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When Old People Suffer Because of the Sex of the Young: A Commentary on Korte, A. & Tschuschke, V. (2023). The Media's Stranglehold on Sturm und Drang - The Sorrows of Generation Z Regarding Sex and Gender Abstract: In their article "Sturm und Drang im Würgegriff der Medien - Die Leiden der jungen Generation am eigenen Geschlecht" in the Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie (volume 51, issue 5), our colleagues Korte and Tschuschke address the question of the extent to which the increase in gender identity deviations among adolescents "also results from upheavals the cultural landscape and, above all, in media technology." The authors look critically at the planned German "Self-Determination Law," the social transition of children and adolescents, the so-called puberty blockade, and hormone therapy in adolescents and justify their preference for a gender-critical over a transaffirmative therapy approach. Although the article introduces some interesting hypotheses from the perspective of cultural studies and philosophy (among others), it may contribute to uncertainty among colleagues in treating trans*people because of its trans-critical tone. This stems from linguistic devices, misleading and erroneous quotations, and incomplete or incorrect descriptions of facts. This contribution therefore takes a critical look at the article by Korte and Tschuschke, using critical linguistic analysis and examining the facts, data, and sources cited by the authors. It encourages our colleagues to engage in a joint, participatory, trans*respectful treatment process with gender-dysphoric children and adolescents while exploring the sizeable intermediate area between "gender-critical" and "transaffirmative" attitudes, which the authors Korte and Tschuschke barely touch on in their article. Zusammenfassung: Im Artikel „Sturm und Drang im Würgegriff der Medien – Die Leiden der jungen Generation am eigenen Geschlecht“ in der Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie (Jahrgang 51, Heft 5) setzen sich die Kollegen Korte und Tschuschke mit der Frage auseinander, inwiefern der Anstieg von Abweichungen im Geschlechtsidentitätserleben bei Jugendlichen „auch ein Resultat kultureller und vor allem medientechnologischer Umbrüche ist“. Die Autoren beziehen kritisch Stellung zum geplanten deutschen „Selbstbestimmungsgesetz“, zu sozialer Transition bei Kindern und Jugendlichen, zur sogenannter Pubertätsblockade sowie zur Hormontherapie bei Jugendlichen, und rechtfertigen den Vorzug eines genderkritischen gegenüber dem eines transaffirmativen Therapieansatzes. Obgleich der Artikel einige interessante Hypothesen aus dem Blickwinkel u. a. der Kulturwissenschaft und Philosophie einbringt, kann er doch auf Grund des transkritischen Grundtenors zur Verunsicherung von Kolleg_innen in der Behandlung von trans*Personen beitragen. Dies ist auf sprachliche Mittel, irreführende und fehlerhafte Zitate und unvollständige bzw. inkorrekte Schilderung von Fakten zurückzuführen. Die vorliegende Arbeit möchte sich daher kritisch mit dem zur Diskussion gestellten Artikel der Autoren Korte und Tschuschke befassen und bedient sich dabei einer sprachkritischen Untersuchung sowie einer Überprüfung der von den Autoren angeführten Fakten, Daten und Quellen. Sie möchte versuchen, Kolleg_innen dazu zu ermuntern, sich mit geschlechtsdysphorischen Kindern und Jugendlichen in einen gemeinsamen, partizipativen, trans*respektvollen Behandlungsprozess zu begeben und den von den Autoren Korte und Tschuschke im Artikel wenig beachteten, großen Zwischenbereich zwischen „genderkritischer“ und „transaffirmativer“ Haltung auszuloten.

One element, potassium, can be identified as the connecting link in the research of Czech neurophysiologist Prof. František Vyskočil. It accompanied him from the first student experiments on the frog muscle (Solandt effect) via sodium-potassium pump and quantum and non-quantum release of neurotransmitters (e.g. acetylcholine) to the most appreciated work on the reversible leakage of K+ from brain neurons during the Leao´s spreading cortical depression, often preceding migraine. He used a wide range of methods at the systemic, cellular and genetic levels. The electrophysiology and biochemistry of nerve-muscle contacts and synapses in the muscles and brain led to a range of interesting findings and discoveries on normal, denervated and hibernating laboratory mammals and in tissue cultures. Among others, he co-discovered the facilitating effects of catecholamines (adrenaline in particular) by end-plate synchronization of individual evoked quanta. This helps to understand the general effectiveness of nerve-muscle performance during actual stress. After the transition of the Czech Republic to capitalism, together with Dr. Josef Zicha from our Institute, he was an avid promoter of scientometry as an objective system of estimating a scientist´s success in basic research (journal Vesmír, 69: 644-645, 1990 in Czech).

Media's Stranglehold on Storm and Stress - The Sorrows of Generation Z about Sex and Gender Abstract: The feeling of not belonging to one's birth sex is not new; one can trace this phenomenon back even to ancient mythology. Although it has always been rare, there has recently been a sharp increase in gender identity deviations among adolescents. This text addresses this problem by asking to what extent this development also results from upheavals in the cultural landscape and, above all, in media technology. Do they cause young people to believe they are in the "wrong gender" and, in extreme cases, to strive for transition? We present the most salient cornerstones of the planned German self-determination law (Self-ID), most of which, however, are unlikely to do justice to the underlying problem. The text concludes by describing several unanswered questions concerning this matter and by attempting to propose first answers. The advantages of a gender-exploratory over the trans affirmative therapy approach are summarized. Zusammenfassung: Das Gefühl der Nichtzugehörigkeit zum Geburtsgeschlecht ist nicht neu, als Phänomen kann es bis in die antike Mythologie zurückverfolgt werden. Aber es war stets selten, wohingegen aktuell ein sprunghafter Anstieg von Abweichungen im Geschlechtsidentitätserleben bei Jugendlichen zu verzeichnen ist. Der Text geht dieser Problematik anhand der Frage nach, inwieweit diese Entwicklung auch ein Resultat kultureller und vor allem aber medientechnologischer Umbrüche ist, die bedingen, dass Jugendliche sich im „falschen Geschlecht“ wähnen und im Extremfall eine Transition anstreben. Die wichtigsten Eckpunkte des geplanten deutschen „Selbstbestimmungsgesetzes“ werden vorgestellt, das allerdings der zugrundeliegenden Problematik kaum gerecht werden dürfte. Der Text schließt damit, dass er diesbezüglich eine Reihe offener Fragen benennt, erste Antworten versucht und die Vorteile eines explorativen, genderkritischen gegenüber einem transaffirmativen Therapieansatz zusammenfasst.

The global coronavirus disease 2019 (COVID-19) crisis has exerted significant psychological impacts on university students who have faced drastic changes in the learning mode and suspension of classes. Despite these challenges, many students maintained subjective well-being. In this study, we examined the role of "hope" as a potential protector to maintain their subjective well-being when facing adversity during this global crisis. Specifically, we explored the mediating role of two hope components (agency thinking and pathways thinking) on the association of positive emotions and life satisfaction among Chinese university students. We conducted an online survey at a local university and recruited a total of 315 undergraduates from the humanities, creative arts, and social sciences programs through convenience sampling. Participants confirmed their informed consent and completed a set of self-administered questionnaires measuring positive emotions, hope, life satisfaction, and demographic variables. The results of mediation testing indicated that, during a global crisis such as COVID-19, positive emotions indirectly influenced life satisfaction through agency thinking rather than pathways thinking. The findings highlight the importance of agency thinking among Chinese university students in adverse situations and provide valuable insights for psychological interventions during a crisis. The article concludes by discussing possible explanations and implications of the findings in a post-pandemic world.

Multiple sclerosis (MS) is an autoimmune demyelinating neurodegenerative disease of the central nervous system (CNS) due to injury of the myelin sheath by immune cells. The clotting factor fibrinogen is involved in the pathogenesis of MS by triggering microglia and the progress of neuroinflammation. Fibrinogen level is correlated with MS severity; consequently, inhibition of the fibrinogen cascade may reduce MS neuropathology. Thus, this review aimed to clarify the potential role of fibrinogen in the pathogenesis of MS and how targeting of fibrinogen affects MS neuropathology. Accumulation of fibrinogen in the CNS may occur independently or due to disruption of blood-brain barrier (BBB) integrity in MS. Fibrinogen acts as transduction and increases microglia activation which induces the progression of inflammation, oxidative stress, and neuronal injury. Besides, brain fibrinogen impairs the remyelination process by inhibiting the differentiation of oligodendrocyte precursor cells. These findings proposed that fibrinogen is associated with MS neuropathology through interruption of BBB integrity, induction of neuroinflammation, and demyelination with inhibition of the remyelination process by suppressing oligodendrocytes. Therefore, targeting of fibrinogen and/or CD11b/CD18 receptors by metformin and statins might decrease MS neuropathology. In conclusion, inhibiting the expression of CD11b/CD18 receptors by metformin and statins may decrease the pro-inflammatory effect of fibrinogen on microglia which is involved in the progression of MS.

Objectives: The aim of this scoping review was to map out the existing evidence of the impact of the COVID-19 lockdown on parents of children and adolescents. We sought to: 1) identify parenting domains that were particularly affected by lockdown measures, 2) describe the challenges and opportunities of lockdown measures in these domains, and 3) define protective and exacerbating factors modulating the effect of lockdown measures on parents. Methods: We identified five main domains investigated in the context of parenting during the early COVID-19 lockdown derived from 84 studies: health and wellbeing, parental role, couple functioning, family and social relationships, and paid and unpaid work. For each domain, we listed challenges and opportunities, as well as discriminant factors. Results: The lockdown impacted all five different but interconnected domains, introduced new roles in parents' lives, and particularly affected women and vulnerable populations. Conclusion: This scoping review highlights the importance of approaching public health policymaking from a social justice perspective. Such an approach argues for social and public health policies to promote health accounting for its social, economic, political, and commercial determinants.

Through a 2 × 2 experimental vignette design, we tested if partner perceived attractiveness in interaction with appearance-related comments from one's partner might affect women and men's body dissatisfaction, body shame, acceptance of cosmetic surgery, and perceived relationship quality. Participants were 154 women and 157 men living in Italy (mean age = 30.97; all of them were in a couple relationship), who read a vignette describing the purchase of a swimsuit, through which partner attractiveness (poor versus high) and partner commentary (negative versus positive) were manipulated. Some ANCOVAs were performed on women and men separately. For men, partner commentary affected body dissatisfaction with low body fat. Moreover, the main effect of partner attractiveness was found in their consideration of undergoing cosmetic procedures. Among women, a significant partner attractiveness X partner commentary interaction effect emerged on acceptance of cosmetic surgery for social reasons. As regards relationship quality, for women, there was a main effect of partner attractiveness on relational communication, while a marginally significant interaction effect between partner attractiveness and partner commentary emerged for men's self-disclosure. Our findings suggest that partner attractiveness is generally beneficial, but when combined with negative feedback concerning the appearance, it might lose its advantages. These findings should be considered for planning interventions aimed at both preventing body dissatisfaction and acceptance of cosmetic surgical procedures for not medical reasons and promoting relationship satisfaction among women and men.

The Sorrows of Young Werther (1774). By Johann Wolfgang von Goethe, translated by Elizabeth Mayer and Louise Bogan. 167 pp. In The Sorrows of Young Werther, and Novella. New York: Random House, 1971.

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This study explores the experiences and adjustment process among older Bhutanese refugees resettled in the United States and identifies their unmet health and social service needs. This phenomenological study design included the conduction of nine in-depth semistructured interviews in the respondents' native language. The researchers adhered to the steps outlined by Moustakas for data analysis. The five identified themes included the following: a better life but with little sorrows, cultural tensions related to adaptation, language as a barrier to success in the United States, isolation and loneliness, and worries about citizenship and its impact on the future. Discussion/Implications for Practice: Psychological adjustment to life in the United States can have profound impact on the health of Bhutanese older adults. Nurses and health care providers should integrate culturally congruent health care, raise awareness of the unique needs, and advocate for policy changes that will benefit this group of older adult refugees whose lives have frequently been upended.

We aimed to provide health practitioners greater insight into the public perception of traditional and complementary medicine (T&CM) use. Our objectives were to identify news media reports of children abandoning conventional treatment for traditional and complementary medicine, analyze the thematic content of these news articles and estimate the tonality portrayed. LexisNexis and Factiva were searched for terms related to cancer, children and T&CM. Inclusion criteria were children less than 18 years, in curative phase of treatment who attempted to abandon conventional therapy for any traditional and complementary medicine use. A secondary search was performed in LexisNexis, Factiva and Google News Archive with the names of children in identified cases. Qualitative analysis of news media reports was completed using a grounded theory approach. Quantitative analysis of article sentiment was performed using a linear support vector machine. Seventeen cases occurring between 2002 and 2016 were included. Five main themes were identified: treatment as torture, power imbalances, rights of parents, evidence versus beliefs and the rights of Indigenous Peoples. Sentiment analysis revealed an overall negative tone, as demonstrated by 73% of the articles. A better understanding of factors that lead to abandonment of conventional therapy for traditional and complementary medicine as portrayed in the news media may help healthcare providers prevent the occurrence of these cases.