Financial news recommender systems are crucial for helping investors and financial analysts access essential market information. Recently, the incorporation of external knowledge into recommendation algorithms serves as supplementary data, aiming to mitigate the challenges associated with cold-start and data scarcity. However, the current research faces challenges in assimilating knowledge from diverse sources into the prompt-based framework. Additionally, multi-task learning methods for recommendation tasks and related tasks enhance recommendation effectiveness. However, the comprehensive consideration of the attributes of the news itself, such as sentiment, topic, and popularity, is neglected. To tackle these challenges, we present a novel multi-task prompt large language model (LLM) approach for financial news recommendation that effectively unifies external knowledge. In this study, we first develop a dual knowledge enhancement strategy to integrate structured and unstructured financial knowledge into the recommendation process to enrich the semantic understanding of news. Second, we design hierarchical knowledge prompt templates to enable LLM to learn diverse knowledge for specific tasks. Finally, we implement a multi-task prompt integration mechanism that jointly optimizes recommendation, sentiment analysis, topic classification, and popularity prediction tasks, leveraging inter-task dependencies. Experimental results show that our approach improves performance significantly on real financial news datasets, particularly in few-shot scenarios.
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This Medical News article discusses findings that genetic variants may affect patients’ responses to glucagon-like peptide-1 receptor agonists such as semaglutide and tirzepatide.
This Medical News article discusses a study linking digital media—particularly social media—use to consistent risks for children’s mental health and development.
Effective postoperative pain management is essential in abdominal surgery. Morphine remains a cornerstone opioid analgesic, yet variability in dosing and its clinical implications warrant further evaluation. To evaluate postoperative morphine, use in patients undergoing abdominal surgery over a one-year period, with emphasis on dose distribution, patient characteristics, underlying diagnoses, surgical procedures, and hospital length of stay (LOS). This retrospective single-center study included adult patients undergoing abdominal surgery who received postoperative morphine. Data on demographics, diagnoses, surgical procedures, morphine dose and route of administration, and LOS were extracted from medical records. Morphine dosing was individualized according to clinical judgment. Continuous variables are presented as mean ± standard deviation (SD) or median with interquartile range (IQR). The cohort comprised 39 patients (24 females, 61.5%) with a mean age of 46.7±18.5 years. Bariatric surgery for obesity was the most common procedure (n 22). Morphine doses ranged from 4-10 mg per administration, predominantly given subcutaneously, with a median dose of 6 mg (IQR 5-7 mg); 5 mg was the most frequently administered dose. Higher doses were more commonly observed in oncologic cases. The overall median hospital length of stay (LOS) was 3 days and differed by surgical approach, with a median of 3 days after laparoscopic procedures and 7 days after open surgery. Adverse events were infrequent and mainly included postoperative nausea and vomiting (PONV), while no cases of respiratory depression were recorded. Morphine remains a widely used option for postoperative analgesia in abdominal surgery and, in this cohort, was predominantly administered subcutaneously with individualized dosing. Dose variability appears influenced by patient and procedural factors. Although minimally invasive procedures were associated with shorter hospital stays, this observation should be interpreted cautiously due to differences in underlying diagnoses and surgical complexity. Larger prospective studies are needed to further optimize postoperative opioid use.
We performed high-precision decay-pion spectroscopy of light Λ hypernuclei at the Mainz Microtron (MAMI) using the A1 spectrometer facility. By measuring the monochromatic π^{-} momentum from the two-body weak decay _{Λ}^{3}H→^{3}He+π^{-} and referencing it to the _{Λ}^{4}H→^{4}He+π^{-} decay, we determined the Λ binding energy of _{Λ}^{3}H with unprecedented accuracy. The obtained value, B_{Λ}(_{Λ}^{3}H)=0.523±0.013_{stat}±0.075_{syst}.  MeV, is consistent with the STAR result, but indicates a significantly deeper binding than inferred from earlier measurements. This result implies a stronger Λ-deuteron interaction and provides stringent constraints on hyperon-nucleon interactions.
A renewed reforming of the higher education system is taking place in the conditions of the Covid-19 pandemic, as well as the perception of the essence and content of the pedagogical profession is changing in the changing conditions of today, as well as new requirements are being put forward to the personality of the teacher. The purpose of the article was to study the dynamics of perceptions and evaluation of the components of the image of an ideal teacher by students in the process of traditional (full-time) and remote (online) learning in a higher education institution. Diagnostic methods were used in the research: free description method on the topic "Portrait of a teacher whom I respect", content analysis, "Educational-cognitive interaction between a student and a teacher of the university" method (author I.I. Snyadanko), methods of statistical data processing. The authors conducted two experimental sections: the first section was conducted during traditional full-time learning before the Covid-19 pandemic, the second section was conducted during the remote learning period during the Covid-19 pandemic. As a result of the research, it was determined that, in general, first-year students prefer strict and demanding teachers, but at the same time value such teacher qualities as kindness and sacrifice. The personal characteristics of the teacher and the ability to perceive the student as a person are more important for second-year students. A comparison of the data of the two sections made it possible to conclude that the ideal teacher should meet much greater characteristics in the process of remote learning than in the process of traditional learning. The results of the article can be used to optimize the educational and cognitive interaction between students and teachers of the university, to improve the professional training of pedagogical personnel.
Despite the growing evidence of persistent cognitive dysfunction after COVID-19, the role of cognitive reserve as a modifying factor of post-infectious neurocognitive outcomes remains insufficiently explored, particularly in relation to disease severity and premorbid lifestyle characteristics. To analyze the characteristics of cognitive reserve in patients after SARS-CoV-2 infection and to assess its impact on the structure and severity of post-COVID cognitive impairments. The study included 247 patients aged 31-67 years who had recovered from COVID-19 (93 hospitalized and 154 treated on an outpatient basis) and 50 age-matched controls without a history of COVID-19. Cognitive reserve and related factors were assessed using the Cognitive Reserve Questionnaire (CRQ), Test of Premorbid Functioning (TOPF), Montreal Cognitive Assessment (MoCA), Trail Making Test A/B, Digit Span Backward, and semantic verbal fluency test. Premorbid lifestyle characteristics, occupational cognitive complexity, physical activity, disease severity, body mass index, and inflammatory markers (peak C-reactive protein) were recorded. Multivariate linear regression models were constructed with global cognitive performance (MoCA score at 12 months) as the dependent variable. Post-COVID patients demonstrated significantly lower CRQ total scores compared with controls (7.82±0.12 vs 9.41±0.15; p<0.001), with the lowest values observed in hospitalized patients. Educational level and premorbid intelligence (TOPF) did not differ between groups, indicating preserved premorbid cognitive capacity. Reduced CRQ scores were primarily driven by lower occupational cognitive complexity and diminished cognitively active lifestyle, suggesting impaired utilization of cognitive reserve rather than loss of reserve capacity. MoCA scores were significantly lower in post-COVID patients (25.4±0.19 vs 27.8±0.22; p<0.001), with predominant impairment of executive functions, attention, and processing speed. In multivariate analysis, better cognitive outcomes were independently associated with higher CRQ scores, greater occupational complexity, and higher premorbid physical activity, while disease severity, elevated inflammatory markers, and older age were associated with poorer MoCA performance (Adjusted R²=0.521; p<0.001). Post-COVID cognitive impairment occurs despite preserved premorbid cognitive reserve and is characterized by reduced utilization and engagement of reserve mechanisms, particularly following severe disease.
A bumper agenda was considered by BVA Council at its most recent meeting on 15 April, with topics including legislative reform, new policy positions and BVA's strategic plan for 2027-2029.
BVA Council has approved a new policy position on the welfare of animals used in performance sports.
To analyze the association between preoperative macular thickness (MT) and the visual prognosis after surgery in patients with diabetic cataract (DC), and to provide some references for preoperative evaluation and surgery selection. From January 2024 to September 2025, a retrospective analysis was conducted on 80 DC patients (80 eyes) who underwent phacoemulsification concomitant with IOL implantation at Jiaozhou Central Hospital of Qingdao. All patients underwent optical coherence tomography (OCT) examination preoperatively to observe the CMT and MT-3mm (the macular thickness in 3mm diameter area). Depending on CMT before surgery, the patients were classified into three groups. The normal group consisted of those with CMT less than 250 μm (n=27). The mild thickening group consisted of those with CMT greater than or equal to and less than 250 (n=32). Finally, the moderate/severe thickening group consisted of those with CMT greater than or equal to 300 μm (n=21). We took note of the best corrected visual acuity (BCVA, converted to logMAR) before surgery, then at 1 month and 3 months after. Statistical methods were used to analyze the correlation between preoperative MT and postoperative BCVA, and to explore the influencing factors of postoperative visual prognosis. There was no statistically significant difference in preoperative BCVA (P > 0.05) between the three groups. According to the results obtained, at the time point of 1 month and 3 months after the operation, the normal group had significantly better BCVA than the group with mild thickening and moderate-severe thickening group (P < 0.05), and that the group with mild thickening had better BCVA than the moderate-severe thickening group (P < 0.05). According to the Pearson correlation analysis, preoperative CMT and MT-3mm positively correlated with postoperative 1-month and 3-month logMAR BCVA (r=0.623, 0.589, 0.651, 0.617; all P < 0.001). The analysis of multivariate linear regression revealed that CMT prior to the surgery (β=0.412, P < 0.001) and duration of diabetes (β=0.235, P=0.021) were influential postoperative 3-month BCVA factors. Macular thickness before surgery is closely related to visual prognosis after surgery in DC patients. Patients with thicker preoperative macular thickness had worse visual recovery post-operatively. Preoperative OCT measurement of macular thickness can be regarded as an important reference for evaluating its visual prognosis after surgery.
The aim of this study is to understand the factors contributing to patients' non-adherence to lifestyle modification plans among visitors of the Lifestyle Clinics in King Abdul-Aziz Medical City, Jeddah. Adherence to these plans is crucial for improving health outcomes and preventing chronic diseases. A cross-sectional study was conducted at the Lifestyle Clinics within the Primary Healthcare department of King Abdulaziz Medical City, Jeddah. Participants were adults referred for weight reduction. Data were collected using a questionnaire covering sociodemographic characteristics, adherence to lifestyle modifications, and barriers to adherence. The adherence level was assessed using a validated 13-item questionnaire, and the data were analyzed using IBM SPSS Statistics. A total of 380 participants were included, with a median age of 42 years (IQR: 32-50 years). Approximately 45.5% were adherent to the lifestyle modification plan, while 54.5% were non-adherent. Significant positive correlations were found between age and adherence (Correlation Coefficient=.205, p<.001), with healthcare workers showing higher adherence levels (p=0.027). Common barriers to adherence included lack of willpower (74.5%), energy (70.8%), and time (68.9%). Statistically significant associations were identified between lack of energy (p=0.019) or time (p=0.023) and non-adherence. This study identified key factors associated with non-adherence to lifestyle modification plans, particularly younger age, non-healthcare occupations, and perceived barriers such as lack of energy and lack of time. Despite high levels of knowledge regarding healthy lifestyle practices, adherence remained suboptimal, highlighting the gap between awareness and behavioral implementation. Addressing practical barriers through targeted, behavior-focused interventions may improve adherence and long-term health outcomes.
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The search for rational synthetic pathways for steroid drugs from accessible plant sources represents an important and relevant objective. Yucca gloriosa presents significant interest as a source of tigogenin-a valuable sapogenin for steroid hormonal drug production. Along with traditionally utilized leaves, the flowers of this plant contain 1.25-1.48% tigogenin and possess several technological advantages: simpler extraction of the target product due to lower lipophilic substance content and softer raw material texture. Endogenous β-glucosidase plays a key role in the tigogenin production process, catalyzing the conversion of oligofurostanoside to oligospirostanoside. This work investigated the properties of β-glucosidase from flowers of Yucca gloriosa cultivated in Georgia. Two enzyme forms differing in substrate specificity were identified. The first form (30% ammonium sulfate saturation fraction) hydrolyzes both natural oligofurostanoside and synthetic substrate 4-nitrophenyl-β-D-glucopyranoside, whereas the second form (80% saturation fraction) cleaves only the synthetic substrate. For the first β-glucosidase form, which has practical significance for tigogenin production, optimal operating conditions were determined: pH6.3 and temperature 47°C. Notably, the temperature optimum for the flower enzyme (47°C) proved higher than for the leaf enzyme (37°C). Heating at 57°C for 10 minutes reduces enzyme activity by 29%, while at 67°C it reduces activity by 79%.
Executive function deficits are consistently associated with attention-deficit/hyperactivity disorder (ADHD), yet the expression of specific executive domains may differ across genders. Emotional regulation difficulties have been increasingly recognized as an important component of ADHD, particularly among adolescent girls, although evidence from large community-based samples remains limited. This study examined gender differences across executive function domains in adolescents, with particular emphasis on emotional regulation among those with elevated ADHD symptoms. A school-based cross-sectional study was conducted with 1,260 adolescents aged 11-18 years. Executive functioning was assessed using the Behavior Rating Inventory of Executive Function - Self Report (BRIEF-SR), and ADHD symptoms were measured with the Youth Self Report (YSR). Participants scoring in the clinical range on the YSR Attention Problems scale were classified as the high ADHD symptom group. A subsample underwent neurocognitive testing using the Stroop Color-Word Test and the Go/No-Go task. Group comparisons, correlational analyses, and interaction models were used to examine executive function domains and the influence of gender. ADHD symptoms were strongly associated with global executive dysfunction (r=0.703, p<0.001). Adolescents in the high ADHD symptom group showed substantially greater impairment across behavioral, emotional, and cognitive regulation domains compared with peers below the clinical threshold. A gender difference was observed specifically in the emotional regulation domain, with females reporting higher levels of impairment than males, while overall ADHD symptom scores did not differ significantly by gender. Neurocognitive testing in the subsample indicated longer reaction times in the incongruent condition of the Stroop task among adolescents with elevated ADHD symptoms. Emotional dysregulation appears to represent a particularly salient executive difficulty among female adolescents with elevated ADHD symptoms. These findings support the inclusion of emotional regulation measures in routine assessment and highlight the potential value of gender-sensitive approaches in the identification and intervention of adolescents with ADHD-related difficulties.
Serum ferritin and iron have high inter-individual variability and inflammatory sensitivity, limiting its diagnostic value in several clinical settings. The Reticulocyte Subpopulation Analysis may indicate iron availability during erythropoiesis in real time. This study investigated the associations between reticulocyte parameters and various hematological and iron-related biomarkers in Iron Deficiency Anemia. In this retrospective study, 150 patients with IDA (Iron Deficiency Anemia) were included (146 females, 97.3%; 23 pregnant, 15.8%; 12 on iron treatment, 8.0%), RET-He, LFR/MFR/HFR, and IRF were correlated with iron markers. Associations between anemia severity and treatment status were examined using Spearman correlation, Kruskal-Wallis, and Mann-Whitney U analyses. While other reticulocyte indices exhibited minor connections, RET-He showed strong positive correlations with ferritin (r=0.430, p<0.001), serum iron (r=0.364, p<0.001), and transferrin saturation (r=0.350, p<0.001 A significant decrease in RET-He was seen in mild anemia (24.6 pg) and severe anemia (15.2 pg, p<0.001). RET-He was marginally reduced (p=0.0750) while serum iron and transferrin saturation were considerably lower in iron-treated subjects (p=0.0023). Reticulocyte and iron characteristics did not correlate with age (p>0.05). A sensitive, independent biomarker of iron status, RET-He measures functional iron availability during erythropoiesis. Strong correlation and severity-stratified discrimination support in populations where inflammation confounds ferritin interpretation, RET-He inclusion into iron deficient diagnostic methods. Prospective studies are needed to establish clinical thresholds and validate RET-He in chronic renal disease, inflammatory conditions, and pregnancy-related iron metabolism.
The objective of this study is to conduct a comparative morphological analysis of the kidneys in the context of various infection pathways in models of acute obstructive pyelonephritis. The study investigated the structural condition of rabbit kidneys (n=40) in relation to the pathogenesis of acute pyelonephritis. The animals were randomly assigned to four groups: two experimental and two control groups. Experimental Groups I and II underwent urethral ligation to induce obstructive pyelonephritis. In Group I, a bacterial strain was introduced into the gastrointestinal tract to examine intestinal translocation, while in Group II, it was introduced into the urinary bladder to study ascending infection. Control Groups III and IV received a similar introduction of the infectious agent without urethral obstruction. On the third day, morphological examination was conducted using optical microscopy and a computerized microscope capable of digital microphotography. In Group I, inflammatory changes were detected in 60% of cases, while in Group II, they were found in 70% of cases. No morphological changes were observed in the control groups. The nature of morphological changes in the kidneys in the model of acute obstructive pyelonephritis did not show statistically significant differences when comparing between the experimental groups. This indicates the involvement of enterorenal bacterial translocation in the development of inflammatory processes in the kidneys in the presence of obstruction.
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