Excess energy intake can trigger an uncontrolled inflammatory response, leading to systemic low-grade inflammation and metabolic disturbances that are hypothesised to contribute to cardiovascular disease and type 2 diabetes. The long chain n-3 polyunsaturated fatty acids (LC n-3 PUFAs) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are suggested to mitigate this inflammatoryresponse,butthemechanismsareunclear,especiallyatthetissuelevel. Adiposetissues, the first tissues to give an inflammatory response, may be an important target site of action for EPA and DHA. To evaluate the effects of EPA and DHA in white and brown adipose tissues, we fed male C57Bl/6J mice either a high fat diet (HFD) with 5% corn oil, an HFD with 40% of the corn oil substituted for purified EPA and DHA triglycerides (HFD-ED), or normal chow, for 8 weeks. Fatty acid profiling and transcriptomics were used to study how EPA and DHA affect retroperitoneal whiteandbrownadiposetissues. HFD-EDfedmiceshowedreducedlipidaccumulationandlevelsof the pro-inflammatory fatty acid arachidonic acid in both white and brown adipose tissues, compared withHFD-cornoilfedanimals. Thetranscriptomicanalysisshowedchangesinβ-oxidationpathways, supporting the decreased lipid accumulation in the HFD-ED fed mice. Therefore, our data suggests that EPA and DHA supplementation of a high fat diet may be anti-inflammatory, as well as reduce lipid accumulation in adipose tissues.
The Editors of the International Journal of Molecular Sciences have established the Best Paper Award to recognize the most outstanding articles published in the areas of molecular biology, molecular physics and chemistry that have been published in the International Journal of Molecular Sciences.[...]
Hepatitis C virus (HCV) is one of the major causes of chronic liver diseases such as cirrhosis apparen tly leading to liver failure or liver cancer. HCV is the leading c ause of liver transplantation and there is no uniqu e effective drug for all hepatitis genotypes. The protein NS5B polym erase is a RNA-dependent RNA polymerase that contributes to the replication of viral RNA. By inhibiting the fun ction of non structural protein 5B (NS5B) polymeras e, the viral RNA of HCV fails to replicate. The present study de als with the development of HCV replication inhibit ors by the volatile compounds extracted from the plant Acacia concinna belonging to family Acaciaceae which is followed b y molecular docking against NS5B polymerase (PDB ID:- 4EO6). Molecular docking studies were performed using iGEMDOCK module and the Absorption Distribution Metabolism Excretion Toxicity (ADMET) properties of the best molecule that fits with NS5B polymerase was pr edicted using admetSAR database. The interaction of the extracted compounds showed their antiviral properti es against NS5B polymerase which could be used for further analysis to inhibit HCV replication.
This is the supplemental file for one manuscript that was submitted to International Journal of Molecular Sciences for considering potential publication.
Previous article Next article Non-Parametric Estimation of a Multivariate Probability DensityV. A. EpanechnikovV. A. Epanechnikovhttps://doi.org/10.1137/1114019PDFBibTexSections ToolsAdd to favoritesExport CitationTrack CitationsEmail SectionsAbout[1] Emanuel Parzen, On estimation of a probability density function and mode, Ann. Math. Statist., 33 (1962), 1065–1076 MR0143282 0116.11302 CrossrefGoogle Scholar[2] Murray Rosenblatt, Remarks on some nonparametric estimates of a density function, Ann. Math. Statist., 27 (1956), 832–837 MR0079873 0073.14602 CrossrefGoogle Scholar[3] G. M. Manija, Remarks on non-parametric estimates of a two-dimensional density function, Soobšč. Akad. Nauk Gruzin. SSR, 27 (1961), 385–390 MR0143303 Google Scholar[4] E. A. Nadaraya, Estimation of a bivariate probability density, Soobshch. Akad. Nauk Gruz. SSR, 36 (1964), 267–268 Google Scholar[5] R. E. Bellman, , I. Glicksberg and , O. A. Gross, Some aspects of the mathematical theory of control processes, Rand Corporation, Santa Monica, Calif., Rep. 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Previous article Next article The NP-Completeness of Edge-ColoringIan HolyerIan Holyerhttps://doi.org/10.1137/0210055PDFBibTexSections ToolsAdd to favoritesExport CitationTrack CitationsEmail SectionsAboutAbstractWe show that it is NP-complete to determine the chromatic index of an arbitrary graph. The problem remains NP-complete even for cubic graphs.[1] S. Fiorini and , Robin James Wilson, Edge-colourings of graphs, Pitman, London, 1977iii+154 58:27599 0421.05023 Google Scholar[2] Michael R. Garey and , David S. Johnson, Computers and intractability, W. H. Freeman and Co., San Francisco, Calif., 1979x+338 80g:68056 0411.68039 Google Scholar[3] Rufus Isaacs, Infinite families of nontrivial trivalent graphs which are not Tait colorable, Amer. Math. Monthly, 82 (1975), 221–239 52:2940 0311.05109 CrossrefISIGoogle Scholar[4] R. Isaacs, Loupekine's snarks: A bifamily of non-Tait-colorable graphs, unpublished Google ScholarKeywordscomputational complexityNP-complete problemschromatic indexedge-coloring Previous article Next article FiguresRelatedReferencesCited ByDetails Regular pattern-free coloringDiscrete Applied Mathematics, Vol. 321 | 1 Nov 2022 Cross Ref Chromatic index of dense quasirandom graphsJournal of Combinatorial Theory, Series B, Vol. 157 | 1 Nov 2022 Cross Ref Subcubic planar graphs of girth 7 are class IDiscrete Mathematics, Vol. 345, No. 10 | 1 Oct 2022 Cross Ref Independence number of edge‐chromatic critical graphsJournal of Graph Theory, Vol. 101, No. 2 | 20 March 2022 Cross Ref Complexity Dichotomy for List-5-Coloring with a Forbidden Induced SubgraphSepehr Hajebi, Yanjia Li, and Sophie SpirklSIAM Journal on Discrete Mathematics, Vol. 36, No. 3 | 30 August 2022AbstractPDF (592 KB)The Overfullness of Graphs with Small Minimum Degree and Large Maximum DegreeYan Cao, Guantao Chen, Guangming 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Previous article Next article On the Construction and Comparison of Difference SchemesGilbert StrangGilbert Stranghttps://doi.org/10.1137/0705041PDFBibTexSections ToolsAdd to favoritesExport CitationTrack CitationsEmail SectionsAbout[1] J. Barkley Rosser, A Runge-Kutta for all seasons, SIAM Rev., 9 (1967), 417–452 10.1137/1009069 MR0219242 0243.65041 LinkISIGoogle Scholar[2] Robert D. Richtmyer and , K. W. Morton, Difference methods for initial-value problems, Second edition. Interscience Tracts in Pure and Applied Mathematics, No. 4, Interscience Publishers John Wiley & Sons, Inc., New York-London-Sydney, 1967xiv+405 MR0220455 0155.47502 Google Scholar[3] Peter D. Lax and , Burton Wendroff, Difference schemes for hyperbolic equations with high order of accuracy, Comm. Pure Appl. Math., 17 (1964), 381–398 MR0170484 0233.65050 CrossrefISIGoogle Scholar[4] Samuel Z. 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Previous article Next article A Method for Constructing Local Monotone Piecewise Cubic InterpolantsF. N. Fritsch and J. ButlandF. N. Fritsch and J. Butlandhttps://doi.org/10.1137/0905021PDFBibTexSections ToolsAdd to favoritesExport CitationTrack CitationsEmail SectionsAboutAbstractA method is described for producing monotone piecewise cubic interpolants to monotone data which is completely local and which is extremely simple to implement.[1] K. W. Brodlie, K. W. Brodlie, A review of methods for curve and function drawingMathematical Methods in Computer Graphics and Design, Academic Press, London, 1980, 1–37 Google Scholar[2] J. Butland, A method of interpolating reasonable-shaped curves through any data, Proc. of Computer Graphics 80, Online Publications Ltd., Northwood Hills, Middlesex, UK, 1980, 409–422 Google Scholar[3] F. N. Fritsch and , J. Butland, An improved monotone piecewise cubic interpolation algorithm, Rep., UCRL-85104, Lawrence Livermore Laboratory, Livermore, CA, 1980, October Google Scholar[4] F. N. Fritsch and , R. E. Carlson, Monotone piecewise cubic interpolation, SIAM J. Numer. Anal., 17 (1980), 238–246 10.1137/0717021 81g:65012 0423.65011 LinkISIGoogle ScholarKeywordsmonotone interpolationcubic Hermite interpolation Previous article Next article FiguresRelatedReferencesCited ByDetails The PUMAS libraryComputer Physics Communications, Vol. 279 | 1 Oct 2022 Cross Ref Microstructure-Sensitive Uncertainty Quantification for Crystal Plasticity Finite Element Constitutive Models Using Stochastic Collocation MethodsFrontiers in Materials, Vol. 9 | 27 September 2022 Cross Ref Determination of the Effects of Transcutaneous Auricular Vagus Nerve Stimulation on the Heart Rate Variability Using a Machine Learning PipelineBioelectricity, Vol. 4, No. 3 | 1 Sep 2022 Cross Ref Mach and Froude Numbers on MarsThe Planetary Science Journal, Vol. 3, No. 7 | 19 July 2022 Cross Ref Implementation of free-space Fourier Ptychography with near maximum system numerical apertureOptics Express, Vol. 30, No. 12 | 23 May 2022 Cross Ref Eye Tracking-Based Stress Classification of Athletes 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The Journal of Bone and Joint Surgery. British volumeVol. 70-B, No. 4 ArticlesFree AccessDoes corrosion matter?J BlackJ BlackSearch for more papers by this authorPublished Online:1 Aug 1988https://doi.org/10.1302/0301-620X.70B4.3403590AboutSectionsPDF/EPUB ToolsAdd to FavouritesDownload CitationsTrack CitationsPermissions ShareShare onFacebookTwitterLinked InRedditEmail FiguresReferencesRelatedDetailsCited byPediatric fractures following implant removal: A systematic review10 November 2022 | Journal of Children's Orthopaedics, Vol. 6Effect of boron oxide on mechanical and thermal properties of bioactive glass coatings for biomedical applications7 March 2022 | Journal of the American Ceramic Society, Vol. 105, No. 6Titanium Wear of Dental Implants from Placement, under Loading and Maintenance Protocols21 January 2021 | International Journal of Molecular Sciences, Vol. 22, No. 3IN VITRO STUDY AND MECHANICAL CHARACTERISTICS OF DENTAL IMPLANTS MADE OF VARIOUS MATERIALS AND FABRICATION METHODS18 February 2021 | Journal of Mechanics in Medicine and Biology, Vol. 21, No. 01Coatings on orthopedic implants to overcome present problems and challenges: A focused reviewMaterials Today: Proceedings, Vol. 45Hardware removal rates after surgical treatment of proximal femur fractures21 January 2020 | Archives of Orthopaedic and Trauma Surgery, Vol. 140, No. 8Recent advancements in Fe-based biodegradable materials for bone repair19 October 2018 | Journal of Materials Science, Vol. 54, No. 3Mandibular Osteotomies1 August 2019Biodegradation of gold and platinum implants in rats studied by electron microscopy27 November 2019 | International Journal of Physics Research and Applications, Vol. 2, No. 1Artificial neural network based optimization of prerequisite properties for the design of biocompatible titanium alloysComputational Materials Science, Vol. 149Detection of Titanium Particles in Soft Tissues Adjacent to the Fixators in Patients with Facial Fractures and Bone Defects30 March 2018 | Journal of Diagnostics and Treatment of Oral and Maxillofacial Pathology, Vol. 2, No. 1Metal-on-Metal Hip Implants: Progress and Problems25 February 2018Dual-surface modification of titanium alloy with anodizing treatment and bioceramic particles for enhancing prosthetic devices21 April 2017 | Journal of Materials Science, Vol. 52, No. 15In Vivo Damage of the Head-Neck Junction in Hard-on-Hard Total Hip Replacements: Effect of Femoral Head Size, Metal Combination, and 12/14 Taper Design1 July 2017 | Materials, Vol. 10, No. 7Influence of process parameters on plasma electrolytic surface treatment of tantalum for biomedical applicationsApplied Surface Science, Vol. 407Fabrication and apatite inducing ability of different porous titania structures by PEO treatmentMaterials Science and Engineering: C, Vol. 66Inorganic characterizations and filler particles morphology of self-adhesive cementsInternational Journal of Adhesion and Adhesives, Vol. 68Study of the bioactivity, wettability and hardness behaviour of the bovine hydroxyapatite-diopside bio-nanocomposite coatingJournal of the Taiwan Institute of Chemical Engineers, Vol. 60Chapter 4 Immune Response12 June 2016Tribocorrosion and TMJ TJR DevicesAnodisation and Sol–Gel Coatings as Surface Modification to Promote Osseointegration in Metallic Prosthesis10 August 2016Corrosion at the Head-Neck Taper Interface Affects the Prognosis of Hip Revision Surgery29 January 2016Is Taper Fretting Corrosion a Threat to the Clinical Performance of Large-Diameter Hips with Highly Crosslinked Polyethylene Bearings?29 January 2016In vivo electrochemical corrosion study of a CoCrMo biomedical alloy in human synovial fluidsActa Biomaterialia, Vol. 21Metal Removal29 October 2014Do Ceramic Femoral Heads Reduce Taper Fretting Corrosion in Hip Arthroplasty? 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Materials for Biomedical Applications — High Long-Term Success Rates might pose new ProblemsAngewandte Chemie, Vol. 101, No. 7Materials for biomedical application- high long-term success rates might pose new problemsAdvanced Materials, Vol. 1, No. 7Blood Analysis for Trace Metals in Patients with Different Bearings in Total Hip ArthroplastyMandibular Osteotomies and Considerations for Rigid Internal Fixation Vol. 70-B, No. 4 Metrics History Published online 1 August 1988 Published in print 1 August 1988 InformationCopyright © 1988, The British Editorial Society of Bone and Joint Surgery: All rights reservedPDF download
Previous article Next article Bounds on Multiprocessing Timing AnomaliesR. L. GrahamR. L. Grahamhttps://doi.org/10.1137/0117039PDFBibTexSections ToolsAdd to favoritesExport CitationTrack CitationsEmail SectionsAbout[1] E. F. Codd, Multiprogram scheduling. I, II. Introduction and theory, Comm. ACM, 3 (1960), 347–350 10.1145/367297.367317 MR0130079 0102.34202 CrossrefISIGoogle Scholar[2] R. L. Graham, Bounds for certain multiprocessing anomalies, Bell System Tech. J., 45 (1966), 1563–1581 0168.40703 CrossrefISIGoogle Scholar[3] J. Heller, Sequencing aspects of multiprogramming, J. Assoc. Comput. Mach., 8 (1961), 426–439 MR0159443 CrossrefGoogle Scholar[4] John L. Kelley, General topology, D. Van Nostrand Company, Inc., Toronto-New York-London, 1955xiv+298 MR0070144 0066.16604 Google Scholar[5] B. Liebesman, The use of a special algebra in schedule analysis, to appear Google Scholar[6] G. K. Manacher, Production and stabilization of real-time task schedules, J. Assoc. Comput. Mach., 14 (1967), 439–465 CrossrefISIGoogle Scholar[7] B. P. Ochsner, Controlling a multiprocessor system, Record, 44, Bell Laboratories, 1966, pp. 59–62 Google Scholar[8] P. Richards, Parallel programming, Rep., TD-B60-27, Technical Operations Inc., 1960 Google Scholar[9] M. Rothkopf, Scheduling independent tasks on one or more processors, Interim Tech. Rep., 2, Operations Research Center, M.I.T., Cambridge, 1964 Google Scholar Previous article Next article FiguresRelatedReferencesCited ByDetails DAG Scheduling and Analysis on Multi-Core Systems by Modelling Parallelism and DependencyIEEE Transactions on Parallel and Distributed Systems, Vol. 33, No. 12 | 1 Dec 2022 Cross Ref The BH-mixed scheduling algorithm for DAG tasks with constrained deadlinesJournal of Systems Architecture, Vol. 131 | 1 Oct 2022 Cross Ref Streaming algorithms for multitasking scheduling with shared processingDiscrete Applied Mathematics, Vol. 320 | 1 Oct 2022 Cross Ref Checkpointing Workflows à la Young/Daly Is Not Good EnoughACM Transactions on Parallel Computing, Vol. 25 | 2 September 2022 Cross Ref Parallel Machine Scheduling Under Uncertainty: Models and Exact AlgorithmsINFORMS Journal on Computing, Vol. 68 | 17 August 2022 Cross Ref EasyFL: A Low-Code Federated Learning Platform for DummiesIEEE Internet of Things Journal, Vol. 9, No. 15 | 1 Aug 2022 Cross 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Previous article Next article Convergence Conditions for Ascent MethodsPhilip WolfePhilip Wolfehttps://doi.org/10.1137/1011036PDFBibTexSections ToolsAdd to favoritesExport CitationTrack CitationsEmail SectionsAboutAbstractLiberal conditions on the steps of a “descent” method for finding extrema of a function are given; most known results are special cases.[1] Haskell B. Curry, The method of steepest descent for non-linear minimization problems, Quart. Appl. Math., 2 (1944), 258–261 MR0010667 0061.26801 CrossrefGoogle Scholar[2] Augustine Cauchy, Méthode générale pour la résolution des systèmes d'équations simultanées, C.R. Acad. Sci., 25 (1847), 536–538 Google Scholar[3] A. A. Goldstein, Minimizing functionals on normed-linear spaces, SIAM J. Control, 4 (1966), 81–89 10.1137/0304008 MR0196900 0147.12701 LinkGoogle Scholar[4] A. A. Goldstein, Cauchy's method of minimization, Numer. 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SIAM control, 5 (1967), 268–274 10.1137/0305018 0158.18805 LinkGoogle Scholar[14] Philip Wolfe, on the convergence of gradient methods under constraints, Rep., RZ-204, IBM watson research center, yorktown heights, new york, 1966 Google Scholar Previous article Next article FiguresRelatedReferencesCited ByDetails Two efficient modifications of AZPRP conjugate gradient method with sufficient descent propertyJournal of Inequalities and Applications, Vol. 2022, No. 1 | 10 January 2022 Cross Ref Optimal Transport Based Seismic Inversion:Beyond Cycle SkippingCommunications on Pure and Applied Mathematics, Vol. 75, No. 10 | 1 April 2021 Cross Ref A robust BFGS algorithm for unconstrained nonlinear optimization problemsOptimization, Vol. 17 | 19 September 2022 Cross Ref Two Methods for the Implicit Integration of Stiff Reaction SystemsComputational Methods in Applied Mathematics, Vol. 0, No. 0 | 14 September 2022 Cross Ref Simple and fast convergent procedure to estimate recursive path analysis modelBehaviormetrika, Vol. 107 | 6 September 2022 Cross Ref Adaptive three-term PRP algorithms without gradient Lipschitz continuity condition for nonconvex functionsNumerical Algorithms, Vol. 91, No. 1 | 20 January 2022 Cross Ref A Hybrid Stochastic Deterministic Algorithm for Solving Unconstrained Optimization ProblemsMathematics, Vol. 10, No. 17 | 23 August 2022 Cross Ref Pseudospectral methods and iterative solvers for optimization problems from multiscale particle dynamicsBIT Numerical Mathematics, Vol. 48 | 11 August 2022 Cross Ref An outlier-resistant κ -generalized approach for robust physical parameter estimationPhysica A: Statistical Mechanics and its Applications, Vol. 600 | 1 Aug 2022 Cross Ref An Active Set Trust-Region Method for Bound-Constrained OptimizationBulletin of the Iranian Mathematical Society, Vol. 48, No. 4 | 27 July 2021 Cross Ref Advancing Three-Dimensional Coupled Water Quality Model of Marine Ranches: Model Development, Global Sensitivity Analysis, and Optimization Based on Observation SystemJournal of Marine Science and Engineering, Vol. 10, No. 8 | 27 July 2022 Cross Ref Robust regression against heavy heterogeneous contaminationMetrika, Vol. 16 | 1 July 2022 Cross Ref A new class of nonlinear conjugate gradient coefficients for unconstrained optimizationAsian-European Journal of Mathematics, Vol. 15, No. 07 | 14 October 2021 Cross Ref New iterative conjugate gradient method for nonlinear unconstrained optimizationRAIRO - Operations Research, Vol. 56, No. 4 | 29 July 2022 Cross Ref Optimizing Oblique Projections for Nonlinear Systems using TrajectoriesSamuel E. 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nanotechnology25 January 2021 | Nanotechnology for Environmental Engineering, Vol. 6, No. 1Antiviral optical techniques as a possible novel approach to COVID-19 treatment6 February 2021 | Journal of Innovative Optical Health Sciences, Vol. 14, No. 03The Potential Role of Photobiomodulation in Long COVID-19 Patients Rehabilitation Reza Fekrazad and Sepehr Fekrazad12 April 2021 | Photobiomodulation, Photomedicine, and Laser Surgery, Vol. 39, No. 4Photodynamic Therapy—An Up-to-Date Review17 April 2021 | Applied Sciences, Vol. 11, No. 8Revisiting Tetra-p-Sulphonated Porphyrin as Antimicrobial Photodynamic Therapy Agent30 March 2021 | Coatings, Vol. 11, No. 4Blue photobiomodulation LED therapy impacts SARS‐CoV ‐2 by limiting its replication in Vero cells1 March 2021 | Journal of Biophotonics, Vol. 14, No. 4Photodynamic Therapy: A Rational Approach Toward COVID-19 Management11 March 2021 | Journal of Exploratory Research in Pharmacology, Vol. 000, No. 000Photobiomodulation und COVID-191 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1Evaluation of Adjunctive Photobiomodulation (PBMT) for COVID-19 Pneumonia via Clinical Status and Pulmonary Severity Indices in a Preliminary Trial1 March 2021 | Journal of Inflammation Research, Vol. Volume 14Pilot Study of Application of Combined Transbronchial and Intravenous Ultraviolet C (UVC) and Laser Beam Application for the Treatment of Critical COVID-19 InfectionJournal of Clinical and Experimental Investigations, Vol. 12, No. 2Photobiomodulation and Antiviral Photodynamic Therapy in COVID-19 Management11 May 2021The bioenergetics of COVID-19 immunopathology and the therapeutic potential of biophysical radiancesJournal of Photochemistry and Photobiology B: Biology, Vol. 213Dental Aerosol as a Hazard Risk for Dental Workers12 November 2020 | Materials, Vol. 13, No. 22Application of Laser Blue Light With a Wavelength of 405 nm in the Treatment of Patients With the Virus COVID-193 October 2020 | Journal of Lasers in Medical Sciences, Vol. 11, No. 4Biophotonics in Health Care and Its Relevance in Fighting the Coronavirus Disease Aldo Brugnera Junior, Fatima Zanin, Samir Nammour, and Sonia Groisman16 September 2020 | Photobiomodulation, Photomedicine, and Laser Surgery, Vol. 38, No. 9Phototherapy as a Rational Antioxidant Treatment Modality in COVID-19 Management; New Concept and Strategic Approach: Critical Review16 September 2020 | Antioxidants, Vol. 9, No. 9Antimicrobial Photodynamic Therapy in the Control of COVID-1911 June 2020 | Antibiotics, Vol. 9, No. 6A Potential Role for Photobiomodulation Therapy in Disease Treatment and Prevention in the Era of COVID-19Aging and disease, Vol. 11, No. 6 Volume 38Issue 5May 2020 InformationCopyright 2020, Mary Ann Liebert, Inc., publishersTo cite this article:Reza Fekrazad.Photobiomodulation and Antiviral Photodynamic Therapy as a Possible Novel Approach in COVID-19 Management.Photobiomodulation, Photomedicine, and Laser Surgery.May 2020.255-257.http://doi.org/10.1089/photob.2020.4868Published in Volume: 38 Issue 5: May 19, 2020Online Ahead of Print:April 23, 2020PDF download
Thirty years ago, responding to the growing interest, rapid expansion, and increase in research in pediatric gastroenterology and nutrition, we established the Journal of Pediatric Gastroenterology and Nutrition (JPGN). The editorial of the first edition began, quo vadis? (1). Thirty years later, we are asking the same question. What should the vision of JPGN be? It seems mandatory to provide the pediatric gastroenterologist with research and knowledge of gastrointestinal ontogenic function and malfunction during early life. It was hoped that the Journal would serve as an intellectual stimulus and an international forum for the presentation and discussion of advances and controversies within the discipline. The findings of differential timing of the expression of the genes controlling various small intestinal disaccharidases, pancreatic exocrine enzymes, and so on, led to a new practical paradigm on gut development (2). The paradigm included interaction of genetic endowment, gene expression, intrinsic biological clocks, endogenous regulatory mechanisms of the hypothalamic-hypophysial-thyroid-adrenal axis, gastrointestinal receptors and mediators, and environmental influences. The environmental influences affecting gut ontogeny included intrauterine growth retardation and malnutrition early in life (2). Barker (3) hypothesized that the effect of intrauterine growth retardation increases the risk of later-onset disease, particularly cardiovascular disease, hypertension, and type 2 diabetes mellitus in adults (3). The ontogeny of gut enzymes in early infancy and the recognition of pancreatic amylase deficiency and the early appearance of intestinal α-glucosidases and salivary amylase led to another ontogenic paradigm of alternate pathways of digestion and absorption in early infancy. The pragmatic outcome of ontogenic research was to use α-glucosides, such as sucrose, maltose, maltodextrins, and short polymers of glucose, during the neonatal period and for the compromised infant. Studies focused on the investigation and clinical applications of gastrointestinal ontogeny exemplify the early emphasis of JPGN. The potential for new therapeutic modalities attributable to age-related changes in the gut can stimulate clinical and basic research. The human genome project, the availability of stem cell biology, advances in molecular mechanisms of growth and development, and discoveries of mucosal growth factors and receptors that occurred as a result of the inception of JPGN have led to dramatic expansion of the basic, translational, and clinical studies in the Journal. We aspired to be one of the journals that publish original articles on gut ontogeny. In addition, we decided to invite ontogenic review articles that provided a basis for understanding the importance of gut ontogeny. Conversely, we were successful publishing age-related clinical studies in pediatric gastroenterology, with an emphasis on early life. An example of clinical disorders that we began to address successfully is celiac disease (CD). Clinical studies in CD emerged in the Journal, including global prevalence and high prevalence of silent preschool- and school-aged children, association with autoimmune disorders, Down syndrome, type 1 diabetes mellitus, and atypical presentations. Mechanistic studies of the effect of several genetic factors together with an environmental trigger were published. The genetic predisposition to CD was studied as a complex of HLA-DQA1*05/DQB1*02 and HLA-DQA*0301/DQB*0302 genes as major factors. Two strategies of genetic research—linkage and association studies—led to the discovery of several susceptibility loci and genes such as a region on 5q, MYO9B, and CTLA4. In addition, a genomewide association study identified 8 new risk regions, 7 of which harbour genes controlling the immune response. Again, we solicited review articles on genetic molecular biology research and the pathogenesis of CD. Another example for specific age-related clinical presentation and therapeutic considerations is failure to gain weight and short stature associated with pediatric inflammatory bowel disease (IBD). Pediatric IBD is different in some major aspects from adult IBD. Early-onset IBD has a distinct phenotype with disease manifestations that are primarily colonic with severe perianal disease and extragastrointestinal manifestations. Furthermore, early-onset IBD is unique in its association with metabolic diseases, neutrophil defects, immunodeficiency states, chronic granulomatous disease, and leukocyte adhesion defects. IBD is thought to result from a complex interplay of multiple genes and environmental factors. Large-scale genotyping techniques have resulted in identification of >30 IBD-associated genes. Pediatric IBD management must consider lifelong disease and treatment. Twenty-five percent of patients with IBD develop the disease in childhood and adolescence. Clinicians need to weigh the risks and benefits of selected therapies, particularly the effects of medications, such as steroids, on growth and development and lifetime of exposure. For the last 30 years, the Journal has published a significant number of articles addressing issues specifically focused on pediatric IBD. We realized that the greatest challenge facing JPGN was reaching out to the world in general and developing countries in particular. We solicited articles from developing countries and found worthwhile clinical observations, but we were challenged by the flaws of study design, such as inclusion and exclusion criteria, sample size, and statistical analyses; data presentation; results; and conclusions. We were confronted with English and grammatical mistakes, leading us to correct and rewrite articles, provided they had a sound scientific message for the pediatric gastroenterology community. A new dimension of the Journal was added when the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition started to develop and update clinical practice guidelines and recommendations (4,5). Overall, it is apparent that JPGN has evolved to become an important cornerstone for the discipline and a reference journal for the societies of pediatric gastroenterology, hepatology, and nutrition. My suggestion for the future is that the clinical research emphasizes acute and chronic gut diseases, all the while continuing to consider the effect of the ontogeny of the gut. In the quest to improve the knowledge of pediatric gastroenterology and nutrition, we should develop new areas of focus and analysis, perspectives, policy forums, and technical comments, similar to the journal Science. Presentation of the basic science news on the ontogeny of the gut, including cell biology, genetics, and immunology, should be a stimulus for inquiry and research to advance the frontiers of pediatric gastroenterology.
Indexed:American Chemical Society's Chemical Abstracts Service (CAS)PubMed (files to appear soon)MedLineScience Citation Expanded (also known as SciSearch®Current Contents®/Clinical MedicineJournal Citation Reports/Science EditionISSN 1176-9114 (Print)ISSN 1178-2013 (Online)An international, peer-reviewed journal focusing on the application of nanotechnology in diagnostics, therapeutics, and drug delivery systems throughout the biomedical field. Reflecting the growing activity in this emerging specialty, the aim of this journal is to highlight research and development leading to potential clinical applications in the prevention and treatment of disease.Key benefitsConcise rapid reportingFocus on basic science, engineering, and nanotechnologyExisting and potential clinical applicationsInternational scopeAn international, peer-reviewed journal of basic science, engineering, diagnostics, and pharmaceutical and clinical development focusing on concise rapid reporting of original research and reviews in nanomedicine. Special attention will be given to papers reporting on actual or potential clinical applications leading to improved prevention or treatment of disease or a greater understanding of pathological processes.Subject areas include:Application of nanotechnology in the diagnosis, prevention, and treatment of disease Diagnostic tools, analytical techniques, including biochips, microarrays, biosensors, molecular sensors, nanoprobes, nanoscale genomic and proteomic research, and nanoimaging Nanodevices and nanomaterials, including nanotubes, fullerenes, biomedical microsystems, device miniaturization, cellular and tissue engineering, nano bioresponsive systems (diagnostic and drug delivery devices), and medical nanorobotics Nanodrug complexes and drug delivery systems including polymer therapeutics (eg, pegylated proteins, polymer drug conjugates, polymeric drugs) for improved drug, protein, or gene transport and targeting Specific focus on development and clinical use from the perspectives of safety, efficacy, economics, and ultimate patient uptake. These areas are addressed through:Original research (full papers and concise rapid reports) Reviews Systematic reviews of individual agents, systems or devices Letters to the editor Expert opinion and commentary.
Aerobiology is usually understood to be the study of passively airborne micro-organisms-of their identity, behaviour, movements, and survival.One characteristic, which it shares with many other population studies in biology, is that the ultimate relevant unit consists of the individual cell or small group of cells.Analysis at the molecular or sub-atomic level is irrelevant to our present purpose.Like geography, aerobiology is an agglutinative study, drawing information from many kinds of scientific research.Although it already has its patron saint, Pierre Miquel, and its martyr, Fred C. Meier, aerobiology is best regarded as an activity whose material will in due course be incorporated into the main body of bio- logical science-without, I hope, any necessity for splinter societies, journals, and international conferences.This book amplifies and extends a course of Intercollegiate Lectures given to botanical students in the University of London in 1956.The theme, which has occupied me for over fifteen years, is as follows.Trans- port through the atmosphere is the main dispersal route for such organic particles as the spores of many micro-organisms.How do the properties of the atmosphere, and the properties of these particles themselves, affect their dispersal?How do the particles get into the air?How far, and in what numbers, are they dispersed?By what processes do they become grounded, so that they can continue growth ?What is in the air, and how can we measure it ?What are the practical consequences of this process for the micro-organisms themselves, and for man, other animals, vegetation, and crops ?Although there are one or two other books on airborne microbes, this is the first to treat the subject as a world-wide phenomenon.It is, perhaps, inevitable that it should be attempted by a mycologist.Few other biologists find their material so dominated by the atmosphere, and no other micro- organisms have so thoroughly exploited the possibilities of aerial dispersal as the fungi.One of the fascinations of the subject is the impact of facets of its knowledge on such apparently diverse topics as artificial rain-making, allergy, smoke screens, effluent of nuclear power-stations, crop protection, icing of aircraft, air hygiene, and many other topics.This book treats of the development and principles of aerobiology rather than applications; yet the stimulus to nearly all aerobiological work comes from applied science.In this book the term 'microbe' is used freely when a general word is wanted; but, like the word 'spore', it has admittedly been stretched beyond its normal meaning.Airborne pollen of flowering plants must be Included and is safely covered by the term 'spore' (botanically : 'micro- spore') ; but are pollen grains and mushroom spores microbes ?There is no other commonly accepted word that covers quite what is meant by the word 'spore' as used here: 'propagule', 'disseminule', 'biota', 'diaspore'?We have isolated part of the continuum for study but find we are not well- equipped verbally for the task of dealing with it.The microbial population of the atmosphere is referred to here as the 'air-spora', using 'spora' as a word analagous to 'flora' and 'fauna'.Botanical nomenclature has presented some difficulties: authorities have not been given for specific names, and the names used by other authors have usually been quoted as given in the original papers-without necessarily attempting to guess what was meant, or following the nomenclature fashionable in i960.I have converted other workers' numerical data to the metric system, and temperature to the Centigrade scale, to aid comparison, and have moreover assessed spore concentrations on the uniform basis of number per cubic metre.Frequently, in making general statements, I have omitted safeguarding, but tedious, escape clauses: this has been done to spare the reader who will understand that biological generalizations aboun-d in exceptions and complexities.Interpretations in this book are mostly my own responsibility, but I am
The Editors of the International Journal of Molecular Sciences have established the Best Paper Award to recognize the most outstanding articles published in the areas of molecular biology, molecular physics and chemistry that have been published in the International Journal of Molecular Sciences. The prizes have been awarded annually since 2012 [...].
The Editors of the International Journal of Molecular Sciences have established the Best Paper Award to recognize the most outstanding articles published in the areas of molecular biology, molecular physics, and chemistry that have been published in the International Journal of Molecular Sciences [...].
The International Journal of Plant, Animal and Environmental Sciences [IJPAES] is a peer reviewed multi-disciplinary an online international journal to promote all fields of Anatomy, Agronomy, Ecology, Biodiversity, Pathology, Entomology, Forest biology Economic Botany, Morphology, Cell and Tissue Culture, Genetics, Phytochemistry, Paleobotany, Horticulture, Cell biology, Molecular Biology, EcoPhysiology, Conservation Biology, Reproductive Biology, Taxonomy, Palaeontology, Anthropology, Biochemistry, Biotechnology, Microbiology, Proteomics, Genomics, Immunology, Pathology, Mammalogy, Nemotalogy, Helminthology, Paracytology, Virology, Mycology, Bacteriology, Animal Breeding, Behavior reproduction, Husbandry, Meat Science, Cloning, Nutrition, Health and Welfare, Environmental Sciences, Environmental chemistry, Environmental Biology, Ecology, Geosciences, Abatement technology, Environmental Physics, Aquatic Environment, Polloution, Environmental health study, Natural resources, Toxicology, Environment, Climate change, Remote sensing Human Biology, Stem Cells, Evolutionary Biology, Endocrinology, Endangered Plants, Immunopathology and Hydrology. IJPAES welcomes research articles, review articles, short communications from Scientists, Biologists and Research scholars involved in Plant, Animal and Environmental Sciences and all other related areas from all over the world to publish high quality and refereed papers.
International Journal of Molecular Science is instituting an annual award to recognize the outstanding papers in the area of chemistry, molecular physics and molecular biology published in the International Journal of Molecular Science. [...]