What determines whether an organism or collective will survive under particular conditions? This question is asked across the life sciences when determining adaptive fit, developing efficacious treatments for diseases, and assessing the risks posed by ecological shifts. To aid their investigations, researchers employ models of agents which must respect particular constraints to remain alive. By constraining the dynamics of these agents to bounded viability regions, these models form a class of extended dynamical systems where transient dynamics can lead to death, making traditional attractors and separatrices insufficient for characterizing the global space of possible behaviors. To remedy this, we develop viability space decomposition, an analysis framework for ordinary differential equation models of agents with viability constraints. We first introduce the general theory, revealing how several new classes of manifolds (mortality, ordering, and collapse) permit a complete decomposition of state space into regions of qualitatively similar survival outcomes: a viability portrait. We then demonstrate the method by completely analyzing the global behavior of three models: a subcellul
This paper investigates the problem of maintaining the safe operation of Waste-to-Energy (WtE) systems under operational constraints and uncertain waste inflows. We model this as a robust viability problem, formulated as a zero-sum differential game between a control policy and an adversarial disturbance. Within a Hamilton-Jacobi framework, the viability kernel is characterized as the zero sublevel set of a value function satisfying a constrained Hamilton-Jacobi-Bellman (HJB) equation in the viscosity sense. This formulation provides formal guarantees for ensuring that system trajectories remain within prescribed operational limits under worst-case scenarios. Compared to existing viability studies, this work introduces a rigorous HJB-based characterization explicitly incorporating uncertainty, tailored to nonlinear WtE dynamics. A numerical scheme based on the Local Lax-Friedrichs method is employed to approximate the viability kernel. Numerical experiments illustrate how increasing inflow uncertainty significantly reduces the viability domain, shrinking the safe operating envelope. The proposed method is computationally tractable for systems of moderate dimension and offers a basi
Diffusion models can be used as a motion planner by sampling from a distribution of possible futures. However, the samples may not satisfy hard constraints that exist only implicitly in the training data, e.g., avoiding falls or not colliding with a wall. We propose learned viability filters that efficiently predict the future success of any given plan, i.e., diffusion sample, and thereby enforce an implicit future-success constraint. Multiple viability filters can also be composed together. We demonstrate the approach on detailed footstep planning for challenging 3D human locomotion tasks, showing the effectiveness of viability filters in performing online planning and control for box-climbing, step-over walls, and obstacle avoidance. We further show that using viability filters is significantly faster than guidance-based diffusion prediction.
In this work, we investigate the viability of some cosmological models derived from generalized horizon entropies, using Big Bang Nucleosynthesis (BBN) constraints. By analyzing the deviations in the expansion rate, we derive bounds on the model parameters from freeze-out temperature, helium, and deuterium abundances. Our results show that the freeze-out condition provides the most stringent constraint, while helium and deuterium bounds remain consistent across all models. Although lithium constraints are not satisfied, this discrepancy is attributed to the well-known cosmological lithium problem. Furthermore, the parameter values required for late-time cosmic acceleration are found to lie well within the BBN bounds, demonstrating consistency between early- and late-Universe behavior. These results establish the viability of the considered models within the framework of BBN.
Our study presents a model of factors influencing the financial viability of Hungarian social enterprises, and tests the model on a sample of 220 Hungarian firms involved in social entrepreneurship. In the model we suggest that the most important factors for financial viability are the Regulatory environment (the transparency of regulations); the Entrepreneurial attributes of the entrepreneur (business orientation, business skills and experience, business planning tendencies); the Financial support provided by the environment (the ratio of grants, donations and subsidies within the total revenues of the firm); and the Strategy followed by the firms (the presence of such generic strategies as cost leadership or differentiation). We find that only two of the model's four factors are significantly associated with Financial viability: Entrepreneurial attributes and Financial support. The results suggest that the best way of strengthening the viability of social enterprises is through entrepreneurship training (to enhance the business skills and experience of the entrepreneurs, and to propagate business planning), and to provide grants and subsidies to these firms. As no significant ass
This paper develops a model to evaluate the viability of blockchain markets as the sole venue for price formation. Blockchains clear at discrete intervals called block time, and transactions are executed sequentially according to priority fees paid by traders who compete for queue position. We show that these features undermine the viability of markets. Paid-priority ordering induces endogenous selection, where only traders with sufficiently high valuations participate. The participation cutoff rises with competition, which intensifies with lower information costs or higher liquidity demand. This hinders price discovery and biases prices. It also impairs liquidity: the cutoff concentrates trading among aggressive traders and increases adverse selection that liquidity suppliers absorb in a single clearing round. Although longer block times enhance consensus security, they amplify these effects and can cause markets to shut down.
In this article, we establish necessary and sufficient viability conditions for continuity inclusions over the 1-Wasserstein space. Depending on the regularity properties of the dynamics, we derive two results which are based on fairly different proof strategies. When the admissible velocities are Lipschitz in the measure variable, we show that it is necessary and sufficient for viable solutions to exist that the latter intersect the graphical derivative of the constraints. On the other hand, when the admissible velocities are merely upper semicontinuous in the measure variable, we provide a sufficient condition for viability involving the infinitesimal behaviour of their Aumann integral over a neighbouring set of measures.
In this paper we aim to study viability and completeness in finite markets. In order to do that, we characterize the set of equivalent martingale measures of two-period markets as convex combinations of a finite number of martingale measures. We provide an algorithm for finding such measures, that can be applied in other problems of convex geometry, and represents the starting point for a study of such characterizations of convex sets' intersections. We apply these results to the study of a discrete-time version of the Korn-Kreer-Lenssen model, and give an example of the limitations of using discrete-time models to understand continuous-time ones.
Ascertaining the collective viability of cells in different cell culture conditions has typically relied on averaging colorimetric indicators and is often reported out in simple binary readouts. Recent research has combined viability assessment techniques with image-based deep-learning models to automate the characterization of cellular properties. However, further development of viability measurements to assess the continuity of possible cellular states and responses to perturbation across cell culture conditions is needed. In this work, we demonstrate an image processing algorithm for quantifying cellular viability in 3D cultures without the need for assay-based indicators. We show that our algorithm performs similarly to a pair of human experts in whole-well images over a range of days and culture matrix compositions. To demonstrate potential utility, we perform a longitudinal study investigating the impact of a known therapeutic on pancreatic cancer spheroids. Using images taken with a high content imaging system, the algorithm successfully tracks viability at the individual spheroid and whole-well level. The method we propose reduces analysis time by 97% in comparison to the e
This paper studies viability and control synthesis for a delayed SIR epidemic. The model integrates a constant delay representing an incubation/latency time. The control inputs model non-pharmaceutical interventions, while an intensive care unit (ICU) state-constraint is introduced to reflect the healthcare system's capacity. The arising delayed control system is analyzed via functional viability tools, providing insights into fulfilling the ICU constraint through feedback control maps. In particular, we consider two scenarios: first, we consider the case of general continuous initial conditions. Then, as a further refinement of our analysis, we assume that the initial conditions satisfy a Lipschitz continuity property, consistent with the considered model. The study compares the (in general, sub-optimal) obtained control policies with the optimal ones for the delay-free case, emphasizing the impact of the delay parameter. The obtained results are supported and illustrated, in a concluding section, by numerical examples.
Pollen grains represent the male gametes of seed plants and their viability is critical for efficient sexual reproduction in the plant life cycle. Pollen analysis is used in diverse research thematics to address a range of botanical, ecological and geological questions. More recently it has been recognized that pollen may also be a vector for transgene escape from genetically modified crops, and the importance of pollen viability in invasion biology has also been emphasized. In this work, we analyse and report an efficient visual method for assessing the viability of pollen using digital holographic microscopy (DHM). We test this method on pollen grains of the invasive Lantana camara, a well known plant invader known to most of the tropical world. We image pollen grains and show that the quantitative phase information provided by the DHM technique can be readily related to the chromatin content of the individual cells and thereby to pollen viability. Our results offer a new technique for pollen viability assessment that does not require staining, and can be applied to a number of emerging areas in plant science.
In clinical In-Vitro Fertilization (IVF), identifying the most viable embryo for transfer is important to increasing the likelihood of a successful pregnancy. Traditionally, this process involves embryologists manually assessing embryos' static morphological features at specific intervals using light microscopy. This manual evaluation is not only time-intensive and costly, due to the need for expert analysis, but also inherently subjective, leading to variability in the selection process. To address these challenges, we develop a multimodal model that leverages both time-lapse video data and Electronic Health Records (EHRs) to predict embryo viability. One of the primary challenges of our research is to effectively combine time-lapse video and EHR data, owing to their inherent differences in modality. We comprehensively analyze our multimodal model with various modality inputs and integration approaches. Our approach will enable fast and automated embryo viability predictions in scale for clinical IVF.
Quadruped animals seamlessly transition between gaits as they change locomotion speeds. While the most widely accepted explanation for gait transitions is energy efficiency, there is no clear consensus on the determining factor, nor on the potential effects from terrain properties. In this article, we propose that viability, i.e. the avoidance of falls, represents an important criterion for gait transitions. We investigate the emergence of gait transitions through the interaction between supraspinal drive (brain), the central pattern generator in the spinal cord, the body, and exteroceptive sensing by leveraging deep reinforcement learning and robotics tools. Consistent with quadruped animal data, we show that the walk-trot gait transition for quadruped robots on flat terrain improves both viability and energy efficiency. Furthermore, we investigate the effects of discrete terrain (i.e. crossing successive gaps) on imposing gait transitions, and find the emergence of trot-pronk transitions to avoid non-viable states. Compared with other potential criteria such as peak forces and energy efficiency, viability is the only improved factor after gait transitions on both flat and discret
Safety is often the most important requirement in robotics applications. Nonetheless, control techniques that can provide safety guarantees are still extremely rare for nonlinear systems, such as robot manipulators. A well-known tool to ensure safety is the Viability kernel, which is the largest set of states from which safety can be ensured. Unfortunately, computing such a set for a nonlinear system is extremely challenging in general. Several numerical algorithms for approximating it have been proposed in the literature, but they suffer from the curse of dimensionality. This paper presents a new approach for numerically approximating the viability kernel of robot manipulators. Our approach solves optimal control problems to compute states that are guaranteed to be on the boundary of the set. This allows us to learn directly the set boundary, therefore learning in a smaller dimensional space. Compared to the state of the art on systems up to dimension 6, our algorithm resulted to be more than 2 times as accurate for the same computation time, or 6 times as fast to reach the same accuracy.
In this paper we study a criterion for the viability of stochastic semilinear control systems on a real, separable Hilbert space. The necessary and sufficient conditions are given using the notion of stochastic quasi-tangency. As a consequence, we prove that approximate viability and the viability property coincide for stochastic linear control systems. We obtain Nagumo's stochastic theorem and we present a method allowing to provide explicit criteria for the viability of smooth sets. We analyze the conditions characterizing the viability of the unit ball. The paper generalizes recent results from the deterministic framework.
We study the problem of maximizing a monotone submodular function with viability constraints. This problem originates from computational biology, where we are given a phylogenetic tree over a set of species and a directed graph, the so-called food web, encoding viability constraints between these species. These food webs usually have constant {depth}. The goal is to select a subset of $k$ species that satisfies the viability constraints and has maximal phylogenetic diversity. As this problem is known to be NP-hard, we investigate approximation algorithms. We present the first constant factor approximation algorithm if the depth is constant. Its approximation ratio is $(1-\frac{1}{\sqrt{e}})$. This algorithm not only applies to phylogenetic trees with viability constraints but for arbitrary monotone submodular set functions with viability constraints. Second, we show that there is no $(1-1/e+ε)$-approximation algorithm for our problem setting (even for additive functions) and that there is no approximation algorithm for a slight extension of this setting.
Onchocerciasis is causing blindness in over half a million people in the world today. Drug development for the disease is crippled as there is no way of measuring effectiveness of the drug without an invasive procedure. Drug efficacy measurement through assessment of viability of onchocerca worms requires the patients to undergo nodulectomy which is invasive, expensive, time-consuming, skill-dependent, infrastructure dependent and lengthy process. In this paper, we discuss the first-ever study that proposes use of machine learning over thermal imaging to non-invasively and accurately predict the viability of worms. The key contributions of the paper are (i) a unique thermal imaging protocol along with pre-processing steps such as alignment, registration and segmentation to extract interpretable features (ii) extraction of relevant semantic features (iii) development of accurate classifiers for detecting the existence of viable worms in a nodule. When tested on a prospective test data of 30 participants with 48 palpable nodules, we achieved an Area Under the Curve (AUC) of 0.85.
Accurate evaluation of liver viability during its procurement is a challenging issue and has traditionally been addressed by taking invasive biopsy on liver. Recently, people have started to investigate on the non-invasive evaluation of liver viability during its procurement using the liver surface thermal images. However, existing works include the background noise in the thermal images and do not consider the cross-subject heterogeneity of livers, thus the viability evaluation accuracy can be affected. In this paper, we propose to use the irregular thermal data of the pure liver region, and the cross-subject liver evaluation information (i.e., the available viability label information in cross-subject livers), for the real-time evaluation of a new liver's viability. To achieve this objective, we extract features of irregular thermal data based on tools from graph signal processing (GSP), and propose an online domain adaptation (DA) and classification framework using the GSP features of cross-subject livers. A multiconvex block coordinate descent based algorithm is designed to jointly learn the domain-invariant features during online DA and learn the classifier. Our proposed frame
Understanding team viability -- a team's capacity for sustained and future success -- is essential for building effective teams. In this study, we aggregate features drawn from the organizational behavior literature to train a viability classification model over a dataset of 669 10-minute text conversations of online teams. We train classifiers to identify teams at the top decile (most viable teams), 50th percentile (above a median split), and bottom decile (least viable teams), then characterize the attributes of teams at each of these viability levels. We find that a lasso regression model achieves an accuracy of .74--.92 AUC ROC under different thresholds of classifying viability scores. From these models, we identify the use of exclusive language such as `but' and `except', and the use of second person pronouns, as the most predictive features for detecting the most viable teams, suggesting that active engagement with others' ideas is a crucial signal of a viable team. Only a small fraction of the 10-minute discussion, as little as 70 seconds, is required for predicting the viability of team interaction. This work suggests opportunities for teams to assess, track, and visualize
We introduce the notion of mean viability for controlled stochastic differential equations and establish counterparts of Nagumo's classical viability theorems (necessary and sufficient conditions for mean viability). As an application, we provide a purely probabilistic proof of a comparison principle and of existence for contingent and viscosity solutions of second-order fully nonlinear path-dependent Hamilton-Jacobi-Bellman equations. We do not use compactness and optimal stopping arguments, which are usually employed in the literature on viscosity solutions for second-order path-dependent PDEs.