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The Journal of Bone and Joint Surgery. British volumeVol. 70-B, No. 1 ArticlesFree AccessPelvic ring fractures: should they be fixed?M TileM TileSearch for more papers by this authorPublished Online:1 Jan 1988https://doi.org/10.1302/0301-620X.70B1.3276697AboutSectionsPDF/EPUB ToolsAdd to FavouritesDownload CitationsTrack CitationsPermissions ShareShare onFacebookTwitterLinked InRedditEmail FiguresReferencesRelatedDetailsCited byPreoperative CT simulation of iliosacral screws for treating unstable posterior pelvic ring injury8 March 2022 | BMC Musculoskeletal Disorders, Vol. 23, No. 1Functional outcome of unstable pelvic fractures treated in a level III hospital in a developing country: a 10-year prospective observational study4 April 2022 | Journal of Orthopaedic Surgery and Research, Vol. 17, No. 1Percutaneous posterior transiliac plate versus iliosacral screw fixation for posterior fixation of Tile C-type pelvic fractures: a retrospective comparative study16 June 2022 | BMC Musculoskeletal Disorders, Vol. 23, No. 1Equestrian-Related Pelvic Trauma in Women of Childbearing Age — a Review of the Experience of a National Pelvic & Acetabular Referral Centre27 July 2022 | SN Comprehensive Clinical Medicine, Vol. 4, No. 1CT of Sacral Fractures: Classification Systems and ManagementRadioGraphics, Vol. 42, No. 7Moving forward with the management of minimally displaced lateral compression pelvic ring injuries18 June 2022 | European Journal of Orthopaedic Surgery & Traumatology, Vol. 32, No. 7Biomechanical Comparison of 4 Transsacral Fixation Constructs in a Type 61C, Zone II Pelvic Fracture ModelJournal of Orthopaedic Trauma, Vol. 36, No. 10Rami Comminution Is Associated With Displacement of Minimally Displaced Lateral Compression Type 1 Injuries on Lateral Stress RadiographsJournal of Orthopaedic Trauma, Vol. 36, No. 10Surgical management of paediatric pelvic fractures: a prospective case series and early experience from a level one Egyptian trauma centre23 July 2022 | International Orthopaedics, Vol. 46, No. 10A Review on Management of Insufficiency Fractures of the Pelvis and AcetabulumOrthopedic Clinics of North America, Vol. 53, No. 4Lumbo-sacral Junction Instability by Traumatic Sacral Fractures: Isler’s Classification Revisited – A Narrative Review22 February 2022 | Global Spine Journal, Vol. 12, No. 8Prolonged ileus in traumatic pelvic ring injury patients who underwent arterial angio-embolization: A retrospective studyMedicine, Vol. 101, No. 39Surgical Versus Non-surgical Treatment of Unstable Lateral Compression Type I (LC1) Injuries of the Pelvis With Complete Sacral Fractures in Non-fragility Fracture Patients: A Systematic ReviewCureus, Vol. 15Analysis of Postoperative Gait, Hip Strength, and Patient-Reported Outcomes After OTA/AO 61-B and 61-C Pelvic Ring InjuriesJournal of Orthopaedic Trauma, Vol. 36, No. 9Dual-Energy CT and Cinematic Rendering to Improve Assessment of Pelvic Fracture InstabilityRadiology, Vol. 304, No. 2Mortality and functional outcomes of fragility fractures of the pelvis by fracture type with conservative treatment: a retrospective, multicenter TRON study1 December 2021 | European Journal of Trauma and Emergency Surgery, Vol. 48, No. 4Pelvic Fracture Urethral Distraction DefectUrologic Clinics of North America, Vol. 49, No. 3Paediatric pelvic fractures – an updated literature review3 July 2022 | ANZ Journal of Surgery, Vol. 36Sakrumfrakturen beim geriatrischen Patienten1 June 2022 | Zeitschrift für Gerontologie und Geriatrie, Vol. 55, No. 4Evolution of the AO Spine Sacral and Pelvic Classification System: a systematic reviewJournal of Neurosurgery: Spine, Vol. 78Nonoperative Management of Minimally Displaced Lateral Compression Type 1 Pelvic Ring Injuries With and Without Occult InstabilityJournal of Orthopaedic Trauma, Vol. 36, No. 6Reliability and reproducibility analysis of the AOSpine Sacral Fractures Classification System by spinal and pelvic surgeonsInjury, Vol. 53, No. 6Outcomes and complications of the INFIX technique for unstable pelvic ring injuries with high-velocity trauma: a systematic review and meta-analysis11 January 2021 | Archives of Orthopaedic and Trauma Surgery, Vol. 142, No. 5Anatomic reduction of the sacroiliac joint in unstable pelvic ring injuries and its correlation with functional outcome30 September 2020 | European Journal of Trauma and Emergency Surgery, Vol. 48, No. 2Emergency Department Stress Radiographs of Lateral Compression Type-1 Pelvic Ring Injuries Are Safe, Effective, and Reliable17 December 2021 | Journal of Bone and Joint Surgery, Vol. 104, No. 4Ligaments stabilizing the sacrum and sacroiliac joint: a comprehensive review25 August 2021 | Neurosurgical Review, Vol. 45, No. 1Pelvic ring and acetabular fracture: Concepts of traumatological forensic interestInjury, Vol. 53, No. 2Danger zone - The spermatic cord during anterior plating of the symphysis pubisInjury, Vol. 53, No. 2The pectineal ligament is a secondary stabilizer in anterior pelvic ring fractures - a biomechanical studyInjury, Vol. 53, No. 2Inter- and intra-observer agreement using the new AOSpine sacral fracture classification, with a comparison between spine and pelvic trauma surgeonsInjury, Vol. 53, No. 2Accuracy of Radiographic Displacement Measurement in a Pelvic Ring Injury Model13 September 2021 | Journal of the American Academy of Orthopaedic Surgeons, Vol. 30, No. 2The Influence of Regional Differences on the Reliability of the AO Spine Sacral Injury Classification System8 January 2022 | Global Spine Journal, Vol. 67Computer and magnetic resonance imaging for pelvic fractures in children12 May 2021 | Medical Visualization, Vol. 25, No. 4Nonoperative Treatment of Select Lateral Compression Type II Pelvic Ring Injuries (OTA/AO 61B2.2) Results in a Low Rate of Radiographic DisplacementJournal of Orthopaedic Trauma, Vol. 36, No. 1BibliographyManagement of Open Tile C Pelvic Fractures and Their Outcomes: A Retrospective Study of 30 Cases1 September 2022 | Therapeutics and Clinical Risk Management, Vol. Volume 18A nomogram to predict arterial bleeding in patients with pelvic fractures after blunt trauma: a retrospective cohort study8 February 2021 | Journal of Orthopaedic Surgery and Research, Vol. 16, No. 1Three‐dimensional‐printed customized prosthesis for pubic defect: clinical outcomes in 5 cases at a mean follow‐up of 24 months30 April 2021 | BMC Musculoskeletal Disorders, Vol. 22, No. 1Which factors influence treatment decision in fragility fractures of the pelvis? - results of a prospective study13 August 2021 | BMC Musculoskeletal Disorders, Vol. 22, No. 1Comparison of lumbopelvic fixation and iliosacral screw fixation for the treatment of bilateral sacral fractures16 October 2021 | Journal of Orthopaedic Surgery and Research, Vol. 16, No. 1Minimally displaced acetabulum fractures in geriatric patients: a comparison of open, percutaneous and non-operative treatment from the German Pelvic Injury Register data8 April 2020 | European Journal of Trauma and Emergency Surgery, Vol. 47, No. 6Transarterial embolisation is associated with improved survival in patients with pelvic fracture: propensity score matching analyses19 September 2020 | European Journal of Trauma and Emergency Surgery, Vol. 47, No. 6A retrospective study about functional outcome and quality of life after surgical fixation of insufficiency pelvic ring injuries13 December 2021 | BMC Musculoskeletal Disorders, Vol. 22, No. 1Is Anterior Plating Superior to the Bilateral Use of Retrograde Transpubic Screws for Treatment of Straddle Pelvic Ring Fractures? A Biomechanical Investigation28 October 2021 | Journal of Clinical Medicine, Vol. 10, No. 21Verification of High-Rate Vertical Loading Laboratory Skeletal Fractures by Comparison with Theater Injury Patterns15 October 2021 | Annals of Biomedical Engineering, Vol. 49, No. 11Reproductibilité intra- et inter-examinateur de la classification AO/OTA 2018 des ruptures de l’anneau pelvien à haute énergie : une étude rétrospectiveRevue de Chirurgie Orthopédique et Traumatologique, Vol. 107, No. 6Inter- and intraobserver reliability assessment of the 2018 AO/OTA classification for high-energy pelvic ring injuries: A retrospective studyOrthopaedics & Traumatology: Surgery & Research, Vol. 107, No. 6Management and outcomes of open pelvic fractures: An updateInjury, Vol. 52, No. 10One sacroiliac screw for posterior ring fixation in unstable pelvic fractures1 November 2021 | Acta Orthopaedica Belgica, Vol. 87, No. 3Endovascular management of haemorrhage in pelvic traumaSurgery in Practice and Science, Vol. 6The FFP-classification: From eminence to evidenceInjury, Vol. 94The Influence of Surgeon Experience and Subspeciality on the Reliability of the AO Spine Sacral Classification SystemSpine, Vol. Publish Ahead of PrintAssociation Between Stability and Urologic Lesions in Pelvic Ring Fractures. A Case Series Report6 January 2020 | Journal of Investigative Surgery, Vol. 34, No. 7Pelvic Ring Fractures and Lower Urinary Tract Injuries8 January 2020 | Journal of Investigative Surgery, Vol. 34, No. 7Validation of the AO Spine Sacral Classification SystemJournal of Orthopaedic Trauma, Vol. Publish Ahead of PrintLateral compression type 1 (LC1) pelvic ring injuries: a spectrum of fracture types and treatment algorithms16 April 2021 | European Journal of Orthopaedic Surgery & Traumatology, Vol. 31, No. 5An independent inter- and intraobserver agreement assessment of the AOSpine sacral fracture classification systemThe Spine Journal, Vol. 21, No. 7Incidence and Clinical Features of Urethral Injuries with Pelvic Fractures in Males: A 6-Year Retrospective Cohort Study at a Single Institution in South KoreaJournal of Trauma and Injury, Vol. 34, No. 2Short-Term Functional Outcomes and Quality of Life after B2.1 Type Pelvic Fractures for Surgically and Non-Surgically Treated Young Patients21 May 2021 | Medicina, Vol. 57, No. 6Pelvic and acetabular trauma in amateur equestrian enthusiasts – A retrospective reviewThe Surgeon, Vol. 120Bilateral vertical shear sacroiliac joint dislocations treated with bilateral triangular Osteosynthesis in a young female: A case reportTrauma Case Reports, Vol. 61Factors Associated With Failure of Superior Pubic Ramus ScrewsJournal of Orthopaedic Trauma, Vol. 35, No. 4Medium-Term Patient-Reported Quality of Life and Activities of Daily Living in Surgically Treated Trauma Patients With Pelvic, Acetabular or Combined Pelvic and Acetabular Fractures in a Retrospective Single-Center StudyJournal of Orthopaedic Trauma, Vol. 35, No. 4Relevant Clinical Findings of Patients with Extraperitoneal Bladder Injury Associated with Pelvic Fracture Who Underwent Operative Management: A 6-Year Retrospective StudyJournal of Acute Care Surgery, Vol. 11, No. 1Comparison of One-Year Functional Outcomes and Quality of Life between Posterior Pelvic Ring Fixation and Combined Anterior-Posterior Pelvic Ring Fixation after Lateral Compression (B2 Type) Pelvic Fracture26 February 2021 | Medicina, Vol. 57, No. 3Patient-reported Outcome in Surgically Treated Pelvic Ring Injuries at 5 Years Post-surgery19 September 2019 | Scandinavian Journal of Surgery, Vol. 110, No. 1Application of Pelvic Circumferential Compression Devices in Pelvic Ring Fractures—Are Guidelines Followed in Daily Practice?21 March 2021 | Journal of Clinical Medicine, Vol. 10, No. 6Interobserver reliability of the Tile classification system for pelvic fractures among radiologists and surgeons8 September 2020 | European Radiology, Vol. 31, No. 3An Automated Deep Learning Method for Tile AO/OTA Pelvic Fracture Severity Grading from Trauma whole-Body CT21 January 2021 | Journal of Digital Imaging, Vol. 34, No. 1The ‘nightstick’ ischial fracture: a unique oddity of the pelvic injury family26 February 2021 | BMJ Case Reports, Vol. 14, No. 2Treatment of Pelvic Fractures15 September 2020The History of Pelvic Fracture Treatment26 November 2020Classification of Pelvic Ring Injuries26 November 2020Biomechanics of the Pelvis26 November 2020Principles of Treatment of Pelvic Ring Injuries26 November 2020Ilium Fractures26 November 2020Retrograde Pubic Rami Screw26 November 2020Ilio-Iliacal Osteosynthesis26 November 2020Posterior pelvic ring injury of straddle fractures: Incidence, fixation methods, and clinical outcomesAsian Journal of Surgery, Vol. 44, No. 1Integrity of the pectineal ligament in MRI correlates with radiographic superior pubic ramus fracture displacement28 April 2020 | Acta Radiologica, Vol. 62, No. 1A systematic review of the transiliac internal fixator (TIFI) for posterior pelvic injuries26 July 2021 | SICOT-J, Vol. 7An Interpretable Approach to Automated Severity Scoring in Pelvic Trauma21 September 2021External Fixation in Pelvi-Acetabular Implantology3 December 2021Three-dimensional-printed customized prosthesis for pubic defect: prosthesis design and surgical techniques13 July 2020 | Journal of Orthopaedic Surgery and Research, Vol. 15, No. 1Radiostereometric Analysis Allows Assessment of the Stability and Inducible Displacement of Pelvic Ring Disruptions during Healing: A Case Series24 October 2020 | Journal of Clinical Medicine, Vol. 9, No. 11Minimal-invasive Stabilisierung bei Frakturen des Sakrums21 August 2020 | Der Unfallchirurg, Vol. 123, No. 10A Water Slide Accident Resulting in an Open Book Pelvic Injury and Subsequent Pulmonary Embolus: A Case Report5 August 2020 | Case Reports in Orthopedic Research, Vol. 3, No. 2Description and Reliability of the AOSpine Sacral Classification System21 April 2020 | Journal of Bone and Joint Surgery, Vol. 102, No. 16MRI Evaluation of the Posterior Pelvic Bony and Soft Tissue Injuries With Tile C Displaced Pelvic Fractures in Young Children20 March 2020 | Journal of Pediatric Orthopaedics, Vol. 40, No. 7Early fixation strategies for high energy pelvic ring injuries – the Zurich algorithmInjuryResults of open reduction internal fixation versus percutaneous iliosacral screw fixation for unstable pelvic ring injuries: retrospective study of 36 patients5 March 2020 | European Journal of Orthopaedic Surgery & Traumatology, Vol. 30, No. 5The Lateral Stress Radiograph Identifies Occult Instability of Lateral Compression Pelvic Ring Injuries Without SedationJournal of Orthopaedic Trauma, Vol. Publish Ahead of PrintFlegmasia cerúlea dolens posquirúrgica inmediata en el tratamiento de una fractura de pelvis. Reporte de Caso2 May 2020 | Revista de la Asociación Argentina de Ortopedia y Traumatología, Vol. 85, No. 2Long-term total hip arthroplasty rates in patients with acetabular and pelvic fractures after surgery: A population-based cohort study3 April 2020 | PLOS ONE, Vol. 15, No. 4Dual-energy CT as an innovative method for diagnosing fragility fractures of the pelvic ring: a retrospective comparison with MRI as the gold standard14 October 2019 | Archives of Orthopaedic and Trauma Surgery, Vol. 140, No. 4Radiologische Diagnostik von Beckenringfrakturen27 February 2020 | Der Radiologe, Vol. 60, No. 3High-energy Lateral Compression Type 1 Injuries of the PelvisJournal of the American Academy of Orthopaedic Surgeons, Vol. 28, No. 4CT-guided fixation of pelvic fractures after high-energy trauma, by interventional radiologists: technical and clinical outcome18 October 2019 | European Radiology, Vol. 30, No. 2Pelvic fractures in children (pelvic ring and acetabulum)Orthopaedics & Traumatology: Surgery & Research, Vol. 106, No. 1Combined 3D Printed Template to Guide Iliosacral Screw Insertion for Sacral Fracture and Dislocation: A Retrospective Analysis19 February 2020 | Orthopaedic Surgery, Vol. 12, No. 1Pelvic Vertical Shear Injuries and Sacroiliac Joint Disruptions2 January 2020Percutaneous removal of sacroiliac screw following iatrogenic neurologic injury in posterior pelvic ring injury: A case reportInternational Journal of Surgery Case Reports, Vol. 66Kinesiology of the pelvisPelvis16 April 2020Vertical shear pelvic ring injuries: do transsacral screws prevent fixation failure?1 September 2020 | OTA International: The Open Access Journal of Orthopaedic Trauma, Vol. 3, No. 3Outcome of pubic rami fractures with or without concomitant involvement of the posterior ring in elderly patients12 June 2018 | European Journal of Trauma and Emergency Surgery, Vol. 45, No. 6Modified less invasive anterior subcutaneous fixator for unstable Tile-C-pelvic ring fractures: a biomechanical study29 March 2019 | BioMedical Engineering OnLine, Vol. 18, No. 1Decision-making, therapy, and outcome in lateral compression fractures of the pelvis – analysis of a single center treatment15 May 2019 | BMC Musculoskeletal Disorders, Vol. 20, No. 1Operative Treatment of Pediatric Pelvic and Acetabulum FracturesJournal of Orthopaedic Trauma, Vol. 33, No. 8Surgery for Unilateral Sacral Fractures: Are the Indications Clear?Journal of Orthopaedic Trauma, Vol. 33, No. 12Is a Fracture of the Transverse Process of L5 an Indicator of the Presence and/or Severity of a Pelvic Fracture?Spine Surgery and Related Research, Vol. 3, No. 4Minimally Invasive Screw Fixation of Unstable Pelvic Fractures Using the “Blunt End” Kirschner Wire Technique Assisted by 3D Printed External TemplateBioMed Research International, Vol. 2019COMPARISON OF X-RAY AND CT METHODS FOR ASSESSING SACRAL SHAPE VARIANTS AND IDENTIFYING A SECURE SACROILIAC SCREW FIXATION CORRIDOR14 May 2020 | Journal of Musculoskeletal Research, Vol. 22, No. 03n04Pelvic TraumaYoung–Burgess classification: Inter-observer and inter-method agreement between pelvic radiograph and computed tomography in emergency polytrauma management8 July 2019 | Hong Kong Journal of Emergency Medicine, Vol. 71Management of male pelvic fracture urethral injuries: Review and current topics20 March 2019 | International Journal of Urology, Vol. 26, No. 6Interactive Flying Frustums (IFFs): spatially aware surgical data visualization12 March 2019 | International Journal of Computer Assisted Radiology and Surgery, Vol. 14, No. 6Ultrasound-guided supra-acetabular pelvic external fixator (US-SA FIX)Injury, Vol. 50AOSpine—Spine Trauma Classification System: The Value of Modifiers: A Narrative Review With Commentary on Evolving Descriptive Principles8 May 2019 | Global Spine Journal, Vol. 9, No. 1_supplTreatment of Partial Traumatic HemipelvectomyJournal of Bone and Joint Surgery, Vol. 101, No. 9Minimally invasive internal fixator for unstable pelvic ring injuries with a pedicle screw–rod system: a retrospective study of 23 patients after 13.5 months8 December 2018 | Archives of Orthopaedic and Trauma Surgery, Vol. 139, No. 4Complex Open Pelvic Fracture in an 8-Year-Old Girl Treated With INFIX—A Case StudyJAAOS: Global Research and Reviews, Vol. 3, No. 4Conventional plate fixation method versus pre-operative virtual simulation and three-dimensional printing-assisted contoured plate fixation method in the treatment of anterior pelvic ring fracture3 May 2018 | International Orthopaedics, Vol. 43, No. 2Levels of evidence in pelvic trauma: a bibliometric analysis of the top 50 cited papers12 May 2018 | Irish Journal of Medical Science (1971 -), Vol. 188, No. 1A biomechanical study comparing minimally invasive anterior pelvic ring fixation techniques to external fixationInjury, Vol. 50, No. 2Unstable Pelvic Ring Injuries: How Soon Can Patients Safely Bear Weight?Journal of Orthopaedic Trauma, Vol. 33, No. 2Long-Term Patient-Reported Functional Outcome of Polytraumatized Patients With Operatively Treated Pelvic FracturesJournal of Orthopaedic Trauma, Vol. 33, No. 2Pediatric Pelvic Injuries29 June 2019Fractures du bassin chez l'enfant (anneau pelvien et cotyle)Biomechanical evaluation of location and mode of failure in three screw fixations for a comminuted transforaminal sacral fracture modelJournal of Orthopaedic Translation, Vol. 16American College of Surgeons Committee on Trauma verification level affects trauma center management of pelvic ring injuries and patient mortalityJournal of Trauma and Acute Care Surgery, Vol. 86, No. 1Sciatic Nerve Palsy After Distal Femoral Traction for Vertically Unstable Pelvic Fracture in a Neurologically Intact Patient1 September 2019 | JAAOS: Global Research and Reviews, Vol. 3, No. 9Intramedullary Stabilization of Pubic Ramus Fractures in Elderly Patients With a Photodynamic Bone Stabilization System (IlluminOss)25 April 2019 | Geriatric Orthopaedic Surgery & Rehabilitation, Vol. 10Open pelvic fracture: the killing fracture?13 April 2018 | Journal of Orthopaedic Surgery and Research, Vol. 13, No. 1Minimally invasive treatment for anterior pelvic ring injuries with modified pedicle screw-rod fixation: a retrospective study17 September 2018 | Journal of Orthopaedic Surgery and Research, Vol. 13, No. 1Clinical and radiographic outcome of isolated sacroiliac joint dislocationsMinerva Ortopedica e Traumatologica, Vol. 69, No. 4Vertical shear pelvic injury: evaluation, management, and fixation strategies26 March 2018 | International Orthopaedics, Vol. 42, No. 11High-Energy Pelvic Ring Disruptions with Complete Posterior Instability3 October 2018 | Journal of Bone and Joint Surgery, Vol. 100, No. 19Paediatric pelvic ring injuriesOrthopaedics and Trauma, Vol. 32, No. 5Quantitative MDCT assessment of binder effects after pelvic ring disruptions using segmented pelvic and March 2018 | European Radiology, Vol. 28, No. Use of External Fixation for the Management of the Unstable Anterior Pelvic of Orthopaedic Trauma, Vol. 32, No. and of Tile C pelvic ring injuries using a external fixation December | European Journal of Orthopaedic Surgery & Traumatology, Vol. 28, No. of After Operative Treatment of Pelvic Ring InjuriesJournal of Orthopaedic Trauma, Vol. 32, No. 7Biomechanical of fixation techniques in sacrum type II fracture with December | Journal of Orthopaedic Vol. 36, No. for Injury after Pelvic Ring Vol. No. of Fractures Using a Clinical and Operative June 2018 | Journal of Orthopaedics, Trauma and Rehabilitation, Vol. No. 1The trauma from a A case study the of vertical Science International, Vol. Posterior Pelvic for Unstable Sacral Fractures: A Fixation of Orthopaedic Trauma, Vol. 32, No. compression type pelvic ring fractures in young patients do May | European Journal of Trauma and Emergency Surgery, Vol. 44, No. analysis of anterior ring fixation of the ramus in type C pelvis April | European Journal of Trauma and Emergency Surgery, Vol. 44, No. of life after pelvic ring fractures: A studyInjury, Vol. 49, No. fractures of the pelvic and Trauma, Vol. 32, No. in Trauma Emergency Vol. 34, No. of and bilateral sacroiliac joint of Neurosurgery: Spine, Vol. 28, No. fixation of and & Traumatology: Surgery & Research, Vol. 104, No. 1Pelvic Ring Injury May for Spine November Fractures in the and How to of the Fracture Vol. 31, No. screws CT to sacroiliac joint in C pelvic Outcomes at 5 of November 2018 | SICOT-J, Vol. 4Minimally invasive treatment of unstable pelvic ring injuries with modified pedicle screw–rod June | Journal of International Medical Research, Vol. 46, No. supra-acetabular in pelvic external fixation: of a surgical technique and Vol. of an anterior pelvic internal fixator to disruptions of the anterior pelvic of and September | The Bone & Joint Journal, Vol. No. of pelvic ring as a in – A case by of Clinical and Trauma, Vol. following anterior pelvic of a traumatic pubic symphysis treated with open reduction and internal of Clinical and Trauma, Vol. e do de Vol. 52, No. of pelvic ring fractures and de Ortopedia Vol. 52, No. and of after acetabular fractures October | Vol. 101, No. reduction internal fixation versus percutaneous iliosacral screw fixation for unstable posterior pelvic ring & Traumatology: Surgery & Research, Vol. No. Stress Pelvic Ring Without DisplacementJournal of Orthopaedic Trauma, Vol. 31, No. of in Analysis on Pelvic Biomechanical March | Orthopaedic Surgery, Vol. 9, No. spine and for or A Case for Care in the August of the internal fixator as an of pelvic ring March outcome of patients with unstable pelvic ring January | Journal of Orthopaedic Surgery, Vol. 25, No. en - Vol. 49, No. AND A FOR November | Journal of in and Vol. 16, No. MDCT Instability in Pelvic Ring Journal of Vol. No. de la Vol. 40, No. of the posterior Vol. 40, No. of Pelvic Ring and Acetabular in Vol. No. Surgery on with Pelvic Ring A Case of Trauma and Injury, Vol. No. Fixation of Pelvic Ring Injuries of Anterior Failure and of Bone and Joint Surgery, Vol. No. of Failure After Plating on Functional Outcome and of Orthopaedic Trauma, Vol. 30, No. internal fixation versus plate fixation for open pelvic ring injuries: a biomechanical study17 April | European Journal of Trauma and Emergency Surgery, Vol. 42, No. in sacral fracture and & Traumatology: Surgery & Research, Vol. 102, No. 1Pelvic ring injuries: management and of Clinical and Trauma, Vol. No. is the internal fixation in pelvic fracture with injury and anterior sacroiliac joint December | Medical Journal of Vol. No. Pelvic in Orthopaedics, Vol. 25, No. Fixation for Pelvic in Orthopaedics, Vol. 25, No. of the sacroiliac joint with unstable fractures of the pelvis and in a a case of Orthopaedic Science, Vol. 20, No. 6The internal fixator an innovative surgical technique for of fragility fractures of the Vol. Sacroiliac Screw Fixation of the Posterior Pelvic Clinics of North America, Vol. 46, No. and factors associated with in patients after pelvic Vol. No. pelvic injury in Journal of Traumatology, Vol. 18, No. iliosacral screw fixation after posterior ring fractures of the pelvis in elderly Vol. 46, No. study of the sacroiliac fracture fixation with and pedicle Vol. 23, No. paediatric pelvic of pelvic ring failure and the of of the May | The Bone & Joint Journal, Vol. No. classification, and of pelvic fracture urethral April 2019 | Journal of Urology, Vol. 13, No. 1Pelvic Ring November and about the Hip and of Pelvic Ring Fractures in November | Journal of Vol. Versus Care in the Treatment of Pelvic Vol. No. of a new of sacroiliac joint

Journal of Palliative MedicineVol. 3, No. 1 Innovations in End-of-Life CareTaking a Spiritual History Allows Clinicians to Understand Patients More FullyDr. Christina Puchalski and Anna L. RomerDr. Christina Puchalski and Anna L. RomerPublished Online:19 Apr 2005https://doi.org/10.1089/jpm.2000.3.129AboutSectionsPDF/EPUB ToolsPermissionsDownload CitationsTrack CitationsAdd to favorites Back To Publication ShareShare onFacebookTwitterLinked InRedditEmail FiguresReferencesRelatedDetailsCited byVerbalizing spiritual needs in palliative care: a qualitative interview study on verbal and non-verbal communication in two Danish hospices4 January 2022 | BMC Palliative Care, Vol. 21, No. 1Implementation of an Educational Toolkit to Increase Nurse Competence in Spirituality and Spiritual Care of Oncology Patients8 November 2022 | Journal of Holistic Nursing, Vol. 5Posicionamento sobre a Saúde Cardiovascular nas Mulheres – 2022Arquivos Brasileiros de Cardiologia, Vol. 119, No. 5Experiences of German health care professionals with spiritual history taking in primary care: a mixed-methods process evaluation of the HoPES3 intervention15 October 2022 | Family Practice, Vol. 29Religious and spiritual journeys of LGBT older adults in rural Southern Appalachia25 October 2021 | Journal of Religion, Spirituality & Aging, Vol. 34, No. 4The CASH assessment tool: A window into existential suffering19 May 2021 | Journal of Health Care Chaplaincy, Vol. 28, No. 4Integrating religion/spirituality into professional social work practice27 July 2022 | Journal of Religion & Spirituality in Social Work: Social Thought, Vol. 41, No. 4The Concept of Spirituality in the Health Sector: Contributions from the Study of Religion27 September 2022 | International Journal of Latin American Religions, Vol. 12Systematic review: The relationship between religion, spirituality and mental health in adolescents who identify as transgender13 September 2022 | Journal of Gay & Lesbian Mental Health, Vol. 26„Des Lebens Ruf an uns wird niemals enden“ – Sinnzentrierte Interventionen im Überblick30 August 2022 | Zeitschrift für Palliativmedizin, Vol. 23, No. 05Case discussion: The critically ill older adult in spiritual distressGeriatric Nursing, Vol. 47Australian Patient Preferences for the Introduction of Spirituality into their Healthcare Journey: A Mixed Methods Study3 August 2022 | Journal of Religion and Health, Vol. 27Religion, Spirituality, and Ethics in Psychiatric Practice30 March 2022 | Journal of Nervous & Mental Disease, Vol. 210, No. 8Spiritual distress in dialysis: A case report21 July 2022 | Progress in Palliative Care, Vol. 211Interprofessional communication training to address spiritual aspects of cancer care19 July 2022 | Journal of Health Care Chaplaincy, Vol. 29Spirituality in Serious Illness and HealthJAMA, Vol. 328, No. 2What is the role of spiritual care specialists in teaching generalist spiritual care? 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Psikoterapilerdeki Dini İzler15 December 2018 | Cumhuriyet İlahiyat Dergisi, Vol. 22, No. 3Women's Perceptions of Using Short Films to Integrate Spirituality in TherapyJournal of Systemic Therapies, Vol. 37, No. 4Content Validation of Advanced Illness Criteria of a Palliative Care Screening Tool Lauren C. DiLello, Karen Mulvihill, Jennifer Delli Carpini, Riddhi Shah, Julia Hermanowski, and Damanjeet Chaubey29 October 2018 | Journal of Palliative Medicine, Vol. 21, No. 11Understanding, assessing, and in the spiritual of medical and October 2018 | Theology, Vol. 11, No. and of in Living with October 2018 | Journal of & Social Services, Vol. No. for the spirituality as October 2018 | Revista de Vol. 71, No. An of an aged psychiatry March 2018 | Psychiatry, Vol. 26, No. de de vida de de Vol. 25, No. support and with in Care in the Care A Narrative June | Journal of Care Medicine, Vol. No. Care in Cancer: in the of of Clinical Oncology Educational Vol. 3, No. religion/spirituality in clinical practice: A among social and and October | Journal of Clinical Psychology, Vol. 74, No. Spirituality in Care December | Journal of Religion and Health, Vol. 57, No. of to spiritual care at the of a phenomenological exploration from the of palliative care February 2018 | Journal for the Study of Spirituality, Vol. 8, No. Existential Distress in Pediatric Cancer December and Patient Spiritual in the through October of Spirituality in November Psychological/Psychiatric, Social, and Spiritual Problems and July and End-of-Life Care in Cancer in Oncology Nursing, Vol. No. Care in Hospice and Palliative Journal of Hospice and Palliative Care, Vol. 20, No. and Spirituality: Literature review and Journal of Counseling, Vol. 18, No. of the tool existential communication between and cancer August | European Journal of General Practice, Vol. 23, No. Education and of Christian Nursing, Vol. 34, No. Care Interventions in to and Therapy C. and D. September | Journal of Palliative Medicine, Vol. 20, No. in Patients with A Qualitative September | Journal of Research in Nursing and Vol. 14, No. theory on the and in an exploratory case study September | Vol. 69, No. of the of Spirituality and Palliative Care Research and of Pain and Symptom Management, Vol. No. of a spiritual care training program for staff on November | Palliative and Supportive Care, Vol. 15, No. 4Spiritual distress and spiritual care in advanced heart July | Reviews, Vol. and Spiritual Patient Simulation in Nursing, Vol. No. Vol. 42, No. 4The impact of a spiritual in patients with and and their support December | Vol. 26, No. 3The Importance of a Spiritual History in Healthcare Vol. No. About Substance Use DisordersJournal of Psychosocial Nursing and Mental Health Services, Vol. No. and Spiritual Beliefs of April | Journal of Religion and Health, Vol. No. Care Perceptions of and With of Hospice & Palliative Nursing, Vol. 19, No. in Substance Use What to Know to Practice30 November | in Mental Health Nursing, Vol. 38, No. End-of-Life Care to Religious and Vol. No. of Social Education, Vol. 53, No. Nursing Care and of Christian Nursing, Vol. 34, No. 1The of taking a religious and spiritual July | Psychiatry, Vol. 24, No. religion and spirituality in Vol. No. the role of religious in the at the of of Vol. No. care spiritual March | Supportive Care in Cancer, Vol. 24, No. Spiritual Care and the Role of An Review of Literature and April | Journal of Religion and Health, Vol. No. of the Spiritual Needs of of with Is in the June | Journal of Palliative Medicine, Vol. 19, No. Impact of a Tool for Comprehensive Assessment of Palliative Care on Assessment at and of Pain and Symptom Management, Vol. No. from Healthcare Students to Understand Spiritual Assessment in Clinical Practice29 October | Journal of Religion and Health, Vol. No. Spirituality in January | Journal of Religion and Health, Vol. No. 3Development and of to Assess Nurse Provision of Spiritual August 2014 | Journal of Holistic Nursing, Vol. 34, No. and Validation of the Practice Assessment September 2014 | Research on Social Practice, Vol. 26, No. and the Medical A of July | Journal of Health Care Chaplaincy, Vol. 22, No. history taking in palliative care: A controlled September | Palliative Medicine, Vol. 30, No. Is Is Using A and the Life With American in Spiritual March | Journal of in Mental Health, Vol. 11, No. and spiritual in September | International Journal of and Mental Health, Vol. No. 1The of Hospital to and Patients’ Spiritual A May | Journal for the Study of Spirituality, Vol. No. 1The and to March End-of-Life Spiritual March in Holistic Patient Journal of Nursing, Vol. No. of spiritual assessment for older September 2014 | and Vol. No. und der der Care, Vol. No. Spirituality and A for Holistic January | Journal of Religion and Health, Vol. No. and Belief, in Care spiritual history tool by C. M. Puchalski as an for an interdisciplinary in January | Journal for of and Social Vol. 21, No. the of Spiritual A Pain and Palliative Care Service Quality of Pain and Symptom Management, Vol. No. of Spiritual Assessment in September | Vol. No. the of Christian Nursing, Vol. 32, No. 4Spiritual care: is the assessment tool for palliative Journal of Palliative Nursing, Vol. 21, No. und Spiritualität in der September | Vol. 60, No. of September of spirituality assessment in palliative care patients in November 2014 | Progress in Palliative Care, Vol. 23, No. 4The for Spiritual A Mixed-Methods July | Oncology Nursing Vol. 42, No. 4The Integration of Religion and Spirituality in Social Practice: A May | Social Vol. 60, No. 3The and Educational of a Spiritual Life Review for Patients with and June 2014 | Journal of Cancer Education, Vol. 30, No. in Geriatric Palliative in Geriatric Medicine, Vol. No. An for Spiritual Well-Being May | Journal of Religion & Spirituality in Social Work: Social Thought, Vol. 34, No. Spiritual Assessment March | Journal of Health Care Chaplaincy, Vol. 21, No. American on Mental Health, and Help April | and Vol. 60, No. of Christian Nursing, Vol. 32, No. the Spiritual Needs and of Oncology Patients in Nursing Practice, Vol. 29, No. Care Training to Healthcare Professionals: A Systematic April | Journal of Pastoral Care & Counseling: Advancing theory and professional practice through scholarly and reflective publications, Vol. 69, No. analysis of spiritual

Previous article Next article Non-Parametric Estimation of a Multivariate Probability DensityV. A. EpanechnikovV. A. Epanechnikovhttps://doi.org/10.1137/1114019PDFBibTexSections ToolsAdd to favoritesExport CitationTrack CitationsEmail SectionsAbout[1] Emanuel Parzen, On estimation of a probability density function and mode, Ann. Math. Statist., 33 (1962), 1065–1076 MR0143282 0116.11302 CrossrefGoogle Scholar[2] Murray Rosenblatt, Remarks on some nonparametric estimates of a density function, Ann. Math. Statist., 27 (1956), 832–837 MR0079873 0073.14602 CrossrefGoogle Scholar[3] G. M. Manija, Remarks on non-parametric estimates of a two-dimensional density function, Soobšč. Akad. Nauk Gruzin. SSR, 27 (1961), 385–390 MR0143303 Google Scholar[4] E. A. Nadaraya, Estimation of a bivariate probability density, Soobshch. Akad. Nauk Gruz. SSR, 36 (1964), 267–268 Google Scholar[5] R. E. Bellman, , I. Glicksberg and , O. A. 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modelling29 September 2021 | Statistical Modelling, Vol. 124 Cross Ref SAFE-STOP System: Tactical Intention Awareness Based Emergency Collision Avoidance for Malicious Cut-in of Surrounding Vehicle Cross Ref Violin graphs to supervise the energy performance of PV arrays Cross Ref Application of a novel structure-adaptative grey model with adjustable time power item for nuclear energy consumption forecastingApplied Energy, Vol. 298 Cross Ref The continuous wavelet derived by smoothing function and its application in cosmology5 August 2021 | Communications in Theoretical Physics, Vol. 73, No. 9 Cross Ref Inertial Sensor Algorithms to Characterize Turning in Neurological Patients With Turn HesitationsIEEE Transactions on Biomedical Engineering, Vol. 68, No. 9 Cross Ref Consistent inference for predictive regressions in persistent economic systemsJournal of Econometrics, Vol. 224, No. 1 Cross Ref Identifying convergence in nitrogen oxides emissions from motor vehicles in China: A spatial panel data approachJournal of Cleaner Production, Vol. 316 Cross Ref Estimating parameters of a stochastic cell invasion model with fluorescent cell cycle labelling using approximate Bayesian computation22 September 2021 | Journal of The Royal Society Interface, Vol. 18, No. 182 Cross Ref Nonparametric pattern recognition algorithm for testing a hypothesis of the independence of random variables1 September 2021 | Computer Optics, Vol. 5, No. 45 Cross Ref Noise and error analysis and optimization in particle-based kinetic plasma simulationsJournal of Computational Physics, Vol. 440 Cross Ref Unsupervised Learning Methods for Molecular Simulation Data4 May 2021 | Chemical Reviews, Vol. 121, No. 16 Cross Ref A robust dynamic screening system by estimation of the longitudinal data distribution26 May 2020 | Journal of Quality Technology, Vol. 53, No. 4 Cross Ref Ellipsoidal one-class constraint acquisition for quadratically constrained programmingEuropean Journal of Operational Research, Vol. 293, No. 1 Cross Ref Uncertainty quantification for Multiphase-CFD simulations of bubbly flows: a machine learning-based Bayesian approach supported by high-resolution experimentsReliability Engineering & System Safety, Vol. 212 Cross Ref Effective disease surveillance by using covariate information30 July 2021 | Statistics in Medicine, Vol. 59 Cross Ref Quasi‐maximum likelihood and the kernel block bootstrap for nonlinear dynamic models6 January 2021 | Journal of Time Series Analysis, Vol. 42, No. 4 Cross Ref between and to the of level and in the of in Research, Vol. 68, No. 2 Cross Ref energy demand spatio-temporal data Vol. Cross Ref Learning for Statistical of June 2021 | Vol. 29 Cross Ref joint distribution analysis of the under semiparametric distribution for the in of Engineering and Science, Vol. No. 2 Cross Ref model of Econometrics, Vol. No. 2 Cross Ref of Based on and Network with the Quantile May 2021 | Applied Vol. 11, No. 11 Cross Ref An to multivariate 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of Vol. No. Cross Ref Analysis of the of the mean of the kernel probability density estimation in the of and random variables1 January 2021 | No. 3 Cross Ref Energy Management of April 2021 Cross Ref for Detecting of July 2021 Cross Ref of a Analysis Method to the of COVID-19 Kernel Density Estimation Using July 2021 Cross Ref On generative as the for August 2021 | Engineering, Vol. 2 Cross Ref and in the January 2021 | Journal of Vol. 27, No. 1 Cross Ref The in January 2021 | Vol. No. 5 Cross Ref Kernel Based for MIMO Radar in Access, Vol. 9 Cross Ref The diffusion of diffusion and Computational Analysis, Vol. Cross Ref of of components of a multidimensional random variable based on a nonparametric pattern recognition algorithm1 January 2021 | No. 9 Cross Ref in energy efficiency of and its for performance Journal of and Engineering, Vol. Cross Ref of Nonlinear Systems with Cross Ref Probability density forecasting of wind power based on quantile neural Systems, Vol. Cross Ref Hypothesis testing based on a of of Econometrics, Vol. No. 2 Cross Ref Analysis of distribution human in the of Lake in Vol. Cross Ref in and May 2020 | Scientific Reports, Vol. 10, No. 1 Cross Ref Assessment of regressions for in the insights from and historical June 2020 | Vol. 17, No. 12 Cross Ref hybrid and for September 2020 | Journal on Communications and Vol. No. 1 Cross Ref of March 2021 | Physics of Vol. No. 12 Cross Ref price and July 2020 | European Review of Agricultural Economics, Vol. No. 5 Cross Ref A of | Applied Vol. 27, No. Cross Ref Risk Estimation to and in November 2020 | Frontiers in Earth Science, Vol. 8 Cross Ref Learning to a A Transactions on Systems Technology, Vol. No. 6 Cross Ref for cell lung Analysis based on and Radiation Vol. Cross Ref Fast for the of the Kernel Density April 2021 | Optoelectronics, Instrumentation and Data Processing, Vol. No. 6 Cross Ref Using Deep Learning: With Systems and November 2020 | Journal of in Earth Systems, Vol. No. 11 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Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a rare, acquired, immune-mediated polyneuropathy that is commonly misdiagnosed. The global, pivotal ADHERE trial pioneered the use of a diagnostic adjudication committee (DAC) to verify accurate CIDP diagnosis for potential participants. The committee consisted of nine independent experts with extensive experience in CIDP diagnosis, trained to review existing evidence for CIDP in patient medical records. Enrollment eligibility was confirmed when 2 of 2 adjudicators agreed on a definite or probable CIDP diagnosis, as defined by the 2010 European Federation of Neurological Societies-Peripheral Nerve Society criteria (2/2 agreement; phase 1). Participants were not enrolled if both adjudicators determined that the eligibility criteria were not met. When the two adjudicators disagreed, a third adjudicator (the DAC Chair or designee) provided a 2 out of 3 majority vote (phase 2). Of the 560 cases reviewed, 391/560 (69.8%) were determined to have definite/probable CIDP and 169/560 (30.2%) did not meet diagnostic eligibility for ADHERE. Of all enrolled participants with phase 1 adjudication data (n = 340), 277 (81.5%) were confirmed with a 2/2 agreement on diagnostic eligibility (phase 1); 50 participants who were determined to have definite/probable CIDP failed other inclusion/exclusion criteria and were not eligible for ADHERE. The top reasons for disagreement between adjudicators in phase 1 were differences in assessment of clinical and electrodiagnostic criteria. Use of a DAC addressed the limitation of CIDP misdiagnosis and increased the likelihood that the ADHERE trial included participants with confirmed CIDP.

The underlying mechanism of neuropsychiatric features of Long COVID remains unclear; however, the most compelling hypothesis is the contribution of excessive neuroinflammation induced by a systemic inflammatory response or cytokine storm. We aimed to investigate the neuropsychiatric features of Long COVID in older adults and the potential association with neuroinflammation measured by [18F]FEPPA positron emission tomography (PET) targeting translocator protein (TSPO). A total of 24 individuals aged 60 or older participated in the study: those with Long COVID symptoms and persistent subjective or objective cognitive impairments for more than six months (n = 12) and age-matched healthy adults without Long COVID (n = 12). After assessments with neuropsychiatric scales and cognitive testing batteries, three Long COVID and three healthy control participants, who were high-affinity binders to TSPO, underwent additional brain [18F]FEPPA PET scans. Long COVID group (n = 12) showed significantly higher levels of depression and fatigue compared to the healthy control group (n = 12). With [18F]FEPPA PET, the Long COVID group (n = 3) showed significantly higher binding levels in all compared brain regions, such as the prefrontal, temporal, parietal, and occipital neocortices, and the hippocampus, thalamus, and cerebellum, compared to the healthy control group (n = 3). Older adults with Long COVID showed greater neuropsychiatric symptoms, such as depression and fatigue, compared to healthy older adults. The [18F]FEPPA PET findings suggest that their persistent neuropsychiatric symptoms could potentially be associated with chronic neuroinflammation.

Neuromyelitis optica spectrum disorder (NMOSD) can occur in the elderly, but the efficacy and safety of conventional immunosuppressive therapies (ISTs) in this population remain unclear. We conducted a retrospective target-trial emulation using the Korean National Health Insurance Service database from 2011 to 2022. We constructed 636 weekly emulated trials and included 1020 patients who initiated ISTs and 1965 untreated patients after propensity score matching. The primary outcome was relapse incidence and safety outcomes included serious infection and other adverse events. Age-stratified analyses were prespecified using 60&#xa0;years as the cutoff. IST recipients had a lower annual relapse incidence than untreated patients, although the adjusted hazard ratio (aHR) did not reach statistical significance (aHR 0.57, 95% CI 0.28-1.19). Age-stratified analyses suggested a numerical relapse reduction in patients aged <60&#xa0;years, but not in those aged &#x2265;60&#xa0;years, although statistical significance was not reached. Over the follow-up period, the overall risk of serious infection was similar between groups (aHR 1.11, 95% CI 0.84-1.46). Within the first 6&#xa0;months after IST initiation, the risk of serious infection was increased, particularly among patients aged &#x2265;60&#xa0;years (aHR 5.80, 95% CI 2.05-16.40). Evidence was insufficient to determine whether the efficacy of ISTs is reduced in elderly patients with NMOSD. However, IST use was associated with an increased early risk of serious infection, especially among patients aged &#x2265;60&#xa0;years, suggesting that treatment decisions in older patients require more careful consideration.

The p.V142I (V122I) transthyretin variant (TTRv) is the most common amyloidogenic TTRv in the United States, particularly among Black people. While p.V142I ATTRv is primarily associated with cardiac amyloidosis, the prevalence and attribution of polyneuropathy (PN) to amyloidosis in individuals with this variant are poorly defined. To determine the prevalence of PN in individuals with the p.V142I TTRv, evaluate how often PN is attributable to ATTRv amyloidosis rather than alternative comorbid conditions, and compare p.V142I TTRv to non-p.V142I TTRv individuals. We conducted a retrospective review of patients with TTRv evaluated at the Penn Amyloidosis Center of the University of Pennsylvania in Philadelphia between 2021 and 2025. Patients who underwent a comprehensive neurologic and cardiac assessment were selected. PN was classified as possible, probable, or definite based on clinical symptoms, examination, and diagnostic testing. PN attribution to amyloidosis was determined using clinical judgment and categorized as unlikely, possible, probable, or definite. Of 153 patients with TTRv who underwent a comprehensive neurologic and cardiac assessment, 82 carried the p.V142I variant. Among these, 41% were found to have PN; 13% had PN possibly or probably attributable to amyloidosis. In the subgroup with confirmed cardiac amyloidosis, 35% had PN possibly or probably attributable to amyloidosis. Comorbid conditions such as diabetes, chronic kidney disease, alcohol use, and neurotoxic medication exposure were common, and often provided alternative explanations for the PN. Although PN is present in over 40% of individuals with the p.V142I TTRv, it is often unrelated to amyloidosis. Accurate attribution is critical to avoid misdiagnosis and overtreatment. In populations with high burdens of comorbidities and health care disparity, cautious interpretation and selective use of confirmatory testing are essential for appropriate management.

Duchenne muscular dystrophy (DMD) is the most common and severe muscle disorder in children, primarily affecting boys, with an incidence of 1 among 5000. This X-linked recessive disease is marked by progressive muscle wasting, leading to loss of ambulation, respiratory impairment, and cardiomyopathy, with symptoms appearing between ages 2 and 5. While advances in care have extended the life expectancy of DMD patients to 30-40&#xa0;years, cardiac and respiratory failure often leads to mortality by age 40. DMD is caused by mutations in the DMD gene, encoding the dystrophin protein, essential for muscle fiber integrity. Some studies performed between the 1980s and 1990s reported significant cellular radiosensitivity in DMD cells, though the mechanisms remained unclear. As a first approach, we investigated whether our Radiation-Induced ATM Nucleo-Shuttling (RIANS) model that describes individual molecular and cellular responses to radiation in fibroblasts of different origins may be also relevant for DMD fibroblasts. We observed moderate but significant cellular radiosensitivity, a high yield of micronuclei, and delayed ATM nucleo-shuttling, indicating impaired DNA double-strand breaks recognition. This delay may be consistent with the sequestration of ATM around the nucleus by mutated dystrophin, forming pATM perinuclear crowns, an accelerated aging biomarker. Such data provide a unified molecular and cellular characterization of radiation response in DMD fibroblasts that should be investigated further.

The heterogeneity of Essential Tremor (ET) complicates how it is diagnosed and studied. ET is often misdiagnosed as other neurological disorders and vice versa. We aimed to better understand ET by comparing brain maps informed by ET common variants to those derived from related phenotypes. A further goal was to enhance the diagnostic precision of ET by accounting for shared genetic signals between ET and genetically overlapping phenotypes. Phenotype variant association mapping to the brain was done for ET, Parkinson's disease (PD), dystonia, and cognition across adult mouse whole brain and cerebellum spatial transcriptomic data through gsMap. Separately, ET genome-wide association study (GWAS) summary statistics were conditioned on PD and cognition to account for shared genetic signals. Using both raw and conditioned GWASes, ET polygenic risk scores (PRS) were calculated across patient cohorts and controls, and their respective ability to classify ET at the 90th percentile was compared using McNemar's test. Spatial mappings of GWAS signals revealed many shared associations between phenotypes. The raw ET PRS model preformed 1.33% (95% CI: [0.30% - 2.35%]; p&#xa0;=&#xa0;0.0129) better than the conditioned ET PRS model. We lack the ability to decern ET from related phenotypes using existing common variant disease associations. Efforts to isolate a core genetic signal for ET by de-noising shared associations reduced the accuracy of patient classification. Rare variants and lesser explored variant types may be key to unlocking informative variants for ET.

White matter hyperintensities (WMH) are common in idiopathic normal pressure hydrocephalus (iNPH), particularly in periventricular regions around the anterior horns. However, their quantitative evaluation using simple and reproducible methods and their association with cerebrospinal fluid (CSF) tap test responsiveness remain insufficiently studied. We investigated whether the extent of periventricular WMH around the anterior horn area is associated with responsiveness to the CSF tap test. We retrospectively reviewed patients who underwent a CSF tap test and preprocedural MRI between January 2020 and September 2023. Periventricular WMH around the anterior horn area was manually quantified on axial T2-weighted fluid-attenuated inversion recovery images using freehand regions of interest. Gait and cognitive function were assessed using the 3-m Timed Up and Go test (3-TUG) and the Frontal Assessment Battery (FAB). Correlation, multivariable regression, and receiver operating characteristic (ROC) analyses were performed. Thirty-six patients were included. Inter-rater reliability for WMH measurements was good (intraclass correlation coefficient&#xa0;=&#xa0;0.73). Larger WMH areas were associated with lower baseline FAB scores and longer disease duration. Although correlations with changes in 3-TUG or FAB scores were not significant, greater WMH burden was associated with smaller improvement after the CSF tap test. Multivariable analysis showed that WMH area independently predicted FAB score improvement. ROC analysis identified a WMH cutoff value of 254&#xa0;mm2 for predicting&#xa0;&#x2265;&#xa0;3-point FAB improvement (area under the curve&#xa0;=&#xa0;0.728). Quantitative assessment of periventricular WMH around the anterior horn area may help predict cognitive responsiveness to the CSF tap test iNPH.

Performance of Parkinson's Disease Multidisciplinary Complex Therapy in specialized units is quite common in Germany. Data on the benefit of this hospitalisation approach in conjunction with standardised performance of instrumental tests are rare. To evaluate the outcome in 271 consecutively referred patients with Parkinson's disease. Disease severity was scored in combination with execution of standardised instrumental procedures in after admission and before discharge. Rating scale scores and test outcomes of simple, repetitive and complex movement series execution improved. There were high correlation coefficients between the applied various evaluations at the two assessment moments. Computed differences of the instrumental test results between both valuation timepoints were weakly associated to each other. The used approach of combined subjective and objective evaluation mirrors the achieved benefit. This concept is suitable to convince payers on the positive effects of this kind of in-patient stays, which also reduces caregiver burden.

Cerebral amyloid angiopathy (CAA) is a frequent cause of lobar intracerebral hemorrhage (ICH). While the Boston criteria version 2.0 enable in vivo CAA diagnosis using MRI features, the simplified Edinburgh CT criteria were proposed to overcome the limited access to MRI. We aimed to assess the agreement between them in a population-based setting. Patients &#x2265;50&#xa0;years with lobar ICH were retrieved from the population-based Dijon Stroke Registry, France. Agreement between Edinburgh and Boston criteria was assessed using Cohen's kappa (&#x3ba;), and a multinomial logistic regression was performed to investigate factors associated with discrepancies. Additionally, characteristics and outcomes were compared between included and excluded patients from the agreement analysis to investigate potential selection bias. Among 164 patients with lobar ICH, 71 had both brain CT and MRI available. Agreement between CT- and MRI-based criteria was poor (observed: 43.7%; &#x3ba;&#xa0;=&#xa0;0.16; SD: 0.075; 95% CI: 0.01-0.31). Patients with lack of agreement (n&#xa0;=&#xa0;40) were older (median: 80.2 versus 73.7&#xa0;years; p&#xa0;=&#xa0;0.04), but the difference was no longer significant in multivariable model. Patients not included in the analysis (n&#xa0;=&#xa0;93, mainly because of lack of MRI: n&#xa0;=&#xa0;81) were older, had greater clinical, larger ICH volume, higher handicap at discharge, and lower 30-day survival than included patients. Agreement between CT and MRI criteria for CAA diagnosis in lobar ICH was poor, which raises questions about the reliability of CT alone for classifying CAA in ICH patients in our population-based registry.

Limited data exist on the impact of secondary stroke prevention and on cognitive function after stroke. This study aims to investigate whether post-stroke care strategies protect cognitive function up to ten-year. Data were collected between 1995 and 2018 from the population-based South London Stroke Register (SLSR, n&#xa0;=&#xa0;6504). Multivariable Poisson regression models with robust standard errors and confounders were constructed to evaluate adjusted relative risks (aRRs) between cognitive impairment and different treatment strategies; before, at acute care or after stroke. Use multiple imputation to manage the missing data. The prevalence of cognitive impairment was 29% (confidence interval (CI) 26-32). 5-years after stroke, in ischemic stroke patients with a history of atrial fibrillation (AF), there was a reduced risk of cognitive impairment of 50% associated with antihypertensive (aRR:0.5, 0.27-0.91), 77% with statin (aRR:0.23, 0.06-0.91) and 82% with anticoagulant (aRR:0.18, CI 0.05-0.64). In ischemic stroke patients with no history of AF, the reduced risk was 26% (aRR:0.74, 0.57-0.95) with antihypertensive and 19% (aRR:0.81, 0.64-1.03) with statin. All these protective associations tend to diminish over time up to ten years after stroke. When clinically indicated, a combined treatment of these were strongly associated with a reduced risk of cognitive impairment. Small risk reduction was observed between cognitive impairment and acute stroke unit admission (aRR:0.96, 0.93-0.98). Consistent use of combined treatments is associated with better cognitive function up to 10&#xa0;years post-stroke. These findings suggest that optimizing medication management could help reduce the risk of long-term cognitive decline.

Psychiatric comorbidities are increasingly recognised in demyelinating diseases, yet their frequency and timing in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) are not well defined. We aimed to characterise the spectrum and temporal pattern of psychiatric illness in MOGAD and compare to multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) with aquaporin-4 antibody (AQP4-IgG). We conducted a cross-sectional study of patients with MOGAD (n=388), age-matched and sex-matched MS (n=257) and AQP4-IgG-positive NMOSD (n=58) evaluated at Mayo Clinic (1991-2025). Psychiatric diagnoses, timing relative to the first attack and patient-reported outcomes were extracted from electronic health records (EHRs). Complementary analyses were conducted using the NeuroBlu real-world EHR database. Among 388 patients with MOGAD, 54.8% had &#x2265;1 psychiatric disorder, most commonly anxiety (47.7%), depression (36.6%) and attention-deficit/hyperactivity disorder (ADHD, 9%). After the first attack, 33.3% of patients with MOGAD developed a new psychiatric disorder, often within the first year. MOGAD showed a lower frequency of depression versus MS (36.6% vs 47.5%, p=0.02) but similar rates of anxiety and ADHD. Temporal patterns differed: psychiatric disorders often appeared years before onset in MS but clustered shortly after onset in MOGAD. NeuroBlu analyses supported high rates of psychiatric disorders across the three conditions. Psychiatric comorbidities are common in MOGAD, particularly depression and anxiety, typically emerging close after onset, whereas in MS they often preceded onset by years. These findings underscore the need for routine psychiatric screening in MOGAD and highlight unresolved questions regarding whether, and to what extent, MOG-IgG-mediated inflammatory demyelination contributes to psychiatric vulnerability.

Duchenne muscular dystrophy (DMD) is a severe genetic disorder characterized by progressive muscle degeneration. This retrospective register and chart review study utilized data from Finnish registers and Helsinki University Hospital to assess the epidemiology, treatment practices, and economic burden of DMD in Finland. Analysis of primary outcomes (incidence, prevalence, and mortality) included all males with a DMD diagnosis from 1996 to 2022 (N&#xa0;=&#xa0;250). Secondary outcomes were studied in the cohort from 2013 to 2022. From 1996 to 2022, mean annual incidence of DMD was 0.98/5000 male newborns, and mean annual prevalence was 2.46/100,000 residents. Mean age at diagnosis was 6.5&#xa0;years and median survival was 18.5&#xa0;years after diagnosis. The most common causes of death were muscular dystrophy, pneumonia, and dilated cardiomyopathy. Secondary analyses of 175 patients found mean age at diagnosis was 5.8&#xa0;years. Common comorbidities included respiratory failure (42.9%), scoliosis (39.4%), and pneumonia (38.3%). Annually, patients had a mean 7.0 primary and 11.0 secondary care contacts related to DMD; all-cause secondary care contacts contributed to 86.0% of patient healthcare costs. Diagnosis of DMD now occurs earlier compared with the beginning of the study period, and burden of disease and healthcare costs remain high and start at an early age.

Posterior reversible encephalopathy syndrome (PRES) and reversible cerebral vasoconstriction syndrome (RCVS) are cerebrovascular dysregulation syndromes, and an overlapping spectrum may exist. We aimed to assess the frequency and features of PRES and RCVS overlaps. We retrospectively included patients diagnosed with PRES or RCVS from our tertiary center during 2008-2018. Subgroups of PRES with vasoconstriction and RCVS with resolving vasogenic brain edema were defined as the overlap group. Inter-group comparisons were performed for clinical, radiological, and laboratory features. Of 360 patients (mean age 48&#xa0;years, 73% female), 242 were diagnosed with PRES, 83 with RCVS, and 35 patients had overlapping features. In the overlap group, ischemic infarcts (31%) and intraparenchymal hemorrhage (34%) were more frequent than in isolated RCVS (15%, p&#xa0;=&#xa0;0.03, and 11%, p&#xa0;<&#xa0;0.01) or isolated PRES (12% and 13%, p-values <0.01). Subarachnoid hemorrhage was more common in overlap (17%) than in isolated PRES (5%, p&#xa0;=&#xa0;0.006), but similar to isolated RCVS (25%, p&#xa0;=&#xa0;0.337). Distal vascular segments were most involved (>50%) by vasoconstriction in RCVS and overlap cases. Neutrophil-to-lymphocyte ratio was higher in overlap (7.4) than in RCVS (2.7, p&#xa0;=&#xa0;0.02), but similar to PRES (7.4). Most patients had a favorable discharge disposition (home or acute rehabilitation). There was one death (1%) with RCVS, one with overlap (3%), and 17 (7%) with PRES. Although more distinct clinical and radiological features exist in typical RCVS and PRES, an overlapping presentation is not uncommon. Overlap may be associated with more ischemic and hemorrhagic complications, but mostly resembles the parent condition.

Epigenetic clocks are composite measures of DNA methylation used as markers of biological age. This study found that epigenetic age acceleration (EAA) exhibits greater variability in individuals with multiple sclerosis (MS) compared to sex- and age-matched healthy controls (HC). Specifically, the standard deviation for PhenoAge in the secondary progressive (SP) MS group was 12.7, which is 1.5 times that of controls. A likelihood ratio test confirmed a significant difference in variance across relapsing remitting (RR) MS, SPMS, and HC groups, with a p-value of 0.017. This heterogeneity suggests future epigenetic aging studies in MS will require larger sample sizes and underscore the need for variance-aware sample size planning.

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