Conversational Agents (CAs, chatbots) are systems with the ability to interact with users using natural human dialogue. While much of the research on CAs for sexual health has focused on adult populations, the insights from such research may not apply to CAs for youth. The study aimed to comprehensively evaluate the state-of-the-art research on sexual health CAs for youth. Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we synthesized peer-reviewed studies specific to sexual health CAs designed for youth over the past 14 years. We found that most sexual health CAs were designed to adopt the persona of health professionals to provide general sexual and reproductive health information for youth. Text was the primary communication mode in all sexual health CAs, with half supporting multimedia output. Many sexual health CAs employed rule-based techniques to deliver pre-written expert knowledge on sexual health; yet most sexual health CAs did not have the safety features in place. While youth appreciated accessibility to non-judgmental and confidential conversations about sexual health topics, they perceived current sexual health CAs pro
Large Language Models (LLMs) have been positioned as having the potential to expand access to health information in the Global South, yet their evaluation remains heavily dependent on benchmarks designed around Western norms. We present insights from a preliminary benchmarking exercise with a chatbot for sexual and reproductive health (SRH) for an underserved community in India. We evaluated using HealthBench, a benchmark for conversational health models by OpenAI. We extracted 637 SRH queries from the dataset and evaluated on the 330 single-turn conversations. Responses were evaluated using HealthBench's rubric-based automated grader, which rated responses consistently low. However, qualitative analysis by trained annotators and public health experts revealed that many responses were actually culturally appropriate and medically accurate. We highlight recurring issues, particularly a Western bias, such as for legal framing and norms (e.g., breastfeeding in public), diet assumptions (e.g., fish safe to eat during pregnancy), and costs (e.g., insurance models). Our findings demonstrate the limitations of current benchmarks in capturing the effectiveness of systems built for differen
As Large Language Models (LLMs) become integrated into daily life, they are increasingly used for personal queries, including Sexual and Reproductive Health (SRH), allowing users to chat anonymously without fear of judgment. However, current evaluation methods primarily focus on accuracy, often for objective queries in high-resource languages, and lack criteria to assess usability and safety, especially for low-resource languages and culturally sensitive domains like SRH. This paper introduces LLM Evaluation Framework (LEAF), that conducts assessments across multiple criteria: accuracy, language, usability gaps (including relevance, adequacy, and cultural appropriateness), and safety gaps (safety, sensitivity, and confidentiality). Using the LEAF framework, we assessed 14K SRH queries in Nepali from over 9K users. Responses were manually annotated by SRH experts according to the framework. Results revealed that only 35.1% of the responses were "proper", meaning they were accurate, adequate and had no major usability or safety related gaps. Insights include differences in performance between ChatGPT versions, such as similar accuracy but varying usability and safety aspects. This ev
The rapid adoption of generative AI (GenAI) chatbots has reshaped access to sexual and reproductive health (SRH) information, particularly following the overturning of Roe v. Wade, as individuals assigned female at birth increasingly turn to online sources. However, existing research remains largely model-centered, paying limited attention to user privacy and safety. We conducted semi-structured interviews with 18 U.S.-based participants from both restrictive and non-restrictive states who had used GenAI chatbots to seek SRH information. Adoption was influenced by perceived utility, usability, credibility, accessibility, and anthropomorphism, and many participants disclosed sensitive personal SRH details. Participants identified multiple privacy risks, including excessive data collection, government surveillance, profiling, model training, and data commodification. While most participants accepted these risks in exchange for perceived utility, abortion-related queries elicited heightened safety concerns. Few participants employed protective strategies beyond minimizing disclosures or deleting data. Based on these findings, we offer design and policy recommendations, such as health-
Social media platforms like TikTok have become a key source of health information, with studies reporting inaccuracies in posts. As Large Language Model (LLM) providers increasingly integrate LLMs into digital platforms to fact-check content (e.g., Grok and Perplexity on X and WhatsApp, respectively) and are being used by people to fact-check information, deploying these systems in critical areas such as reproductive health without rigorous evaluation can cause serious harm. We introduce RELIANCE, an expert-annotated dataset of health information on TikTok surrounding pregnancy and postpartum queries, serving as both an analysis of the reproductive health information landscape and an evaluation of LLMs' capabilities in fact-checking this content. Our dataset comprises 409 annotated sentences from 336 videos across 56 clinician-reviewed queries, annotated by three expert clinicians in Obstetrics, Gynecology, and Internal Medicine. Our findings reveal that nearly 60\% of the health information in the videos we sampled is accurate. Furthermore, LLM evaluations reveal a gap between evaluating specific claims and evaluating the entire content (15\%). We believe that our methodology, dat
While Artificial Intelligence (AI) shows promise in healthcare applications, existing conversational systems often falter in complex and sensitive medical domains such as Sexual and Reproductive Health (SRH). These systems frequently struggle with hallucination and lack the specialized knowledge required, particularly for sensitive SRH topics. Furthermore, current AI approaches in healthcare tend to prioritize diagnostic capabilities over comprehensive patient care and education. Addressing these gaps, this work at the UNC School of Nursing introduces SARHAchat, a proof-of-concept Large Language Model (LLM)-based chatbot. SARHAchat is designed as a reliable, user-centered system integrating medical expertise with empathetic communication to enhance SRH care delivery. Our evaluation demonstrates SARHAchat's ability to provide accurate and contextually appropriate contraceptive counseling while maintaining a natural conversational flow. The demo is available at https://sarhachat.com/}{https://sarhachat.com/.
There is an abundance of digital sexual and reproductive health technologies that presents a concern regarding their potential sensitive data breaches. We analyzed 15 Internet of Things (IoT) devices with sexual and reproductive tracking services and found this ever-extending collection of data implicates many beyond the individual including partner, child, and family. Results suggest that digital sexual and reproductive health data privacy is both an individual and collective endeavor.
In this paper, we have discussed initial findings and results of our experiment to predict sexual and reproductive health vulnerabilities of migrants in a data-constrained environment. Notwithstanding the limited research and data about migrants and migration cities, we propose a solution that simultaneously focuses on data gathering from migrants, augmenting awareness of the migrants to reduce mishaps, and setting up a mechanism to present insights to the key stakeholders in migration to act upon. We have designed a webapp for the stakeholders involved in migration: migrants, who would participate in data gathering process and can also use the app for getting to know safety and awareness tips based on analysis of the data received; public health workers, who would have an access to the database of migrants on the app; policy makers, who would have a greater understanding of the ground reality, and of the patterns of migration through machine-learned analysis. Finally, we have experimented with different machine learning models on an artificially curated dataset. We have shown, through experiments, how machine learning can assist in predicting the migrants at risk and can also help
Access to sexual and reproductive health information remains a challenge in many communities globally, due to cultural taboos and limited availability of healthcare providers. Public health organizations are increasingly turning to Large Language Models (LLMs) to improve access to timely and personalized information. However, recent HCI scholarship indicates that significant challenges remain in incorporating context awareness and mitigating bias in LLMs. In this paper, we study the development of a culturally-appropriate LLM-based chatbot for reproductive health with underserved women in urban India. Through user interactions, focus groups, and interviews with multiple stakeholders, we examine the chatbot's response to sensitive and highly contextual queries on reproductive health. Our findings reveal strengths and limitations of the system in capturing local context, and complexities around what constitutes "culture". Finally, we discuss how local context might be better integrated, and present a framework to inform the design of culturally-sensitive chatbots for community health.
Following the recent release of various Artificial Intelligence (AI) based Conversation Agents (CAs), adolescents are increasingly using CAs for interactive knowledge discovery on sensitive topics, including mental and sexual health topics. Exploring such sensitive topics through online search has been an essential part of adolescent development, and CAs can support their knowledge discovery on such topics through human-like dialogues. Yet, unintended risks have been documented with adolescents' interactions with AI-based CAs, such as being exposed to inappropriate content, false information, and/or being given advice that is detrimental to their mental and physical well-being (e.g., to self-harm). In this position paper, we discuss the current landscape and opportunities for CAs to support adolescents' mental and sexual health knowledge discovery. We also discuss some of the challenges related to ensuring the safety of adolescents when interacting with CAs regarding sexual and mental health topics. We call for a discourse on how to set guardrails for the safe evolution of AI-based CAs for adolescents.
Childhood Sexual Abuse (CSA) is a menace to society and has long-lasting effects on the mental health of the survivors. From time to time CSA survivors are haunted by various mental health issues in their lifetime. Proper care and attention towards CSA survivors facing mental health issues can drastically improve the mental health conditions of CSA survivors. Previous works leveraging online social media (OSM) data for understanding mental health issues haven't focused on mental health issues in individuals with CSA background. Our work fills this gap by studying Reddit posts related to CSA to understand their mental health issues. Mental health issues such as depression, anxiety, and Post-Traumatic Stress Disorder (PTSD) are most commonly observed in posts with CSA background. Observable differences exist between posts related to mental health issues with and without CSA background. Keeping this difference in mind, for identifying mental health issues in posts with CSA exposure we develop a two-stage framework. The first stage involves classifying posts with and without CSA background and the second stage involves recognizing mental health issues in posts that are classified as be
Penile measurement is clinically relevant across male reproductive and urogenital health, including conditions such as micropenis, congenital and endocrine disorders, and sexual or urinary dysfunction. However, quantitative assessment of penile size has relied mainly on external length or circumference measurements, which are difficult to standardize, sensitive to measurement conditions, and unable to capture the internal portion of the penis. MRI enables volumetric assessment of the whole penis in vivo, but automated segmentation has not previously been established at population scale. Automated whole-organ volumetry would enable high-throughput phenotyping for multi-omics and clinical studies of male reproductive disease. Here, we present a deep learning framework for whole-penis segmentation in multi-channel DIXON MRI. Using a newly curated expert-annotated training dataset ($n = 145$ subjects; $13,050$ annotated slices) and a double-annotated independent test benchmark ($n = 24$ subjects; $2,160$ double-annotated slices), we optimized a 3D nnU-Net architecture. The model achieved a 5-fold cross-validation Dice score of $0.90$ and performed at observer-level accuracy on the inde
YouTube has rapidly emerged as a predominant platform for content consumption, effectively displacing conventional media such as television and news outlets. A part of the enormous video stream uploaded to this platform includes health-related content, both from official public health organizations, and from any individual or group that can make an account. The quality of information available on YouTube is a critical point of public health safety, especially when concerning major interventions, such as vaccination. This study differentiates itself from previous efforts of auditing YouTube videos on this topic by conducting a systematic daily collection of posted videos mentioning vaccination for the duration of 3 months. We show that the competition for the public's attention is between public health messaging by institutions and individual educators on one side, and commentators on society and politics on the other, the latest contributing the most to the videos expressing stances against vaccination. Videos opposing vaccination are more likely to mention politicians and publication media such as podcasts, reports, and news analysis, on the other hand, videos in favor are more li
Mobile health has the potential to revolutionize health care delivery and patient engagement. In this work, we discuss how integrating Artificial Intelligence into digital health applications-focused on supply chain, patient management, and capacity building, among other use cases-can improve the health system and public health performance. We present an Artificial Intelligence and Reinforcement Learning platform that allows the delivery of adaptive interventions whose impact can be optimized through experimentation and real-time monitoring. The system can integrate multiple data sources and digital health applications. The flexibility of this platform to connect to various mobile health applications and digital devices and send personalized recommendations based on past data and predictions can significantly improve the impact of digital tools on health system outcomes. The potential for resource-poor settings, where the impact of this approach on health outcomes could be more decisive, is discussed specifically. This framework is, however, similarly applicable to improving efficiency in health systems where scarcity is not an issue.
The COVID-19 pandemic has highlighted the dire necessity to improve public health literacy for societal resilience. YouTube, the largest video-sharing social media platform, provides a vast repository of user-generated health information in a multi-media-rich format which may be easier for the public to understand and use if major concerns about content quality and accuracy are addressed. This study develops an automated solution to identify, retrieve and shortlist medically relevant and understandable YouTube videos that domain experts can subsequently review and recommend for disseminating and educating the public on the COVID-19 pandemic and similar public health outbreaks. Our approach leverages domain knowledge from human experts and machine learning and natural language processing methods to provide a scalable, replicable, and generalizable approach that can also be applied to enhance the management of many health conditions.
Gynandromorphs are creatures where at least two different body sections are a different sex. Bilateral gynandromorphs are half male and half female. Here we develop a theory of gynandromorph ontogeny based on developmental control networks. The theory explains the embryogenesis of all known variations of gynandromorphs found in multicellular organisms. The theory also predicts a large variety of more subtle gynandromorphic morphologies yet to be discovered. The network theory of gynandromorph development has direct relevance to understanding sexual dimorphism (differences in morphology between male and female organisms of the same species) and medical pathologies such as hemihyperplasia (asymmetric development of normally symmetric body parts in a unisexual individual). The network theory of gynandromorphs brings up fundamental open questions about developmental control in ontogeny. This in turn suggests a new theory of the origin and evolution of species that is based on cooperative interactions and conflicts between developmental control networks in the haploid genomes and epigenomes of potential sexual partners for reproduction. This network-based theory of the origin of species
Linking clinical narratives to standardized vocabularies and coding systems is a key component of unlocking the information in medical text for analysis. However, many domains of medical concepts lack well-developed terminologies that can support effective coding of medical text. We present a framework for developing natural language processing (NLP) technologies for automated coding of under-studied types of medical information, and demonstrate its applicability via a case study on physical mobility function. Mobility is a component of many health measures, from post-acute care and surgical outcomes to chronic frailty and disability, and is coded in the International Classification of Functioning, Disability, and Health (ICF). However, mobility and other types of functional activity remain under-studied in medical informatics, and neither the ICF nor commonly-used medical terminologies capture functional status terminology in practice. We investigated two data-driven paradigms, classification and candidate selection, to link narrative observations of mobility to standardized ICF codes, using a dataset of clinical narratives from physical therapy encounters. Recent advances in lang
Software engineering for digital health applications entails several challenges, including heterogeneous data acquisition, data standardization, software reuse, security, and privacy considerations. We explore these challenges and how our Stanford Spezi ecosystem addresses these challenges by providing a modular and standards-based open-source digital health ecosystem. Spezi enables developers to select and integrate modules according to their needs and facilitates an open-source community to democratize access to building digital health innovations.
Large AI models, or foundation models, are models recently emerging with massive scales both parameter-wise and data-wise, the magnitudes of which can reach beyond billions. Once pretrained, large AI models demonstrate impressive performance in various downstream tasks. A prime example is ChatGPT, whose capability has compelled people's imagination about the far-reaching influence that large AI models can have and their potential to transform different domains of our lives. In health informatics, the advent of large AI models has brought new paradigms for the design of methodologies. The scale of multi-modal data in the biomedical and health domain has been ever-expanding especially since the community embraced the era of deep learning, which provides the ground to develop, validate, and advance large AI models for breakthroughs in health-related areas. This article presents a comprehensive review of large AI models, from background to their applications. We identify seven key sectors in which large AI models are applicable and might have substantial influence, including 1) bioinformatics; 2) medical diagnosis; 3) medical imaging; 4) medical informatics; 5) medical education; 6) pu
Mobile health apps are revolutionizing the healthcare ecosystem by improving communication, efficiency, and quality of service. In low- and middle-income countries, they also play a unique role as a source of information about health outcomes and behaviors of patients and healthcare workers, while providing a suitable channel to deliver both personalized and collective policy interventions. We propose a framework to study user engagement with mobile health, focusing on healthcare workers and digital health apps designed to support them in resource-poor settings. The behavioral logs produced by these apps can be transformed into daily time series characterizing each user's activity. We use probabilistic and survival analysis to build multiple personalized measures of meaningful engagement, which could serve to tailor content and digital interventions suiting each health worker's specific needs. Special attention is given to the problem of detecting churn, understood as a marker of complete disengagement. We discuss the application of our methods to the Indian and Ethiopian users of the Safe Delivery App, a capacity-building tool for skilled birth attendants. This work represents an