The Alzheimer's Disease Neuroimaging Initiative (ADNI) provides a comprehensive multimodal neuroimaging resource for studying aging and Alzheimer's disease (AD). Since its second wave, ADNI has increasingly collected resting-state functional MRI (rs-fMRI), a valuable resource for discovering brain connectivity changes predictive of cognitive decline and AD. A major barrier to its use is the considerable variability in acquisition protocols and data quality, compounded by missing imaging sessions and inconsistencies in how functional scans temporally align with clinical assessments. As a result, many studies only utilize a small subset of the total rs-fMRI data, limiting statistical power, reproducibility, and the ability to study longitudinal functional brain changes at scale. Here, we describe a pipeline for ADNI rs-fMRI data that encompasses the download of necessary imaging and clinical data, temporally aligning the clinical and imaging data, preprocessing, and quality control. We integrate data curation and preprocessing across all ADNI sites and scanner types using a combination of open-source software (Clinica, fMRIPrep, and MRIQC) and bespoke tools. Quality metrics and repor
We present Clinica (www.clinica.run), an open-source software platform designed to make clinical neuroscience studies easier and more reproducible. Clinica aims for researchers to i) spend less time on data management and processing, ii) perform reproducible evaluations of their methods, and iii) easily share data and results within their institution and with external collaborators. The core of Clinica is a set of automatic pipelines for processing and analysis of multimodal neuroimaging data (currently, T1-weighted MRI, diffusion MRI and PET data), as well as tools for statistics, machine learning and deep learning. It relies on the brain imaging data structure (BIDS) for the organization of raw neuroimaging datasets and on established tools written by the community to build its pipelines. It also provides converters of public neuroimaging datasets to BIDS (currently ADNI, AIBL, OASIS and NIFD). Processed data include image-valued scalar fields (e.g. tissue probability maps), meshes, surface-based scalar fields (e.g. cortical thickness maps) or scalar outputs (e.g. regional averages). These data follow the ClinicA Processed Structure (CAPS) format which shares the same philosophy
In this paper, we look into Signed Product Cordial Labeling for Splitting Graphs of Bull graph and Splitting graph of Star graph , Square of Path graph, Coronaand also for the graph obtained by joining two copies of Helm by a Path of arbitrary length.
This paper describes the final prototype of an assistive robot used for increasing engagement of older adults in the context of SHAPES project. It then highlights lessons learned from hands-on training during the first phases of the pilots at Clinica Humana and Can Granada residence in Mallorca (Spain).
Creatine is best known as a muscle-building supplement, but scientists are now investigating whether it could also help treat depression by boosting the brain's energy supply。 A new review examined five randomized clinical trials involving 238 participants and found mixed results。 Two studies, both involving women with major depressive disorder, re
In this paper we present a delay induced model for hepatitis C virus incorporating the healthy and infected hepatocytes as well as infectious and noninfectious virions. The model is mathematically analyzed and characterized, both for the steady states and the dynamical behavior of the model. It is shown that time delay does not affect the local asymptotic stability of the uninfected steady state. However, it can destabilize the endemic equilibrium, leading to Hopf bifurcation to periodic solutions with realistic data sets. The model is also validated using 12 patient data obtained from the study, conducted at the University of Sao Paulo Hospital das clinicas.
Research in Sports Sciences is supported often by inferences based on the declaration of the value of the statistic statistically significant or nonsignificant on the bases of a P value derived from a null-hypothesis test. Taking into account that studies are manly conducted in sample, the use of null hypothesis testing only allows estimating the true values (population) of the statistics used. However, evidence has grown in many areas of knowledge that this approach often leads to confusion and misinterpretation. To overcome this limitation they have recently emerged recommendations to support the statistical analysis with approaches that make use of more intuitive interpretations and more practical, especially based on the magnitudes (certainty / uncertainty) of the true values found. With the intent to provide alternative solutions to methodological designs recurrently used in research in sports sciences, this paper will seek to i) briefly spell out some of the weaknesses associated with the null hypothesis tests based in the P value; ii) reflect on the implications of the use of practical/clinical significance as opposed to statistical significance; iii) submit proposals for us
What if some black holes aren’t black holes at all。 A new theoretical study suggests that when a massive star collapses, it might not form a singularity hidden behind an event horizon。 Instead, the collapse could trigger the birth of a tiny new universe inside the dying star
A newly proposed quantum sensing technique could make it much easier to identify one of physics’ newest and most intriguing classes of magnets: altermagnets。 These unusual materials, discovered only a few years ago, appear to combine the speed and efficiency of antiferromagnets with some of the useful electronic properties of traditional magnets, m
NASA’s Lucy spacecraft discovered that asteroid Donaldjohanson is a wobbling, peanut-shaped relic born from a violent collision and slowly reshaped by the subtle force of sunlight。 It also carries traces of ancient water, making it an important clue to the solar system’s mysterious past
A new AI-powered framework could transform how astronomers measure the expansion of the Universe。 By analyzing images of Type Ia supernovae and modeling their environments in unprecedented detail, researchers can estimate cosmic distances with near-spectroscopic accuracy。 The technique is designed for the flood of data expected from the upcoming Ve
A new technique could solve one of the biggest challenges in making future computer chips from ultrathin materials。 Researchers found that coating molybdenum disulfide with oxygen or fluorine lets manufacturers remove just the top layer of atoms much more safely during plasma processing。 The result is a cleaner, more controlled path toward smaller
But the system would require a massive leap from any of its existing hardware
NASA’s quiet supersonic flight tests could eventually go on a national tour
Astronomers have finally cracked the mystery of the famous “Pink Planet,” a strange world 57 light-years away that has puzzled scientists for more than a decade。 Using the James Webb Space Telescope, researchers discovered that its atmosphere contains water vapor, methane, carbon dioxide, ammonia, and something never directly confirmed before in su
NASA’s upgraded Cold Atom Lab is turning the International Space Station into a frontier for quantum research, creating ultra-cold matter that behaves in astonishing ways。 The experiments could unlock new discoveries about the universe while paving the way for powerful future technologies in space and on Earth
Scientists have uncovered a surprising connection between quantum gravity and an exotic quantum state of matter that could explain why the universe isn’t expanding wildly fast。 The study suggests that the very shape of space-time may protect the cosmological constant from disruptive quantum effects
A distant galaxy nicknamed Shadow Blaster may have revealed a surprising source of cosmic neutrinos: extreme star formation instead of a supermassive black hole。 The discovery suggests that hidden, dust-filled starburst galaxies could account for a significant fraction of the Universe’s high-energy neutrinos
A new catalyst design could significantly improve the conversion of CO2 into methanol, an important fuel and chemical feedstock。 Researchers separated key reaction steps across different catalyst sites, avoiding a long-standing trade-off between speed and efficiency。 The result was about three times more methanol production than standard commercial
A new theory suggests the universe is constantly recording its own history in the fabric of spacetime。 If correct, this cosmic memory could help solve some of the biggest puzzles in physics, from black holes to dark matter and the universe’s ultimate fate