搜索结果：Preventing chronic disease

Chronic diseases are long-lasting conditions that require lifelong medical attention. Using big EMR data, we have developed early disease risk prediction models for five common chronic diseases: diabetes, hypertension, CKD, COPD, and chronic ischemic heart disease. In this study, we present a novel approach for disease risk models by integrating survival analysis with classification techniques. Traditional models for predicting the risk of chronic diseases predominantly focus on either survival analysis or classification independently. In this paper, we show survival analysis methods can be re-engineered to enable them to do classification efficiently and effectively, thereby making them a comprehensive tool for developing disease risk surveillance models. The results of our experiments on real-world big EMR data show that the performance of survival models in terms of accuracy, F1 score, and AUROC is comparable to or better than that of prior state-of-the-art models like LightGBM and XGBoost. Lastly, the proposed survival models use a novel methodology to generate explanations, which have been clinically validated by a panel of three expert physicians.

Acute vascular endothelial dysfunction is a central event in the pathogenesis of sepsis,increasing vascular permeability, promoting activation of the coagulation cascade, tissue edema and compromising perfusion of vital organs. Aging and chronic diseases(hypertension,dyslipidaemia,diabetes mellitus,chronic kidney disease,cardiovascular disease,cerebrovascular disease, chronic pulmonary disease,liver disease or cancer)are recognized risk factors for sepsis. In this article we review the features of endothelial dysfunction shared by sepsis,aging and the chronic conditions preceding this disease. Clinical studies and review articles on endothelial dysfunction associated to sepsis,aging and chronic diseases published in PubMed were considered. The main features of endothelial dysfunction shared by sepsis,aging and chronic diseases were 1.increased oxidative stress and systemic inflammation, 2.glycocalyx degradation and shedding, 3.disassembly of intercellular junctions,endothelial cell death,blood tissue barrier disruption, 4.enhanced leukocyte adhesion and extravasation, 5.induction of a pro-coagulant and anti-fibrinolytic state. In addition,chronic diseases impair the mechanisms of e

This paper presents an explainable artificial intelligence (XAI)-based framework for the spectral analysis of cough sounds associated with chronic respiratory diseases, with a particular focus on Chronic Obstructive Pulmonary Disease (COPD). A Convolutional Neural Network (CNN) is trained on time-frequency representations of cough signals, and occlusion maps are used to identify diagnostically relevant regions within the spectrograms. These highlighted areas are subsequently decomposed into five frequency subbands, enabling targeted spectral feature extraction and analysis. The results reveal that spectral patterns differ across subbands and disease groups, uncovering complementary and compensatory trends across the frequency spectrum. Noteworthy, the approach distinguishes COPD from other respiratory conditions, and chronic from non-chronic patient groups, based on interpretable spectral markers. These findings provide insight into the underlying pathophysiological characteristics of cough acoustics and demonstrate the value of frequency-resolved, XAI-enhanced analysis for biomedical signal interpretation and translational respiratory disease diagnostics.

This study addresses a critical gap in the healthcare system by developing a clinically meaningful, practical, and explainable disease surveillance system for multiple chronic diseases, utilizing routine EHR data from multiple U.S. practices integrated with CureMD's EMR/EHR system. Unlike traditional systems--using AI models that rely on features from patients' labs--our approach focuses on routinely available data, such as medical history, vitals, diagnoses, and medications, to preemptively assess the risks of chronic diseases in the next year. We trained three distinct models for each chronic disease: prediction models that forecast the risk of a disease 3, 6, and 12 months before a potential diagnosis. We developed Random Forest models, which were internally validated using F1 scores and AUROC as performance metrics and further evaluated by a panel of expert physicians for clinical relevance based on inferences grounded in medical knowledge. Additionally, we discuss our implementation of integrating these models into a practical EMR system. Beyond using Shapley attributes and surrogate models for explainability, we also introduce a new rule-engineering framework to enhance the i

Chronic diseases, such as cardiovascular disease, diabetes, chronic kidney disease, and thyroid disorders, are the leading causes of premature mortality worldwide. Early detection and intervention are crucial for improving patient outcomes, yet traditional diagnostic methods often fail due to the complex nature of these conditions. This study explores the application of machine learning (ML) and deep learning (DL) techniques to predict chronic disease and thyroid disorders. We used a variety of models, including Logistic Regression (LR), Random Forest (RF), Gradient Boosted Trees (GBT), Neural Networks (NN), Decision Trees (DT) and Native Bayes (NB), to analyze and predict disease outcomes. Our methodology involved comprehensive data pre-processing, including handling missing values, categorical encoding, and feature aggregation, followed by model training and evaluation. Performance metrics such ad precision, recall, accuracy, F1-score, and Area Under the Curve (AUC) were used to assess the effectiveness of each model. The results demonstrated that ensemble methods like Random Forest and Gradient Boosted Trees consistently outperformed. Neutral Networks also showed superior perfor

Chronic Kidney Disease (CKD) is one of the widespread Chronic diseases with no known ultimo cure and high morbidity. Research demonstrates that progressive Chronic Kidney Disease (CKD) is a heterogeneous disorder that significantly impacts kidney structure and functions, eventually leading to kidney failure. With the progression of time, chronic kidney disease has moved from a life-threatening disease affecting few people to a common disorder of varying severity. The goal of this research is to visualize dominating features, feature scores, and values exhibited for early prognosis and detection of CKD using ensemble learning and explainable AI. For that, an AI-driven predictive analytics approach is proposed to aid clinical practitioners in prescribing lifestyle modifications for individual patients to reduce the rate of progression of this disease. Our dataset is collected on body vitals from individuals with CKD and healthy subjects to develop our proposed AI-driven solution accurately. In this regard, blood and urine test results are provided, and ensemble tree-based machine-learning models are applied to predict unseen cases of CKD. Our research findings are validated after len

Chronic diseases have become the leading cause of death worldwide, a challenge intensified by strained medical resources and an aging population. Individually, patients often struggle to interpret early signs of deterioration or maintain adherence to care plans. In this paper, we introduce VitalDiagnosis, an LLM-driven ecosystem designed to shift chronic disease management from passive monitoring to proactive, interactive engagement. By integrating continuous data from wearable devices with the reasoning capabilities of LLMs, the system addresses both acute health anomalies and routine adherence. It analyzes triggers through context-aware inquiries, produces provisional insights within a collaborative patient-clinician workflow, and offers personalized guidance. This approach aims to promote a more proactive and cooperative care paradigm, with the potential to enhance patient self-management and reduce avoidable clinical workload.

Clinical data informs the personalization of health care with a potential for more effective disease management. In practice, this is achieved by subgrouping, whereby clusters with similar patient characteristics are identified and then receive customized treatment plans with the goal of targeting subgroup-specific disease dynamics. In this paper, we propose a novel mixture hidden Markov model for subgrouping patient trajectories from chronic diseases. Our model is probabilistic and carefully designed to capture different trajectory phases of chronic diseases (i.e., "severe", "moderate", and "mild") through tailored latent states. We demonstrate our subgrouping framework based on a longitudinal study across 847 patients with non-specific low back pain. Here, our subgrouping framework identifies 8 subgroups. Further, we show that our subgrouping framework outperforms common baselines in terms of cluster validity indices. Finally, we discuss the applicability of the model to other chronic and long-lasting diseases.

Chronic diseases such as diabetes are the leading causes of morbidity and mortality worldwide. Numerous research studies have been attempted with various deep learning models in diagnosis. However, most previous studies had certain limitations, including using publicly available datasets (e.g. MIMIC), and imbalanced data. In this study, we collected five-year electronic health records (EHRs) from the Taiwan hospital database, including 1,420,596 clinical notes, 387,392 laboratory test results, and more than 1,505 laboratory test items, focusing on research pre-training large language models. We proposed a novel Large Language Multimodal Models (LLMMs) framework incorporating multimodal data from clinical notes and laboratory test results for the prediction of chronic disease risk. Our method combined a text embedding encoder and multi-head attention layer to learn laboratory test values, utilizing a deep neural network (DNN) module to merge blood features with chronic disease semantics into a latent space. In our experiments, we observe that clinicalBERT and PubMed-BERT, when combined with attention fusion, can achieve an accuracy of 73% in multiclass chronic diseases and diabetes

The increasing prevalence of chronic diseases poses a significant challenge to global efforts to alleviate poverty, promote health equity, and control healthcare costs. This study adopts a structural approach to explore how patients manage chronic diseases by making trade-offs between inpatient care and ambulatory care outpatient services. Specifically, it investigates whether disadvantaged populations make distinct trade-offs compared to the general population and examines the impact of anti-poverty programs that reduce inpatient cost-sharing. Using health insurance claims data from a rural county in China, the study reveals that disadvantaged individuals tend to avoid ambulatory care unless it substantially lowers medical expenses. In contrast, the general population is more likely to prioritize ambulatory care, even at higher costs, to prevent disease progression. The findings also indicate that current anti-poverty insurance policies, which focus predominantly on hospitalization, inadvertently decrease ambulatory care usage by 23\%, resulting in increased healthcare costs and a 46.2\% decline in patient welfare. Counterfactual analysis suggests that reducing cost-sharing for am

The recent increase in morbidity is primarily due to chronic diseases including Diabetes, Heart disease, Lung cancer, and brain tumours. The results for patients can be improved, and the financial burden on the healthcare system can be lessened, through the early detection and prevention of certain disorders. In this study, we built a machine-learning model for predicting the existence of numerous diseases utilising datasets from various sources, including Kaggle, Dataworld, and the UCI repository, that are relevant to each of the diseases we intended to predict. Following the acquisition of the datasets, we used feature engineering to extract pertinent features from the information, after which the model was trained on a training set and improved using a validation set. A test set was then used to assess the correctness of the final model. We provide an easy-to-use interface where users may enter the parameters for the selected ailment. Once the right model has been run, it will indicate whether the user has a certain ailment and offer suggestions for how to treat or prevent it.

Chronic diseases are long-term, manageable, yet typically incurable conditions, highlighting the need for effective preventive strategies. Machine learning has been widely used to assess individual risk for chronic diseases. However, many models rely on medical test data (e.g. blood results, glucose levels), which limits their utility for proactive self-assessment. Additionally, to gain public trust, machine learning models should be explainable and transparent. Although some research on self-assessment machine learning models includes explainability, their explanations are not validated against established medical literature, reducing confidence in their reliability. To address these issues, we develop deep learning models that predict the risk of developing 13 chronic diseases using only personal and lifestyle factors, enabling accessible, self-directed preventive care. Importantly, we use SHAP-based explainability to identify the most influential model features and validate them against established medical literature. Our results show a strong alignment between the models' most influential features and established medical literature, reinforcing the models' trustworthiness. Crit

Chronic Wasting Disease (CWD) is a neurological disease impacting deer, elk, moose, and other cervid populations and is caused by a misfolded protein known as a prion. CWD is difficult to control due to the persistence of prions in the environment. Prions can remain infectious for more than a decade and have been found in soil as well as other environmental vectors, such as ticks and plants. Here, we provide a bifurcation analysis of a mathematical model of CWD spread in a cervid population, and use a modification of the Gillespie algorithm to explore if wolves can be used as an ecological control strategy to limit the spread of the disease in several relevant scenarios. We then analytically compute the probability that the disease spreads given one infected member enters a fully healthy population and the probability of elimination, given a fully susceptible population and remaining prions in the environment. From our analysis, we conclude that wolves can be used as an effective control strategy to limit the spread of CWD in cervid populations, and hunting or other means of lowering the susceptible population are beneficial to controlling the spread of CWD, although it is importan

Early detection of chronic diseases is beneficial to healthcare by providing a golden opportunity for timely interventions. Although numerous prior studies have successfully used machine learning (ML) models for disease diagnoses, they highly rely on medical data, which are scarce for most patients in the early stage of the chronic diseases. In this paper, we aim to diagnose hyperglycemia (diabetes), hyperlipidemia, and hypertension (collectively known as 3H) using own collected behavioral data, thus, enable the early detection of 3H without using medical data collected in clinical settings. Specifically, we collected daily behavioral data from 629 participants over a 3-month study period, and trained various ML models after data preprocessing. Experimental results show that only using the participants' uploaded behavioral data, we can achieve accurate 3H diagnoses: 80.2\%, 71.3\%, and 81.2\% for diabetes, hyperlipidemia, and hypertension, respectively. Furthermore, we conduct Shapley analysis on the trained models to identify the most influential features for each type of diseases. The identified influential features are consistent with those reported in the literature.

Traditional diagnosis of chronic diseases involves in-person consultations with physicians to identify the disease. However, there is a lack of research focused on predicting and developing application systems using clinical notes and blood test values. We collected five years of Electronic Health Records (EHRs) from Taiwan's hospital database between 2017 and 2021 as an AI database. Furthermore, we developed an EHR-based chronic disease prediction platform utilizing Large Language Multimodal Models (LLMMs), successfully integrating with frontend web and mobile applications for prediction. This prediction platform can also connect to the hospital's backend database, providing physicians with real-time risk assessment diagnostics. The demonstration link can be found at https://www.youtube.com/watch?v=oqmL9DEDFgA.

learning algorithms. In this paper, we review the classification algorithms used in the health care system (chronic diseases) and present the neural network-based Ensemble learning method. We briefly describe the commonly used algorithms and describe their critical properties. Materials and Methods: In this study, modern classification algorithms used in healthcare, examine the principles of these methods and guidelines, and to accurately diagnose and predict chronic diseases, superior machine learning algorithms with the neural network-based ensemble learning Is used. To do this, we use experimental data, real data on chronic patients (diabetes, heart, cancer) available on the UCI site. Results: We found that group algorithms designed to diagnose chronic diseases can be more effective than baseline algorithms. It also identifies several challenges to further advancing the classification of machine learning in the diagnosis of chronic diseases. Conclusion: The results show the high performance of the neural network-based Ensemble learning approach for the diagnosis and prediction of chronic diseases, which in this study reached 98.5, 99, and 100% accuracy, respectively.

Chronic disease is a long-lasting condition that can be controlled but not cured. Owing to the portability and continuous action, wearable devices are regarded as promising ways for management and rehabilitation of patients with chronic diseases. Although the monitoring functions of mobile health care are in full swing, the research direction along wearable therapy devices has not been paid with enough attention. The aim of this review paper is to summarize recent developments in the field of wearable devices, with particular focus on specific interpretations of therapy for chronic diseases including diabetes, heart disease, Parkinson's disease, chronic kidney disease and movement disability after neurologic injuries. A brief summary on the key enabling technologies allowing for the implementation of wearable monitoring and therapy devices is given, such as miniaturization of electronic circuits, data analysis techniques, telecommunication strategy and physical therapy etc. For future developments, research directions worth of pursuing are outlined.

Mobile Health (mHealth) applications have demonstrated considerable potential in supporting chronic disease self-management; however, they remain under-utilised due to low engagement, limited accessibility, and poor long-term adherence. These issues are particularly prominent among users with chronic disease, whose needs and capabilities vary widely. To address this, Adaptive User Interfaces (AUIs) offer a dynamic solution by tailoring interface features to users' preferences, health status, and contexts. This paper presents a two-stage study to develop and validate actionable AUI design guidelines for mHealth applications. In stage one, an AUI prototype was evaluated through focus groups, interviews, and a standalone survey, revealing key user challenges and preferences. These insights informed the creation of an initial set of guidelines. In stage two, the guidelines were refined based on feedback from 20 end users and evaluated by 43 software practitioners through two surveys. This process resulted in nine finalized guidelines. To assess real-world relevance, a case study of four mHealth applications was conducted, with findings supported by user reviews highlighting the utility

The RECONNECT project addresses the fragmentation of Ireland's public healthcare systems, aiming to enhance service planning and delivery for chronic disease management. By integrating complex systems within the Health Service Executive (HSE), it prioritizes data privacy while supporting future digital resource integration. The methodology encompasses structural integration through a Federated Database design to maintain system autonomy and privacy, semantic integration using a Record Linkage module to facilitate integration without individual identifiers, and the adoption of the HL7-FHIR framework for high interoperability with the national electronic health record (EHR) and the Integrated Information Service (IIS). This innovative approach features a unique architecture for loosely coupled systems and a robust privacy layer. A demonstration system has been implemented to utilize synthetic data from the Hospital Inpatient Enquiry (HIPE), Chronic Disease Management (CDM), Primary Care Reimbursement Service (PCRS) and Retina Screen systems for healthcare queries. Overall, RECONNECT aims to provide timely and effective care, enhance clinical decision-making, and empower policymakers