Palliative care provides a proactive, family-centered approach for infants with life-threatening conditions. We examined the frequency of palliative care consultations among NICU tracheostomy patients and their associated demographics, hypothesizing that it is mainly used for high-risk infants but could benefit a broader group. Charts of all NICU patients who underwent tracheostomy between 1/1/2012-12/31/2020 at a tertiary care NICU were reviewed for demographics, comorbidities, and palliative care consults. Outcomes were compared for preoperative consult vs. no-consult groups using chi-square and fisher's exact tests, with significance set at p < 0.05. Among 171 infants, 13.5% received perioperative palliative care consults. Sex did not differ, but race did (p < 0.001), with African-American/Black infants predominating. Infants receiving palliative care consults had greater gestational age (36.7 vs 32.5 weeks, p = 0.02), more neurologic indications (43.5% vs 17.5%, p = 0.01), and fewer cardiac (21.9% vs 57.1%, p = 0.002) and pulmonary comorbidities (34.8% vs 59.1%, p = 0.04). Median rates of perioperative consults were higher in the consulted group (15 vs 13, p = 0.04). No differences were seen in rates of discharge on a ventilator (95.6% vs 80.5%, p = 0.1), 1-year decannulation (0% vs 3.4%, p = 1), or mortality (4.4% vs 12.2%, p = 0.5). At 5 years, palliative care patients were less likely to be decannulated (4.35% vs 35.81%, p = 0.001), with no differences in mortality (47.83% vs 32.43%, p = 0.2). Palliative care was underutilized in NICU tracheostomy patients. Consults were more frequent in neurologic cases and less common in cardiac, pulmonary, or anatomic obstruction, despite similarly complex post-discharge courses. Expanding palliative care access in this population could improve family-centered decision-making, coordination, and long-term planning.
Taxonomies are widely used in sport science to classify disciplines according to structural, cognitive, and physiological demands, yet their robustness in differentiating athletes' cognitive performance remains uncertain. This study examined whether commonly applied sport classification frameworks-open versus closed skills, strategic-static-interceptive, participant classification, and multidimensional team/precision-skill/speed-strength-meaningfully represent cognitive differences within junior and senior national squad athletes. A total of 595 national squad athletes from eight sports (artistic gymnastics, rhythmic gymnastics, trampoline, basketball, volleyball, ice hockey, table tennis, modern pentathlon) completed standardized measures of basic (processing speed, attention) and higher (working memory, inhibition, cognitive flexibility) cognitive functions. Using a model comparison approach, we show that the usefulness of taxonomic contrasts is limited because taxonomy-based models did not improve model fit relative to the null model or the model containing single sport disciplines. For processing speed, single disciplines provided the best fit. Supplementary analyses showed that processing-speed-based norm scores were above population means and moderately related to attention, but only weakly related to working memory and unrelated to executive control measures. Together, these findings suggest that conclusions about cognitive differences among high-performance athletes cannot be reliably made using taxonomic classifications as they lack robustness under realistic sampling conditions. The results underscore the importance of sport-specific and individual-level approaches when investigating cognitive functioning in high-performance sport contexts.
Communication with parents in the Neonatal Intensive Care Unit (NICU) setting is both important and uniquely challenging. Prior research has established that communication quality directly effects patient and parent outcomes in the NICU. A range of provider types comprise the interprofessional NICU team, each bringing a unique perspective. Yet, there is limited literature reflecting these diverse points of view. Although NICU staff often endorse the sentiment that high-quality communication is essential for excellent patient care, it is not clear that providers in different roles define "high-quality communication" in the same way. To explore interprofessional perspectives of NICU personnel on communication quality. One-question semi-structured interviews were conducted with NICU staff. Thematic analysis was used to explore and compare themes across disciplines. Sixty-two staff members were interviewed. Two thematic categories emerged: messaging and dynamics. Messaging sub-themes included: 1) clarity (setting goals; clear and direct language; avoiding jargon; ensuring parents understand) and 2) timing and approach (unhurried; frequent; timely; proactive). Dynamics sub-themes included: 1) team interactions (inclusivity; respect; consistency) and 2) parent-centeredness (parents as key stakeholders; identifying and adapting to needs; creating a safe space; empathy; offering flexible modes of communication). Although staff members across disciplines have different foci relative to communication quality, excellent communication among teams is essential to ensuring high-quality communication with families. Improving team dynamics, equipping teams with a shared model of communication quality, and ensuring adequate staffing may improve communication.
Integrating cancer genetics, genomics and cancer risk assessment is increasingly relevant to the care of patients and there is a need for clinicians across practice disciplines to acquire and demonstrate knowledge and clinical competency in cancer genetics and cancer risk assessment. National Consortium of Breast Centers (NCBC's) certification program in Cancer Genetic Risk Assessment (CGRA) is a voluntary nationally (NCCA) accredited, examination-based certification program created to provide the assurance that healthcare providers with certification in CGRA possess the knowledge, skills and competency to provide cancer risk assessment services to patients and families. The certification has achieved recognition by national accrediting organizations (National Accreditation Program for Breast Centers/Commission on Cancer) and payor policies. NCBC's CGRA certification was developed by a multidisciplinary committee of dedicated breast care, oncology, and cancer genetics professionals and approved by NCBC's board of trustees. Testing first became available in May 2020 with testing opportunities provided throughout the year. Testing options include both remote and in-person examination. The target audiences for certification are physicians, advanced practice providers, nurses and other skilled health care practitioners who care for at-risk unaffected and affected patients and their families. Here we describe demographics and outcomes from the first six years of certification examination availability. A retrospective cohort of CGRA examination takers was collected from May 2020 (initial examination availability) through December 2025. Analyzed data includes total number of examination takers, pass/fail rates, and professional background and practice setting of the passing cohort. Descriptive statistics were used for analysis. 2020-2025 Total number of CGRA examination takers: 235 Total number (percent) passed: 207/235 (88.1%); failed: 28/235 (11.9%) Professional background of CGRA certificants: APRN - 109/207 (52.7%) RN - 37/207 (17.9%) PA - 30/207 (14.5%) MD - 26/207 (12.6%) RT - 5/207 (2.4%) Practice focus of CGRA certificants: Oncology - 132/207 (63.8%) Surgery - 26/207 (12.6%) High Risk/Genetics - 16/207 (7.7%) Gynecology - 14/207 (6.8%) Breast Center - 12/207 (5.8%) Radiology - 4/207 (1.9%) Primary Care - 1/207 (0.5%) Other - 2/207 (<1%). During the first 6 years of CGRA certification eligibility, a notable number of healthcare providers and other healthcare professionals have sought and obtained certification in CGRA through NCBC's CGRA certification program. Seventy percent of all certificant holders have a professional background in nursing. Two-thirds of all certificant holders are advanced practice providers, including advanced practice nurses/nurse practitioners and physician assistants. Twelve percent of certificant holders are physicians and two percent comprise radiologic technologists. The most prominent practice setting for certificant holders is oncology comprising approximately two-thirds of all represented specialties, followed by surgery at approximately twelve percent. Many other specialty practice settings are represented, including the screening and preventive care spaces. ln conclusion, the CGRA certification is a sought-after credential appealing to a broad range of healthcare providers/professionals across practice disciplines allowing for a diverse patient population, both affected and unaffected, to obtain competent cancer genetic and cancer risk assessment-related care.
The One Health (OH) approach emphasizes the interconnectedness of human, animal, plant, and environmental health within shared ecosystems, aiming to foster multisectoral collaboration to address complex health challenges such as zoonoses, antimicrobial resistance, and climate change. Despite its global recognition, the operationalization of OH in Somaliland remains limited, hindered by systemic challenges, inadequate awareness, and insufficient intersectoral coordination. This study assesses the knowledge and perceptions of health professionals regarding OH in Somaliland to inform policy and capacity-building strategies. A descriptive cross-sectional survey was conducted from June to August 2024 across six regions of Somaliland, involving 422 licensed health professionals from diverse disciplines, including physicians, veterinarians, nurses, environmental health specialists, and public health officers. Data were collected using a structured, pretested questionnaire translated into Somali, encompassing socio-demographic variables, knowledge, and perceptions of OH. Data analysis was used SPSS Version 25 and involved descriptive statistics, chi-square tests, and multivariate logistic regression to identify factors associated with knowledge and perception levels. The findings revealed that 71.8% of participants demonstrated poor knowledge of OH, with only 28.2% exhibiting adequate understanding. Over half (56.6%) held negative perceptions of OH, citing limited awareness, lack of formal training, and absence of institutional support as contributing factors. Multivariate analysis indicated that higher educational attainment, age above 39 years, and being a physician significantly increased the likelihood of possessing good knowledge (AOR = 30.71, p < 0.001) and positive perceptions. Conversely, health professionals with less experience or in non-medical disciplines demonstrated lower awareness and less favorable attitudes toward OH. The study underscores substantial gaps in knowledge and perception of the OH approach among Somaliland's health professionals, impeding effective multisectoral engagement. To advance OH implementation, targeted capacity-building initiatives, curriculum integration, policy development, and enhanced intersectoral collaboration are imperative. Strengthening awareness and professional training will be critical to fostering a resilient health system capable of addressing zoonotic and environmental health threats in Somaliland.
Despite the growing use of assistive technologies in Alzheimer's disease (AD) and dementia care, adoption remains fragmented because the existing technology acceptance models overlook the relational, cultural, and ethical dimensions. This concept analysis aims to clarify the defining attributes, antecedents, consequences, and empirical referents of technology adoption in AD and dementia care. Using Walker & Avant's concept analysis framework, 25 studies from 2015 to 2025 across gerontology, nursing, computer science, and rehabilitation disciplines were systematically reviewed. Data were synthesized to identify defining attributes, model and contrary cases, antecedents, consequences, and empirical referents. Six defining attributes of adoption were identified: perceived usefulness, ease of use, emotional resonance, trust and privacy, personalization, and cultural-ethical fit. Antecedents included caregiver mediation, user motivation, and facilitating conditions, while consequences ranged from enhanced well-being, autonomy, and caregiver relief to over-reliance and ethical concerns. Empirical referents included validated scales such as the Technology Acceptance Model (TAM), System Usability Scale (SUS), and measures of trust, privacy, and social connectedness. Technology adoption in AD and dementia care is a contextual and multidimensional process shaped by functionality as well as emotional, cultural, and ethical factors requiring co-design with users and caregivers, cultural responsiveness, and robust privacy protections. This conceptual framework advances understanding of adoption by providing practical guidance for developers, practitioners, and policymakers seeking to design, evaluate, and implement inclusive gerontechnologies.
Sleep quality is an important component of recovery and performance in athletes. Combat sport athletes may be at increased risk of sleep disturbances due to high training demands and weight-management practices. This cross-sectional study included 498 athletes competing in Olympic and non-Olympic combat sports (mean age ≈21 years). Poor sleep quality (PSQI > 5) was examined using multivariable logistic regression to assess associations with sex, sport type, rapid weight loss (>4%), and sport age. A secondary model was conducted in the Olympic subsample. Continuous sleep outcomes were analyzed using two-way ANOVA. Poor sleep quality was common among athletes, with 65% of participants classified as poor sleepers (PSQI > 5). In the full sample, male sex (OR = 1.65, 95% CI: 1.20-2.30), Olympic sport participation (OR = 1.75, 95% CI: 1.25-2.45), and rapid weight loss >4% (OR = 2.70, 95% CI: 1.80-4.00) were associated with higher odds of poor sleep quality, and sport age was also positively associated (OR = 1.03, 95% CI: 1.01-1.05). Similar associations were observed in the Olympic subsample. In addition, athletes competing in Olympic combat sports showed higher scores across several PSQI components compared to those in non-Olympic disciplines. Poor sleep quality is common among combat sport athletes and is associated with sport type and weight-management practices. These findings suggest that sleep disturbances may be related to sport-specific demands. Further research using longitudinal designs and objective sleep measures is needed to clarify these associations.
The National Quality Measures for Breast Centers (NQMBC) originated as an idea in 2003 by the National Consortium of Breast Centers (NCBC) board who felt that increased attention was warranted, initiated by the institute of medicine, to measure, evaluate and improve the quality of breast cancer care. To serve the widespread membership of NCBC, any quality assessment program would need to be web-based so that no matter where your breast center was located, your center could assess their own level of their quality care performance. The focus of quality performance was on the level of care actually delivered for each performance measure. The NQMBC is a set of quality measures including each discipline in the breast center; imaging, surgery, pathology, medical oncology, radiation oncology, genetics, navigation and the newly added inflammatory breast cancer. The NQMBC looks at real time data from participating breast centers across the country. Once a center's data on a particular is entered into the NQMBC, the website immediately provides comparisons with other centers' performance. The results show the submitted center's data and the comparison 25th, 50th and 75th percentile performance of all the other centers who have submitted data on that measure. A center can identify the level of performance on that specific measure and decide whether improvement is neded or congratulations is deserved. All data is confidential and hot shared with any other center. No patient data is used. Recently a government grant was awarded to a group headed by Aurora Inc., striving to improve the quality of care provided in China. Experts in breast cancer care were identified to aid in this effort. Many clinicians from China have been sent for two-month observerships to Montefiore-Einstein Medical Center to see how the US approaches breast cancer. To assess the quality of care provided, the NQMBC was chosen to assess the resultant quality of care it in at least three large breast centers in China. In-person exchanges occurred this last month to initiate the integration of NQMBC as a measure of their quality breast cancer care. Goals of these three facilities is to achieve the level of a quality breast center of excellence. Three main medical centers in three separate provinces, each serving a population of over 100 million, have agreed to integrate the NQMBC quality program as a measure of their breast care. This long-term pilot program has positive implications to improve the level of breast care in China, and a valuable extension of the international use of NQMBC.
While social bees are a primary focus of research and monitoring efforts among pollinators, more than 80% of bee species are solitary. For solitary bees, foraging behavior and efficiency directly impact the reproductive outcomes of individuals (fitness), as the consequences of foraging performance are not buffered by a colony. Cavity-nesting bees (e.g., Osmia spp. and Megachile spp. (Megachilidae)) progressively provision pollen in cells within hollow stems and other cavities, with each cell generally containing one offspring, making their reproductive output easily quantifiable. Cavity-nesting bees thus represent an ideal system to study fitness effects of individual variation in foraging niche, including differences in foraging activity and responses to environmental conditions. Understanding the links between individual performance and fitness can improve our understanding of solitary bee behavior, physiology, and ecology, particularly in response to environmental change. However, quantifying both foraging activity and provisioning rates within nests is prohibitively labor-intensive in many cases, especially for the extended time periods (i.e., weeks or months) over which nests are provisioned and under naturalistic ecological conditions. While recent work has established computer vision tools for automated monitoring of foraging activity at solitary bee nests, combining these approaches with in-nest monitoring could help better link foraging to fitness in solitary bees. Here we introduce Osmia Camera Activity Monitoring (osmiaCAM), a low-cost, open-source, automated monitoring system for foraging and nest-provisioning behavior of cavity-nesting bees, including key pollinator and research model organisms, such as Osmia spp. and Megachile spp. We demonstrate the potential of this system in a small validation experiment in Central California, where we quantified foraging transits and nest provisioning rates of Osmia spp. under variable weather conditions. This validation experiment yielded accurate, near-continuous monitoring for several weeks continuously. The osmiaCAM system has broad applications across cavity-nesting solitary bee species, facilitating research on their behavior, ecology, and responses to rapid environmental change. The development of autonomous monitoring systems and associated data analysis pipelines provide an opportunity for open-source ecological methods that would be applicable across a multitude of systems and disciplines.
Conferences are critical but often underleveraged vehicles for advancing nursing practice and leadership. Barriers, including staffing constraints, costs, and limited organizational support, dampen access and impact. This article offers a practical, structured approach that positions conference attendance as a strategic investment for both nurses and healthcare organizations. Scientific conferences serve as vital platforms for the exchange of knowledge, ideas, and advancements across disciplines. These gatherings bring together practitioners, researchers, scholars, and leaders, fostering collaboration and innovation. Through presentations, workshops, and discussions, attendees share emerging findings and methodologies, contributing to collective growth and advancement. Conferences provide opportunities for networking, enabling professionals to establish valuable connections and partnerships that may lead to future collaborations and interdisciplinary projects. Moreover, they create forums for peer review, where participants receive constructive feedback on their work, refine their approaches, and identify new directions for inquiry. Ultimately, these events shape clinical practice, operational strategies, and research priorities, thereby advancing both healthcare delivery and professional development.
This study investigates the nonlinear relationship between faculty mentoring and undergraduate innovation capacity within a universal tutorial system. Drawing on survey data from 1066 students at a Chinese provincial university, and grounded in motivational synergy theory and self-determination theory, we examine an inverted U-shaped effect of mentoring frequency, with an estimated inflection point of 13.35 sessions per semester. Bootstrap-based conditional indirect effects suggest that this pattern is consistent with both extrinsic (mentor pressure, peer influence) and intrinsic (academic identity, self-efficacy) motivational pathways, with the indirect effects themselves shifting from positive to negative as mentoring intensifies. Furthermore, the curvilinear pattern is more pronounced under low mentor-student research alignment, in smaller meeting cohorts, and within STEM disciplines. The mentoring benefits concentrate among students with moderate innovation capacity, suggesting an "expanding the middle" effect. These findings provide convergent evidence that the synergy-versus-crowding-out logic operates across mentoring intensity, motivational pathways, and student capacity, offering a more differentiated and mechanism-based understanding of how faculty mentoring shapes undergraduate innovation.
To characterize the multisystem presentation and care requirements of rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation (ROHHAD) syndrome from an interdisciplinary perspective. A retrospective analysis of clinically confirmed ROHHAD cases managed within a specialized pediatric palliative care service over a 13-year period (2012-2025). Collected data included demographic and socio-familial characteristics, clinical manifestations, care needs, management strategies, disease trajectories, and outcomes. Descriptive statistics and exploratory Spearman's rank correlation were applied. Six patients (three females and three males) were identified, with a median age at onset of 3.3 years and a median diagnostic delay of 1.6 years. Central hypoventilation represented a key driver of clinical complexity, with most children rapidly progressing to tracheostomy and long-term invasive ventilation. Endocrine involvement was multisystemic and frequently associated with electrolyte and metabolic instability. Autonomic dysregulation was recurrent but clinically heterogeneous. Neurodevelopmental concerns were common, and many children later developed severe behavioral dysregulation and additional neuropsychiatric symptoms that significantly affected treatment adherence and overall management. No neuroendocrine tumors were identified on the available imaging studies. At the time of data collection, four children had died, predominantly due to cardiorespiratory arrest. The clinical complexity of ROHHAD requires coordinated, interdisciplinary care. However, real-world data comprehensively defining patient needs and clarifying the contribution of different specialties remain limited. Our findings provide novel insights and highlight how the evolving course challenges traditional discipline-centered approaches, instead demanding ongoing, integrated collaboration to ensure adaptable, individualized care pathways.
Proctology is a useful test case for low-waste surgery because the central premise of routine sterile set-up is contestable. These procedures are common, short and material intensive, but they are performed at a mucocutaneous site that cannot be rendered sterile. The distal gut contains thousands of bacterial species, with one third of them potential pathogens. Antiseptic preparation reduces this burden, but does not eliminate it. In this context, the relevant question is not whether every opened sterile item can be recycled, but whether it needed to be opened at all. This article argues for a disciplined, indication-based approach to benign anorectal surgery. Instrument sterility, aseptic handling, skin preparation, sharps safety and antibiotic prophylaxis should remain unchanged. The proposed change is narrower: avoid routine drapes where they do not alter the operation, use clean non-sterile protective equipment for proceduralists where appropriate, and keep suction and diathermy immediately available but unopened until required. Infection prevention objections deserve respect, and selected cases will still require conventional sterile set-up. However, routine sterile consumables should not be defended by habit when the field itself is already contaminated. Proctology should lead a simple hierarchy: use less, open on demand and recycle only where true material recovery is available.
Antimicrobial stewardship programs (ASPs) promote optimal antimicrobial use in pediatrics; however, data describing structure, personnel effort allocation, and activity distribution across regular and after-hours workflows remain limited. We conducted a cross-sectional survey of pediatric ASPs across the U.S. from September to October 2024 using ASP/ID-related listservs. Respondents reported institutional structure, personnel effort allocation, initiatives, and participation in an after-hours ASP on-call model, with additional details from programs reporting on-call participation. Twenty-two pediatric ASP responses were included, most from academic medical centers (81.8%) and programs covering 101-250 beds (41%). Median physician full-time equivalents (FTEs) increased with institutional size, ranging from 0.1 for institutions with < 100 beds to 0.8 for those with >500 beds. Pharmacist FTEs were a median of 1 for institutions with ≤ 500 beds and increased to 2.25 for programs >500 beds. Most programs reported to Quality and Safety (45%) or discipline-specific departments (41%), with funding primarily attributed to Pharmacy (73%). During regular working hours, nearly all programs performed prospective audit and feedback (100%), responded to ASP-related inquiries (95.5%), and facilitated antimicrobial de-escalation (90.9%). Six programs (27.4%) reported participation in an ASP on-call model, most commonly providing remote coverage during evenings, weekends, and holidays. After-hours activities were largely limited to time-sensitive interventions, including preauthorization and responding to inquiries. Pediatric ASPs demonstrate variability in structure, personnel effort allocation, and stewardship activities. ASP on-call coverage remains uncommon and is typically focused on time-sensitive interventions, reflecting targeted deployment of stewardship resources outside regular working hours.
In this editorial we reflect on recent contributions that have focused on how researchers should involve qualitative research in implementation science. Implementation science as a discipline has firmly entered the zeitgeist and is now attracting a wealth of qualitative inquiry. We welcome qualitative manuscript submissions which focus on profound and reflexive explorations of topics relevant to the journal and call for a greater methodological diversity of qualitative methods and analytic reportage. Novel theoretical and methodological developments are considered. Finally, as we usher in a new era of guiding principles for qualitative research in the field, we set out our new expectations for reporting qualitative research and explain why it will no longer be necessary to include a 'checklist' for qualitative submissions to the journal.
Thyroid hormones have a crucial impact on all physiological systems. Diagnosis of thyroid diseases using salivary biomarkers is an emerging discipline and requires consolidation of existing information. This systematic review is aimed at identifying and analyzing salivary biomarkers that are associated with thyroid diseases and evaluate their potential as diagnostic applicability as non-invasive indicators of thyroid dysfunction. Literature search was conducted in PubMed, Cochrane, EBSCO, ProQuest, and Google Scholar from date of inception to May 2025. Human observational studies, clinical trials, and diagnostic accuracy studies published in the English language, that related biomarkers in saliva to thyroid diseases were collected and analyzed for relevant information. The search resulted in 35 records, followed by PRISMA 2020 compliant screening which resulted in 9 records included for data synthesis. Data extraction, tabulation and Risk of Bias assessment was carried out by 2 independent reviewers. Included studies suggest that FT3, amino acids, salivary metabolic profiling, glycan profiles, microbiome, and thyroid antibodies present in saliva could be putative and noninvasive biomarkers of diagnostic and prognostic importance. Heterogeneity in study design and analytical techniques has limited definitive conclusions about said markers, necessitating future well-designed clinical studies for validation of these biomarkers for noninvasive thyroid screeing and diagnosis. Hormones produced by thyroid glands have a role to play in all systems of the body. Hence abnormal thyroid function needs to be detected and treated earlier. Currently tests require blood samples that are invasive to collect requiring exploration of non invasive samples from the body. saliva is one such source and is being currently explored. This review searched studies that analyzed various substances in saliva that could indicate disorders in thyroid function. The analysis pointed at some compounds in saliva, viz. free T3 hormone, thyroid-related antibodies, certain amino acids, oral microbiomes to reflect thyroid problems. Among these, free T3 and thyroid antibodies are apparently the most promising variables in saliva that help diagnose and monitor thyroid diseases.
Tesofensine (NS-2330) is a pharmacologically active compound with weight-reducing effects in obese patients. Although still under regulatory review, it has been marketed online as a dietary supplement promoted for weight management and metabolic enhancement. Due to its impact on body weight, tesofensine could be relevant in competitive sports, particularly in weight-class disciplines and sports where power-to-weight ratio is decisive. It is classified under "S6 stimulants" on the World Anti-Doping Agency's Prohibited List and is prohibited in-competition only, making detailed knowledge of its metabolism and excretion essential for anti-doping purposes. Although the pharmacological effects and elimination of tesofensine and one dealkylated metabolite were described previously, elimination profiles and structural information on additional metabolites have been limited. In this study, in vitro metabolism experiments were conducted, followed by investigation of urinary metabolism and elimination in six volunteers after ingestion of 483 μg tesofensine as a dietary supplement. Urine was collected for up to 600 h, prepared by solid-phase extraction, and analyzed by LC-HRMS. Four principal metabolites were identified: three dealkylated metabolites (M1-M3) and one hydroxylated and glucuronidated metabolite (M4), supported by MS/MS dissociation patterns. The validated analytical method for human urine showed an LOD of 0.01 ng/mL, 34% recovery, and 8% interday imprecision. Marked interindividual variability was observed, with peak concentrations of 1-4 ng/mL after 4-46 h and detection windows up to 500 h. The findings enhance analytical procedures and suggest that recommended dosing is unlikely to result in concentrations constituting an Adverse Analytical Finding (AAF) under currently applicable stimulant minimum reporting levels.
National educational policies emphasize integrating ideological and political education into curricula to enhance talent development. Clinical practice is vital in nursing education for shaping professional competencies. This study aimed to evaluate the effectiveness of a novel teaching model that integrates the Bridge-In, Objective, Pre-assessment, Participatory Learning, Post-assessment, and Summary (BOPPPS) framework with a narrative-based approach for clinical nursing education in gastrointestinal surgery. This combined model incorporates ideological-political elements to address the needs of this complex discipline, which requires innovative pedagogical methods. Ninety-two nursing students undergoing clinical training in gastrointestinal surgery from March 2023 to October 2024 were divided into a control group (n = 45) receiving traditional instruction and an experimental group (n = 47) receiving the combined BOPPPS and narrative-based approach. Outcomes were assessed using the Professional Identity Questionnaire for Nursing Students, the Nurse Core Competence Scale, clinical practice performance evaluations, and a teaching satisfaction survey. The experimental group achieved significantly higher scores across all measured domains, including professional identity, core competencies, clinical performance, and teaching satisfaction, as well as in total scores compared to the control group (all p < 0.001). The Cohen's d effect sizes ranged from 0.465 to 2.067, with partial η 2 ranging from 0.462 to 0.970, all indicating moderate to large effects. The integrated BOPPPS and narrative-based teaching model significantly improved nursing students' professional identity, core competence, clinical performance, and satisfaction, offering an innovative and effective strategy for enhancing clinical nursing education.
Traditional markets in Mexico are longstanding centers of biocultural exchange where wild plants are commercialized for diverse purposes, with important socio‑ecological implications. However, research in this topic remains fragmented across disciplines. This review critically examines and synthesizes scientific literature on the trade of wild plants in traditional Mexican markets to assess accumulated knowledge, prevailing theoretical approaches, and the extent to which this activity has been conceptualized within a socio‑ecological systems (SES) framework. We conducted a systematic search of major academic databases and analyzed studies documenting wild plant trade in traditional markets across Mexico. We identified traded species, their origin, and their uses, and examined reported social, ecological, and economic variables, emphasized their integration within an SES perspective. Ethnobotanical potential and knowledge gaps were also evaluated for each Mexican state. Based on 32 studies documenting 60 traditional markets, we recorded 902 species (528 genera, 131 families), primarily Orchidaceae, Asteraceae, Fabaceae, Cactaceae, and Bromeliaceae. Most of the species were native to Mexico and were frequently harvested from the wild, including numerous taxa listed under conservation status. Medicinal and food uses predominated, while ornamental and ritual uses reflected strong cultural drivers of demand. Although most studies reported variables relevant to SES analyses, they were largely descriptive and rarely applied integrative, hypothesis‑driven SES frameworks. Oaxaca, Chiapas, Veracruz, State of Mexico, and Puebla exhibited the highest ethnobotanical potential; while the highest ethnobotanical gap values were found in Chiapas, Veracruz, Guerrero, and San Luis Potosí. Key ethnobotanical theories guiding plant selection and use where identified, along with critical research gaps related to governance, consumer behavior, ecological impacts, and management practices. Traditional markets represent strategic settings for advancing SES‑based ethnobotanical research and promoting sustainability that balance biodiversity conservation, livelihoods, and cultural continuity.
Breastfeeding is widely recognized as one of the most cost-effective public health interventions for improving maternal and child health outcomes. Nevertheless, breastfeeding indicators remain suboptimal worldwide despite strong international recommendations. In recent years, digital technologies have emerged as tools to support breastfeeding promotion, education, and continuity. However, the evidence on digital and multimedia breastfeeding interventions is heterogeneous and scattered across disciplines, limiting a comprehensive understanding of their scope and effectiveness. For the purposes of this review, "digital resources" refers broadly to digital platforms and technologies used to deliver breastfeeding-related information or support; "interactive multimedia tools" refers to resources integrating two or more media formats (e.g., text, audio, video, graphics) with user interaction; and "digital interventions" is used as an umbrella term encompassing both concepts. To systematically map and synthesize available evidence on digital resources and interactive multimedia tools used to promote and support breastfeeding, describing their characteristics, implementation contexts, target populations, reported outcomes, and limitations. A scoping review was conducted following the Arksey and O'Malley methodological framework and reported in accordance with PRISMA-ScR guidelines. The methodological approach was also aligned with selected recommendations from the Joanna Briggs Institute for scoping reviews. Searches were carried out in PubMed, the Virtual Health Library (VHL), Google Scholar, and the AI-powered tool Consensus between April 2023 and July 2024. Peer-reviewed publications in English and Spanish from the last 10 years addressing digital resources or interactive multimedia tools for breastfeeding promotion or support were included. Data were extracted and synthesized using a descriptive analytical approach. A total of 23 studies published between 2019 and 2024 were included. The review identified a range of digital interventions, including social media platforms, mobile health (mHealth) applications, web-based resources, educational videos, telemedicine services, and multimedia materials. Most studies targeted pregnant women and breastfeeding mothers, often in contexts of social or economic vulnerability. Overall, digital interventions were associated with increased breastfeeding knowledge, improved maternal self-efficacy, enhanced access to information and peer support, and favorable perceptions. However, evidence regarding breastfeeding duration and exclusivity was inconsistent, and substantial variability was observed in intervention design, implementation strategies, and outcome measurement. Studies from both high-income countries (HICs) and low- and middle-income countries (LMICs) were identified, with social media campaigns and low-cost mobile approaches appearing particularly relevant in resource-constrained contexts. Digital resources and interactive multimedia tools represent promising complementary strategies for breastfeeding promotion and support. This scoping review highlights both the potential benefits and the heterogeneity of existing digital interventions, emphasizing the need for standardized, theory-informed, and context-sensitive approaches to strengthen evidence-based practice and future research in digital breastfeeding support.