Let me begin by offering a toast to biomedical science and biotechnology: May they live and be well. And may our children and grandchildren continue to reap their ever tastier fruit but without succumbing to their seductive promises of a perfect, better-than-human future, in which we shall all be as gods, ageless and blissful. As nearly everyone appreciates, we live near the beginning of the golden age of biotechnology. For the most part, we should be very glad that we do. We are many times over the beneficiaries of its cures for diseases, prolongation of life, and amelioration of suffering, psychic as well as somatic. We should be deeply grateful for the gifts of human ingenuity and cleverness, and for the devoted efforts of scientists, physicians, and entrepreneurs who have used these gifts to make those benefits possible. And, mindful that modern biology is just entering puberty, we suspect that the finest fruit is yet to come. Yet, notwithstanding these blessings, present and projected, we have also seen more than enough to make us anxious and concerned. For we recognize that the powers made possible by biomedical science can be used for non-therapeutic or ignoble purposes, serving ends that range from the frivolous and disquieting to the offensive and pernicious. These powers are available as instruments of bioterrorism (e.g., genetically engineered drug-resistant bacteria or drugs that obliterate memory); as agents of social control (e.g., drugs to tame rowdies or fertility-blockers for welfare recipients); and as means of trying to improve or perfect our bodies and minds and those of our children (e.g., genetically engineered super-muscles or drugs to improve memory). Anticipating possible threats to our security, freedom, and even our very humanity, many people are increasingly worried about where biotechnology may be taking us. We are concerned about what others might do to us, but also about what we might do to ourselves. We are concerned that our society might be harmed and that we ourselves might be diminished, indeed, in ways that could undermine the highest and richest possibilities of human life.
Drawing from a collection of over 160 North American print advertisements for anti-aging skin care products from January to December of 2009, this paper examines the discourse of agelessness, a vision of esthetic perfection and optimal health that is continually referred to by gerontologists, cultural theorists, and scientific researchers as a state of being to which humankind can aspire. Employing critical discourse analysis through the use of semiotics and visual rhetoric, this paper explores the means through which anti-aging skin care advertisements present to their viewers a particular object of desire, looking, more specifically, at how agelessness is presented as a way out and ultimate transcendence of age. Through the analytical tools of semiotics and visual rhetoric, four visions of agelessness are identified and explored in this paper: Agelessness as Scientific Purity, Agelessness as Genetic Impulse, Agelessness as Nature's Essence, and Agelessness as Myth. Whether found in the heights of scientific purity, the inner core of our genetic impulse, the depths of nature's essence, or whether agelessness itself has reached its own, untouchable, mythic status, the advertisements in this study represent one of the most pervasive vehicles through which our current vision(s) of ageless perfection are reflected, reinforced, and suspended in a drop of cream.
While aging is a nearly universal biological process, certain species exhibit negligible senescence, maintaining reproductive capacity and physiological function over extended lifespans. Notable examples include the Greenland shark (exceeding 400 years), naked mole-rat (over 30 years), ocean quahog (507 years), and Hydra (theoretically immortal). These organisms defy typical aging patterns through enhanced DNA repair, oxidative stress resistance, robust stem cell maintenance, and unique proteostasis and epigenetic regulation. Comparative analysis reveals common adaptations such as: 1) late age of sexual maturation; 2) long-term maintenance of sexual activity; 3) reduced metabolic rate; 4) tolerance to hypoxia; 5) neoplastic suppression. The molecular mechanisms underlying their longevity—including high-molecular-weight hyaluronan in naked mole-rats and specialized lipid membranes in sharks—offer transformative insights for anti-aging interventions. Understanding these strategies could pave the way for novel therapies targeting age-related diseases, potentially redefining human healthspan. This review synthesizes current knowledge on negligibly senescent species, highlighting their evolutionary, physiological, and biomedical significance.
The kinetics of the reaction of Ageless™ with oxygen were studied and an expression was obtained for the rate of oxygen reaction with Ageless: an empirical first order rate equation which involves the chamber volume and the Ageless capacity as well as the concentration of oxygen. Two factors which decrease the rate of reaction, low relative humidity and restricted access of oxygen to the Ageless packets, were evaluated. The usefulness of an oxygen scavenger such as Ageless in prolonging the lifespan of an oxygen-free atmosphere in a museum case is discussed.
In recent years, many researchers in the study of ageing have adopted a terminology of ‘agelessness’. They argue that old age is nothing more than a social construct and that until it is eliminated as a conceptual category, ageism will continue to flourish. This article challenges this view, stating that the current tendency towards ‘agelessness’ is itself a form of ageism, depriving the old of one of their most hard-earned resources: their age. Specific theories of ageing (successful ageing, mask of ageing, continuity theory) are assessed in this light, and original data are presented as evidence of old age as a unique phase of the lifecycle replete with continued developmental possibilities.
Book Review| November 01 1965 The Ageless Chinese: A History The Ageless Chinese: A History. By Dun J. Li. New York: Charles Scribner's Sons, 1965. xvi, 586. Suggested Readings, Chronology, Maps, Index, Illustrations. $8.95 (paper, $5.95). John Meskill John Meskill Barnard College Search for other works by this author on: This Site Google Journal of Asian Studies (1965) 25 (1): 141–142. https://doi.org/10.2307/2051060 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Permissions Cite Icon Cite Search Site Citation John Meskill; The Ageless Chinese: A History. Journal of Asian Studies 1 November 1965; 25 (1): 141–142. doi: https://doi.org/10.2307/2051060 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search Books & JournalsAll JournalsJournal of Asian Studies Search Advanced Search The text of this article is only available as a PDF. Copyright © The Association for Asian Studies, Inc. 19651965 Article PDF first page preview Close Modal You do not currently have access to this content.
BACKGROUND: Rapid population aging occurring in developing nations necessitates innovation to ensure we continue to gain ground on aging research despite pandemic threats. While developed nations have resorted to virtual communications, this is challenging in developing nations due to poor internet connectivity and digital literacy. OBJECTIVES: The aim of this study was to determine the feasibility of virtual data collection for a longitudinal study of aging assessing cognitive frailty in a middle-income Southeast Asian country. METHODS: The Transforming Cognitive Frailty into Later-Life Self-Sufficiency (AGELESS) longitudinal study of aging involved community-dwelling participants aged 60 years and above. A semi-structured focus group discussion was conducted via videoconferencing with selected representatives from existing participants. The survey instrument was compiled during a hybrid meeting and refined using a virtual Delphi process involving 51 AGELESS investigators. The final draft survey and recruitment strategy were then piloted among selected participants. RESULTS: Twelve individuals participated in the virtual focus group interview. Smartphone, tablet computer, laptops, and desktop personal computers were used for information gathering, communication, banking, shopping, leisure, religion, and education, within this group. The survey instrument was redacted from 362 items in 18 sections to 141 items in 12 sections through 3 virtual Delphi rounds facilitated by email, social media messaging, and videoconferencing which attracted 213 comments. Of 45 participants selected for the pilot survey, 30 were successfully contacted after one attempt and 18 completed the survey. Cognitive frailty was present in 13%, cognitive impairment in 20%, frailty in 20%, and 47% were robust. CONCLUSION: A virtual survey instrument was developed for the AGELESS longitudinal survey of aging which was vital for determining the effects of the COVID-19 pandemic on our older population as well as sustaining research into aging despite barriers posed by the pandemic.
Owing to the hierarchical structure of cellulose, nanoparticles can be extracted from this naturally occurring polymer. Multiple mechanical shearing actions allow the release of more or fewer individual microfibrils. Longitudinal cutting of these microfibrils can be achieved by a strong acid hydrolysis treatment, allowing dissolution of amorphous domains. The impressive mechanical properties, reinforcing capabilities, abundance, low density, and biodegradability of these nanoparticles make them ideal candidates for the processing of polymer nanocomposites. With a Young's modulus in the range 100–130 GPa and a surface area of several hundred m2 g−1, new promising properties can be considered for cellulose.
Ageless Talent: Enhancing the Performance and Well-Being of Your Age-Diverse Workforce provides organizational leaders, managers, and supervisors with clear, evidence-based tactics by which to develop and manage an aging and age-diverse talent pool. This volume provides an easy-to-implement set of tools for addressing the difficult problems related to employee performance and well-being amid ongoing technological and social change. Ageless Talent introduces a straightforward framework (PIERA) that translates scientific advances into actionable steps and strategies. Using this framework, this book provides practical illustrations to help readers design their own small-scale interventions to achieve desirable goals under diverse organizational constraints. Furthermore, the book addresses modern management challenges arising across the globe, and offers suggestions for leaders interested in short-term and long-term change. These suggestions, grounded in time-tested and leading-edge research evidence, include specific step-by-step guidelines, customizable to different types of organizations and industries. With economic, cultural, technological, and demographic shifts making the changing nature of work a pressing concern for organizations around the globe, Ageless Talent is an essential text for practitioners – HR professionals, organizational leaders, and managers – as well as management education programs and professional training and leadership programs. It will also appeal to instructors and students in the field of industrial/organizational psychology.
In the 21st Century, the world faces a unique challenge – global aging. The simultaneous manifestation of this challenge in so many countries is unprecedented and will have major social and economic ramifications. The impending tsunami of silver populations also presents unique opportunities for forward thinking nations and businesses. These elderly citizens command major purchasing power, and possess invaluable knowledge, wisdom and skills accumulated over many years. Countries and businesses which develop and adopt innovative technologies to allow elderly citizens to continue making important contributions to society will derive enormous benefits. In this paper, we analyze how computing technologies can be used to help us build an ageless society in the future. We identify six major challenges facing today’s elderly populations and propose six corresponding research directions in computing technologies. A vision for forming an ageless computing ecosystem that serves the needs of the elderly and other stakeholders is proposed based on this analysis. Keyword: population aging, ageless computing, age-friendly, ecosystem.
In Ageless Marketing, authors David Wolfe and Robert Snyder document the results of a groundbreaking research project on the aging boomer generation, detailing the core values, buying behaviors, and emotional factors that distinguish the New Customer Majority. As more companies seek sales from multiple age groups, ageless marketing becomes critical to financial performance.
AbstractAbstractThe chemical and physical properties of AgelessR oxygen absorber, a commercial oxygen scavenger, are described. The active ingredient in Ageless is finely divided iron, but the key to its use as a practical method of removing oxygen is the method of preparation, additives and packaging. Criteria for museum use are put forward and certain problems, such as heat generation and hydrogen evolution, are discussed.
Among the many studies of aging and the aged, there is comparatively little material in which the aged speak for themselves. In this compelling study, Sharon Kaufman encourages just such expression, recording and presenting the voices of a number of old Americans. Her informants tell their life stories and relate their most personal feelings about becoming old. Each story is unique, and yet, presented together, they inevitable weave a clear pattern, one that clashes sharply with much current gerontological thought. With this book, Sharon Kaufman allows us to understand the experience of the aging by listening to the aged themselves. Kaufman, while maintaining objectivity, is able to draw an intimate portrait of her subjects. We come to know these people as individuals and we become involved with their lives. Through their words, we find that the aging process is not merely a period of sensory, functional, economic, and social decline. Old people continue to participate in society, and more important continue to interpret their participation in the social world. Through themes constructed from these stories, we can see how the old not only cope with losses, but how they create new meaning as they reformulate and build viable selves. Creating identity, Kaufman stresses, is a lifelong process. Sharon Kaufman's book will be of interest and value not only to students of gerontology and life span development, and to professionals in the field of aging, but to everyone who is concerned with the aging process itself. As Sharon Kaufman says, If we can find the sources of meaning held by the elderly and see how individuals put it all together, we will go a long way toward appreciating the complexity of human aging and the ultimate reality of coming to terms with one's whole life.
In recent years, many researchers in the study of ageing have adopted a terminology of ‘agelessness’. They argue that old age is nothing more than a social construct and that until it is eliminated as a conceptual category, ageism will continue to flourish. This article challenges this view, stating that the current tendency towards ‘agelessness’ is itself a form of ageism, depriving the old of one of their most hard-earned resources: their age. Specific theories of ageing (successful ageing, mask of ageing, continuity theory) are assessed in this light, and original data are presented as evidence of old age as a unique phase of the lifecycle replete with continued developmental possibilities.
Oxygen plays a critical role in the deterioration of museum objects. Ageless™, which is one of the most widely used commercial oxygen absorbers, can be an extremely efficient and cost-effective means of generating low-oxygen atmospheres for the long-term storage of air-sensitive museum objects. Relatively little technical expertise or equipment is required. Ageless is non-toxic and residue-free and can be safely handled with only minor precautions. Its use has a number of advantages over traditional purging techniques which are not economical when used to maintain oxygen levels of less than 1% over prolonged periods of time.
Silver nanotechnology has received tremendous attention in recent years, owing to its wide range of applications in various fields and its intrinsic therapeutic properties. In this review, an attempt is made to critically evaluate the chemical, physical, and biological synthesis of silver nanoparticles (AgNPs) as well as their efficacy in the field of theranostics including microbiology and parasitology. Moreover, an outlook is also provided regarding the performance of AgNPs against different biological systems such as bacteria, fungi, viruses, and parasites (leishmanial and malarial parasites) in curing certain fatal human diseases, with a special focus on cancer. The mechanism of action of AgNPs in different biological systems still remains enigmatic. Here, due to limited available literature, we only focused on AgNPs mechanism in biological systems including human (wound healing and apoptosis), bacteria, and viruses which may open new windows for future research to ensure the versatile application of AgNPs in cosmetics, electronics, and medical fields.
暂无摘要（点击查看原文获取完整内容）
暂无摘要（点击查看原文获取完整内容）
The loss of internal pores, a process known as physical aging, inhibits the long-term use of the most promising gas-separation polymers. Previously we reported that a porous aromatic framework (PAF-1) could form a remarkable nanocomposite with gas-separation polymers to stop aging. However, PAF-1 synthesis is very onerous both from a reagent and reaction-condition perspective, making it difficult to scale-up. We now reveal a highly dispersible and scalable additive based on α,α'-dichloro-p-xylene (p-DCX), that inhibits aging more effectively, and crucially almost doubles gas-transport selectivity. These synergistic effects are related to the intimately mixed nanocomposite that is formed though the high dispersibility of p-DCX in the gas-separation polymer. This reduces particle-size effects and the internal free volume is almost unchanged over time. This study shows this inexpensive and scalable polymer additive delivers exceptional gas-transport performance and selectivity.