As large language models (LLMs) become primary sources of health information for millions, their accuracy in women's health remains critically unexamined. We introduce the Women's Health Benchmark (WHB), the first benchmark evaluating LLM performance specifically in women's health. Our benchmark comprises 96 rigorously validated model stumps covering five medical specialties (obstetrics and gynecology, emergency medicine, primary care, oncology, and neurology), three query types (patient query, clinician query, and evidence/policy query), and eight error types (dosage/medication errors, missing critical information, outdated guidelines/treatment recommendations, incorrect treatment advice, incorrect factual information, missing/incorrect differential diagnosis, missed urgency, and inappropriate recommendations). We evaluated 13 state-of-the-art LLMs and revealed alarming gaps: current models show approximately 60\% failure rates on the women's health benchmark, with performance varying dramatically across specialties and error types. Notably, models universally struggle with "missed urgency" indicators, while newer models like GPT-5 show significant improvements in avoiding inappro
Mobile health has the potential to revolutionize health care delivery and patient engagement. In this work, we discuss how integrating Artificial Intelligence into digital health applications-focused on supply chain, patient management, and capacity building, among other use cases-can improve the health system and public health performance. We present an Artificial Intelligence and Reinforcement Learning platform that allows the delivery of adaptive interventions whose impact can be optimized through experimentation and real-time monitoring. The system can integrate multiple data sources and digital health applications. The flexibility of this platform to connect to various mobile health applications and digital devices and send personalized recommendations based on past data and predictions can significantly improve the impact of digital tools on health system outcomes. The potential for resource-poor settings, where the impact of this approach on health outcomes could be more decisive, is discussed specifically. This framework is, however, similarly applicable to improving efficiency in health systems where scarcity is not an issue.
Large language models are increasingly used for medical guidance, but women's health remains under-evaluated in benchmark design. We present the Women's Health Benchmark (WHBench), a targeted evaluation suite of 47 expert-crafted scenarios across 10 women's health topics, designed to expose clinically meaningful failure modes including outdated guidelines, unsafe omissions, dosing errors, and equity-related blind spots. We evaluate 22 models using a 23-criterion rubric spanning clinical accuracy, completeness, safety, communication quality, instruction following, equity, uncertainty handling, and guideline adherence, with safety-weighted penalties and server-side score recalculation. Across 3,102 attempted responses (3,100 scored), no model mean performance exceeds 75 percent; the best model reaches 72.1 percent. Even top models show low fully correct rates and substantial variation in harm rates. Inter-rater reliability is moderate at the response label level but high for model ranking, supporting WHBench utility for comparative system evaluation while highlighting the need for expert oversight in clinical deployment. WHBench provides a public, failure-mode-aware benchmark to trac
Recent advancements in large language models (LLMs) have significantly transformed medical systems. However, their potential within specialized domains such as nursing remains largely underexplored. In this work, we introduce NurseLLM, the first nursing-specialized LLM tailored for multiple choice question-answering (MCQ) tasks. We develop a multi-stage data generation pipeline to build the first large scale nursing MCQ dataset to train LLMs on a broad spectrum of nursing topics. We further introduce multiple nursing benchmarks to enable rigorous evaluation. Our extensive experiments demonstrate that NurseLLM outperforms SoTA general-purpose and medical-specialized LLMs of comparable size on different benchmarks, underscoring the importance of a specialized LLM for the nursing domain. Finally, we explore the role of reasoning and multi-agent collaboration systems in nursing, highlighting their promise for future research and applications.
Selecting the right monitoring level in Remote Patient Monitoring (RPM) systems for e-healthcare is crucial for balancing patient outcomes, various resources, and patient's quality of life. A prior work has used one-dimensional health representations, but patient health is inherently multidimensional and typically consists of many measurable physiological factors. In this paper, we introduce a multidimensional health state model within the RPM framework and use dynamic programming to study optimal monitoring strategies. Our analysis reveals that the optimal control is characterized by switching curves (for two-dimensional health states) or switching hyper-surfaces (in general): patients switch to intensive monitoring when health measurements cross a specific multidimensional surface. We further study how the optimal switching curve varies for different medical conditions and model parameters. This finding of the optimal control structure provides actionable insights for clinicians and aids in resource planning. The tunable modeling framework enhances the applicability and effectiveness of RPM services across various medical conditions.
The rapid spread of health misinformation on online social networks (OSNs) during global crises such as the COVID-19 pandemic poses challenges to public health, social stability, and institutional trust. Centrality metrics have long been pivotal in understanding the dynamics of information flow, particularly in the context of health misinformation. However, the increasing complexity and dynamism of online networks, especially during crises, highlight the limitations of these traditional approaches. This study introduces and compares three novel centrality metrics: dynamic influence centrality (DIC), health misinformation vulnerability centrality (MVC), and propagation centrality (PC). These metrics incorporate temporal dynamics, susceptibility, and multilayered network interactions. Using the FibVID dataset, we compared traditional and novel metrics to identify influential nodes, propagation pathways, and misinformation influencers. Traditional metrics identified 29 influential nodes, while the new metrics uncovered 24 unique nodes, resulting in 42 combined nodes, an increase of 44.83%. Baseline interventions reduced health misinformation by 50%, while incorporating the new metrics
Large language models (LLMs) hold substantial promise for clinical decision support. However, their widespread adoption in medicine, particularly in healthcare, is hindered by their propensity to generate false or misleading outputs, known as hallucinations. In high-stakes domains such as women's health (obstetrics & gynaecology), where errors in clinical reasoning can have profound consequences for maternal and neonatal outcomes, ensuring the reliability of AI-generated responses is critical. Traditional methods for quantifying uncertainty, such as perplexity, fail to capture meaning-level inconsistencies that lead to misinformation. Here, we evaluate semantic entropy (SE), a novel uncertainty metric that assesses meaning-level variation, to detect hallucinations in AI-generated medical content. Using a clinically validated dataset derived from UK RCOG MRCOG examinations, we compared SE with perplexity in identifying uncertain responses. SE demonstrated superior performance, achieving an AUROC of 0.76 (95% CI: 0.75-0.78), compared to 0.62 (0.60-0.65) for perplexity. Clinical expert validation further confirmed its effectiveness, with SE achieving near-perfect uncertainty discr
The growing demand for home healthcare calls for tools that can support care delivery. In this study, we explore automatic health assessment from voice using real-world home care visit data, leveraging the diverse patient information it contains. First, we utilize Large Language Models (LLMs) to integrate Subjective, Objective, Assessment, and Plan (SOAP) notes derived from unstructured audio transcripts and structured vital signs into a holistic illness score that reflects a patient's overall health. This compact representation facilitates cross-visit health status comparisons and downstream analysis. Next, we design a multi-stage preprocessing pipeline to extract short speech segments from target speakers in home care recordings for acoustic analysis. We then employ an Audio Language Model (ALM) to produce plain-language descriptions of vocal biomarkers and examine their association with individuals' health status. Our experimental results benchmark both commercial and open-source LLMs in estimating illness scores, demonstrating their alignment with actual clinical outcomes, and revealing that SOAP notes are substantially more informative than vital signs. Building on the illness
Global rates of mental health concerns are rising, and there is increasing realization that existing models of mental health care will not adequately expand to meet the demand. With the emergence of large language models (LLMs) has come great optimism regarding their promise to create novel, large-scale solutions to support mental health. Despite their nascence, LLMs have already been applied to mental health related tasks. In this paper, we summarize the extant literature on efforts to use LLMs to provide mental health education, assessment, and intervention and highlight key opportunities for positive impact in each area. We then highlight risks associated with LLMs' application to mental health and encourage the adoption of strategies to mitigate these risks. The urgent need for mental health support must be balanced with responsible development, testing, and deployment of mental health LLMs. It is especially critical to ensure that mental health LLMs are fine-tuned for mental health, enhance mental health equity, and adhere to ethical standards and that people, including those with lived experience with mental health concerns, are involved in all stages from development through
Although serious games have been increasingly used for mental health applications, few explicitly address coping with grief as a core mechanic and narrative experience for patients. Existing grief-related digital games often focus on clinical training for medical professionals rather than immersive storytelling and agency in emotional processing for the patient. In response, we designed Road to Acceptance, a VR game that presents grief through first-person narrative and gameplay. As the next phase of evaluation, we propose a workshop-based study with 12 licensed mental health professionals to assess the therapeutic impacts of the game and the alignment with best practices in grief education and interventions. This will inform iterative game design and patient evaluation methods, ensuring that the experience is clinically appropriate. Potential findings can contribute to the design principles of grief-related virtual reality experiences, bridging the gap between interactive media, mental health interventions, and immersive storytelling.
This research paper presents a meta-analysis of the multifaceted role of technology in mental health. The pervasive influence of technology on daily lives necessitates a deep understanding of its impact on mental health services. This study synthesizes literature covering Behavioral Intervention Technologies (BITs), digital mental health interventions during COVID-19, young men's attitudes toward mental health technologies, technology-based interventions for university students, and the applicability of mobile health technologies for individuals with serious mental illnesses. BITs are recognized for their potential to provide evidence-based interventions for mental health conditions, especially anxiety disorders. The COVID-19 pandemic acted as a catalyst for the adoption of digital mental health services, underscoring their crucial role in providing accessible and quality care; however, their efficacy needs to be reinforced by workforce training, high-quality evidence, and digital equity. A nuanced understanding of young men's attitudes toward mental health is imperative for devising effective online services. Technology-based interventions for university students are promising, al
Nursing notes, an important part of Electronic Health Records (EHRs), track a patient's health during a care episode. Summarizing key information in nursing notes can help clinicians quickly understand patients' conditions. However, existing summarization methods in the clinical setting, especially abstractive methods, have overlooked nursing notes and require reference summaries for training. We introduce QGSumm, a novel query-guided self-supervised domain adaptation approach for abstractive nursing note summarization. The method uses patient-related clinical queries for guidance, and hence does not need reference summaries for training. Through automatic experiments and manual evaluation by an expert clinician, we study our approach and other state-of-the-art Large Language Models (LLMs) for nursing note summarization. Our experiments show: 1) GPT-4 is competitive in maintaining information in the original nursing notes, 2) QGSumm can generate high-quality summaries with a good balance between recall of the original content and hallucination rate lower than other top methods. Ultimately, our work offers a new perspective on conditional text summarization, tailored to clinical app
In this paper, we present a comprehensive survey on the pervasive issue of medical misinformation in social networks from the perspective of information technology. The survey aims at providing a systematic review of related research and helping researchers and practitioners navigate through this fast-changing field. Specifically, we first present manual and automatic approaches for fact-checking. We then explore fake news detection methods, using content, propagation features, or source features, as well as mitigation approaches for countering the spread of misinformation. We also provide a detailed list of several datasets on health misinformation and of publicly available tools. We conclude the survey with a discussion on the open challenges and future research directions in the battle against health misinformation.
The COVID-19 pandemic has highlighted the dire necessity to improve public health literacy for societal resilience. YouTube, the largest video-sharing social media platform, provides a vast repository of user-generated health information in a multi-media-rich format which may be easier for the public to understand and use if major concerns about content quality and accuracy are addressed. This study develops an automated solution to identify, retrieve and shortlist medically relevant and understandable YouTube videos that domain experts can subsequently review and recommend for disseminating and educating the public on the COVID-19 pandemic and similar public health outbreaks. Our approach leverages domain knowledge from human experts and machine learning and natural language processing methods to provide a scalable, replicable, and generalizable approach that can also be applied to enhance the management of many health conditions.
Prognostics is concerned with predicting the future health of the equipment and any potential failures. With the advances in the Internet of Things (IoT), data-driven approaches for prognostics that leverage the power of machine learning models are gaining popularity. One of the most important categories of data-driven approaches relies on a predefined or learned health indicator to characterize the equipment condition up to the present time and make inference on how it is likely to evolve in the future. In these approaches, health indicator forecasting that constructs the health indicator curve over the lifespan using partially observed measurements (i.e., health indicator values within an initial period) plays a key role. Existing health indicator forecasting algorithms, such as the functional Empirical Bayesian approach, the regression-based formulation, a naive scenario matching based on the nearest neighbor, have certain limitations. In this paper, we propose a new `generative + scenario matching' algorithm for health indicator forecasting. The key idea behind the proposed approach is to first non-parametrically fit the underlying health indicator curve with a continuous Gauss
Predicting pregnancy has been a fundamental problem in women's health for more than 50 years. Previous datasets have been collected via carefully curated medical studies, but the recent growth of women's health tracking mobile apps offers potential for reaching a much broader population. However, the feasibility of predicting pregnancy from mobile health tracking data is unclear. Here we develop four models -- a logistic regression model, and 3 LSTM models -- to predict a woman's probability of becoming pregnant using data from a women's health tracking app, Clue by BioWink GmbH. Evaluating our models on a dataset of 79 million logs from 65,276 women with ground truth pregnancy test data, we show that our predicted pregnancy probabilities meaningfully stratify women: women in the top 10% of predicted probabilities have a 89% chance of becoming pregnant over 6 menstrual cycles, as compared to a 27% chance for women in the bottom 10%. We develop a technique for extracting interpretable time trends from our deep learning models, and show these trends are consistent with previous fertility research. Our findings illustrate the potential that women's health tracking data offers for pred
Large AI models, or foundation models, are models recently emerging with massive scales both parameter-wise and data-wise, the magnitudes of which can reach beyond billions. Once pretrained, large AI models demonstrate impressive performance in various downstream tasks. A prime example is ChatGPT, whose capability has compelled people's imagination about the far-reaching influence that large AI models can have and their potential to transform different domains of our lives. In health informatics, the advent of large AI models has brought new paradigms for the design of methodologies. The scale of multi-modal data in the biomedical and health domain has been ever-expanding especially since the community embraced the era of deep learning, which provides the ground to develop, validate, and advance large AI models for breakthroughs in health-related areas. This article presents a comprehensive review of large AI models, from background to their applications. We identify seven key sectors in which large AI models are applicable and might have substantial influence, including 1) bioinformatics; 2) medical diagnosis; 3) medical imaging; 4) medical informatics; 5) medical education; 6) pu
Electronic Health Record (EHR) has become an essential tool in the healthcare ecosystem, providing authorized clinicians with patients' health-related information for better treatment. While most developed countries are taking advantage of EHRs to improve their healthcare system, it remains challenging in developing countries to support clinical decision-making and public health using a computerized patient healthcare information system. This paper proposes a novel EHR architecture suitable for developing countries--an architecture that fosters inclusion and provides solutions tailored to all social classes and socioeconomic statuses. Our architecture foresees an internet-free (offline) solution to allow medical transactions between healthcare organizations, and the storage of EHRs in geographically underserved and rural areas. Moreover, we discuss how artificial intelligence can leverage anonymous health-related information to enable better public health policy and surveillance.
YouTube has rapidly emerged as a predominant platform for content consumption, effectively displacing conventional media such as television and news outlets. A part of the enormous video stream uploaded to this platform includes health-related content, both from official public health organizations, and from any individual or group that can make an account. The quality of information available on YouTube is a critical point of public health safety, especially when concerning major interventions, such as vaccination. This study differentiates itself from previous efforts of auditing YouTube videos on this topic by conducting a systematic daily collection of posted videos mentioning vaccination for the duration of 3 months. We show that the competition for the public's attention is between public health messaging by institutions and individual educators on one side, and commentators on society and politics on the other, the latest contributing the most to the videos expressing stances against vaccination. Videos opposing vaccination are more likely to mention politicians and publication media such as podcasts, reports, and news analysis, on the other hand, videos in favor are more li
FemTech, a rising trend in mobile apps, empowers women to digitally manage their health and family planning. However, privacy and security vulnerabilities in period-tracking and fertility-monitoring apps present significant risks, such as unintended pregnancies and legal consequences. Our approach involves manual observations of privacy policies and app permissions, along with dynamic and static analysis using multiple evaluation frameworks. Our research reveals that many of these apps gather personally identifiable information (PII) and sensitive healthcare data. Furthermore, our analysis identifies that 61% of the code vulnerabilities found in the apps are classified under the top-ten Open Web Application Security Project (OWASP) vulnerabilities. Our research emphasizes the significance of tackling the privacy and security vulnerabilities present in period-tracking and fertility-monitoring mobile apps. By highlighting these crucial risks, we aim to initiate a vital discussion and advocate for increased accountability and transparency of digital tools for women's health. We encourage the industry to prioritize user privacy and security, ultimately promoting a safer and more secure