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Inclusive teaching in its truest form requires teaching approaches that both recognize society's current inequities and cultivate students' agency to continue to shape and remake society in more equity-minded and just ways. Here, I identify the issues in our current approach toward pedagogical development, including the untethering of science teaching from the broader social realities of our students and society and the persistent aversion that higher education pedagogy still displays toward non-cognitive pedagogical approaches. I suggest here an acceleration of a paradigm shift of teaching praxis, focusing on the intentionality needed behind infusing sociopsychological contexts in our approaches. Such a shift can recenter humanism in the teaching process and relink our pedagogies to broader social growth.
The integration of novel systemic therapies including antibody-drug conjugates (ADCs), immune checkpoint inhibitors (ICIs), and cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitors with radiotherapy (RT) presents new opportunities in breast cancer (BC) management. However, clinical guidance on concurrent administration remains limited, particularly for advanced techniques. A multidisciplinary panel of radiation and medical oncologists from AROME and the Moroccan Medical Oncology Association conducted a literature review and established expert consensus recommendations during the fourth Moroccan Congress of Medical Oncology Private Practice. An evidence-informed, structured consensus process was used to achieve agreement on safety profiles across six RT modalities. Trastuzumab deruxtecan has shown a favorable safety profile with whole-breast irradiation and palliative RT, while trastuzumab emtansine combined with stereotactic radiosurgery shows elevated radionecrosis risk. ICIs are generally feasible with most RT modalities and toxicity monitoring applied; however, risk is context dependent, and evidence supporting stereotactic body radiotherapy-ICI benefit in oligometastatic BC remains limited. The use of CDK4/6 inhibitors concurrently with conventional and stereotactic RT seems feasible, although caution is advised for visceral metastases. These experts' agreements are supported by retrospective data and preclinical evidence, highlighting the need for prospective validation. This expert consensus statement provides pragmatic, modality-specific guidance on combining contemporary RT techniques with selected novel systemic agents in BC, complementing existing European Society for Medical Oncology /European Society for Radiotherapy and Oncology‑oriented frameworks and highlighting areas where prospective data are still needed. The findings underscore the importance of toxicity monitoring, particularly for ADCs in CNS-directed therapies, and call for biomarker-driven studies to optimize combination strategies. These recommendations aim to guide safe integration of novel agents with RT across resource-variable settings, including low- and middle-income countries.
Childhood hypoglycemia is associated with relevant morbidity and likely long-term neurological sequelae. Diagnostic thresholds and management strategies remain quite heterogeneous, particularly beyond the neonatal period. We aimed to evaluate current diagnostic and therapeutic practices for pediatric hypoglycemia management in Italy among members of the Italian Society of Pediatric Endocrinology and Diabetology (SIEDP) and the Italian Society of Metabolic Diseases and Newborn Screening (SIMMESN). An anonymous electronic survey including 43 questions about management of pediatric hypoglycemia was sent to SIEDP and SIMMESN members. Descriptive statistics and comparative statistical analysis between respondents of the two societies were run. A total of 118 respondents participated. Most of them reported direct clinical experience in pediatric hypoglycemia and routinely used critical sampling during hypoglycemic episodes. Diagnostic thresholds were heterogeneous: 34.7% reported 50 mg/dL, 33.1% 60 mg/dL, and 22.0% 70 mg/dL. Comparative analysis between societies showed no differences in most diagnostic procedures, but significant differences emerged in diagnostic thresholds (p = 0.005), with SIMMESN members selected 60 mg/dL more frequently (adjusted p = 0.020), and SIEDP members more frequently 70 mg/dL (adjusted p = 0.013). SIMMESN members reported more frequent use of genetic testing for etiological diagnosis. SIEDP respondents showed a frequent used of continuous glucose monitoring in the follow-up. Management of pediatric hypoglycemia in Italy is largely aligned with international recommendations. Clinically relevant variability persists, particularly in diagnostic thresholds, adoption of molecular analysis, and technologies, likely reflecting different clinical focus and patient populations. Our findings highlight the need for harmonized national recommendations and shared diagnostic definitions across scientific societies.
Exclusive breastfeeding (EBF) is a cornerstone for infant development and maternal health, offering nutritional, emotional, and public health benefits. Despite its importance, global EBF rates remain below targets, with barriers varying by socioeconomic context. In Argentina, while 91.7% of infants start breastfeeding, only 44.6% sustain EBF at six months. A qualitative study was conducted using 32 focus groups involving 231 mothers from four Argentine urban areas with varying EBF prevalence. Participants were segmented by maternal experience, education level, and breastfeeding continuity. Thematic analysis was performed using MAXQDA and Atlas.ti, identifying key facilitators and barriers to EBF. Key facilitators included prenatal breastfeeding education, postpartum support, conducive workplace policies, and strengthened mother-infant bonding. Barriers encompassed physical pain, psychological distress, delivery complications, workplace tensions, and sociocultural pressures such as the perception of insufficient milk supply. Digital platforms emerged as vital tools for information exchange and support, particularly for primipara mothers, although insufficient public policies limit their impact on sustaining EBF. Access to education, professional guidance, and digital support platforms significantly contributes to EBF success. However, persistent challenges, including family dynamics, cultural stigmas, and work-related tensions, undermine EBF continuity. Comprehensive public policies promoting shared responsibility among families, employers, and society are critical to sustaining EBF practices. Targeted interventions addressing these multifaceted challenges can enhance maternal and child health outcomes globally.
Digital transformation offers substantial opportunities to strengthen health systems and accelerate progress towards universal health coverage (UHC). However, endorsement and operationalization of national digital health blueprints remain uneven across the World Health Organization (WHO) South-East Asia Region (SEAR). This study describes and evaluates a structured, convergence-based methodology applied to co-develop and refine national digital health blueprints in three Member States-Maldives, Nepal, and Timor-Leste-and distils transferable lessons for replication, subject to appropriate contextualization to each country's needs and realities. An implementation case study was conducted across the three countries between September 2024 and April 2025. A six-stage methodology was applied, comprising (i) formal request and scoping, (ii) situational analysis including in-country assessment and peer-country benchmarking, (iii) drafting anchored in the WHO-International Telecommunication Union (ITU) Digital Health Strategy Building Blocks, (iv) a standardized two-day multi-stakeholder convergence workshop adapted from the Asian Development Bank (ADB) Digital Health Convergence Meeting Toolkit, (v) systematic feedback integration, and (vi) formal handover to Ministries of Health. Workshop deliberations were captured through structured rapporteur notes, group presentations, and written feedback; thematic coding was performed independently by two analysts with a third acting as arbiter, and country focal points performed member-check validation of the synthesised findings. Workshop outputs were thematically synthesized against the WHO-ITU seven eHealth strategy building blocks. Stakeholders from government, international agencies, academia, the private sector, and civil society participated across the three workshops. Cross-country synthesis identified convergent strategic priorities, including strengthened governance and institutional coordination, interoperability through Fast Healthcare Interoperability Resources (FHIR)-based architectures, infrastructure investment, workforce capacity-building, and robust legal frameworks for data protection. Country-specific recommendations reflected differing baseline maturities and institutional arrangements. All three blueprints were formally handed over to the respective Ministries of Health within an approximately fifteen-month cycle from initial request. A structured convergence methodology can produce contextually relevant, nationally owned digital health blueprints adaptable across diverse low- and middle-income country settings. Refinements in pre-workshop preparation, in-workshop processes, structured elicitation of feedback, broader stakeholder composition, and local-language facilitation would further enhance generalizability, inclusivity, and representativeness. These findings offer a replicable model for SEAR Member States and comparable settings advancing digital health transformation.
Higher-level practice development within nursing reflects the demands of a changing society. Nurses require not only the underpinning theory, but also an effective and structured clinical community of practice, derived from a collaborative relationship between higher education institutions and clinical partners. To reflect on the findings of two qualitative research studies that examined higher-level practice, associated education, practice assessment and required clinical supervision. Exploration of the experiences of clinical supervisors supporting students undertaking an MSc in Specialist Community Practice and students and their medical supervisors undertaking an MSc in Advanced Practice, using constant comparative and thematic analysis of semi-structured individual interviews, follow-up focus groups and diaries. Effective clinical supervision facilitates the transition from experienced practitioner to 'initiatee' and finally to advanced practitioner, strengthening theory and its application to clinical practice via a collaborative clinical/academic community of practice. Collaboration between higher education and clinical partners cultivates an effective, well-supported community of practice, nurturing the transition from established professional nurse to advanced level practitioner.
There is an increasing global focus on Hospital Avoidance for Older People with urgent healthcare needs. In the UK, five main service models for crisis response have been identified by the British Geriatric Society; Same Day Emergency Care (SDEC), Hospital at Home (HaH), Urgent Community Response (UCR), Acute Frailty Units (AFU) and Virtual Wards (VW).ObjectivesThis article evaluated how Community Alternatives to Acute Hospital (CAtCH) assessment services have been implemented in the UK by analysing the published literature with the aim of developing key design principles for global policy makers involved in acute community care for older adults.MethodsA critical review and narrative synthesis approach was used to develop key conceptual design principles for CAtCH services. Significant papers in the field were collated as services developed between 2016-2021 and complemented by systematic searches of OVID Medline, Embase and CINAHL in September 2024 and January 2026, and citation searches, key author searches and grey literature searches on Google Scholar and NHS websites, in 2025 and 2026. Articles were analysed using an evaluation framework based on categories developed in the BGS 2021 report. A narrative synthesis approach was used to compare the different CAtCH services.ResultsThis article provides an overview of the current provision and supporting evidence. Key principles for implementation of CAtCH Assessment services include timely access to patients with an urgent healthcare need, the ability to intervene after a rapid assessment and the need for wider public input into service design.ConclusionsThese design principles are planned to support policy makers and service providers when commissioning, implementing or evaluating CAtCH services. The article also highlights implementation challenges including rapid scale-up, regional variation, heterogeneity in service provision and limited public awareness of CAtCH services.
This study explores older adults' perceptions of the ageing experience in Trinidad and Tobago, and gains insight into their self-perceptions of ageing. A concurrent mixed-methods approach was utilized, targeting older adults living in Trinidad or Tobago. For this paper, only the qualitative component of the study will be discussed. Thirty-eight (38) participants engaged in six focus group discussions about their physical, mental, and social health and ageing experiences. The focus groups were audio-recorded and transcribed verbatim. The data were analyzed with MAXQDA software and themes found. Participants lived experiences were garnered from various aspects of their lives, including personal matters and cultural and societal influences with major themes such as ageism and disrespect, undesirable cultural norms, and fear of crime. Most themes reflected positive perceptions, including positive outlook on ageing, positive perceptions of one's health, enjoying retirement, satisfaction with available resources, and spirituality/religion. Negative experiences focused on the health system and in navigating financial challenges. The findings of our study show the need for a change in the framing of age and ageing at both the individual and societal level and shows the relevance of continued societal participation and adequate health care among older adults for a healthy ageing society. Multilevel and multisector efforts are required to reduce everyday ageism and promote positive beliefs, practices, and policies related to aging and older adults.
Bystander cardiopulmonary resuscitation (CPR) and early use of automated external defibrillators (AEDs) are key measures to improve neurologically intact survival after out-of-hospital cardiac arrest (OHCA). In Germany, however, heterogeneous emergency medical service structures, insufficient legal frameworks for public-access defibrillation, and only partially implemented CPR training in schools limit the full realization of this potential. This review summarizes the available evidence on school-based CPR training, national and international programs (including "Kids Save Lives"), and innovative mobile AED strategies. As an example, a regional project in the city and district of Osnabrück is presented, in which a non-profit organization has been implementing CPR training in schools since 2020, training both teachers and students. Building on this, regional initiatives have been launched to systematically record and improve the availability of AED locations. Based on these findings, key fields of action for policymakers, emergency medical service providers, and civil society stakeholders are identified. Nationwide, legally mandated CPR training in schools, a structured public-access defibrillation concept including AED registries, and the consistent involvement of local non-profit organizations appear crucial to strengthening the early links in the chain of survival and to sustainably improving outcomes after OHCA. Laienreanimation und der frühzeitige Einsatz automatisierter externer Defibrillatoren (AED) sind zentrale Maßnahmen zur Verbesserung des neurologisch intakten Überlebens nach außerklinischem Herz-Kreislauf-Stillstand (OHCA). In Deutschland verhindern jedoch heterogene rettungsdienstliche Strukturen, unzureichende gesetzliche Rahmenbedingungen für Public-Access-Defibrillation (PAD) und ein bislang nur teilweise implementierter Reanimationsunterricht an Schulen eine optimale Ausschöpfung dieses Potenzials. Diese Übersichtsarbeit bündelt die verfügbare Evidenz zu schulbasiertem Reanimationstraining, zu nationalen und internationalen Programmen (u. a. „Kids Save Lives“) sowie zu innovativen mobilen AED-Strategien. Exemplarisch wird ein regionales Projekt in Stadt und Landkreis Osnabrück vorgestellt, in dem eine gemeinnützige Organisation seit dem Jahr 2020 Reanimationsunterricht an Schulen implementiert und Lehrkräfte sowie Schüler schult. Darauf aufbauend wurden regionale Initiativen zur systematischen Erfassung und verbesserten Verfügbarkeit von AED-Standorten angestoßen. Aus den dargestellten Befunden werden Handlungsfelder für Politik, Rettungsdienstträger und zivilgesellschaftliche Akteure abgeleitet. Flächendeckender, gesetzlich verankerter Reanimationsunterricht, ein strukturiertes PAD-Konzept einschließlich AED-Register sowie die konsequente Einbindung lokaler Non-Profit-Organisationen erscheinen entscheidend, um die ersten Glieder der Rettungskette zu stärken und das Outcome nach OHCA nachhaltig zu verbessern.
Integrative oncology (IO) modalities aim to improve the quality of life of persons with cancer, including strategies to manage treatment and disease-related symptoms. As evidence increases to include IO in supportive care, interest grows globally. Understanding barriers to IO recommendation is key to facilitating its uptake. Members of the Multinational Association of Supportive Care in Cancer (MASCC) and the Society for Integrative Oncology (SIO) were invited to complete an online survey in Fall 2023 assessing barriers to IO recommendation on a 5-point scale. Descriptive statistics assessed demographic data and general counts of scaled agreement, while logistic regression analysis evaluated perceived barriers in relation to relevant covariates. Over 80% of respondents believed that healthcare professionals' (HCP) lack of knowledge with IO and lack of insurance/out-of-pocket costs were barriers to recommending IO. Approximately 80% agreed that lack of referral pathways was a logistical barrier and 85% reported lack of confidence in IO as an individual-level barrier. Respondents from Europe were 2.2 times more likely to agree with the perceived barrier of HCP knowledge, compared to respondents from North America (OR 2.22, 95% CI 1.05-4.67, p = 0.036). Lastly, compared to general physicians, integrative professionals were more likely to report perceptions that IO would delay conventional care delivery (OR 3.62, 95% CI 1.56-8.43, p = 0.0003). Results of this study highlight important barriers and facilitators of IO integration into standard supportive care globally. These findings represent perspectives from an international sample of MASCC and SIO members and may not apply to all oncology professionals. Further research is necessary to understand the global roadblocks that exist among practitioners interested in IO use.
To evaluate the association between early mechanical circulatory support (MCS) use and mortality in patients with cardiogenic shock (CS). We identified adults aged 18 years or older hospitalized from October 1, 2015, to June 30, 2023, with a diagnosis of CS. Patients receiving MCS within the first 2 days of admission were included in the study. Using inverse probability of treatment weighting, we assessed the association between receiving MCS on day 1 vs day 2 and in-hospital mortality. Among 69,085 patients, 75.7% (n=52,307) and 24.3% (n=16,778) received MCS on day 1 and day 2, respectively. Devices included the intra-aortic balloon pump (62.9% [n=43,467]), percutaneous left ventricular assist device (25.0% [n=17,236]), and extracorporeal membrane oxygenation (22.0% [n=14,920]). The unadjusted mortality was 38.7% (n= 20,225 of 52,307) and 37.9% (n= 6,353 of 16,778) for MCS use on day 1 vs day 2, respectively (P=.06). After inverse probability of treatment weighting, MCS on day 1 was associated with a 7.4% (weighted mean; 95% CI, -8.4% to -6.4%; P<.001) reduction in mortality. Results persisted when each device was assessed separately and among patients presenting with acute myocardial infarction or heart failure as the shock etiology (all P<.001). When assessed by admission Society for Cardiovascular Angiography and Interventions shock stage, MCS on day 1 remained associated with lower mortality for each stage (stage C, -11.1%; 95% CI, -12.4 to -9.8%; stage D, -9.1%; 95% CI, -10.8% to -7.3%; stage E, -2.7%; 95% CI, -5.0% to -0.4%). For patients with CS, MCS on the first compared with the second day of admission was associated with a lower in-hospital mortality.
Perioperative myocardial injury (PMI) is associated with a higher mortality after noncardiac surgery. Ischemic symptoms are uncommon postoperatively due to analgesics used perioperatively, necessitating nonsymptomatic surveillance. Although ST-segment deviation indicates myocardial ischemia, its association with PMI remains poorly understood. This study explored the association between continuous perioperative ST-segment monitoring and PMI in patients undergoing intermediate- to high-risk vascular surgery. This was a prospective, single-center cohort study. In addition to standard monitoring, all patients were monitored using a six-lead continuous electrocardiography (ECG) with ST-segment analysis perioperatively. ST events were analyzed according to the fourth universal myocardial infarction definition and as individualized deviations from lead-specific baseline values. The primary outcome was PMI, defined by an increase in high-sensitivity cardiac troponin T measured preoperatively and at 4 to 6, 24, and 48 hours postoperatively. Multivariable Poisson regression was used for primary analysis. In total, 498 patients were included, and 46 (9%) incurred PMI. ST-elevation was seen in 89 (18%) and not significantly associated with PMI (adjusted relative risk [RR], 1.75; 95% confidence interval [CI], 0.87-3.53; P = .12), whereas ST-depression was seen in 38 (8%) and showed a significant association with PMI (adjusted RR, 3.85; 95% CI, 1.86-7.94; P < .001). Absolute ST-segment deviation >1 mm from individualized lead baseline was also associated with PMI (RR, 2.03; 95% CI, 1.01-4.06; P = .046). When ST-depression was added to the baseline model, including age and the American Society of Anesthesiologists (ASA) physical status classification system, overall net risk classification improved (NRI, 0.50; 95% CI, 0.16-0.86). ST-depression meeting universal myocardial infarction criteria and ST deviations >1 mm from individualized baseline were associated with PMI. Intra- and postoperative ST-segment monitoring may facilitate detection of PMI.
Intraoperative (IOCA) and perioperative cardiac arrest (POCA) in pediatric patients represents a rare but catastrophic event with significant implications for morbidity and mortality. Despite advances in anesthetic techniques, monitoring technology, and resuscitation protocols, the incidence of IOCA and POCA in children has remained relatively stable over the past two decades. In the pediatric noncardiac surgery population, the incidence ranges from approximately 3 to 22 per 10 000 cases. Key risk factors include young age, particularly neonates and infants, high American Society of Anesthesiologists (ASA) physical status classification, emergency surgery, the presence of congenital heart disease (CHD), and pulmonary hypertension. Respiratory events remain the leading cause of anesthesia-related cardiac arrest, with cardiovascular causes carrying a higher mortality. Prevention strategies emphasize preoperative risk stratification, team communication, and preparedness. Management requires rapid recognition, high-quality cardiopulmonary resuscitation, and consideration of extracorporeal cardiopulmonary resuscitation (ECPR) in refractory cases. This review synthesizes current evidence regarding the epidemiology, risk factors, mechanisms, and provides clinicians with management strategies for pediatric IOCA and POCA.
To present a day surgery protocol for primary palatoplasty and assess its safety and efficacy through surgical outcomes and health economic indicators. A single-center retrospective study was conducted at Shanghai Ninth People's Hospital between January 2018 and August 2025, screening patients undergoing primary palatoplasty. A 1:1 propensity score matching was performed for sex, age, cleft palate classification, and American Society of Anesthesiologists grade from the day surgery group and the inpatient group. Postoperative outcomes, medication utilization patterns, and health economic indicators were compared. Each cohort included 374 patients. Baseline characteristics were well-balanced after matching (all P>0.05). The day surgery group exhibited significantly shorter operative time (50 versus 50 min, P=0.025), anesthesia time (70 versus 75 min, P<0.001), and Post-Anesthesia Care Unit discharge time (80 versus 90 min, P<0.001). No significant between-group differences were observed in intraoperative blood loss, overall complications, 30-day readmission or reoperation rates (P>0.05), and no severe complication was reported. One patient in the day surgery group developed postoperative upper airway edema requiring an extended hospital stay for 1 additional day. The day surgery group had a shorter length of stay (24 versus 119.05 h, P<0.001) and reduced total hospitalization costs (median 70.7% of the inpatient group's costs, P<0.001). For low-risk cleft palate patients, surgery performed under a mature protocol at a day surgery ward is safe, shortens hospital stays, reduces costs, and aligns with enhanced recovery after surgery principles.
Richard D. Alba, a path-breaking sociologist who studied immigrant assimilation and its impact on mainstream cultures, in the United States and in Western Europe, passed away on June 4, 2025, at the age of 82. His early work rigorously chronicled the upward mobility, suburbanization, intermarriage, and mixed ethnic identities of later-generation European immigrants. He found similar patterns among recent immigrants and the second generation from Latin America, the Caribbean, and Asia. Together with Victor Nee, he developed "neoassimilation" theory, describing a two-way process involving changes among immigrants and the emergence of a multiracial, multicultural mainstream, emphasizing the conditions under which a society can integrate newcomers with less resistance. Alba was a beloved mentor, friend, and colleague to generations of social scientists.
This study examined inter-community-based variations in spirometry parameters in 243 Aboriginal patients aged >18 years from 14 individual remote communities (61% female, with a median age of 54.6 years). Mixed ventilatory impairment was the most common pattern (51.6%), followed by restrictive (32.4%) and obstructive (9.8%). Significant inter-community variability was observed, ranging for mixed (85.7% to 37.5%), restrictive (62.5% to none) and obstructive (20% to none). These findings indicate a more tailored approach is needed to address lung health in rural and remote residing adult Aboriginal Australians.
BackgroundTransitioning to parenthood is stressful for relationships. Women with endometriosis face several health challenges, which may further strain their relationships when they become parents. However, it remains uncertain whether this transition compromises their relationships beyond what is observed in the general population.ObjectivesTo compare the risk of relationship dissolution, relationship satisfaction, anxiety, and depression between women with and without endometriosis.DesignLongitudinal population-based cohort study including 99,531 singleton pregnancies to 84,642 women.Methods1,476 pregnancies to women with self-reported endometriosis were compared to 98,064 pregnancies in women without endometriosis, using data from the Norwegian Mother, Father and Child Cohort Study (1999-2017). Women were followed up to 8 years postpartum. Adjusted risk ratios (aRR) with 95 % confidence intervals (CI) were calculated by multivariable log-binomial regression, adjusting for age, education and income.ResultsWe observed increasing trends of mothers not living with the biological father (12% at 8 years postpartum) and of relationship dissatisfaction (4.7% at 5 years postpartum), without significant differences in the risk of relationship dissolution (10% vs. 12%) or dissatisfaction (4.8% vs. 4.7%) between women with and without endometriosis. However, women with endometriosis had significantly higher risks of anxiety (aRR: 1.30, 95% CI: 1.06-1.58) and depression (aRR: 1.32, 95% CI: 1.16-1.50) at 8 years postpartum.ConclusionMothers with endometriosis did not exhibit increased relationship dissolution or dissatisfaction compared to those without, despite experiencing a greater mental health burden. While these findings are encouraging, they should not trivialize the potential impact of endometriosis on quality of life.
Childhood overweight and obesity are prevalent in Chile and globally. Health care responses typically emphasise biomedical and risk-focused approaches, with limited attention to children's own perspectives. This study explored how children clinically classified as overweight or obese understand health, growth and weight within health contexts. Participants were recruited from primary care clinics in two municipalities in Santiago, Chile. Semi-structured online interviews were conducted with 18 children aged 10-12 years during COVID-19 restrictions, incorporating visual tools such as body silhouettes and body mapping to facilitate discussion. Data were analysed using reflexive thematic analysis. Three major themes were identified: Translating Fatness: everyday words and the softening of body labels; Body shapes, shame, and the making of 'unhealthy' bodies; and Making Sense of Measurement: Receiving, Interpreting and Negotiating Medical Labels. The study highlights that children actively interpret and negotiate weight-related messages, drawing on emotional, social, and cultural frames rather than biomedical ones. Clinical encounters can heighten body awareness and stigma. Clinical practice should prioritise non-stigmatising communication, value children's perspectives, and adopt approaches that support wellbeing during growth and identity development.