Esquizofrenia é uma doença crônica, de natureza multifatorial, prevalente em 1% da população mundial. O tratamento é realizado com antipsicóticos convencionais ou atípicos. A evolução no tratamento da esquizofrenia se deu com os antipsicóticos atípicos, pois eles oferecem menos efeitos e permitem uma atuação simultânea sobre os sintomas positivos e negativos da doença. Esses fármacos são usados tanto para o controle da esquizofrenia quanto de outras psicopatologias, por exemplo, o Transtorno Afetivo Bipolar (CID F31). As bulas dos medicamentos antipsicóticos alertam para o cuidado ao utilizar o medicamento em pacientes diabéticos ou que apresentem risco de desenvolver a diabetes, sendo recomendado o monitoramento glicêmico de tais pacientes. Em decorrência desse efeito, o presente trabalho tem como objetivo realizar um levantamento de informações a respeito do desenvolvimento de diabetes, em decorrência do uso de antipsicóticos atípicos para o tratamento de esquizofrenia, transtornos esquizotípicos, transtornos delirantes e outros transtornos que se assemelham à esquizofrenia. Essa é uma pesquisa descritiva, de análise quantitativa, com ênfase em dados bibliográficos e pesquisa de campo, na qual foram coletados dados, por meio de prontuários, com pacientes de área de abrangência do centro de atenção psicossocial (CAPS II), da cidade de Maringá-PR. Os resultados encontrados por meio desse estudo foram os efeitos colaterais dos fármacos, sua relação com idade, gênero, posologia e tempo de uso. Além disso, pode-se perceber a influência multifatorial para o desenvolvimento de outras comorbidades. Com isso, é possível contribuir para orientações adequadas, enfatizando os malefícios que a administração inadequada desses medicamentos pode gerar.
Introdução: A terapia com anticoagulantes orais é o esquema terapêutico complexo para a prevenção de eventos tromboembólicos. Atualmente, com todas as exigências para melhoria da qualidade assistencial e diminuição de custos na atual demanda de desenvolvimento de pesquisa, faz necessário intervenções multiprofissionais com componentes educativos para auxiliar no manejo da TACO. No âmbito da contribuição da enfermagem, a utilização de linguagem padronizada pode auxiliar enfermeiros de diferentes contextos e nacionalidades para que assim possam atuar respaldados em evidências. Objetivos: identificar na literatura as intervenções em saúde dentro da terapia e estratificá-las com nível de evidência e mapear as ações de enfermagem encontradas na literatura as intervenções/atividades propostas pela Nursing Interventions Classification. Métodos: Trata-se de um estudo de revisão integrativa, seguido de mapeamento cruzado, através da Biblioteca Virtual em Saúde, que trará artigos do IBECS, LILACS, BDENF e MEDLINE. Para realização do mapeamento cruzado foram utilizadas as regras adaptadas, baseadas em Lucena e Barros (2005). Resultados: Foram selecionados 16 artigos conforme fluxograma PRISMA, com dados sociodemográficos e nível de evidência. As intervenções para adesão foram agrupadas em grupos: educação, autogestão e tratamento diretamente observados, com o mapeamento realizado de acordo com o Nursing Interventions Classification. Conclusão: As intervenções incluem questões educacionais, de autogerenciamento e tratamento diretamente observado a fim de promover a adesão do paciente dentro da terapia, para isso as evidências apontam para o tratamento em centros especializados que por sua vez despendem da utilização de m-health, pill boxes, recursos áudio visuais, cartilhas, consultas voltadas para as particularidades do paciente.
O presente trabalho aborda sobre a dispensação de medicamentos, em especial psicotrópicos, dentro da Penitenciária de Segurança Máxima de Cariri do Tocantins, conhecida como Centro de Reeducação Social Luz do Amanhã. O consumo de benzodiazepínicos, antidepressivos, neurolépticos entre outras classes de psicotrópicos dentro de unidades prisionais dá-se devido a fatores ligados ao histórico do próprio indivíduo, transtornos psíquicos, além das condições dentro do ambiente do sistema prisional, caracterizados na maior parte das vezes por serem insalubres, apresentarem riscos e precariedade. A metodologia utilizada foi tabular os dados por meio do software Excel 2013, tendo como variáveis cinco classes medicamentosas prescritas dentro da instituição (antidepressivo, anti-histamínico, antiepilépticos, benzodiazepínicos e neurolépticos) e o período entre 2021 e 2022. Os resultados obtidos demonstraram que os antidepressivos e benzodiazepínicos obtiveram um aumento percentual de respectivamente 71% e 121% dentro do período da coleta de dados. Desse modo, tem-se o uso de dessas drogas lícitas como forma de amenizar sofrimentos psíquicos, dar continuidade a tratamentos de transtornos mentais comuns dentro de unidades prisionais, mas também com fins que vão além do uso terapêutico, servindo para autonomia do sujeito.
A study of the Revista General de Informacion y Documentacion, from 2005 to 2022. The objective is aimed at qualifying the structure of the research field and assessing the trajectory of the thematic areas covered. Applying as methodology the analysis of co-words, the construction of bibliometric networks and the creation of scientific maps. 514 documents are extracted from the Web of Science (WoS) database. The keywords assigned by the authors of the documents are selected and divided into three subperiods: 2005-2010, 2011-2016 and 2017-2022. In the results, 1701 author keywords and 37 bibliometric networks are obtained. In the period 2005-2010, the structure of the research field is represented on the scientific map with very few central and specialized topics, considering an initial and underdeveloped organization. In the period 2011-2016, the structure of the research field is distributed on the scientific map with a more varied number of central and specialized topics, but still insufficient, considering an organization in the process of development. In the period 2017-2022, the structure of the research field is shown on the map with all kinds of family of topics (central, sp
In this work, deep learning techniques for brain age prediction from magnetic resonance images are investigated, aiming to assist in the identification of biomarkers of the natural aging process. The identification of biomarkers is useful for detecting an early-stage neurodegenerative process, as well as for predicting age-related or non-age-related cognitive decline. Two techniques are implemented and compared in this work: a 3D Convolutional Neural Network applied to the volumetric image and a 2D Convolutional Neural Network applied to slices from the axial plane, with subsequent fusion of individual predictions. The best result was obtained by the 2D model, which achieved a mean absolute error of 3.83 years. -- Neste trabalho são investigadas técnicas de aprendizado profundo para a predição da idade cerebral a partir de imagens de ressonância magnética, visando auxiliar na identificação de biomarcadores do processo natural de envelhecimento. A identificação de biomarcadores é útil para a detecção de um processo neurodegenerativo em estágio inicial, além de possibilitar prever um declínio cognitivo relacionado ou não à idade. Duas técnicas são implementadas e comparadas neste tra
Starting from the Einstein equations in Schwarzschild-de Sitter (SdS) spacetime and imposing Friedmann-Robertson-Walker coordinates at large distances, we find two coordinate systems with time-dependent metrics that are smooth across both the black hole and cosmological horizons. These coordinates require a positive cosmological constant for regularity, and thus they are not de Sitter extensions of the Kruskal-Szekeres or Israel coordinates. One of the coordinate systems was only found in 1999 (Abbassi coordinates), and it has led to conflicting interpretations in the literature, while the other was briefly commented on and promptly dismissed as unphysical or incompatible with SdS. We derive that the second solution is equivalent to the first one, and that both are indeed equivalent descriptions of SdS spacetime. We also derive explicit coordinate transformations linking these coordinate systems to the Kottler coordinates and the maximally extended Lake-Israel coordinates. Among other applications, these results, which extend the largely used cosmological and local coordinates, should be useful for further developments in understanding the exact interplay between black holes and th
A measurement of the CKM angle $γ$ and related strong-phase parameters is performed using a novel, model-independent approach in ${B^{\pm}\rightarrow D(\rightarrow K^{0}_{\rm S} h^{\prime+}h^{\prime-}) h^{\pm}}$ decays, where $h^{(\prime)} \equiv π, K$. The analysis uses a joint data sample of electron-positron collisions collected by the BESIII experiment at the Beijing Electron-Positron Collider II during 2010--2011 and 2021--2022, corresponding to an integrated luminosity of 8 fb$^{-1}$, and proton-proton collisions collected by the LHCb experiment at the Large Hadron Collider during 2011--2018, corresponding to an integrated luminosity of 9 fb$^{-1}$. The two datasets are analyzed simultaneously by applying per-event weights based on the amplitude variation over the $D$-decay phase space to enhance the sensitivity to $C\!P$-violating observables. The CKM angle $γ$ is determined to be $γ= (71.3\pm 5.0)^{\circ}$, which constitutes the most precise single measurement to date.
Facial recognition powered by Artificial Intelligence has achieved high accuracy in specific scenarios and applications. Nevertheless, it faces significant challenges regarding privacy and identity management, particularly when unknown individuals appear in the operational context. This paper presents the design, implementation, and evaluation of a facial recognition system within a federated learning framework tailored to open-set scenarios. The proposed approach integrates the OpenMax algorithm into federated learning, leveraging the exchange of mean activation vectors and local distance measures to reliably distinguish between known and unknown subjects. Experimental results validate the effectiveness of the proposed solution, demonstrating its potential for enhancing privacy-aware and robust facial recognition in distributed environments. -- El reconocimiento facial impulsado por Inteligencia Artificial ha demostrado una alta precisión en algunos escenarios y aplicaciones. Sin embargo, presenta desafíos relacionados con la privacidad y la identificación de personas, especialmente considerando que pueden aparecer sujetos desconocidos para el sistema que lo implementa. En este tr
The granting process of all credit institutions rejects applicants who seem risky regarding the repayment of their debt. A credit score is calculated and associated with a cut-off value beneath which an applicant is rejected. Developing a new score implies having a learning dataset in which the response variable good/bad borrower is known, so that rejects are de facto excluded from the learning process. We first introduce the context and some useful notations. Then we formalize if this particular sampling has consequences on the score's relevance. Finally, we elaborate on methods that use not-financed clients' characteristics and conclude that none of these methods are satisfactory in practice using data from Crédit Agricole Consumer Finance. ----- Un système d'octroi de crédit peut refuser des demandes de prêt jugées trop risquées. Au sein de ce système, le score de crédit fournit une valeur mesurant un risque de défaut, valeur qui est comparée à un seuil d'acceptabilité. Ce score est construit exclusivement sur des données de clients financés, contenant en particulier l'information `bon ou mauvais payeur', alors qu'il est par la suite appliqué à l'ensemble des demandes. Un tel sc
Neste artigo discutimos uma nova demonstracao experimental da independencia das propriedades dos corpos (massa, composicao quimica, forma, etc.) na queda livre. Eh uma das experiencias mais simples, porem uma das mais importantes da Mecanica, tendo sido realizada e repensada repetidamente por diversos cientistas tais como Galileu e Newton. Nossa versao eh introduzir dentro de uma garrafa fechada e transparente uma pena e uma pedra observando a queda simultanea destes corpos. Por nao haver a necessidade de produzir vacuo, esta versao pode ser repetida por qualquer aluno e professor de ensino medio e universitario em qualquer ambiente, evidenciando sua viabilidade e aplicabilidade na sala de aula. English version of abstract: In this paper we discuss a new experimental demonstration of the independence of the properties of bodies (mass, chemical composition, shape, etc) in free fall. This is one of the simplest experiments in mechanics, though one of the most important ones, having been repeatedly carried out and rethought by several scientists such as Galileo and Newton. Our version of this famous experiment uses one bottle (closed and transparent), in which we introduce a feather a
A search for the radiative leptonic decays $B^+\toμ^+ν_μγ$ and $B^+_c\toμ^+ν_μγ$ is performed using proton-proton collision data collected with the LHCb experiment at a center-of-mass energy of $13~{\rm TeV}$, corresponding to an integrated luminosity of $5.4~{\rm fb}^{-1}$. No evidence for an excess of events over background is observed for either signal decay. Upper limits at 90% confidence level are set on the branching fractions: \begin{align} {\cal{B}}(B^+\toμ^+ν_μγ)_{E_γ^\ast > 1\,\rm{GeV}} &< 4.0 \times 10^{-6},\\ {\cal{B}}(B_c^+\toμ^+ν_μγ)_{E_γ^\ast > 1\,\rm{GeV}} &< 1.6 \times 10^{-3}, \end{align} where the photon energy in the $B$-meson rest frame, $E_γ^\ast$, is required to be greater than $1~{\rm GeV}$. This constitutes the first search for these decays at a hadron collider and the first experimental investigation of the $B_c^+\toμ^+ν_μγ$ decay to date.
The LHCb upgrade represents a major change of the experiment. The detectors have been almost completely renewed to allow running at an instantaneous luminosity five times larger than that of the previous running periods. Readout of all detectors into an all-software trigger is central to the new design, facilitating the reconstruction of events at the maximum LHC interaction rate, and their selection in real time. The experiment's tracking system has been completely upgraded with a new pixel vertex detector, a silicon tracker upstream of the dipole magnet and three scintillating fibre tracking stations downstream of the magnet. The whole photon detection system of the RICH detectors has been renewed and the readout electronics of the calorimeter and muon systems have been fully overhauled. The first stage of the all-software trigger is implemented on a GPU farm. The output of the trigger provides a combination of totally reconstructed physics objects, such as tracks and vertices, ready for final analysis, and of entire events which need further offline reprocessing. This scheme required a complete revision of the computing model and rewriting of the experiment's software.
Este estudio tiene como objetivo analizar distintas dimensiones del estigma social en mujeres reclusas en proceso de semilibertad, a partir de diferentes variables relacionadas con las trayectorias previas a prisión y la actualidad, las percepciones y realidades del estigma y, las valoraciones de las consecuencias en la vida. La investigación ha empleado métodos cuantitativos, con una muestra de 310 mujeres reclusas y 66 profesionales penitenciarios, en 31 centros penitenciarios españoles mediante un cuestionario mixto. Los resultados muestran una autopercepción inicial favorable socialmente y respecto a su reinserción, cuestión que contrasta con la opinión de los profesionales del medio que relacionan el estigma social con las dificultades de la reinserción; siendo las mujeres con problemas de salud mental las que peor se autoperciben y las de etnia gitana las que mejor autopercepción presentan. Los datos presentan el estigma relacionado a la condición de reclusión y sus afecciones en la reinserción, lo cual aumenta los procesos de discriminación, estigmatización, marginación y exclusión. Sin embargo, es alentador la asunción del delito cometido en aquellas que han realizado programas, lo cual evidencia la importancia y necesidad de una intervención socioeducativa en el contexto penitenciario y en el acompañamiento que favorezca la reinserción social.
In this work, we initiate the study of light-ray operators in four-dimensional de Sitter space focusing on null integrals of the stress tensor. In Minkowski space, the null integral of the stress tensor unifies several ostensibly different constructions, functioning simultaneously as the energy flux operator, the angular contribution to a conserved charge, the averaged null energy operator, and the light transform of the stress tensor. However, we show that the de Sitter analogs of these various interpretations do not necessarily coincide but rather lead to distinct, observer-dependent light-ray operators. We construct four such de Sitter analogs and analyze their matrix elements in a free, conformally coupled scalar theory, showing that they exhibit the expected symmetry and positivity properties.
This work explores the use of Role Playing Games (RPG) as an active methodology in teaching Modern Physics, focusing on a game called Newton's Revenge. The game was developed with the aim of engaging students in collaborative and investigative learning processes, using gamification elements to increase motivation and involvement. Based on the constructivist theories of Piaget and Vygotsky, the RPG stimu- ewline lates cognitive and social development by placing students in the roles of historical science figures. Through contextualized physical challenges, such as understanding the Photoelectric Effect, participants actively construct knowledge. This study presents preliminary learning data obtained through pre- and post-tests, as well as evaluates students' perceptions of using educational games in science education. The results indicate that the use of RPG can be an effective tool for teaching Modern Physics, promoting greater engagement and understanding of scientific concepts.
Galaxy clusters are important cosmological probes since their abundance and spatial distribution are directly linked to structure formation on large scales. The principal uncertainty source on the cosmological parameter constraints concerns the cluster mass estimation from mass proxies. In addition, future surveys will provide a large amount of data, requiring an improvement in the accuracy of other elements used in the construction of cluster likelihoods. Therefore, accurate modeling of the mass-observable relations and reducing the effect of different systematic errors are fundamental steps for the success of cluster cosmology. In this work, we briefly review the abundance of galaxy clusters and discuss many sources of uncertainty. Os aglomerados de galáxias são importantes sondas cosmológicas, já que a abundância e a distribuição espacial desses objetos estão diretamente ligadas à formação de estruturas em grandes escalas. A maior fonte de incerteza nas restrições de parâmetros cosmológicos é originária das estimativas das massas dos aglomerados a partir da relação massa-observável. Além disso, os próximos grandes levantamentos fornecerão uma grande quantidade de dados, requeren
Este trabajo presenta resultados del proyecto de investigación orientada “Vida cotidiana y acceso a derechos en la cárcel. Trazas de sentidos”, cuyo objetivo central fue profundizar en el conocimiento y análisis de las condiciones de la vida diaria de las cárceles de la zona centro de la Provincia de Buenos Aires, Argentina. Con un corte cualitativo, se propuso identificar y caracterizar las trazas en la construcción subjetiva de las personas que asisten a los programas académicos y de extensión de la Universidad Nacional del Centro de la Provincia de Buenos Aires como modo de valorar la presencia y tarea de la universidad en este territorio. Como tema emergente, se identificaron aspectos vinculados al acceso al trabajo en la detención y su proyección al regreso a la vida en libertad.
Linguistic ambiguity continues to represent a significant challenge for natural language processing (NLP) systems, notwithstanding the advancements in architectures such as Transformers and BERT. Inspired by the recent success of instructional models like ChatGPT and Gemini (In 2023, the artificial intelligence was called Bard.), this study aims to analyze and discuss linguistic ambiguity within these models, focusing on three types prevalent in Brazilian Portuguese: semantic, syntactic, and lexical ambiguity. We create a corpus comprising 120 sentences, both ambiguous and unambiguous, for classification, explanation, and disambiguation. The models capability to generate ambiguous sentences was also explored by soliciting sets of sentences for each type of ambiguity. The results underwent qualitative analysis, drawing on recognized linguistic references, and quantitative assessment based on the accuracy of the responses obtained. It was evidenced that even the most sophisticated models, such as ChatGPT and Gemini, exhibit errors and deficiencies in their responses, with explanations often providing inconsistent. Furthermore, the accuracy peaked at 49.58 percent, indicating the need
The methodology for measuring financial assets in defined contribution (DC) pension plans has significant implications whether wealth transfers will occur among participants. In December 2024, a regulatory act was issued for Closed Pension Entities, allowing the use of the hold-to-maturity (HTM) measurement method of treasury bonds in DC plans. This article quantifies the financial impact on participants of adopting HTM valuation in these plans, using real data from the term structure of the real interest rates to assess the resulting wealth transfers. The analysis highlights how HTM valuation creates asymmetries in financial outcomes, benefiting some participants at the expense of others. Wealth transfers occur both during any withdrawal of funds and at the time of contributions, including portfolio reallocations that involve buying or selling bonds. Partial use of HTM or attempts to immunize outflows do not completely eliminate wealth transfers. The results reinforce that the use of mark-to-market (MTM) valuation of assets in DC plans prevents wealth transfers and, consequently, financial losses for participants. O método de mensuração de ativos financeiros em planos de previdênc
BACKGROUND: The Scale of Externalizing Problem Behaviors in Adults (SEPBA) was developed as a hybrid psychometric instrument designed to assess both dimensional traits and categorical diagnoses associated with externalizing psychopathology. Based on an integrative operational framework drawing on Diagnostic and Statistical Manual of Mental Disorders (DSM-5) and the Hierarchical Taxonomy of Psychopathology (HiTOP) model, the SEPBA assesses 15 traits/facets and 6 disorders within the domains of antagonism and disinhibition. METHODS: The present study analyzed the psychometric properties of the SEPBA in a combined community and prisoner sample (n = 922). The final version of the SEPBA included 144 items rated on a 4-point Likert scale. Reliability (α, ω), item discrimination, convergent/discriminant validity, confirmatory factor analyses, and gender measurement invariance were examined. RESULTS: The results indicated adequate item discrimination and internal consistency across all scales. Confirmatory factor analyses supported the unidimensionality of the individual scales and the hypothesized hierarchical organization of traits and facets. Gender invariance of the measure was demonstrated. In addition, evidence of convergent and discriminant validity was provided through correlations with external measures. CONCLUSION: The findings support the SEPBA as a suitable assessment instrument. Its hybrid structure offers an integrative approach to transdiagnostic assessment, enhancing both the clinical utility of categorical diagnoses and the empirical applicability of dimensional profiles for assessing externalizing behaviors in adults.