搜索结果：Journal of prosthodontic research

The molecular mechanisms guiding osseointegration and soft tissue sealing remain poorly understood. Additionally, conventional assays provide limited insight. RNA sequencing (RNA-seq) offers an unbiased, genome-wide profiling of biological events. This review summarizes RNA-seq applications in implant research, highlighting current evidence and future opportunities. A structured search was conducted in PubMed to identify studies that included RNA-seq analyses with titanium surface experiments, including in vitro experiments with osteoblasts/mesenchymal stem cells, fibroblasts, macrophages, soft tissue cells, and in vivo animal models. An overview of the RNA-seq methodology and emerging applications of biomaterials was also included in the search. RNA-seq contributions comprised three categories: (1) confirmation of known responses, such as upregulation of osteogenic differentiation genes on microrough surfaces; (2) discovery of novel functions, including non-canonical Wnt signaling, oxidative stress regulators, and non-coding RNAs mediating osteogenesis and immune modulation; and (3) mechanistic explanations of paradoxes, such as the osteoblast "dilemma" of reduced proliferation but enhanced differentiation. Fibroblast studies linked ultraviolet-activated titanium to proteoglycan/glycosaminoglycan signaling, and macrophage analyses identified zinc-induced metallothioneins as immunomodulatory biomarkers. In vivo, RNA-seq revealed strontium-driven CDH2/β-catenin signaling, age-related suppression of Wnt/angiogenesis, and keratin-mediated soft tissue sealing. Notably, we presented new RNA-seq data demonstrating distinct osteoblast reprogramming on microrough titanium, including the activation of oxidative stress defense, lipid metabolism, and immune-osteoblast crosstalk. RNA-seq is highly useful for establishing implant-tissue interactions, validating clinical observations, and revealing mechanistic explanations. Despite limited studies and protocol heterogeneity, RNA-seq offers a transformative framework for biologically informed and immune-smart implants.

This study aimed to extend the prosthodontic digital guide concept beyond intraoral applications by developing a method to capture and reproduce extraoral perioral spatial relationships using a digitally fabricated positioning guide in a proof-of-concept case. An air-reed musical instrument guide was developed to digitally record and replicate the target distance and angulation between the lips and instrument. Facial and intraoral scans were obtained from an experienced shakuhachi player using a face scanner and an intraoral scanner. The integrated 3D datasets were manually aligned using CAD software using anatomical reference landmarks and used to design a positioning guide by applying principles similar to those used in the fabrication of surgical guides. The guide was designed as a hollow structure and was exported in a Standard Tessellation Language file format. It was fabricated using a stereolithography 3D printer with a photopolymer material commonly employed in dental surgical guides, followed by post-curing and surface polishing. Preliminary usability and fit were assessed through a practical application by the musician and a self-evaluation questionnaire using six categories rated on a 10-point scale. No objective validation of the positional accuracy or reproducibility was performed. The proposed digital workflow demonstrates the feasibility of fabricating a positioning guide for recording and transferring lip-instrument relationships in this proof-of-concept case. This approach suggests the potential applicability of prosthodontic digital guide concepts for capturing and reproducing extraoral perioral spatial positioning.

This study used chitosan (CS)-coated iron oxide nanoparticles (IONPs) to create a dual-nanocarrier consisting of chlorhexidine (CHX) and miconazole (MCZ) and assessed their impact on a denture stomatitis microcosm biofilm. CHX and MCZ were immobilized on IONPs functionalized with CS and the nanocarriers were characterized by physicochemical tests. Biofilms originating from the saliva of patients with denture stomatitis were formed on acrylic surfaces and were treated with IONPs-CS carrying different concentrations of CHX-MCZ (7.8, 19.5, 39, or 78 µg/mL). Untreated biofilms served as the negative control (NC), whereas IONPs, CS, and CHX-MCZ served as controls. Biomass, metabolism, lactic acid generation, number of cultivable cells, cell viability, and biofilm thickness were assessed. Analysis of Variance (ANOVA) or Kruskal-Wallis tests were used to examine all results, and then the Student-Newman-Keuls post hoc test was applied (α=0.05). The nanocarriers were spherical with a diameter of 6.6 nm. The nanocarrier concentration of 78 µg/mL increased the biomass compared with NC. This nanocarrier compound also reduced metabolism and lactic acid generation, surpassing the effects of CHX-MCZ. For the total microorganism and Streptococcus mutans loads, IONPs-CS-CHX-MCZ behaved similarly to CHX-MCZ, and both led to significant reductions relative to NC. The nanocarrier reduced cell viability and increased biofilm thickness compared with the NC. The dual nanocarriers showed an antibiofilm effect equal to or greater than that of CHX-MCZ, depending on the variable analyzed. Nanotherapy has potential for use in mouthwashes, denture cleaning solutions, or anti-biofilm mucoadhesive coatings.

We evaluated the effects of the particle size and content of surface pre-reacted glass-ionomer (S-PRG) filler on the mechanical properties and antimicrobial efficacy of a hard denture relining material. S-PRG microfiller (0.8-1 μm; 5, 10, and 20 wt%) and nanofiller (0.3-0.5 μm; 2.5, 5, and 10 wt%) were incorporated into a Shofu denture liner. The control group did not contain S-PRG fillers. The surface morphology (scanning electron microscopy), roughness (confocal scanning laser microscopy; Shapiro-Wilk's test followed by Dunnett or Steel's test), ion release after 24 h immersion in ultrapure water (fluoride, aluminum, borate, sodium, silicate, strontium ions; Shapiro-Wilk's test followed by one-way ANOVA with Tukey's test or Kruskal-Wallis and Dunn's tests), three-point flexural strength (Weibull analysis), shear bond strength after 24 h water immersion or 10,000 thermal cycles (linear mixed-effects model), and antimicrobial activity against Candida albicans (confocal microscopy, Shapiro-Wilk's test followed by Dunnett's or Steel's test) were analyzed and compared. The significance level was set at α = 0.05. Although a higher S-PRG filler content reduced the flexural and bond strengths, it increased the surface roughness and ion release. Groups treated with 10 wt% nanofiller or 20 wt% microfiller displayed significantly inhibited C. albicans adhesion. The nanofiller-containing groups maintained flexural strength comparable to that of the control. The incorporation of 10 wt% S-PRG nanofiller provided the best balance between antimicrobial efficacy and mechanical performance, indicating that this formulation may be clinically acceptable for use in hard denture relining materials.

The Standardized Tool for the Assessment of Bruxism (STAB) and Bruxism Screener (BruxScreen) are instruments developed to support the structured evaluation of bruxism across clinical and research settings. For effective use in different populations, translation, cultural adaptation, and preliminary data collection are essential. This study aimed to translate the STAB and BruxScreen into Turkish and evaluate their comprehensibility, feasibility, acceptability, and preliminary clinical applicability. Translation and cultural adaptation of both instruments into Turkish were performed according to original developers' guidelines. A panel of 12 experts in prosthodontics and/or orofacial pain supervised the process. Independent forward and backward translations were conducted and pilot-tested using the "Three-Step Test Interview" among patients, dentists, and dental students. Additionally, preliminary data were collected using selected components of both instruments to explore their clinical utility. Both instruments were translated and culturally adapted. Pilot testing confirmed the face validity and demonstrated high levels of comprehensibility, feasibility, and acceptability across participant groups. Preliminary data collected from patients supported the instruments' applicability and initial clinical utility within the Turkish population. The Turkish versions of both instruments appear to be valid and feasible tools for standardized bruxism assessment. The observed alignment between the outcomes of both instruments underscores their complementary nature and supports their combined use. Their integration may enhance the multidimensional evaluation of bruxism and contribute to international efforts aimed at refining and harmonizing assessment protocols across populations.

Large language models (LLMs) are increasingly used in dental esthetic assessment, yet evidence of their feasibility and reliability for objective scoring of single-tooth restorations remains limited. This preliminary study explored the potential of GPT-5.0 for esthetic evaluation using established indices and compared its performance with experienced clinicians and senior dental students. A retrospective dataset of 46 maxillary central incisor restorations with natural adjacent teeth and standardized, high-quality photographs was analyzed. Each case was independently scored using the Pink Esthetic Score (PES) and White Esthetic Score (WES) by three expert prosthodontists, three calibrated senior dental students, and GPT-5.0 guided by a detailed prompt and expert examples. Intra- and inter-group reliability were assessed using intraclass correlation coefficients (ICCs), and group differences were evaluated with repeated-measures analysis of variance. GPT-5.0 showed high internal consistency and strong agreement with human raters, particularly for restorative (WES) parameters. ICCs between GPT-5.0 and expert consensus were 0.944 (total), 0.868 (PES), and 0.943 (WES). Minor but significant differences occurred in certain soft tissue (PES) subitems (P = 0.035), with slightly greater variability than that of the human raters. Reliability was lower for subjective soft tissue parameters, especially the mesial papilla and soft tissue convexity/color/texture subitems; generalizability beyond idealized conditions remains to be established. With detailed guidance, GPT-5.0 can approach expert-level performance for objective scoring of single-tooth restorations in a controlled setting, but reliability is lower for subjective soft tissue parameters, and broader clinical validation is needed before routine implementation.

This study compared the mechanical properties, wear behavior, and shear bond strength (SBS) of resin luting agents in additive-manufactured composite crown materials intended for definitive restorations with those of conventional computer-aided design/computer-aided manufacturing (CAD-CAM) hybrid composite resin (HCR) block materials. Sprintray Ceramic Crown (SP) was used as the representative vat photopolymerization (VPP)-fabricated material based on additive manufacturing, whereas Shofu Block HC Hard II (HC) and Cerasmart Prime (CS) were selected as CAD-CAM HCR block materials. The mechanical properties were evaluated using three-point flexural strength and Vickers hardness tests. The wear behavior was examined via a reciprocating sliding test using an alumina ball antagonist. The SBS was measured between each material and various resin-luting agents. SP showed ~50-60% of the flexural strength and 30-40% of the Vickers hardness of HC and CS. Wear testing revealed that SP exhibited greater wear loss than those of CAD-CAM HCRs. The SBS values of SP with each resin cement were slightly lower than those of HC and CS under most conditions; however, all values exceeded 15 MPa, indicating a clinically acceptable bond strength. The VPP-fabricated definitive crown material (SP) demonstrated inferior mechanical properties and wear resistance compared to those of conventional CAD-CAM HCRs. However, the acceptable levels of bond strength were observed, highlighting the importance of careful case selection for definitive restorations.

Oral hypofunction (OHF) is defined as a multidimensional impairment of oral function that may contribute to the development of geriatric syndromes. This cross-sectional study aimed to assess the relative importance of seven OHF components in relation to physical frailty, sarcopenia, and nutritional impairment, using machine learning methods that are robust to multicollinearity. Data were pooled from two observational studies involving community-dwelling adults aged ≥65 years. Light Gradient Boosting Machine (LightGBM) algorithm was used to calculate the SHapley Additive exPlanation (SHAP) values, reflecting the relative contribution of each OHF component in the identification of three outcomes: physical frailty, sarcopenia, and nutritional impairment. Incremental contributions were further evaluated using integrated discrimination improvement (IDI) and C-statistics, weighted by the SHAP magnitudes. A total of 1,133 participants (mean age 74.4 years) were included. Low tongue pressure had the highest composite SHAP value among the three outcomes (5.20), followed by low masticatory performance, occlusal force, and articulatory oral motor skills. The IDI analysis confirmed that these four components provided incremental value in identifying frailty and sarcopenia. A simplified "OHF-4" model consisting of these four components alone demonstrated comparable discriminatory performance to the full seven-component model across all outcomes based on the C-statistics comparisons. Four OHF components-low tongue pressure, masticatory performance, occlusal force, and articulatory oral motor skills -were the most informative indicators of geriatric syndromes. Targeting these specific functions may aid the development of effective oral function management strategies to mitigate the risk of geriatric syndromes.

The patient was an 11-year-old boy with a medical history of congenital acute myeloid leukemia (AML). He received a series of treatments between 1 and 8 months of age, including chemotherapy, total body irradiation, and peripheral blood stem cell transplantation. Although the permanent incisors had erupted, both crown and root formation were incomplete. No tooth buds were observed for the remaining permanent teeth. The deciduous teeth were still present; however, their roots were shortened and showed mobility. At 18 years of age, growth of the upper and lower jaws had ceased; therefore, occlusal rehabilitation was performed using implants. All teeth except the first molars were extracted, and six implants were placed in the jaws. A screw-retained, implant-supported bridge was fitted, and regular follow-up and maintenance were scheduled. Four years and 9 months after placement of the final prosthesis, the occlusion has remained stable. This patient had congenital AML and received chemotherapy during early childhood, coinciding with the critical period of tooth development and resulting in root shortening, tooth microdontia, and absence of tooth buds for the permanent teeth. Following completion of maxillofacial growth, occlusal rehabilitation was performed using implants, and the occlusion has remained stable. The findings of the present case suggest that implant-supported prosthetic treatment represents an effective option for full occlusal reconstruction in congenital AML survivors with severe hypodontia. Dental implant treatment for full occlusal reconstruction in a patient with severe hypodontia who had received chemotherapy for AML is described herein.

Two female patients aged 55 and 65 presented with persistent occlusal discomfort diagnosed as phantom bite syndrome (PBS) despite multiple prosthetic interventions. Neither had significant psychiatric comorbidity. Both underwent psychosomatic evaluation after non-pharmacological approaches proved insufficient. Pharmacotherapy included low-dose amitriptyline at 10-35 mg/day with aripiprazole augmentation at 1 mg/day in Case 1, and low-dose aripiprazole monotherapy at 1 mg/day in Case 2 after amitriptyline intolerance. Both patients showed marked improvement on the Oral Discomfort/Dysesthesia Rating Scale misalignment subscale, achieved stable occlusion without excessive adjustments, and reported no severe adverse effects during 27-33 months of follow-up. These cases show that pharmacotherapy targeting central hypersensitivity can facilitate successful prosthetic rehabilitation, even in patients without major psychiatric comorbidity. Continued medication during definitive prosthetic procedures helped prevent relapse, highlighting the value of integrated psychopharmacological and prosthodontic management. Clear communication, reframing the condition as hypersensitivity, and shared decision-making further improved adherence and long-term stability. Maintaining pharmacotherapy throughout prosthetic treatment stabilized PBS symptoms, reduced relapse risk, and improved acceptance of definitive restorations. Recognition of possible central nervous system involvement, even without overt psychiatric comorbidity, broadens therapeutic options and supports better outcomes. Future studies should expand clinical case data, refine medication strategies, define optimal treatment timing, and strengthen interdisciplinary collaboration in PBS management.

This study evaluated the effects of build orientation on the mechanical and surface properties of polyetheretherketone (PEEK) fabricated using fused deposition modeling (FDM). Rectangular and six disc-shaped specimens were fabricated in three build orientations (0, 45, and 90°) using an FDM printer with a PEEK filament (PP) (n = 6 per group). Three-point bending tests were conducted on the rectangular specimens to assess the flexural strength (FS) and flexural modulus (FM), whereas Vickers hardness (HV) and surface roughness (Ra) tests were performed on the disc specimens. A scanning electron microscope (SEM) was employed to observe the cross-section of the deformed and undeformed parts of the rectangular specimen after a three-point bending test. The mean FS, FM, HV, and Ra of PP were analyzed using a one-way analysis of variance. Tukey's multiple comparison test was also performed (α = 0.05). The 90° PP had the highest FS and FM, followed by the 45° PP; the 0° PP had the lowest FS and FM. The surface of the 0° PP had no connecting surfaces between the layers, suggesting that its HV was the highest for the PP groups. For the 45° PP, the surface roughness may have increased because of the addition of a support structure to the specimen. Build orientation affects the mechanical and surface properties of the FDM-fabricated PEEK. Overall, the 90° PP demonstrated the most reasonable build orientation.

This study investigated the effects of different post-curing atmospheres and thermal aging on the surface characteristics and mechanical properties of a 3D-printed splint material fabricated using liquid crystal display technology. The 3D-printed specimens were divided into three groups based on the post-curing atmosphere (air, nitrogen, and vacuum) and subjected to either water storage at 37 &#xb0;C for 50 h or 10,000 thermal cycles (5-55 &#xb0;C). The degree of conversion, surface morphology and roughness, and water sorption/solubility of the specimens were evaluated. The surface hardness was measured using the Vickers hardness test, and the flexural strength was assessed using a three-point bending test. Data were analyzed using two-way ANOVA followed by Tukey's post-hoc test (P < 0.05) after confirming the normality and homogeneity of variances using Shapiro-Wilk and Levene's tests, respectively. The nitrogen and vacuum groups exhibited comparable values for degree of conversion, surface roughness, and water sorption/solubility, which were all significantly higher than those of the air group. A significant difference in the surface hardness was observed among the three post-curing atmospheres (P < 0.001); however, the flexural strength was unaffected. After thermal aging, the surface hardnesses and flexural strengths of all the groups significantly decreased. The post-curing atmosphere significantly influenced the degree of conversion, surface roughness, and water sorption/solubility of the additively manufactured specimens, whereas thermal aging degraded their mechanical properties.

We functionalized a three-dimensionally (3D) printed denture base resin with &#x3b1;-Ag2WO4 microcrystals and evaluated its chemical and surface properties, flexural strength, antimicrobial activity, biocompatibility, and inflammatory response. Resin specimens were characterized using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). The surface roughness was evaluated by profilometry and wettability, whereas the surface free energy was determined using a goniometer. The flexural strength of the resin was assessed by three-point mechanical flexural testing. Antimicrobial activity was evaluated against Candida albicans, Staphylococcus aureus, and Escherichia coli in the adhesion and biofilm formation phases by counting colony-forming units (CFU)/mL and using confocal laser scanning microscopy (CLSM). Time-kill curve assays were performed using the Alamar Blue (AB) reagent, and the biocompatibility of the materials was evaluated in a 3D organotypic model of the oral mucosa using AB and CLSM. Inflammatory response was assessed by measuring cytokine production using flow cytometry. XRD, FTIR, and SEM analyses demonstrated that &#x3b1;-Ag2WO4 was incorporated into the resin with its structure preserved. The surface roughness did not change, and the surface free energy increased; however, the flexural strength decreased slightly. The evaluated resins exhibited antifungal and antibacterial effects at both the adhesion and biofilm formation stages. Functionalization did not alter the biocompatibility of the resins and did not cause an exacerbated inflammatory response. Functionalization of a 3D-printed denture base resin with &#x3b1;-Ag2WO4 demonstrated antimicrobial activity without any detrimental effects to the surface, mechanical, and biocompatibility properties of the material.

This study evaluated the effects of auxiliary devices on the scanning accuracy of scan bodies and implant positioning accuracy for dental prosthetic design. Four implants were placed in an edentulous maxillary model and fitted with scan bodies. Two types of removable auxiliary devices were designed and 3D-printed for intraoral scanning, categorized into three groups: non-auxiliary device (NAD), geometric-shaped device (GAD), and tooth-shaped device (TAD) groups. Scanning was performed using three intraoral scanners (i700, i500, and Primescan), with ten scans acquired per group. The scanning accuracy of scan bodies was assessed using 3D inspection software (Zeiss Inspect; Zeiss), whereas implant positioning accuracy after scan body library alignment was analyzed using Geomagic Control X (3D Systems) and Zeiss Inspect. Statistical analyses were performed using one-way and two-way ANOVA followed by Tukey HSD tests to compare the performance among the three groups (&#x3b1; = 0.05). The TAD group demonstrated significantly lower linear discrepancy in the anterior and posterior scan body distance for the i700 and i500 (P < 0.001). However, in terms of implant position accuracy after scan body library alignment, the NAD group with the i700 system showed significantly lower root mean square (RMS) values (P = 0.001) and also demonstrated significantly lower deviation in the apical region (P = 0.005). The use of auxiliary devices for intraoral scanning improved the accuracy of the scan body; however, these devices had little or even a detrimental effect on implant positioning accuracy after scan body library alignment in the CAD process.

To map and synthesize the existing evidence on the association between dental prosthesis use and glycemic control, nutritional status, and oral health-related quality of life (OHRQoL) in diabetes. This scoping review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews and the Joanna Briggs Institute methodology. Systematic searches of PubMed and Google Scholar were conducted up to November 10, 2024. The eligible studies included observational and interventional studies of patients with diabetes who used dental prostheses (removable, fixed, or implant-supported). Evidence was synthesized across three predefined research questions, and exploratory meta-analyses were performed when feasible. Six studies addressed the association between dental prosthesis use and glycemic control. Five reported findings suggesting favorable associations, and exploratory quantitative synthesis showed a pooled mean difference in glycated hemoglobin (HbA1c) of -0.65% (95% confidence interval (CI): -0.89 to -0.40), suggesting a possible association with lower HbA1c levels. Only one study assessed body mass index (BMI), reporting a non-significant mean difference of 0.58 kg/m2 (95% CI: -0.29 to 1.45). Five studies investigated the relationship between dental prosthesis use and OHRQoL in diabetes. Evidence on OHRQoL was inconsistent, with some subgroups showing relatively favorable scores, whereas the pooled results remain inconclusive owing to high heterogeneity. This scoping review provides preliminary, hypothesis-generating evidence that dental prostheses may be associated with lower HbA1c levels in diabetes, while effects on BMI and OHRQoL remain unclear, highlighting the potential role of prosthodontic interventions in holistic diabetes care.

We aimed to verify the hypothesis that patients who undergo prosthetic treatment with a definitive obturator following maxillectomy for oral tumors show decreased oral functions when the maxillary defects are extensive. This study comprised 77 patients (46 men, 31 women; mean age, 71.0 years) who underwent prosthetic treatment with definitive obturators designed to restore maxillary defects following maxillectomy owing to an oral tumor. Oral function, masticatory performance, maximum bite force, tongue pressure, and tongue-lip motor function (oral diadochokinesis /pa/, /ta/, /ka/) were evaluated. The extent of maxillary defects was evaluated based on Aramany's classification. The maxillary defects were classified into three groups, namely, no oroantral communication (NOC), small oroantral communication (SOC), and large oroantral communication (LOC) groups. Multiple regression analyses were performed with each oral function as the objective variable and age, sex, maximal mouth opening, history of radiotherapy, number of functional teeth, and the extent of the maxillary defect as explanatory variables. The number of functional teeth and LOC were significant as explanatory variables for masticatory performance, while sex, number of functional teeth, and LOC were significant as explanatory variables for maximum bite force. Regarding other oral functions, the extent of the jaw defect was not significant as an explanatory variable. In patients with maxillary defects wearing definitive obturators, a defect exceeding half of the palate and communicating with the nasal cavity was significantly associated with lower masticatory performance and maximum bite force.

This study retrospectively investigated the clinical outcomes of computer-aided design/computer-aided manufacturing (CAD-CAM) resin composite crowns for molars and analyzed the morphological factors contributing to crown failure using three-dimensional (3D) digital data. The clinical outcomes of 117 crowns in 101 patients treated at Osaka University Dental Hospital were analyzed. 3D digital data were evaluated to identify factors influencing crown debonding, focusing on luting methods, abutment morphology, and crown parameters. Survival analyses, multivariate analyses, and regression modeling were performed. During an observation period of up to 1281 days, the cumulative success and survival rates were 83.3% and 95.5%, respectively. Debonding (12.0%) was the most frequent complication and was significantly associated with the choice of luting materials (P < 0.001). In addition, 3D analysis identified greater buccolingual taper, insufficient occlusal thickness, smaller abutment surface area, and reduced abutment height as predictors of debonding. Nonlinear regression analysis revealed significant differences in the abutment parameters between SA Luting and PANAVIA V5 at the lower percentiles (P = 0.02). Combining clinical outcomes with 3D data highlights the importance of precise abutment preparation and material selection to reduce the risk of crown debonding.

Open-source environments offer interesting opportunities to democratize digital workflows in dentistry, thereby reducing dependency on costly proprietary systems. This proof of concept aimed to demonstrate a method for creating a semi-adjustable virtual articulator by integrating intraoral, facial, and cone-beam computed tomography (CBCT) scans into freeware software. CBCT-derived mandibular segmentation was combined with intraoral and facial scans within Meshmixer (v. 3.5; Autodesk Inc, San&#x202f;Francisco, USA), with anatomical condylar pivots defining the hinge axis. Alignment was achieved using dental surfaces as common references. The workflow enabled simulation of mandibular opening, closure, protrusion, and lateral excursions based on patient-specific anatomy in a virtual semi-adjustable articulator. This proof of concept demonstrated how freeware environments can democratize access to virtual patient simulation, serving as a stepping-stone toward validated, cost-effective clinical workflows, fostering innovation beyond proprietary constraints and traditional facebows.

The purpose of this systematic review was to evaluate the 5-year clinical performance of posterior resin bonded fixed partial dentures (P-RBFPDs). Electronic literature searches were conducted on PubMed/Medline, Embase, Scopus and Web of Science for clinical studies with 5-year or more follow-up periods and screened by 2 independent reviewers. Information on P-RBFPDs with its clinical outcomes were extracted. Statistical analysis was performed based on the defined failure rates to estimate the 5-year and 10-year survival rates along with annual failure rates of P-RBFPDs. A total of 15 out of 283 studies were analyzed statistically based on the inclusion criteria. The overall estimated 5-year and 10-year survival rate were 82.77% (95% CI: 75.88-87.85%) and 68.51% (95% CI: 57.57-77.17%), respectively. The estimated annual failure rate was 3.78% (95% CI: 2.59-5.52), with no significant differences among P-RBFPDs based on prosthesis type (Fixed-Fixed, Fixed-Movable, Cantilever) or framework materials at the 95% confidence level. Despite this, non-cantilevered P-RBFPDs demonstrated nearly twice the estimated annual failure rate compared to two-unit cantilevered P-RBFPDs (4.19% Vs 2.20%). Two-unit cantilevered P-RBFPDs exhibited higher estimated survival rates at 5 and 10 years compared to non-cantilevered prostheses, although this difference was not statistically significant. The type of prosthesis and framework material did not significantly impact the clinical outcomes. Two-unit cantilevered P-RBFPDs demonstrate higher 5- and 10-year survival rates compared to non-cantilevered options. Further high-quality long-term clinical trials are still needed.