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Introduction: Substance use disorders (SUDs) have emerged as a pressing public health concern in the United States, with adolescent substance use often leading to SUDs in adulthood. Effective strategies are needed to stem this progression. To help fulfill this need, we developed a novel absolute risk prediction model for cannabis use disorder (CUD) for adolescents or young adults who use cannabis. Methods: We trained a Bayesian machine learning model that provides a personalized CUD absolute risk for adolescents or young adults who use cannabis with data from the National Longitudinal Study of Adolescent to Adult Health. Model performance was assessed using 5-fold cross-validation (CV) with area under the curve (AUC) and ratio of the expected to observed number of cases (E/O). Independent validation of the final model was conducted using two datasets. Results: The proposed model has five risk factors: biological sex, delinquency, and scores on personality traits of conscientiousness, neuroticism, and openness. For predicting CUD risk within five years of first cannabis use, AUC values for the training dataset and two validation datasets were 0.68, 0.64, and 0.75, respectively, and

The primary goal of conditional cash transfers (CCTs) is to alleviate short-term poverty while preventing the intergenerational transmission of deprivation by promoting the accumulation of human capital among children. Although a substantial body of research has evaluated the short-run impacts of CCTs, studies on their long-term effects are relatively scarce, and evidence regarding their influence on resilience to future economic shocks is limited. As human capital accumulation is expected to enhance individuals' ability to cope with risk and uncertainty during turbulent periods, we investigate whether receiving a conditional cash transfer -- specifically, the Human Development Grant (HDG) in Ecuador -- during childhood improves the capacity to respond to unforeseen exogenous economic shocks in adulthood, such as the COVID-19 pandemic. Using a regression discontinuity design (RDD) and leveraging merged administrative data, we do not find an overall effect of the HDG on the target population. Nevertheless, we present evidence that individuals who were eligible for the programme and lived in rural areas (where previous works have found the largest effects in terms of on short-term im

Extracranial tissues visible on brain magnetic resonance imaging (MRI) may hold significant value for characterizing health conditions and clinical decision-making, yet they are rarely quantified. Current tools have not been widely validated, particularly in settings of developing brains or underlying pathology. We present TissUnet, a deep learning model that segments skull bone, subcutaneous fat, and muscle from routine three-dimensional T1-weighted MRI, with or without contrast enhancement. The model was trained on 155 paired MRI-computed tomography (CT) scans and validated across nine datasets covering a wide age range and including individuals with brain tumors. In comparison to AI-CT-derived labels from 37 MRI-CT pairs, TissUnet achieved a median Dice coefficient of 0.79 [IQR: 0.77-0.81] in a healthy adult cohort. In a second validation using expert manual annotations, median Dice was 0.83 [IQR: 0.83-0.84] in healthy individuals and 0.81 [IQR: 0.78-0.83] in tumor cases, outperforming previous state-of-the-art method. Acceptability testing resulted in an 89% acceptance rate after adjudication by a tie-breaker(N=108 MRIs), and TissUnet demonstrated excellent performance in the b

We study the impact of teenage sports participation on early-adulthood health using longitudinal data from the National Study of Youth and Religion. We focus on two primary outcomes measured at ages 23--28 -- self-rated health and total score on the PHQ9 Patient Depression Questionnaire -- and control for several potential confounders related to demographics and family socioeconomic status. To probe the possibility that certain types of sports participation may have larger effects on health than others, we conduct a matched observational study at each level within a hierarchy of exposures. Our hierarchy ranges from broadly defined exposures (e.g., participation in any organized after-school activity) to narrow (e.g., participation in collision sports). We deployed an ordered testing approach that exploits the hierarchical relationships between our exposure definitions to perform our analyses while maintaining a fixed family-wise error rate. Compared to teenagers who did not participate in any after-school activities, those who participated in sports had statistically significantly better self-rated and mental health outcomes in early adulthood.

Embedded information displays (EIDs) are becoming increasingly ubiquitous on home appliances and devices such as microwaves, coffee machines, fridges, or digital thermostats. These displays are often multi-purpose, functioning as interfaces for selecting device settings, communicating operating status using simple visualizations, and displaying notifications. However, their usability for people in the late adulthood (PLA) development stage is not well-understood. We report on two focus groups with PLA (n = 11, ages 76-94) from a local retirement community. Participants were shown images of everyday home electronics and appliances, answering questions about their experiences using the EIDs. Using open coding, we qualitatively analyzed their comments to distill key themes regarding how EIDs can negatively affect PLA's ability to take in information (e.g., poor labels) and interact with these devices (e.g., unintuitive steps) alongside strategies employed to work around these issues. We argue that understanding the equitable design and communication of devices' functions, operating status, and messages is important for future information display designers. We hope this work stimulates

Little research has investigated the design of conversational styles of voice assistants (VA) for adults in their later adulthood with varying personalities. In this Wizard of Oz experiment, 34 middle-aged (50 to 64 years old) and 24 older adults (65 to 80 years old) participated in a user study at a simulated home, interacting with a VA using either formal or informal language. Older adults with higher agreeableness perceived VA as being more likeable than middle-aged adults. Middle-aged adults showed similar technology acceptance toward the informal and formal VA, and older adults preferred using informal VA, especially those with low agreeableness. Further, while both middle-aged and older adults frequently anthropomorphized VAs by using human metaphors for them, older adults compared formal VA with professionals (e.g., librarians, teachers) and informal VA with their close ones (e.g., spouses, relatives). Overall, the conversational style showed differential effects on the perceptions of middle-aged and older adults, suggesting personalized design implications.

Transition to Adulthood is an essential life stage for many families. The prior research has shown that young people with intellectual or development disabil-ities (IDD) have more challenges than their peers. This study is to explore how to use natural language processing (NLP) methods, especially unsupervised machine learning, to assist psychologists to analyze emotions and sentiments and to use topic modeling to identify common issues and challenges that young people with IDD and their families have. Additionally, the results were compared to those obtained from young people without IDD who were in tran-sition to adulthood. The findings showed that NLP methods can be very useful for psychologists to analyze emotions, conduct cross-case analysis, and sum-marize key topics from conversational data. Our Python code is available at https://github.com/mlaricheva/emotion_topic_modeling.

We will study the impact of adolescent sports participation on early-adulthood health using longitudinal data from the National Study of Youth and Religion. We focus on two primary outcomes measured at ages 23--28 -- self-rated health and total score on the PHQ9 Patient Depression Questionnaire -- and control for several potential confounders related to demographics and family socioeconomic status. Comparing outcomes between sports participants and matched non-sports participants with similar confounders is straightforward. Unfortunately, an analysis based on such a broad exposure cannot probe the possibility that participation in certain types of sports (e.g., collision sports like football or soccer) may have larger effects on health than others. In this study, we introduce a hierarchy of exposure definitions, ranging from broad (participation in any after-school organized activity) to narrow (e.g., participation in limited-contact sports). We will perform separate matched observational studies, one for each definition, to estimate the health effects of several levels of sports participation. In order to conduct these studies while maintaining a fixed family-wise error rate, we d

Achieving high performance for facial age estimation with subjects in the borderline between adulthood and non-adulthood has always been a challenge. Several studies have used different approaches from the age of a baby to an elder adult and different datasets have been employed to measure the mean absolute error (MAE) ranging between 1.47 to 8 years. The weakness of the algorithms specifically in the borderline has been a motivation for this paper. In our approach, we have developed an ensemble technique that improves the accuracy of underage estimation in conjunction with our deep learning model (DS13K) that has been fine-tuned on the Deep Expectation (DEX) model. We have achieved an accuracy of 68% for the age group 16 to 17 years old, which is 4 times better than the DEX accuracy for such age range. We also present an evaluation of existing cloud-based and offline facial age prediction services, such as Amazon Rekognition, Microsoft Azure Cognitive Services, How-Old.net and DEX.

Economists have mainly focused on human capital accumulation rather than on the causes and consequences of human capital depreciation in late adulthood. To investigate how human capital depreciates over the life cycle, we examine how a newly introduced pension program, the National Rural Pension Scheme, affects cognitive performance in rural China. We find significant adverse effects of access to pension benefits on cognitive functioning among the elderly. We detect the most substantial impact of the program on delayed recall, a cognition measure linked to the onset of dementia. In terms of mechanisms, cognitive deterioration in late adulthood is mediated by a substantial reduction in social engagement, volunteering, and activities fostering mental acuity.