both have evolved is central to research on the origins of human communication. Written by one of the pioneers of the field, this is the first book to explain how speech and gesture evolved together into a system that all humans possess. Nearly all theorizing about the origins of language either ignores gesture, views it as an add-on or supposes that language began in gesture and was later replaced by speech. David McNeill challenges the popular 'gesture-first' theory that language first emerged in a gesture-only form and proposes a groundbreaking theory of the evolution of language which explains how speech and gesture became unified.
Larry Neal , How it all began: the monetary and financial architecture of Europe during the first global capital markets, 1648–1815 The Treaty of Westphalia created the modern nation-state system of Europe and set the stage for the long-term success of financial capitalism. The new sovereign states experimented with competing monetary regimes during their wars over the next century and two-thirds while they extended and perfected the financial innovations in war finance developed during the Thirty Years War. The Dutch maintained fixed exchange rates, the French insisted on exercising monetary independence, while the English placed priority on free movement of international capital. In struggling with the trilemma of choosing among the goals of maintaining fixed exchange rates, monetary independence and free movement of capital, the governments of early modern Europe learned many valuable lessons. By the time of the Napoleonic wars, the innovations that emphasised reliance on financial markets rather than on financial institutions proved their superiority.
Modern-style plate tectonics are mostly driven by the excess density of oceanic lithosphere sinking deeply in subduction zones and can be sustained as long as melt is produced at mid-ocean ridges. Among the silicate planets, the mechanism of plate tectonics is unique to Earth, indicating that special circumstances are required. Given that the potential temperature of Earth’s mantle has decreased by several hundred degrees Celsius since Archean time, the density of oceanic lithosphere must have systematically increased, which has profound implications for the viability of plate tectonics through time. Two things must be done to advance our understanding of Earth’s tectonic history: (1) uncritical uniformitarianism should be avoided; and (2) the geologic record must be thoughtfully and objectively interrogated. Theoretical considerations should motivate the exploration, but geologic evidence will provide the answers. The debate needs to address the criteria for identifying tectonic style in ancient rocks, whether this evidence is likely to be preserved, and what the record indicates. The most important criteria are the temporal distribution of ophiolites, blueschists, ultrahigh-pressure terranes, eclogites, paired metamorphic belts, passive margins, subduction-related batholiths, arc igneous rocks, isotopic evidence of recycling, and paleomagnetic constraints. This list of criteria should evolve; objective redefinitions and reviews of, especially, the eclogite paired metamorphic belt and subduction-related batholith records are needed. Also, the likely effects of major tectonic changes on other Earth systems should be considered, such as true polar wander, climate change, and biosphere changes. The modern episode of plate tectonics began in Neoproterozoic time, <1.0 Ga ago, with earlier alternating episodes of proto–plate tectonics (1.8–2.0 and 2.5–2.7 Ga); unstable stagnant-lid tectonics dominated the rest of Proterozoic time and an unknown part of Archean time.
Contents List of Illustrations Preface Introduction: Love and Art 1. Mutuality 2. Belonging 3. Finding and Making Meaning 4. iHands-oni Competence 5. Elaborating 6. Taking the Arts Seriously Appendix: Toward a Naturalistic Aesthetics Notes References Cited
Taking as its starting-point the ambiguous heritage left by the British Empire to its former colonies, dominions and possessions, And the Birds Began to Sing marks a new departure in the interdisciplinary study of religion and literature. Gathered under the rubric Christianity and Colonialism, essays on Brian Moore. Timothy Findley, Margaret Atwood and Marian Engel, Thomas King, Les A. Murray, David Malouf, Mudrooroo and Philip McLaren, R.A.K. Mason, Maurice Gee, Keri Hulme, Epeli Hau'ofa, J.M. Coetzee, Christopher Okigbo, Chinua Achebe, Amos Tutuola and Ngugi wa Thiong'o explore literary portrayals of the effects of British Christianity upon settler and native cultures in Northern Ireland, Canada, Australia, New Zealand and the South Pacific, and the Africas. These essays share a sense of the dominant presence of Christianity as an inherited system of religious thought and practice to be adapted to changing post-colonial conditions or to be resisted as the lingering ideology of colonial times. In the second section of the collection, Empire and World Religions, essays on Paule Marshall and George Lamming, Jean Rhys, Olive Senior and Caribbean poetry, V.S. Naipaul, Anita Desai, Kamala Markandaya, and Bharati Mukherjee interrogate literature exploring relations between the scions of British imperialism and religious traditions other than Christianity. Expressly concerned with literary embodiments of belief-systems in post-colonial cultures (particularly West African religions in the Caribbean and Hinduism on the Indian subcontinent), these essays also share a sense of Christianity as the pervasive presence of an ideological rhetoric among the economic, social and political dimensions of imperialism. In a polemical Afterword, the editor argues that modes of reading religion and literature in post-colonial cultures are characterised by a theodical preoccupation with a praxis of equity.
Infection with hepatitis B virus (HBV) may lead to acute or chronic hepatitis. HBV infections were previously much more frequent but there are still 240 million chronic HBV carriers today and ca. 620,000 die per year from the late sequelae liver cirrhosis or hepatocellular carcinoma. Hepatitis B was recognized as a disease in ancient times, but its etiologic agent was only recently identified. The first clue in unraveling this mystery was the discovery of an enigmatic serum protein named Australia antigen 50 years ago by Baruch Blumberg. Some years later this was recognized to be the HBV surface antigen (HBsAg). Detection of HBsAg allowed for the first time screening of inapparently infected blood donors for a dangerous pathogen. The need to diagnose clinically silent HBV infections was a strong driving force in the development of modern virus diagnostics. HBsAg was the first infection marker to be assayed with a highly sensitive radio immune assay. HBV itself was among the first viruses to be detected by assay of its DNA genome and IgM antibodies against the HBV core antigen were the first to be selectively detected by the anti-μ capture assay. The cloning and sequencing of the HBV genome in 1978 paved the way to understand the viral life cycle, and allowed development of efficient vaccines and drugs. Today's hepatitis B vaccine was the first vaccine produced by gene technology. Among the problems that still remain today are the inability to achieve a complete cure of chronic HBV infections, the recognition of occult HBV infections, their potential reactivation and the incomplete protection against escape mutants and heterologous HBV genotypes by HBV vaccines.
The road to low-dose aspirin therapy for the prevention of preeclampsia began in the 1980s with the discovery that there was increased thromboxane and decreased prostacyclin production in placentas of preeclamptic women. At the time, low-dose aspirin therapy was being used to prevent recurrent myocardial infarction and other thrombotic events based on its ability to selectively inhibit thromboxane synthesis without affecting prostacyclin synthesis. With the discovery that thromboxane was increased in preeclamptic women, it was reasonable to evaluate whether low-dose aspirin would be effective for preeclampsia prevention. The first clinical trials were very promising, but then two large multi-center trials dampened enthusiasm until meta-analysis studies showed aspirin was effective, but with caveats. Low-dose aspirin was most effective when started <16 weeks of gestation and at doses >100 mg/day. It was effective in reducing preterm preeclampsia, but not term preeclampsia, and patient compliance and patient weight were important variables. Despite the effectiveness of low-dose aspirin therapy in correcting the placental imbalance between thromboxane and prostacyclin and reducing oxidative stress, some aspirin-treated women still develop preeclampsia. Alterations in placental sphingolipids and hydroxyeicosatetraenoic acids not affected by aspirin, but with biologic actions that could cause preeclampsia, may explain treatment failures. Consideration should be given to aspirin's effect on neutrophils and pregnancy-specific expression of protease-activated receptor 1, as well as additional mechanisms of action to prevent preeclampsia.
Written by one of the world's top scholars in the field of Pali Buddhism, this new and updated edition of How Buddhism Began, discusses various important doctrines and themes in early Buddhism. It takes 'early Buddhism' to be that reflected in the Pali canon, and to some extent assumes that these doctrines reflect the teachings of the Buddha himself. Two themes predominate. Firstly, the author argues that we cannot understand the Buddha unless we understand that he was debating with other religious teachers, notably Brahmins. The other main theme concerns metaphor, allegory and literalism. This accessible, well-written book is mandatory reading for all serious students of Buddhism.
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