Ablative radiotherapy (RT) improves clinical outcomes in patients with unresectable intrahepatic cholangiocarcinoma (ICC). Applicability to "supermassive" ICC remains uncertain given smaller tumor diameters in previous studies. We hypothesize that supermassive ICCs are not mutationally or histopathologically different from nonsupermassive ICCs and so would respond favorably to ablative RT. This is a retrospective study of patients with supermassive ICC treated at the University of Texas MD Anderson Cancer Center (MDACC) and the National Cancer Database (NCDB). Patients treated at MDACC with unresectable ICC, ≥10 cm in diameter, treated with ablative RT or chemotherapy alone were included. Among NCDB patients, patients treated with chemotherapy alone were included. We analyzed overall survival (OS), tumor-related liver failure (TRLF), and treatment toxicity. We further analyzed mutational status and histopathology in supermassive and nonsupermassive ICC tumors. We identified 63 patients treated at MDACC. Patients treated with RT showed improved OS compared with patients treated with chemotherapy alone (median OS: 28.7 vs. 11.9 months; adjusted HR = 0.4; P = 0.02). Patients treated with chemotherapy alone had a higher rate of TRLF compared with those who received RT (47.1% vs. 12.1%; P = 0.01). The RT cohort had improved OS compared with a frequency-matched NCDB chemotherapy-only cohort of supermassive ICC (37.6 vs. 8.9 months, P < 0.001). No major differences in mutational status or histopathology were noted between supermassive and nonsupermassive ICC tumors. Patients with supermassive ICC did not show a distinct mutational or histopathologic profile compared with those with nonsupermassive ICC and had promising outcomes with manageable toxicity when treated with ablative RT.
Because they are likely to accrete substantial amounts of interstellar gas, merging supermassive binary black holes are expected to be strong multimessenger sources, radiating gravitational waves, photons from thermal gas, and photons from relativistic electrons energized by relativistic jets. Here we report on a numerical simulation that covers the late inspiral, merger, and initial postmerger phase of such a system where both black holes have the same mass and spin, and both spin axes are parallel to the orbital angular momentum. The simulation incorporates both 3D general relativistic magnetohydrodynamics and numerical relativity. The thermal photon power during the late inspiral, merger, and immediate postmerger phases is drawn from strong shocks rather than dissipation of turbulence inside a smoothly structured accretion disk as typically found around accreting single black holes. We find that the thermal photon and jet Poynting flux outputs are closely related in time, and we posit a mechanism that enforces this relation. The power radiated in both photons and jets diminishes gradually as merger is approached, but jumps sharply at merger to a noisy plateau. Such a distinct lightcurve should aid efforts to identify supermassive black hole mergers, with or without accompanying gravitational wave detections.
A semianalytical model for the evolution of galaxies and supermassive black holes within the cold dark matter paradigm has been shown to yield stellar-black hole mass relations that reproduce both the James Webb Space Telescope and pre-Webb telescope observations. Either fuzzy or warm dark matter would suppress the formation of the smaller galactic halos that play important roles in the cold dark matter fit to the high-redshift supermassive black hole data. Our analysis of the stellar-black hole mass relation disfavors fuzzy dark matter fields with masses <2.0×10^{-20}  eV and warm dark matter particles with masses <7.2  keV, both at the 95% confidence level.
Relativistic jets from supermassive black holes in active galactic nuclei are amongst the most powerful phenomena in the universe. Similar jets from stellar-mass black holes offer a chance to study the phenomena on accessible observation time scales. However, such comparative studies across black hole masses and time scales remain hampered by the long-standing perception that stellar-mass black hole jets are in a less relativistic regime. Here, we show the detection of two distinct, relativistic jet ejections from the Galactic black hole X-ray binary 4U 1543-47 during a single outburst, with radio interferometry monitoring observations. Our measurements reveal a likely Lorentz factor of approximately 8 and a minimum of 4.6 at launch with 95% confidence, demonstrating that stellar-mass black holes in X-ray binaries can launch jets as relativistic as those seen in active galactic nuclei.
The dusty and molecular torus is an elusive structure surrounding supermassive black holes, yet its importance is unequivocal for understanding feedback and accretion mechanisms. The torus and accretion disk feed the inspiraling gas onto the active nucleus, launching outflows that fundamentally connect the active nucleus's activity to the host galaxy. In this work, we utilize the aperture-masking interferometric mode onboard the JWST to achieve a resolution of 0.08" at 4.3 μm and bring out the fainter features in the central 10 pc of the Circinus galaxy. We show that most of the dust mass is located along the equatorial axis in the form of a 5 × 3 pc disk feeding the active nucleus. Only  < 1% of the dust emission arises from an arc structure composed of hot dust entrained in a molecular and ionized outflow, while the extended emission is associated with dust heated by the active galaxy at large scales.
Supermassive black hole (SMBH) binary systems are an unavoidable outcome of galaxy mergers. Their dynamics encode valuable information about their formation and growth, the composition of their host galactic nuclei, the evolution of galaxies, and the nature of gravity. Many SMBH binaries with separations pc-kpc have been found, but closer (subparsec) binaries remain to be confirmed. Identifying these systems may elucidate how binaries evolve past the "final parsec" until gravitational radiation drives them to coalescence. Methods to discover and characterize SMBH binaries can shed light on these important questions and potentially open new multimessenger channels. Here we show that SMBH binaries in nonactive galactic nuclei can be identified and characterized by the gravitational lensing of individual bright stars, located behind them in the host galaxy. The rotation of "caustics"-regions where sources are hugely magnified due to the SMBH binary's orbit and inspiral-leads to quasiperiodic lensing of starlight (QPLS). The extreme lensing magnification of individual bright stars produces a significant variation in the host galaxies' luminosity; their lightcurve traces the orbit of the SMBH binary and its evolution, analogous to the waveforms recorded by gravitational-wave (GW) detectors. QPLS probes the population of sources observable by pulsar timing arrays and space detectors (LISA, TianQin), offering advance warning triggers for merging SMBHs for coincident or follow-up GW detections. SMBH population models predict 1-50 [190-5000](n_{⋆}/pc^{-3}) QPLS binaries with period less than 10[40] yr with comparable masses and redshift z<0.3, where n_{⋆} is the stellar number density. Additionally, stellar and orbital motion will lead to frequent instances of single or double flares caused by SMBHBs with longer periods. This novel signature can be searched for in a wealth of existing and upcoming time-domain photometric data: identifying quasiperiodic variability in galactic lightcurves will reveal an ensemble of binary systems and illuminate outstanding questions around them.
Tidal disruption events (TDEs), which occur when stars enter the tidal radii of supermassive black holes (SMBHs) and are subsequently torn apart by their tidal forces, represent intriguing phenomena that stimulate growing research interest and pose an increasing number of puzzles in the era of time-domain astronomy. Here, we report an unusual X-ray transient, XID 935, discovered in the 7 Ms Chandra Deep Field-South, the deepest X-ray survey ever. XID 935 experienced an overall X-ray dimming by a factor of more than 40 between 1999 and 2016. Not monotonically decreasing during this period, its X-ray luminosity increased by a factor > 27 within 2 months, from L 0.5 - 7 keV < 10 40.87 erg s-1 (October 10, 2014-January 4, 2015) to L 0.5 - 7 keV = 10 42.31 ± 0.20 erg s-1 (March 16, 2015). The X-ray position of XID 935 is located at the center of its host galaxy with a spectroscopic redshift of 0.251, whose optical spectra do not display emission characteristics associated with an active galactic nucleus. The peak 0.5-2.0 keV flux is the faintest among all the X-ray-selected TDE candidates to date. Thanks to a total exposure of ∼ 9.5 Ms in the X-ray bands, we manage to secure relatively well-sampled, 20-year-long X-ray light curves of this deepest X-ray-selected TDE candidate. We find that a partial TDE model could not explain the main declining trend. An SMBH binary TDE model is in acceptable accordance with the light curves of XID 935; however, it fails to match short-timescale fluctuations exactly. Therefore, the exceptional observational features of XID 935 provide a key benchmark for refining quantitative TDE models and simulations.
The James Webb Space Telescope (JWST) has uncovered many compact galaxies at high redshift with broad hydrogen and helium lines, including the enigmatic population of little red dots (LRDs)1,2. The nature of these galaxies is debated and is attributed to supermassive black holes (SMBHs)3,4 or intense star formation5. They exhibit unusual properties for SMBHs, such as black holes that are overmassive for their host galaxies4 and extremely weak X-ray6-10 and radio6,11-13 emission. Here we show that in most objects studied with the highest-quality JWST spectra, the lines are broadened by electron scattering with a narrow intrinsic core. The data require very high electron column densities and compact sizes (light days), which, when coupled with their high luminosities, can be explained only by SMBH accretion. The narrow intrinsic line cores imply black hole masses of 105-7M⊙, two orders of magnitude lower than previous estimates. These are the lowest mass black holes known at high redshift, to our knowledge, and suggest a population of young SMBHs. They are enshrouded in a dense cocoon of ionized gas producing broad lines from which they are accreting close to the Eddington limit, with very mild neutral outflows. Reprocessed nebular emission from this cocoon dominates the optical spectrum, explaining most LRD spectral characteristics, including the weak radio and X-ray emission14,15.
Recent discoveries from time-domain surveys are defying our expectations for how matter accretes onto supermassive black holes (SMBHs). The increased rate of short-timescale, repetitive events around SMBHs, including the recently discovered quasi-periodic eruptions1-5, are garnering further interest in stellar-mass companions around SMBHs and the progenitors to millihertz-frequency gravitational-wave events. Here we report the discovery of a highly significant millihertz quasi-periodic oscillation (QPO) in an actively accreting SMBH, 1ES 1927+654, which underwent a major optical, ultraviolet and X-ray outburst beginning in 20186,7. The QPO was detected in 2022 with a roughly 18-minute period, corresponding to coherent motion on a scale of less than 10 gravitational radii, much closer to the SMBH than typical quasi-periodic eruptions. The period decreased to 7.1 minutes over 2 years with a decelerating period evolution ( P ¨ greater than zero). To our knowledge, this evolution has never been seen in SMBH QPOs or high-frequency QPOs in stellar-mass black holes. Models invoking orbital decay of a stellar-mass companion struggle to explain the period evolution without stable mass transfer to offset angular-momentum losses, and the lack of a direct analogue to stellar-mass black-hole QPOs means that many instability models cannot explain all of the observed properties of the QPO in 1ES 1927+654. Future X-ray monitoring will test these models, and if it is a stellar-mass orbiter, the Laser Interferometer Space Antenna (LISA) should detect its low-frequency gravitational-wave emission.
Observations of massive supermassive black holes (SMBHs) in the early Universe challenge existing black hole formation models. We propose that soliton cores in fuzzy dark matter (FDM) offer a potential solution to this timing problem. Our FDM cosmological zoom-in simulations confirm that, for a particle mass m_{FDM}∼10^{-22}  eV, solitons are well developed at redshift z∼7 with masses of ∼10^{9}M_{⊙}, comparable to the observed SMBHs. We then demonstrate using hydrodynamic simulations that, compared to cold dark matter, these high-z massive FDM solitons with mass M_{s} can provide additional gravitational potential to accrete gas and boost the Bondi accretion rate of a growing black hole seed with mass M_{BH} by up to 2-4 orders of magnitude, in the regime of efficient cooling and negligible radiation pressure. This accretion boosting mechanism is effective for 10^{-22}≲m_{FDM}≲10^{-20}  eV and potentially beyond as long as M_{s}>M_{BH}.
Constraining the origin of the nanohertz gravitational-wave background necessitates precise noise modelling to avoid parameter estimation biases. In this work, we find the inferred properties of the putative gravitational wave background in the second data release of the European Pulsar Timing Array to be in better agreement with theoretical expectations under the improved noise model. In particular, our improved noise models show consistency of the background's strain spectral index with the value of  -2/3, favoring the population of supermassive black hole binaries as the origin of the background. Our results further suggest that the observed gravitational wave emission is the dominant source of the binary energy loss, with no evidence of environmental effects or eccentric orbits. At the reference gravitational wave frequency of yr-1, we also find a lower power-law strain amplitude of the background than in previous data analyses. This mitigates some of the tensions of the strain amplitude with the expected number density and mass scale of binaries discussed in the literature. Our analysis demonstrates the importance of accurate modelling of radio pulsar pulse profile variations, hierarchical properties of noise across pulsars, as well as noise model averaging, when inferring properties of the gravitational wave background.
High-velocity stars and peculiar G objects orbit the central supermassive black hole (SMBH) Sagittarius A* (Sgr A*). Together, the G objects and high-velocity stars constitute the S cluster. In contrast with theoretical predictions, no binary system near Sgr A* has been identified. Here, we report the detection of a spectroscopic binary system in the S cluster with the masses of the components of 2.80  ±  0.50 M⊙ and 0.73  ±  0.14 M⊙, assuming an edge-on configuration. Based on periodic changes in the radial velocity, we find an orbital period of 372±3 days for the two components. The binary system is stable against the disruption by Sgr A* due to the semi-major axis of the secondary being 1.59±0.01 AU, which is well below its tidal disruption radius of approximately 42.4 AU. The system, known as D9, shows similarities to the G objects. We estimate an age for D9 of 2 . 7 - 0.3 + 1.9 × 1 0 6 yr that is comparable to the timescale of the SMBH-induced von Zeipel-Lidov-Kozai cycle period of about 106 yr, causing the system to merge in the near future. Consequently, the population of G objects may consist of pre-merger binaries and post-merger products. The detection of D9 implies that binary systems in the S cluster have the potential to reside in the vicinity of the supermassive black hole Sgr A* for approximately 106 years.
Blood transfusions are common during combat casualty care, aiming to address the loss of blood volume that often accompanies severe battlefield injuries. This scoping review delves into the existing military combat casualty data to analyze the efficacy, challenges, and advances in the use of massive and super-massive transfusions in the management of critically injured warfighters. We performed a scoping review of combat-related literature published between 2006 and 2023 pertaining to massive transfusions used during combat deployments. We utilized PubMed to identify relevant studies and utilized the PRISMA-ScR Checklist to conduct the review. We identified 53 studies that met the inclusion criteria with the majority being retrospective studies from registries used by the United States, British, French, and Dutch Militaries. Most of the studies focused on transfusion ratios, the movement of blood transfusions to more forward locations, implementation of massive transfusions with different fibrinogen-to-red blood cell ratios, the addition of recombinant factor VII, and the use of predictive models for transfusion. Lastly, we identified reports of improved survival for casualties with the rapid implementation of various blood products (warm fresh whole blood, cold-stored low titer group O blood, freeze-dried plasma, and component therapy) and literature relating to pediatric casualties and submassive transfusions. Notable findings include the establishment of hemodynamic and cell blood count parameters as predictors of the requirement for massive transfusions and the association of higher fibrinogen-to-red blood cell ratios with decreased mortality. We identified 53 studies focused on blood transfusions from the Global War on Terrorism conflicts. The majority were related to transfusion ratios and the movement of blood transfusions to more forward locations. We highlight key lessons learned on the battlefield that have been translated into scientific developments and changes in civilian trauma methods.
Dark Stars (DSs), i.e., early stars composed almost entirely of hydrogen and helium but powered by Dark Matter (DM), could form in zero metallicity clouds located close to the center of high redshift DM halos. In 2023, three of us identified (in a PNAS work) the first three photometric DS candidates: JADES-GS-z11-0, JADES-GS-z12-0, and JADES-GS-z13-0. We report here our results of a follow-up analysis based on available NIRSpec JWST data. We find that JADES-GS-z11-0 and JADES-GS-z13-0 are spectroscopically consistent with a DS interpretation. Moreover, we find two additional spectroscopic DS candidates: JADES-GS-z14-0 and JADES-GS-z14-1, with the former being the second most distant luminous object ever observed. We furthermore identify, in the spectrum of JADES-GS-z14-0, a tentative feature ([Formula: see text]) indicative of the smoking gun signature of DSs: the He II [Formula: see text]1640 absorption line. In view of ALMA's recent identification of a probable O III nebular emission line in the spectrum of JADES-GS-z14-0, the simple interpretation of this object as an isolated DS is unlikely. If both spectral features survive follow-up observations, it would imply a DS embedded in a metal rich environment, requiring theoretical refinements of the formation of evolution of DSs, which in previous studies were assumed to form in isolation, without any companions.
Binary systems of supermassive black holes are promising sources of low-frequency gravitational waves (GWs) and bright electromagnetic emission. Pulsar timing array GW searches for individual binaries have been limited to only a few candidate systems due to computational demands, which get worse as more pulsars are added. By modeling the GW signal using only components from when the GW passes Earth (rather than also each pulsar), we find constraints on the binary's total mass and GW frequency that are similar to a full signal analysis, yet ∼70 times more efficient.
An accretion disk formed around a supermassive black hole after it disrupts a star is expected to be initially misaligned with respect to the equatorial plane of the black hole. This misalignment induces relativistic torques (the Lense-Thirring effect) on the disk, causing the disk to precess at early times, whereas at late times the disk aligns with the black hole and precession terminates1,2. Here we report, using high-cadence X-ray monitoring observations of a tidal disruption event (TDE), the discovery of strong, quasi-periodic X-ray flux and temperature modulations. These X-ray modulations are separated by roughly 15 days and persist for about 130 days during the early phase of the TDE. Lense-Thirring precession of the accretion flow can produce this X-ray variability, but other physical mechanisms, such as the radiation-pressure instability3,4, cannot be ruled out. Assuming typical TDE parameters, that is, a solar-like star with the resulting disk extending at most to the so-called circularization radius, and that the disk precesses as a rigid body, we constrain the disrupting dimensionless spin parameter of the black hole to be 0.05 ≲ ∣a∣ ≲ 0.5.
Evidence for a stochastic gravitational wave (GW) background, plausibly originating from the merger of supermassive black holes (SMBHs), is accumulating with observations from pulsar timing arrays. An outstanding question is how inspiraling SMBHs get past the "final parsec" of separation, where they have a tendency to stall before GW emission alone can make the binary coalesce. We argue that dynamical friction from the dark matter (DM) spike surrounding the black holes is sufficient to resolve this puzzle, if the DM has a self-interaction cross section of order cm^{2}/g. The same effect leads to a softening of the GW spectrum at low frequencies as suggested by the current data. For collisionless cold DM, the friction deposits so much energy that the spike is disrupted and cannot bridge the final parsec, while for self-interacting DM, the isothermal core of the halo can act as a reservoir for the energy liberated from the SMBH orbits. A realistic velocity dependence, such as generated by the exchange of a massive mediator like a dark photon, is favored to give a good fit to the GW spectrum while providing a large enough core. A similar velocity dependence has been advocated for solving the small-scale structure problems of cold DM.
As a key science project of the Square Kilometre Array (SKA), the discovery and timing observations of radio pulsars in the Galactic Center would provide high-precision measurements of the spacetime around the supermassive black hole, Sagittarius A* (Sgr A*), and initiate novel tests of general relativity. The spin of Sgr A* could be measured with a relative error of ≲1% by timing one pulsar with timing precision that is achievable for the SKA. However, the real measurements depend on the discovery of a pulsar in a very compact orbit, P_{b}≲0.5  yr. Here for the first time we propose and investigate the possibility of probing the spin of Sgr A* with two or more pulsars that are in orbits with larger orbital periods, P_{b}∼2-5  yr, which represents a more realistic situation from population estimates. We develop a novel method for directly determining the spin of Sgr A* from the timing observables of two pulsars, and it can be readily extended for combining more pulsars. With extensive mock data simulations, we show that combining a second pulsar improves the spin measurement by 2-3 orders of magnitude in some situations, which is comparable to timing a pulsar in a very tight orbit.
We investigate the formation of high-redshift supermassive black holes (SMBHs) via the direct collapse of baryonic clouds, where the unwanted formation of molecular hydrogen is successfully suppressed by a Lyman-Werner (LW) photon background from relic particle decay. We improve on existing studies by dynamically simulating the collapse, accounting for the adiabatic contraction of the DM halo, as well as the in situ production of the LW photons within the cloud which reduce the impact of the cloud's shielding. We find a viable parameter space where the decay of either some of the dark matter or all of a subdominant decaying species successfully allows direct collapse of the cloud to a SMBH.
Supermassive black holes and their host galaxies grow together over time, producing correlations between the black hole mass and various galaxy properties. Determining the evolution of these correlations requires precise measurements of the masses of distant black holes. We observed the gravitationally lensed quiescent galaxy MRG-M0138 at redshift 1.95 using James Webb Space Telescope integral field spectroscopy to spatially resolve the kinematics of stars within the black hole's sphere of influence. By using a foreground lens model and fitting stellar dynamical models, we determined the mass of its inactive black hole to be [Formula: see text] solar masses. Comparing this measurement to local galaxies, we found that [Formula: see text] is higher than expected given the galaxy's bulge mass but consistent with the correlation of [Formula: see text] with stellar velocity dispersion.