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Examination of the effect of experimental lead poisoning on permeability of lysosomal membranes in albino rats demonstrated activation of lysosomal enzymes (alpha-manosidase and beta-acetylglucosaminidase) in the blood serum as soon as the third day after daily administration of lead acetate (20 mg/kg). Apparently damage of the lysosomal membrane played an important role in the pathogenesis of lead poisoning.
The results of treatment of 23 patients with pefloxacin, administered because of the infectional complications in surgery development (1 group), and of 11 patients --for the infection development prophylaxis (2 group) were discussed. In the first group the recovery was noted in 83.3%, and significant improvement of condition--in 16.7% of patients. In the second group the infectional complications in postoperative period were absent.
The influence of precursor of biosynthesis of nitric oxide L-arginine on the level of transport enzymes Na+, K(+)-, Ca(2+)- and Na(+)-ATPases activity under rabbits experimental hypercholesterolemia have been studied. The significant changes in Na+, K(+)-, Ca(2+)- and Na(+)-ATPases activity in different tissues (the cortex of kidney, the endothelium of aorta, the epithelium of small intestine, the liver) had been found for the rabbits with inhibition of the activity of this enzymes to the different levels in all these tissues. Injection of L-arginine during the hypercholesterolemia caused the recovery of Na+, K(+)-, Ca(2+)- and Na(+)-ATPases approximately to the control levels. Obtained results demonstrate that exogenous L-arginine may participate in the correction of the activity of membrane transport enzymes under the condition of the rabbits experimental hypercholesterolemia. The authors discuss the possible mechanisms of L-arginine effect on the studied transport enzymes under the experimental atherosclerosis.
Catalytic properties and thermostability of leucyl-tRNA-synthetase were studied both in free form and in the form of high molecular complexes, isolated from pig myocardium under normal state and after 15 min and 30 min ischemia. Km values of free and associated forms of leucyl-tRNA-synthetase were similar either in normal state or after 15-30 min ischemia. Complex-formation protected the enzyme from thermic inactivation under normal and ischemic conditions. Reverse redistribution of the leucyl-tRNA-synthetase activity was found in the fractions of free enzyme and high molecular complex depending on duration of ischemia.
Application of endovascular interventions conduction in 174 patients with multistory occlusive-stenotic affection of the lower extremities arteries is summarized. Indications for transcutaneous balloon angioplasty, laser and vibromechanical recanalization of the vessel are substantiated, the tactics of roentgensurgical treatment is proposed. Good early result of treatment was noted in 62.7% of patients, fair-in 23.6%. In 48.3% of observed patients good result was retained up to 5-year of follow-up.
The general characteristics of cefalosporins was done, the principle of their division on generations, the pharmacokinetics differences of some preparations were indicated in the article. On the ground of microbiological data the perspective of klaforan, orelox, cefpirom application in the clinic was shown.
It has been shown that 30 min ischemia followed by 30 min reperfusion inhibits cardiac contractility. The addition of adenosine at a concentration of 50 or 100 mumol/l into the perfusate normalized a decreased cardiac contractility and prevented the onset of contracture.
Investigation of manufacturing of home-produced dissolving suture material was conducted. Influence of the material on tissues in the region of threads location and on the organism as a whole was studied up. The material resolved actively, did not cause pathological changes in surrounding tissues and in general pathological processes in the organism of animals. During 180 days the majority of the suture material quantity have resolved.
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Data on complex examination and surgical treatment of 415 patients with occlusions of abdominal aorta, iliac and femoral arteries are adduced. According to the stage of ischemia of the extremity tissue three groups of patients were determined while making examination-middle degree (II stage of the disease), severe (III stage) and extremely severe (IY stage). Positive immediate results of treatment were obtained in 402 (96.87%) of patients due to the differential approach application in patients examination, taking into account the regional blood flow and microcirculation indexes.
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Experience of treatment of 115 patients with late consequences of the fingers flexors tendons traumatic damage, complicated by cicatricial transformation of soft tissues was reflected. Results of application of methods using microsurgical autotransplantation of complex flaps to replace the cicatricial and necrotic-purulent defects of soft tissues with subsequent autotendoplasty were analyzed. Method of treatment providing the tendons isolation from the cicatricial tissues for the functional results improvement, elaborated in the department of microsurgery and plastic surgery, is presented.
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Mice with a submissive stereotype of behaviour developed a fast habituation to novelty of environment. A subsequent training revealed a deficit of passive avoidance learning and prolongation of the memory trace extinction. Aggressive mice are characterised by a delay of the habituation and absence of any significant changes in the memory trace retrieval. The findings suggest that responses to environmental novelty and use of its estimation in learning and retention of memory traces are essentially predetermined by the basic strategy of behaviour.
The experience of the purulent complications treatment occurring while synthetic prosthesis application in the aorto-femoral region and venous shunts-in femoral-popliteal zone is presented. Reconstructive procedures on the abdominal aorta and peripheral arteries were conducted in 4462 patients of whom in 158 (3.5%) the transplant infecting occurred. All the patients were divided conventionally on three groups: with local and total infecting of the transplant and with angiogenic sepsis. New methods of reoperative procedures depending on the infecting kind were proposed. Application of the surgical tactics elaborated for the transplant infecting on aorto-ileal and femoral-popliteal levels have permitted to reduce the lethality from 49.8 to 13.2%, to save the life in 158 (75.5%) patients and to achieve the lower extremities revascularization.
The age anatomy of the abdominal aorta (AA) was studied up using magnetic-resonance tomography (MRT) in 60 patients aging 55-75 years old with diseases of vertebral column and spinal cord. The method advantages were established in diagnosis of the AA aneurysm in 32 patients, aging 55-74 years, for the thrombi detection in aneurysm, for estimation of renal, upper mesenterial and iliac arteries, truncus coeliacus state.
The state of the cortical neuron dendrites was studied in rats at various stages of alcohol intoxication; two categories of changes occurred in dendrites--destructive and compensatory. These changes depended on the stages of alcohol intoxication and individual peculiarities of the central nervous system of the animals.
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Necessity of the mother-fetus-newborn model usage in toxicological experiments for the xenobiotics environmental content standardization was shown in the toxicological study of Ricid-P pesticide.