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The Vera C. Rubin Observatory's Legacy Survey of Space and Time (LSST) will produce unprecedented volumes of heterogeneous astronomical data (images, catalogs, and alerts) that challenge traditional analysis pipelines. The LSST Dark Energy Science Collaboration (DESC) aims to derive robust constraints on dark energy and dark matter from these data, requiring methods that are statistically powerful, scalable, and operationally reliable. Artificial intelligence and machine learning (AI/ML) are already embedded across DESC science workflows, from photometric redshifts and transient classification to weak lensing inference and cosmological simulations. Yet their utility for precision cosmology hinges on trustworthy uncertainty quantification, robustness to covariate shift and model misspecification, and reproducible integration within scientific pipelines. This white paper surveys the current landscape of AI/ML across DESC's primary cosmological probes and cross-cutting analyses, revealing that the same core methodologies and fundamental challenges recur across disparate science cases. Since progress on these cross-cutting challenges would benefit multiple probes simultaneously, we ide

There are significant differences in innovation performance between countries. Additionally, the pharmaceutical sector is stronger in some countries than in others. This suggests that the development of the pharmaceutical industry can influence a country's innovation performance. Using the Global Innovation Index and selected performance measures of the pharmaceutical sector, this study examines how the pharmaceutical sector influences the innovation performance of countries from the European context. The dataset of 27 European countries was analysed using simple, and multiple linear regressions and Pearson correlation. Our findings show that only three indicators of the pharmaceutical industry, more precisely pharmaceutical Research and Development, pharmaceutical exports, and pharmaceutical employment explain the innovation performance of a country largely. Pharmaceutical Research and Development and exports have a significant positive impact on a country's innovation performance, whereas employment in the pharmaceutical industry has a slightly negative impact. Additionally, global innovation performance has been found to positively influence life expectancy. We further outline t

GREX-PLUS (Galaxy Reionization EXplorer and PLanetary Universe Spectrometer) is a mission candidate for a JAXA strategic L-class mission to be launched in the 2030s. Its primary science goals are two-fold: galaxy formation and evolution, and planetary system formation and evolution. The GREX-PLUS spacecraft will carry a telescope with a 1 m primary mirror aperture cooled down to 50 K. The two science instruments will be onboard: a wide-field camera in the 2--8 $μ$m wavelength band and a high-resolution spectrometer with a wavelength resolution of 30,000 in the 10--18 $μ$m band. The GREX-PLUS wide-field camera aims to detect the first generation of galaxies at redshift $z>15$. The GREX-PLUS high-resolution spectrometer aims to identify the location of the water ``snowline'' in protoplanetary disks. Both instruments will provide unique datasets for a broad range of scientific topics, including galaxy mass assembly, the origin of supermassive blackholes, infrared background radiation, molecular spectroscopy in the interstellar medium, transit spectroscopy of exoplanet atmospheres, planetary atmospheres in the Solar System, and so on. This document is the second version of a collect

Current definitions of Information Science are inadequate to comprehensively describe the nature of its field of study and for addressing the problems that are arising from intelligent technologies. The ubiquitous rise of artificial intelligence applications and their impact on society demands the field of Information Science acknowledge the sociotechnical nature of these technologies. Previous definitions of Information Science over the last six decades have inadequately addressed the environmental, human, and social aspects of these technologies. This perspective piece advocates for an expanded definition of Information Science that fully includes the sociotechnical impacts information has on the conduct of research in this field. Proposing an expanded definition of Information Science that includes the sociotechnical aspects of this field should stimulate both conversation and widen the interdisciplinary lens necessary to address how intelligent technologies may be incorporated into society and our lives more fairly.

The large instantaneous sensitivity, a wide frequency coverage and flexible observation modes with large number of beams in the sky are the main features of the SKA observatory's two telescopes, the SKA-Low and the SKA-Mid, which are located on two different continents. Owing to these capabilities, the SKAO telescopes are going to be a game-changer for radio astronomy in general and pulsar astronomy in particular. The eleven articles in this special issue on pulsar science with the SKA Observatory describe its impact on different areas of pulsar science. In this lead article, a brief description of the two telescopes highlighting the relevant features for pulsar science is presented followed by an overview of each accompanying article, exploring the inter-relationship between different pulsar science use cases.

Mauve is a low-cost small satellite developed and operated by Blue Skies Space Ltd. The payload features a 13 cm telescope connected with a fibre that feeds into a UV-Vis spectrometer. The detector covers the 200-700 nm range in a single shot, obtaining low resolution spectra at R~20-65. Mauve has launched on 28th November 2025, reaching a 510 km Low-Earth Sun-synchronous orbit. The satellite will enable UV and visible observations of a variety of stellar objects in our Galaxy, filling the gaps in the ultraviolet space-based data. The researchers that have already joined the mission have defined the science themes, observational strategy and targets that Mauve will observe in the first year of operations. To date 10 science themes have been developed by the Mauve science collaboration for year 1, with observational strategies that include both long duration monitoring and short cadence snapshots. Here, we describe these themes and the science that Mauve will undertake in its first year of operations.

Pharmaceutical research and development has accumulated vast and heterogeneous archives of data. Much of this knowledge stems from discontinued programs, and reusing these archives is invaluable for reverse translation. However, in practice, such reuse is often infeasible. In this work, we introduce DiscoVerse, a multi-agent co-scientist designed to support pharmaceutical research and development at Roche. Designed as a human-in-the-loop assistant, DiscoVerse enables domain-specific queries by delivering evidence-based answers: it retrieves relevant data, links across documents, summarises key findings and preserves institutional memory. We assess DiscoVerse through expert evaluation of source-linked outputs. Our evaluation spans a selected subset of 180 molecules from Roche's research and development repositories, encompassing over 0.87 billion BPE tokens and more than four decades of research. To our knowledge, this represents the first agentic framework to be systematically assessed on real pharmaceutical data for reverse translation, enabled by authorized access to confidential archives covering the full lifecycle of drug development. Our contributions include: role-specialized

Many drugs have been withdrawn from the market worldwide, at a cost of billions of dollars, because of patient fatalities due to them unexpectedly disturbing heart rhythm. Even drugs for ailments as mild as hay fever have been withdrawn due to an unacceptable increase in risk of these heart rhythm disturbances. Consequently, the whole pharmaceutical industry expends a huge effort in checking all new drugs for any unwanted side effects on the heart. The predominant root cause has been identified as drug molecules blocking ionic current flows in the heart. Block of individual types of ionic currents can now be measured experimentally at an early stage of drug development, and this is the standard screening approach for a number of ion currents in many large pharmaceutical companies. However, clinical risk is a complex function of the degree of block of many different types of cardiac ion currents, and this is difficult to understand by looking at results of these screens independently. By using ordinary differential equation models for the electrical activity of heart cells (electrophysiology models) we can integrate information from different types of currents, to predict the effect

Large language models (LLMs) have exhibited exceptional capabilities in natural language understanding and generation, image recognition, and multimodal tasks, charting a course towards AGI and emerging as a central issue in the global technological race. This manuscript conducts a comprehensive review of the core technologies that support LLMs from a user standpoint, including prompt engineering, knowledge-enhanced retrieval augmented generation, fine tuning, pretraining, and tool learning. Additionally, it traces the historical development of Science of Science (SciSci) and presents a forward looking perspective on the potential applications of LLMs within the scientometric domain. Furthermore, it discusses the prospect of an AI agent based model for scientific evaluation, and presents new research fronts detection and knowledge graph building methods with LLMs.

The Large Synoptic Survey Telescope (LSST) will enable revolutionary studies of galaxies, dark matter, and black holes over cosmic time. The LSST Galaxies Science Collaboration has identified a host of preparatory research tasks required to leverage fully the LSST dataset for extragalactic science beyond the study of dark energy. This Galaxies Science Roadmap provides a brief introduction to critical extragalactic science to be conducted ahead of LSST operations, and a detailed list of preparatory science tasks including the motivation, activities, and deliverables associated with each. The Galaxies Science Roadmap will serve as a guiding document for researchers interested in conducting extragalactic science in anticipation of the forthcoming LSST era.

Data science and technology offer transformative tools and methods to science. This review article highlights latest development and progress in the interdisciplinary field of data-driven plasma science (DDPS). A large amount of data and machine learning algorithms go hand in hand. Most plasma data, whether experimental, observational or computational, are generated or collected by machines today. It is now becoming impractical for humans to analyze all the data manually. Therefore, it is imperative to train machines to analyze and interpret (eventually) such data as intelligently as humans but far more efficiently in quantity. Despite the recent impressive progress in applications of data science to plasma science and technology, the emerging field of DDPS is still in its infancy. Fueled by some of the most challenging problems such as fusion energy, plasma processing of materials, and fundamental understanding of the universe through observable plasma phenomena, it is expected that DDPS continues to benefit significantly from the interdisciplinary marriage between plasma science and data science into the foreseeable future.

Deep learning has enabled major advances across most areas of artificial intelligence research. This remarkable progress extends beyond mere engineering achievements and holds significant relevance for the philosophy of cognitive science. Deep neural networks have made significant strides in overcoming the limitations of older connectionist models that once occupied the centre stage of philosophical debates about cognition. This development is directly relevant to long-standing theoretical debates in the philosophy of cognitive science. Furthermore, ongoing methodological challenges related to the comparative evaluation of deep neural networks stand to benefit greatly from interdisciplinary collaboration with philosophy and cognitive science. The time is ripe for philosophers to explore foundational issues related to deep learning and cognition; this perspective paper surveys key areas where their contributions can be especially fruitful.

Data Science is a modern Data Intelligence practice, which is the core of many businesses and helps businesses build smart strategies around to deal with businesses challenges more efficiently. Data Science practice also helps in automating business processes using the algorithm, and it has several other benefits, which also deliver in a non-profitable framework. In regards to data science, three key components primarily influence the effective outcome of a data science project. Those are 1.Availability of Data 2.Algorithm 3.Processing power or infrastructure

We investigate the development of scientific content knowledge of volunteers participating in online citizen science projects in the Zooniverse (www.zooniverse.org), including the astronomy projects Galaxy Zoo (www.galaxyzoo.org) and Planet Hunters (www.planethunters.org). We use econometric methods to test how measures of project participation relate to success in a science quiz, controlling for factors known to correlate with scientific knowledge. Citizen scientists believe they are learning about both the content and processes of science through their participation. Won't don't directly test the latter, but we find evidence to support the former - that more actively engaged participants perform better in a project-specific science knowledge quiz, even after controlling for their general science knowledge. We interpret this as evidence of learning of science content inspired by participation in online citizen science.

The Aryabhatta Research Institute of Observational Sciences (ARIES), a premier autonomous research institute under the Department of Science and Technology, Government of India has a legacy of about seven decades with contributions made in the field of observational sciences namely atmospheric and astrophysics. The Survey of India used a location at ARIES, determined with an accuracy of better than 10 meters on a world datum through institute participation in a global network of Earth artificial satellites imaging during late 1950. Taking advantage of its high-altitude location, ARIES, for the first time, provided valuable input for climate change studies by long term characterization of physical and chemical properties of aerosols and trace gases in the central Himalayan regions. In astrophysical sciences, the institute has contributed precise and sometime unique observations of the celestial bodies leading to a number of discoveries. With the installation of the 3.6 meter Devasthal optical telescope in the year 2015, India became the only Asian country to join those few nations of the world who are hosting 4 meter class optical telescopes. This telescope, having advantage of geog

Current pharmaceutical formulation development still strongly relies on the traditional trial-and-error approach by individual experiences of pharmaceutical scientists, which is laborious, time-consuming and costly. Recently, deep learning has been widely applied in many challenging domains because of its important capability of automatic feature extraction. The aim of this research is to use deep learning to predict pharmaceutical formulations. In this paper, two different types of dosage forms were chosen as model systems. Evaluation criteria suitable for pharmaceutics were applied to assessing the performance of the models. Moreover, an automatic dataset selection algorithm was developed for selecting the representative data as validation and test datasets. Six machine learning methods were compared with deep learning. The result shows the accuracies of both two deep neural networks were above 80% and higher than other machine learning models, which showed good prediction in pharmaceutical formulations. In summary, deep learning with the automatic data splitting algorithm and the evaluation criteria suitable for pharmaceutical formulation data was firstly developed for the predi

We present the motivation, experience and learnings from a data challenge conducted at a large pharmaceutical corporation on the topic of subgroup identification. The data challenge aimed at exploring approaches to subgroup identification for future clinical trials. To mimic a realistic setting, participants had access to 4 Phase III clinical trials to derive a subgroup and predict its treatment effect on a future study not accessible to challenge participants. 30 teams registered for the challenge with around 100 participants, primarily from Biostatistics organisation. We outline the motivation for running the challenge, the challenge rules and logistics. Finally, we present the results of the challenge, the participant feedback as well as the learnings, and how these learnings can be translated into statistical practice.

Researchers may be tempted to attract attention through poetic titles for their publications, but would this be mistaken in some fields? Whilst poetic titles are known to be common in medicine, it is not clear whether the practice is widespread elsewhere. This article investigates the prevalence of poetic expressions in journal article titles 1996-2019 in 3.3 million articles from all 27 Scopus broad fields. Expressions were identified by manually checking all phrases with at least 5 words that occurred at least 25 times, finding 149 stock phrases, idioms, sayings, literary allusions, film names and song titles or lyrics. The expressions found are most common in the social sciences and the humanities. They are also relatively common in medicine, but almost absent from engineering and the natural and formal sciences. The differences may reflect the less hierarchical and more varied nature of the social sciences and humanities, where interesting titles may attract an audience. In engineering, natural science and formal science fields, authors should take extra care with poetic expressions, in case their choice is judged inappropriate. This includes interdisciplinary research overlapp

Ensuring fairness is essential for every education system. Machine learning is increasingly supporting the education system and educational data science (EDS) domain, from decision support to educational activities and learning analytics. However, the machine learning-based decisions can be biased because the algorithms may generate the results based on students' protected attributes such as race or gender. Clustering is an important machine learning technique to explore student data in order to support the decision-maker, as well as support educational activities, such as group assignments. Therefore, ensuring high-quality clustering models along with satisfying fairness constraints are important requirements. This chapter comprehensively surveys clustering models and their fairness in EDS. We especially focus on investigating the fair clustering models applied in educational activities. These models are believed to be practical tools for analyzing students' data and ensuring fairness in EDS.