Adaptive therapy (AT) is designed to postpone the emergence of drug resistance by exploiting evolutionary competition among tumor subclones. Most mathematical models of AT assume a binary population structure of drug-sensitive and drug-resistant cells, which neglects the continuous nature of phenotypic plasticity. In this study, we propose a mathematical model that integrates a continuous drug susceptibility index with a probabilistic inheritance function to describe clonal dynamics under therapy. The resulting integro-differential system generalizes traditional two-type competition models and captures both heterogeneity and plasticity of tumor cells. Analytical and numerical studies show that (i) continuous therapy drives rapid expansion of resistant clones, (ii) adaptive therapy maintains long-term tumor control by dynamically regulating sensitive populations, and (iii) high phenotypic plasticity accelerates phenotype switching, leading to earlier tumor relapse following continuous therapy. These results identify critical parameter regimes where adaptive therapy outperforms fixed regimens and highlight the essential role of plasticity in shaping treatment outcomes. The proposed f
This paper develops Virtual Speech Therapist (VST), an intelligent agent-based platform that streamlines stuttering assessment and delivers customized therapy planning through automated and adaptive AI-driven workflows. VST integrates state-of-the-art deep learning-based stuttering classification, and multi-agent large language model (LLM) reasoning to support evidence-based clinical decision-making. The VST begins with the acquisition and feature extraction of patient speech samples, followed by robust classification of stuttering types. Building on these outputs, VST initiates an agentic reasoning process in which specialized LLM agents autonomously generate, critique, and iteratively refine individualized therapy plans. A dedicated critic agent evaluates all generated therapy plans to ensure clinical safety, methodological soundness, and alignment with peer-reviewed evidence and established professional guidelines. The resulting output is a comprehensive, patient-specific therapy draft intended for clinician review. Incorporating clinician feedback, the system then produces a finalized therapy plan suitable for patient delivery, thereby maintaining a clinician-in-the-loop paradi
Fear of flying is a serious problem that affects millions of individuals. Exposure therapy for fear of flying is an effective therapy technique. However, exposure therapy is also expensive, logistically difficult to arrange, and presents significant problems of patient confidentiality and potential embarrassment. We have developed a virtual airplane for use in fear of flying therapy. Using the virtual airplane for exposure therapy is a potential solution to many of the current problems of fear of flying exposure therapy. We describe the design of the virtual airplane and present a case report on its use for fear of flying exposure therapy.
Objective: The objectives encompassed (1) the creation of Recuerdame, a digital app specifically designed for occupational therapists, aiming to support these professionals in the processes of planning, organizing, developing, and documenting reminiscence therapies for older people with dementia, and (2) the evaluation of the designed prototype through a participatory and user-centered design approach, exploring the perceptions of end-users. Methods: This exploratory research used a mixed-methods design. The app was developed in two phases. In the first phase, the research team identified the requirements and designed a prototype. In the second phase, experienced occupational therapists evaluated the prototype. Results: The research team determined the app's required functionalities, grouped into eight major themes: register related persons and caregivers; record the patient's life story memories; prepare a reminiscence therapy session; conduct a session; end a session; assess the patient; automatically generate a life story; other requirements. The first phase ended with the development of a prototype. In the second phase, eight occupational therapists performed a series of tasks
In an era of rapid technological advancements and macroeconomic shifts, worker reallocation is necessary, yet responses to labor market shocks remain sluggish, making it crucial to identify bottlenecks in occupational transitions to understand labor market dynamics and improve mobility. In this study, we analyze French occupational data to uncover patterns of worker mobility and pinpoint specific occupations that act as bottlenecks which impede rapid reallocation. We introduce two metrics, transferability and accessibility, to quantify the diversity of occupational transitions and find that bottlenecks can be explained by a condensation effect of occupations with high accessibility but low transferability. Transferability measures the variety of transitions from an occupation to others, while accessibility assesses the variety of transitions into an occupation. We provide a comprehensive framework for analyzing occupational complexity and mobility patterns, offering insights into potential barriers and pathways for efficient retraining programs. We argue that our approach can inform policymakers and stakeholders aiming to enhance labor market efficiency and support workforce adapta
The term bacteriophage means killer or eater of bacteria. They were initially discovered by F.W. Twort and later on, Felix d'Herelle unveiled them to the world in 1910. Phage therapy has arisen as a favorable option to conventional antibiotics by reducing the multinational problem of increasing antibacterial resistance. These virulent viruses particularly prey on and contaminate bacterial strains and aid in fighting bacterial diseases. Researchers are performing various clinical trials on the bacteriophage to tackle pathogenic bacterial infections, varying from typical illnesses to highly invulnerable biofilms that cannot be treated with antibiotics. The primary experiments demonstrated that phage therapy has fewer consequences than traditional antimicrobial drugs. It is safer to use and show results within a few days. Although phage therapy has a wide range of promising results, but it also encounters diverse obstacles. One is that they are host-specific and can merely be used for personalized therapy. As thousands of bacteria can cause disease, clinicians have to construct a library of phage viruses. For successful treatment, an analysis of versatility, stability, and immune inte
This paper presents a Virtual Reality (VR) art therapy known as "Break Times" which aims to enhance students' mental well-being and foster creative expression. The proposed "Break Times" application mimics the art therapy sessions in the VR environment design. Pilot user acceptance test with 10 participants showed a notable reduction in stress levels, with 50% reporting normal stress levels post-intervention, compared to 20% pre-intervention. Participants praised the "Break Times" therapy's functionality and engagement features and suggested improvements such as saving creations, incorporating 3D painting, and expanding the artmaking scene variety. The study highlights that VR art therapy has potential as an effective tool for stress management, emphasizing the need for continued refinement to maximize its therapeutic benefits.
Attention Deficit Hyperactivity Disorder (ADHD) is a neurodevelopmental condition characterized by inattention, hyperactivity, and impulsivity, which can significantly impact an individual's daily functioning and quality of life. Occupational therapy plays a crucial role in managing ADHD by fostering the development of skills needed for daily living and enhancing an individual's ability to participate fully in school, home, and social situations. Recent studies highlight the potential of integrating Large Language Models (LLMs) like ChatGPT and Socially Assistive Robots (SAR) to improve psychological treatments. This integration aims to overcome existing limitations in mental health therapy by providing tailored support and adapting to the unique needs of this sensitive group. However, there remains a significant gap in research exploring the combined use of these advanced technologies in ADHD therapy, suggesting an opportunity for novel therapeutic approaches. Thus, we integrated two advanced language models, ChatGPT-4 Turbo and Claude-3 Opus, into a robotic assistant to explore how well each model performs in robot-assisted interactions. Additionally, we have compared their perfo
Background: Gravity confounds arm movement ability in post-stroke hemiparesis. Reducing its influence allows effective practice leading to recovery. Yet, there is a scarcity of wearable devices suitable for personalized use across diverse therapeutic activities in the clinic. Objective: In this study, we investigated the safety, feasibility, and efficacy of anti-gravity therapy using the ExoNET device in post-stroke participants. Methods: Twenty chronic stroke survivors underwent six, 45-minute occupational therapy sessions while wearing the ExoNET, randomized into either the treatment (ExoNET tuned to gravity-support) or control group (ExoNET tuned to slack condition). Clinical outcomes were evaluated by a blinded-rater at baseline, post, and six-week follow-up sessions. Kinetic, kinematic, and patient experience outcomes were also assessed. Results: Mixed-effect models showed a significant improvement in Box and Blocks scores in the post-intervention session for the treatment group (effect size: 2.1, p = .04). No significant effects were found between the treatment and control groups for ARAT scores and other clinical metrics. Direct kinetic effects revealed a significant reducti
This study examines the impact of the COVID-19 pandemic on information-seeking behaviors among international students, with a focus on the r/f1visa subreddit. Our study indicates a considerable rise in the number of users posting more than one question during the pandemic. Those asking recurring questions demonstrate more active involvement in communication, suggesting a continuous pursuit of knowledge. Furthermore, the thematic focus has shifted from questions about jobs before COVID-19 to concerns about finances, school preparations, and taxes during COVID-19. These findings carry implications for support policymaking, highlighting the importance of delivering timely and relevant information to meet the evolving needs of international students. To enhance international students' understanding and navigation of this dynamic environment, future research in this field is necessary.
We are in a golden age of progress in artificial intelligence (AI). Radiotherapy, due to its technology-intensive nature as well as direct human-machine interactions, is perfectly suited for benefitting from AI to enhance accuracy and efficiency. Over the past few years, a vast majority of AI research have already been published in the field of photon therapy, while the applications of AI specifically targeted for particle therapy remain scarcely investigated. There are two distinct differences between photon therapy and particle therapy: beam interaction physics (photons vs. charged particles) and beam delivery mode (e.g. IMRT/VMAT vs. pencil beam scanning). As a result, different strategies of AI deployment are required between these two radiotherapy modalities. In this article, we aim to present a comprehensive survey of recent literatures exclusively focusing on AI-powered particle therapy. Six major aspects are included: treatment planning, dose calculation, range and dose verification, image guidance, quality assurance and adaptive replanning. A number of perspectives as well as potential challenges and common pitfalls, are also discussed.
Despite the high prevalence and burden of mental health conditions, there is a global shortage of mental health providers. Artificial Intelligence (AI) methods have been proposed as a way to address this shortage, by supporting providers with less extensive training as they deliver care. To this end, we developed the AI-Assisted Provider Platform (A2P2), a text-based virtual therapy interface that includes a response suggestion feature, which supports providers in delivering protocolized therapies empathetically. We studied providers with and without expertise in mental health treatment delivering a therapy session using the platform with (intervention) and without (control) AI-assistance features. Upon evaluation, the AI-assisted system significantly decreased response times by 29.34% (p=0.002), tripled empathic response accuracy (p=0.0001), and increased goal recommendation accuracy by 66.67% (p=0.001) across both user groups compared to the control. Both groups rated the system as having excellent usability.
The sixth international conference AsiaHaptics 2024 took place at Sunway University, Malaysia on 28-30 October 2024. AsiaHaptics is an exhibition type of international conference dedicated to the haptics domain, engaging presentations accompanied by hands-on demonstrations. It presents the state-of-the-art of the diverse haptics (touch)-related research, including perception and illusion, development of haptics devices, and applications to a wide variety of fields such as education, medicine, telecommunication, navigation and entertainment. This proceedings volume is a valuable resource not only for active haptics researchers, but also for general readers wishing to understand the status quo in this interdisciplinary area of science and technology.
Occupational mobility is an emergent strategy to cope with technological unemployment by facilitating efficient labor redeployment. However, previous studies analyzing networks show that the boundaries to smooth mobility are constrained by a fragmented structure in the occupation network. In this study, positing that this structure will significantly change due to automation, we propose the skill automation view, which asserts that automation substitutes for skills, not for occupations, and simulate a scenario of skill automation drawing on percolation theory. We sequentially remove skills from the occupation-skill bipartite network and investigate the structural changes in the projected occupation network. The results show that the accumulation of small changes (the emergence of bridges between occupations due to skill automation) triggers significant structural changes in the occupation network. The structural changes accelerate as the components integrate into a new giant component. This result suggests that automation mitigates the bottlenecks to smooth occupational mobility.
Stuttering is a complex speech disorder that negatively affects an individual's ability to communicate effectively. Persons who stutter (PWS) often suffer considerably under the condition and seek help through therapy. Fluency shaping is a therapy approach where PWSs learn to modify their speech to help them to overcome their stutter. Mastering such speech techniques takes time and practice, even after therapy. Shortly after therapy, success is evaluated highly, but relapse rates are high. To be able to monitor speech behavior over a long time, the ability to detect stuttering events and modifications in speech could help PWSs and speech pathologists to track the level of fluency. Monitoring could create the ability to intervene early by detecting lapses in fluency. To the best of our knowledge, no public dataset is available that contains speech from people who underwent stuttering therapy that changed the style of speaking. This work introduces the Kassel State of Fluency (KSoF), a therapy-based dataset containing over 5500 clips of PWSs. The clips were labeled with six stuttering-related event types: blocks, prolongations, sound repetitions, word repetitions, interjections, and
The question of whether or not neutron therapy works has been answered. It is a qualified yes, as is the case with all of radiation therapy. But, neutron therapy has not kept pace with the rest of radiation therapy in terms of beam delivery techniques. Modern photon and proton based external beam radiotherapy routinely implements image-guidance, beam intensity-modulation and 3-dimensional treatment planning. The current iteration of fast neutron radiotherapy does not. Addressing these deficiencies, however, is not a matter of technology or understanding, but resources. The future of neutron therapy lies in better understanding the interaction processes of radiation with living tissue. A combination of radiobiology and computer simulations is required in order to optimize the use of neutron therapy. The questions that need to be answered are: Can we connect the macroscopic with the microscopic? What is the optimum energy? What is the optimum energy spectrum? Can we map the sensitivity of the various tissues of the human body and use that knowledge to our advantage? And once we gain a better understanding of the above radiobiological issues will we be able to capitalize on this under
Optical clocks have improved their frequency stability and estimated accuracy by more than two orders of magnitude over the best caesium microwave clocks that realise the SI second. Accordingly, an optical redefinition of the second has been widely discussed, prompting a need for the consistency of optical clocks to be verified worldwide. While satellite frequency links are sufficient to compare microwave clocks, a suitable method for comparing high-performance optical clocks over intercontinental distances is missing. Furthermore, remote comparisons over frequency links face fractional uncertainties of a few $10^{-18}$ due to imprecise knowledge of each clock's relativistic redshift, which stems from uncertainty in the geopotential determined at each distant location. Here, we report a landmark campaign towards the era of optical clocks, where, for the first time, state-of-the-art transportable optical clocks from Japan and Europe are brought together to demonstrate international comparisons that require neither a high-performance frequency link nor information on the geopotential difference between remote sites. Conversely, the reproducibility of the clocks after being transporte
This paper explores the adaptation and application of i-TED Compton imagers for real-time dosimetry in Boron Neutron Capture Therapy (BNCT). The i-TED array, previously utilized in nuclear astrophysics experiments at CERN, is being optimized for detecting and imaging 478 keV gamma-rays, critical for accurate BNCT dosimetry. Detailed Monte Carlo simulations were used to optimize the i-TED detector configuration and enhance its performance in the challenging radiation environment typical of BNCT. Additionally, advanced 3D image reconstruction algorithms, including a combination of back-projection and List-Mode Maximum Likelihood Expectation Maximization (LM-MLEM), are implemented and validated through simulations. Preliminary experimental tests at the Institut Laue-Langevin (ILL) demonstrate the potential of i-TED in a clinical setting, with ongoing experiments focusing on improving imaging capabilities in realistic BNCT conditions.
Intermittent Androgen Suppression (IAS) is a treatment strategy for delaying or even preventing time to relapse of advanced prostate cancer. IAS consists of alternating cycles of therapy (in the form of androgen suppression) and off-treatment periods. The level of prostate specific antigen (PSA) in a patient's serum is frequently monitored to determine when the patient will be taken off therapy and when therapy will resume. In spite of extensive recent clinical experience with IAS, the design of an ideal protocol for any given patient remains one of the main challenges associated with effectively implementing this therapy. We use a threshold-based policy for optimal IAS therapy design that is parameterized by lower and upper PSA threshold values and is associated with a cost metric that combines clinically relevant measures of therapy success. We apply Infinitesimal Perturbation Analysis (IPA) to a Stochastic Hybrid Automaton (SHA) model of prostate cancer evolution under IAS and derive unbiased estimators of the cost metric gradient with respect to various model and therapy parameters. These estimators are subsequently used for system analysis. By evaluating sensitivity estimates
This publication presents a relation computation or calculus for international relations using a mathematical modeling. It examined trust for international relations and its calculus, which related to Bayesian inference, Dempster-Shafer theory and subjective logic. Based on an observation in the literature, we found no literature discussing the calculus method for the international relations. To bridge this research gap, we propose a relation algebra method for international relations computation. The proposed method will allow a relation computation which is previously subjective and incomputable. We also present three international relations as case studies to demonstrate the proposed method is a real-world scenario. The method will deliver the relation computation for the international relations that to support decision makers in a government such as foreign ministry, defense ministry, presidential or prime minister office. The Department of Defense (DoD) may use our method to determine a nation that can be identified as a friendly, neutral or hostile nation.