Background: Many people who could benefit from therapy do not receive it. Conversational AI is increasingly used for mental health support, yet it is unclear which barriers AI helps mitigate. We examined whether evaluation-sensitive (shame/stigma) and structural barriers (cost/coverage/access) to psychotherapy predict perceived helpfulness of an AI mental health conversational tool (Ash), and whether effects differ by prior therapy experience or user engagement. Methods: Participants (n=395) rated Ash's helpfulness (1-5) and described barriers to therapy. Open-text responses were coded for shame/stigma, access, and cost/coverage themes. Linear regressions examined associations between barriers and perceived helpfulness, adjusting for demographics and mental health, with moderation by therapy experience. Results: Shame/stigma (B=.45, p<.001) and access barriers (B=.31, p=.020) predicted higher perceived helpfulness but cost/coverage did not (B=.13, p=.262). Prior therapy experience moderated the shame effect (interaction B=.56, p=.036): shame predicted higher helpfulness among therapy-experienced users ($Δ$=.62, p<.001) but not therapy-naive users ($Δ$=.03, p=.877). Among ther
Stigma, a recognized global barrier to effective disease management, impacts social interactions, resource access, and psychological well-being. In this study, we developed a patient-centered framework for deriving design requirements and interventions for health conditions subject to social stigma. This study introduces a patient-centered framework, grounded in sociotechnical systems theory, to create tailored interventions and design requirements for health conditions influenced by social stigma. We tested this framework through a mixed-method study on chronic pelvic pain patients. Our approach led to the identification of ten design requirements that encompass behavioral and psychological support and strategies for day-to-day living. The findings reveal a preference among CPP patients for priming and social support interventions. This study underscores the value of a systems-based perspective in healthcare, advocating for a nuanced, patient-centered approach that addresses the complex nature of health conditions affected by social stigma. It contributes to the ongoing discourse on integrating STS theory into healthcare frameworks, highlighting the need for targeted strategies to
Should a large language model (LLM) be used as a therapist? In this paper, we investigate the use of LLMs to *replace* mental health providers, a use case promoted in the tech startup and research space. We conduct a mapping review of therapy guides used by major medical institutions to identify crucial aspects of therapeutic relationships, such as the importance of a therapeutic alliance between therapist and client. We then assess the ability of LLMs to reproduce and adhere to these aspects of therapeutic relationships by conducting several experiments investigating the responses of current LLMs, such as `gpt-4o`. Contrary to best practices in the medical community, LLMs 1) express stigma toward those with mental health conditions and 2) respond inappropriately to certain common (and critical) conditions in naturalistic therapy settings -- e.g., LLMs encourage clients' delusional thinking, likely due to their sycophancy. This occurs even with larger and newer LLMs, indicating that current safety practices may not address these gaps. Furthermore, we note foundational and practical barriers to the adoption of LLMs as therapists, such as that a therapeutic alliance requires human ch
Global rates of mental health concerns are rising, and there is increasing realization that existing models of mental health care will not adequately expand to meet the demand. With the emergence of large language models (LLMs) has come great optimism regarding their promise to create novel, large-scale solutions to support mental health. Despite their nascence, LLMs have already been applied to mental health related tasks. In this paper, we summarize the extant literature on efforts to use LLMs to provide mental health education, assessment, and intervention and highlight key opportunities for positive impact in each area. We then highlight risks associated with LLMs' application to mental health and encourage the adoption of strategies to mitigate these risks. The urgent need for mental health support must be balanced with responsible development, testing, and deployment of mental health LLMs. It is especially critical to ensure that mental health LLMs are fine-tuned for mental health, enhance mental health equity, and adhere to ethical standards and that people, including those with lived experience with mental health concerns, are involved in all stages from development through
Human immunodeficiency virus (HIV)-related stigma is a critical psychosocial determinant of health for people living with HIV (PLWH), influencing mental health, engagement in care, and treatment outcomes. Although stigma-related experiences are documented in clinical narratives, there is a lack of off-the-shelf tools to extract and categorize them. This study aims to develop a large language model (LLM)-based tool for identifying HIV stigma from clinical notes. We identified clinical notes from PLWH receiving care at the University of Florida (UF) Health between 2012 and 2022. Candidate sentences were identified using expert-curated stigma-related keywords and iteratively expanded via clinical word embeddings. A total of 1,332 sentences were manually annotated across four stigma subscales: Concern with Public Attitudes, Disclosure Concerns, Negative Self-Image, and Personalized Stigma. We compared GatorTron-large and BERT as encoder-based baselines, and GPT-OSS-20B, LLaMA-8B, and MedGemma-27B as generative LLMs, under zero-shot and few-shot prompting. GatorTron-large achieved the best overall performance (Micro F1 = 0.62). Few-shot prompting substantially improved generative model
While large language models (LLMs) are increasingly being explored for mental health applications, recent studies reveal that they can exhibit stigma toward individuals with psychological conditions. Existing evaluations of this stigma primarily rely on multiple-choice questions (MCQs), which fail to capture the biases embedded within the models' underlying logic. In this paper, we analyze the intermediate reasoning steps of LLMs to uncover hidden stigmatizing language and the internal rationales driving it. We leverage clinical expertise to categorize common patterns of stigmatizing language directed at individuals with psychological conditions and use this framework to identify and tag problematic statements in LLM reasoning. Furthermore, we rate the severity of these statements, distinguishing between overt prejudice and more subtle, less immediately harmful biases. To broaden the reasoning domain and capture a wider array of patterns, we also extend an existing mental health stigma benchmark by incorporating additional psychological conditions. Our findings demonstrate that evaluating model reasoning not only exposes substantially more stigma than traditional MCQ-based methods
Menstrual health education (MHE) in Pakistan is constrained by cultural taboos and inadequate formal curricula, leaving women with few trusted resources to lean on. In response to these challenges, we introduce a WhatsApp-based chatbot powered by a large language model (LLM) and Retrieval Augmented Generation (RAG), co-designed with Pakistani college women. Workshops (N=30) revealed key design requirements -- support for Roman Urdu, use of subsidized platforms, and an expert -- curated knowledge base. We then deployed the chatbot with 13 participants for two weeks (403 messages and interviews). Women used it to challenge cultural taboos, legitimize health concerns often dismissed as normal, and build reproductive health knowledge through iterative questioning. Yet, interactions also exposed tensions: reliance on cultural explanatory models, questions of trust and validation, and gendered persona of the chatbot itself. We contribute empirical insights, a stigma-aware design framework for culturally sensitive conversational AI, and a methodological lens foregrounding expert validation in intimate health domains.
Objective: To characterize stigma dimensions, social, and related behavioral circumstances in people living with HIV(PLWHs) seeking care, using NLP methods applied to a large collection of EHR clinical notes from a large integrated health system in the southeast United States. Methods: We identified a cohort of PLWHs from the UF Health IDR and performed topic modeling analysis using Latent Dirichlet Allocation to uncover stigma-related dimensions and related social and behavioral contexts. Domain experts created a seed list of HIV-related stigma keywords, then applied a snowball strategy to review notes for additional terms until saturation was reached iteratively. To identify more target topics, we tested three keyword-based filtering strategies. The detected topics were evaluated using three widely used metrics and manually reviewed by specialists. In addition, we conducted word frequency analysis and topic variation analysis among subgroups to examine differences across age and sex-specific demographics. Results: We identified 9140 PLWHs at UF Health and collected 2.9 million clinical notes. Through the iterative keyword approach, we generated a list of 91 keywords associated wi
Mental health stigma prevents many individuals from receiving the appropriate care, and social psychology studies have shown that mental health tends to be overlooked in men. In this work, we investigate gendered mental health stigma in masked language models. In doing so, we operationalize mental health stigma by developing a framework grounded in psychology research: we use clinical psychology literature to curate prompts, then evaluate the models' propensity to generate gendered words. We find that masked language models capture societal stigma about gender in mental health: models are consistently more likely to predict female subjects than male in sentences about having a mental health condition (32% vs. 19%), and this disparity is exacerbated for sentences that indicate treatment-seeking behavior. Furthermore, we find that different models capture dimensions of stigma differently for men and women, associating stereotypes like anger, blame, and pity more with women with mental health conditions than with men. In showing the complex nuances of models' gendered mental health stigma, we demonstrate that context and overlapping dimensions of identity are important considerations
Reproductive well-being education remains widely stigmatized across diverse cultural contexts, constraining how individuals access and interpret reproductive health knowledge. We designed and evaluated OpenBloom, a stigma-sensitive, AI-mediated system that uses LLMs to transform reproductive health articles into reflective, question-based learning prompts. We employed OpenBloom as a design probe, aiming to explore the emerging challenges of reproductive well-being stigma through LLMs. Through surveys, semi-structured interviews, and focus group discussions, we examine how sociocultural stigma shapes participants' engagements with AI-generated questions and the opportunities of inquiry-based reproductive health education. Our findings identify key design considerations for stigma-sensitive LLM, including empathetic framing, inclusive language, values-based reflection, and explicit representation of marginalized identities. However, while current LLM outputs largely meet expectations for cultural sensitivity and non-offensiveness, they default to superficial rephrasing and factual recall rather than critical reflection. This guides well-being HCI design in sensitive health domains to
The growing demand for home healthcare calls for tools that can support care delivery. In this study, we explore automatic health assessment from voice using real-world home care visit data, leveraging the diverse patient information it contains. First, we utilize Large Language Models (LLMs) to integrate Subjective, Objective, Assessment, and Plan (SOAP) notes derived from unstructured audio transcripts and structured vital signs into a holistic illness score that reflects a patient's overall health. This compact representation facilitates cross-visit health status comparisons and downstream analysis. Next, we design a multi-stage preprocessing pipeline to extract short speech segments from target speakers in home care recordings for acoustic analysis. We then employ an Audio Language Model (ALM) to produce plain-language descriptions of vocal biomarkers and examine their association with individuals' health status. Our experimental results benchmark both commercial and open-source LLMs in estimating illness scores, demonstrating their alignment with actual clinical outcomes, and revealing that SOAP notes are substantially more informative than vital signs. Building on the illness
YouTube has rapidly emerged as a predominant platform for content consumption, effectively displacing conventional media such as television and news outlets. A part of the enormous video stream uploaded to this platform includes health-related content, both from official public health organizations, and from any individual or group that can make an account. The quality of information available on YouTube is a critical point of public health safety, especially when concerning major interventions, such as vaccination. This study differentiates itself from previous efforts of auditing YouTube videos on this topic by conducting a systematic daily collection of posted videos mentioning vaccination for the duration of 3 months. We show that the competition for the public's attention is between public health messaging by institutions and individual educators on one side, and commentators on society and politics on the other, the latest contributing the most to the videos expressing stances against vaccination. Videos opposing vaccination are more likely to mention politicians and publication media such as podcasts, reports, and news analysis, on the other hand, videos in favor are more li
Mobile health has the potential to revolutionize health care delivery and patient engagement. In this work, we discuss how integrating Artificial Intelligence into digital health applications-focused on supply chain, patient management, and capacity building, among other use cases-can improve the health system and public health performance. We present an Artificial Intelligence and Reinforcement Learning platform that allows the delivery of adaptive interventions whose impact can be optimized through experimentation and real-time monitoring. The system can integrate multiple data sources and digital health applications. The flexibility of this platform to connect to various mobile health applications and digital devices and send personalized recommendations based on past data and predictions can significantly improve the impact of digital tools on health system outcomes. The potential for resource-poor settings, where the impact of this approach on health outcomes could be more decisive, is discussed specifically. This framework is, however, similarly applicable to improving efficiency in health systems where scarcity is not an issue.
Mental-health stigma remains a pervasive social problem that hampers treatment-seeking and recovery. Existing resources for training neural models to finely classify such stigma are limited, relying primarily on social-media or synthetic data without theoretical underpinnings. To remedy this gap, we present an expert-annotated, theory-informed corpus of human-chatbot interviews, comprising 4,141 snippets from 684 participants with documented socio-cultural backgrounds. Our experiments benchmark state-of-the-art neural models and empirically unpack the challenges of stigma detection. This dataset can facilitate research on computationally detecting, neutralizing, and counteracting mental-health stigma. Our corpus is openly available at https://github.com/HanMeng2004/Mental-Health-Stigma-Interview-Corpus.
Robots are becoming more prominent in assisting persons with disabilities (PwD). Whilst there is broad consensus that robots can assist in mitigating physical impairments, the extent to which they can facilitate social inclusion remains equivocal. In fact, the exposed status of assisted workers could likewise lead to reduced or increased perceived stigma by other workers. We present a vignette study on the perceived cognitive and behavioral stigma toward PwD in the workplace. We designed four experimental conditions depicting a coworker with an impairment in work scenarios: overburdened work, suitable work, and robot-assisted work only for the coworker, and an offer of robot-assisted work for everyone. Our results show that cognitive stigma is significantly reduced when the work task is adapted to the person's abilities or augmented by an assistive robot. In addition, offering robot-assisted work for everyone, in the sense of universal design, further reduces perceived cognitive stigma. Thus, we conclude that assistive robots reduce perceived cognitive stigma, thereby supporting the use of collaborative robots in work scenarios involving PwDs.
The government's effort to alleviate HIV stigma has been justified by the suppression effect of stigma on the HIV testing rate. Nevertheless, the deterrence effect of stigma on undesirable sexual behaviours has long been overlooked. This study adapts the existing framework on HIV stigma with an additional stage that formally models people's choices on whether to take preventive measures in sex. The model shows that, when sex is explicitly modelled, the suppression and deterrence effects coexist, which makes the net societal impact of HIV stigma ambiguous. A utilitarian welfare analysis concludes that the welfare-maximizing stigma level can be higher than its natural level, implying that the government's effort to reduce stigma is not always welfare-improving. Instead, the study provides a rationale for maintaining a certain level of HIV stigma to maximize social welfare.
Artificial intelligence (AI) has shown great promise in revolutionizing the field of digital health by improving disease diagnosis, treatment, and prevention. This paper describes the Health Guardian platform, a non-commercial, scientific research-based platform developed by the IBM Digital Health team to rapidly translate AI research into cloud-based microservices. The platform can collect health-related data from various digital devices, including wearables and mobile applications. Its flexible architecture supports microservices that accept diverse data types such as text, audio, and video, expanding the range of digital health assessments and enabling holistic health evaluations by capturing voice, facial, and motion bio-signals. These microservices can be deployed to a clinical cohort specified through the Clinical Task Manager (CTM). The CTM then collects multi-modal, clinical data that can iteratively improve the accuracy of AI predictive models, discover new disease mechanisms, or identify novel biomarkers. This paper highlights three microservices with different input data types, including a text-based microservice for depression assessment, a video-based microservice for
The COVID-19 pandemic has highlighted the dire necessity to improve public health literacy for societal resilience. YouTube, the largest video-sharing social media platform, provides a vast repository of user-generated health information in a multi-media-rich format which may be easier for the public to understand and use if major concerns about content quality and accuracy are addressed. This study develops an automated solution to identify, retrieve and shortlist medically relevant and understandable YouTube videos that domain experts can subsequently review and recommend for disseminating and educating the public on the COVID-19 pandemic and similar public health outbreaks. Our approach leverages domain knowledge from human experts and machine learning and natural language processing methods to provide a scalable, replicable, and generalizable approach that can also be applied to enhance the management of many health conditions.
The rapid spread of health misinformation on online social networks (OSNs) during global crises such as the COVID-19 pandemic poses challenges to public health, social stability, and institutional trust. Centrality metrics have long been pivotal in understanding the dynamics of information flow, particularly in the context of health misinformation. However, the increasing complexity and dynamism of online networks, especially during crises, highlight the limitations of these traditional approaches. This study introduces and compares three novel centrality metrics: dynamic influence centrality (DIC), health misinformation vulnerability centrality (MVC), and propagation centrality (PC). These metrics incorporate temporal dynamics, susceptibility, and multilayered network interactions. Using the FibVID dataset, we compared traditional and novel metrics to identify influential nodes, propagation pathways, and misinformation influencers. Traditional metrics identified 29 influential nodes, while the new metrics uncovered 24 unique nodes, resulting in 42 combined nodes, an increase of 44.83%. Baseline interventions reduced health misinformation by 50%, while incorporating the new metrics
Objective: To enhance health literacy and accessibility of health information for a diverse patient population by developing a patient-centered artificial intelligence (AI) solution using large language models (LLMs) and Fast Healthcare Interoperability Resources (FHIR) application programming interfaces (APIs). Materials and Methods: The research involved developing LLM on FHIR, an open-source mobile application allowing users to interact with their health records using LLMs. The app is built on Stanford's Spezi ecosystem and uses OpenAI's GPT-4. A pilot study was conducted with the SyntheticMass patient dataset and evaluated by medical experts to assess the app's effectiveness in increasing health literacy. The evaluation focused on the accuracy, relevance, and understandability of the LLM's responses to common patient questions. Results: LLM on FHIR demonstrated varying but generally high degrees of accuracy and relevance in providing understandable health information to patients. The app effectively translated medical data into patient-friendly language and was able to adapt its responses to different patient profiles. However, challenges included variability in LLM responses a