搜索结果：International archives of allergy and applied immunology

The Archives of Photographic PLates for Astronomical USE (APPLAUSE) project is aimed at digitising astronomical photographic plates from three major German plate collections, making them accessible through integration into the International Virtual Observatory (IVO). Photographic plates and related materials (logbooks, envelopes, etc.) were scanned with commercial flatbed scanners. Astrometric and photometric calibrations were carried out with the developed PyPlate software, using Gaia EDR3 data as a reference. The APPLAUSE data publication complies with IVO standards. The latest data release contains images and metadata from 27 plate collections from the partner institutes in Hamburg, Bamberg, and Potsdam, along with digitised archives provided by Tautenburg, Tartu, and Vatican observatories. Altogether, over two billion calibrated measurements extracted from about 70,000 direct photographic plates can readily be used to create long-term light curves. For instance, we constructed the historic light curve of the enigmatic dipping star KIC 8462852. We found no evidence of previously assumed variations on timescales of decades in our light curve. Potential uses of APPLAUSE images for

The digitization of displaced archives is of great historical and cultural significance. Through the construction of digital humanistic platforms represented by MISS platform, and the comprehensive application of IIIF technology, knowledge graph technology, ontology technology, and other popular information technologies. We can find that the digital framework of displaced archives built through the MISS platform can promote the establishment of a standardized cooperation and dialogue mechanism between the archives authoritiess and other government departments. At the same time, it can embed the works o fichives ction of digital government and the economy, promote the exploration of the integration of archives management, data management, and information resource management, and ultimately promote the construction of a digital society. By fostering a new partnership between archives departments and enterprises, think tanks, research institutes, and industry associations, the role of multiple social subjects in the modernization process of the archives governance system and governance capacity will be brought into play. The National Archives Administration has launched a special oper

The article examines the theoretical, methodological, and technical foundations of research on audiovisual corpora within the field of digital humanities. It outlines the main transversal issues underlying the processes of constructing, exploiting, and interpreting such corpora, which are conceived as specific forms of textual data in the broad sense - that is, as sets of semiotic traces (written, visual, sound, or multimodal) that make it possible to document, analyze, and transmit domains of knowledge. The analysis is organized around five complementary themes. The first concerns the status and structure of textual data lato sensu: any data, regardless of its medium, participates in a meaningful representation of a domain and therefore requires a unified theoretical and methodological framework based on a transdisciplinary semiotic approach. The second theme addresses the documentary value of data and corpora, understood as the relevance of materials for documenting a research object in relation to the goals and perspectives of the projects in which they are used. This value depends both on provenance and reasoned selection, and on the pragmatic context of their use. The third th

Within the archival sector, digitization has long been a strategic initiative to ensure greater availability of historical documents. In recent years, the promotion of guidelines and standards, combined with technological advancements, has established methodologies and best practices and developed tools to facilitate massive digitization projects. However, despite the availability of technological solutions and guidelines, digitization is intended mostly to scan documents and make the outcome images available online. This practice can be problematic in representing the complex fonds structure made of relations, the archival bond that establishes the natural ordering of documents into archival units. This is particularly relevant when the fonds also has a multimedia component, such as an audiovisual component, that is often reproduced on different platforms disconnected from textual documents. This article addresses the challenges linked to digitization in the archival sector and proposes a methodological framework for representing fonds with respect to their native organization. For this purpose, the International Image Interoperability Framework (IIIF) is employed to configure a s

In a recent article [Phys. Rev. Applied 6, 014017 (2016)], Chyba and Hand propose a new scheme to generate electric power continuously at the expense of Earth's kinetic energy of rotation, by using an appropriately shaped cylindrical shell of a well chosen conducting ferrite, rigidly attached to the Earth. No experimental confirmation is reported for the new prediction. In the present Refutation, I first use today's standard electromagnetism and essentially the same model as Chyba and Hand to show in a very simple way that no device of the proposed type can produce continuous electric power, whatever its configuration or size, in agreement with widespread expectation. Next, I show that the prediction of non-zero continuous power by Chyba and Hand results from a confusion of frames of reference at a critical step of their derivation. When the confusion is clarified, the prediction becomes exactly zero and the article under discussion appears as pointless. At the end, I comment about the persistent invocation by Chyba and Hand of the misleading legacy notion that quasi-static magnetic fields have an intrinsic velocity, and other questionable concepts.

We attempt to set a mathematical foundation of immunology and amino acid chains. To measure the similarities of these chains, a kernel on strings is defined using only the sequence of the chains and a good amino acid substitution matrix (e.g. BLOSUM62). The kernel is used in learning machines to predict binding affinities of peptides to human leukocyte antigens DR (HLA-DR) molecules. On both fixed allele (Nielsen and Lund 2009) and pan-allele (Nielsen et.al. 2010) benchmark databases, our algorithm achieves the state-of-the-art performance. The kernel is also used to define a distance on an HLA-DR allele set based on which a clustering analysis precisely recovers the serotype classifications assigned by WHO (Nielsen and Lund 2009, and Marsh et.al. 2010). These results suggest that our kernel relates well the chain structure of both peptides and HLA-DR molecules to their biological functions, and that it offers a simple, powerful and promising methodology to immunology and amino acid chain studies.

We investigate how ideas from the International Environmental Agreement (IEA) literature can be applied to the problem of space debris mitigation. The problem of space debris is similar to other international environmental problems in that there is a potential for a tragedy of the commons effect--individual nations bear all the cost of their mitigation measures but share only a fraction of the benefit. Consequently, nations have a tendency to underinvest in mitigation. Coalitions of nations, brought together by IEAs, have the potential to lessen the tragedy of the commons effect by pooling the costs and benefits of mitigation. This work brings together two recent modeling advances: i) a game theoretic model for studying the potential gains from IEA cooperation between nations with asymmetric costs and benefits, ii) an orbital debris model that gives the societal cost that specific actions, such as failing to deorbit an inactive satellite, have on the environment. We combine these two models with empirical launch share data for a "proof of concept" of an IEA for a single mitigation measure, deorbiting spacecraft at the end of operational lifetime. Simulations of all possible coaliti

Web archiving is the process of collecting portions of the Web to ensure that the information is preserved for future exploitation. However, despite the increasing number of web archives worldwide, the absence of efficient and meaningful exploration methods still remains a major hurdle in the way of turning them into a usable and useful information source. In this paper, we focus on this problem and propose an RDF/S model and a distributed framework for building semantic profiles ("layers") that describe semantic information about the contents of web archives. A semantic layer allows describing metadata information about the archived documents, annotating them with useful semantic information (like entities, concepts and events), and publishing all this data on the Web as Linked Data. Such structured repositories offer advanced query and integration capabilities, and make web archives directly exploitable by other systems and tools. To demonstrate their query capabilities, we build and query semantic layers for three different types of web archives. An experimental evaluation showed that a semantic layer can answer information needs that existing keyword-based systems are not able

Every year many scholars are funded by the China Scholarship Council (CSC). The CSC is a funding agency established by the Chinese government with the main initiative of training Chinese scholars to conduct research abroad and to promote international collaboration. In this study, we identified these CSC-funded scholars sponsored by the China Scholarship Council based on the acknowledgments text indexed by the Web of Science. Bibliometric data of their publications were collected to track their scientific mobility in different fields, and to evaluate the performance of the CSC scholarship in promoting international collaboration by sponsoring the mobility of scholars. Papers funded by the China Scholarship Council are mainly from the fields of natural sciences and engineering sciences. There are few CSC-funded papers in the field of social sciences and humanities. CSC-funded scholars from mainland China have the United States, Australia, Canada, and some European countries, such as Germany, the UK, and the Netherlands, as their preferential mobility destinations across all fields of science. CSC-funded scholars published most of their papers with international collaboration during

Web archives are a historically valuable source of information. In some respects, web archives are the only record of the evolution of human society in the last two decades. They preserve a mix of personal and collective memories, the importance of which tends to grow as they age. However, the value of web archives depends on their users being able to search and access the information they require in efficient and effective ways. Without the possibility of exploring and exploiting the archived contents, web archives are useless. Web archive access functionalities range from basic browsing to advanced search and analytical services, accessed through user-friendly interfaces. Full-text and URL search have become the predominant and preferred forms of information discovery in web archives, fulfilling user needs and supporting search APIs that feed complex applications. Both full-text and URL search are based on the technology developed for modern web search engines, since the Web is the main resource targeted by both systems. However, while web search engines enable searching over the most recent web snapshot, web archives enable searching over multiple snapshots from the past. This m

Hydraulic systems have been one of the most used technologies in many industries due to their reliance on incompressible fluids that facilitate energy and power transfer. Within such systems, hydraulic cylinders are prime devices that convert hydraulic energy into mechanical energy. Some of the genuine and very common problems related to hydraulic cylinders are leakages. Leakage in hydraulic systems can cause a drop in pressure, general inefficiency, and even complete failure of such systems. The various ways leakage can occur define the major categorization of leakage: internal and external leakage. External leakage is easily noticeable, while internal leakage, which involves fluid movement between pressure chambers, can be harder to detect and may gradually impact system performance without obvious signs. When leakage surpasses acceptable limits, it is classified as a fault or failure. In such cases, leakage is divided into three categories: no leakage, low leakage, and high leakage. It suggests a fault detection algorithm with the basic responsibility of detecting minimum leakage within the Hydraulic system, and minimizing detection time is the core idea of this paper. In order

We present a methodology providing a one-directional link from within-host individual heterogeneity to population-level disease transmission dynamics. The methodology works in several steps. A within-host model is investigated numerically to determine pathogen and immunological parameters leading to the largest variation of model responses. These key parameters are used to generate a synthetic population of individuals whose temporal immunological response profiles are recorded. These responses are ranked in terms of the severity of experienced outcomes, from mild infections to death, as a function of time since infection. This is used to parametrise an age-of-infection structured epidemiological model to study the transmission dynamics of the disease at the population level. The approach is illustrated using a within-host model describing SARS-CoV-2 infection and an SIR population-level model.

For over a century, immunology has masterfully discovered and dissected the components of our immune system, yet its collective behavior remains fundamentally unpredictable. In this perspective, we argue that building on the learnings of reductionist biology and systems immunology, the field is poised for a third revolution. This new era will be driven by the convergence of purpose-built, large-scale causal experiments and predictive, generalizable AI models. Here, we propose the Predictive Immunology Loop as the unifying engine to harness this convergence. This closed loop iteratively uses AI to design maximally informative experiments and, in turn, leverages the resulting data to improve dynamic, in silico models of the human immune system across biological scales, culminating in a Virtual Immune System. This engine provides a natural roadmap for addressing immunology's grand challenges, from decoding molecular recognition to engineering tissue ecosystems. It also offers a framework to transform immunology from a descriptive discipline into one capable of forecasting and, ultimately, engineering human health.

In an era where astronomical data is expanding at an unprecedented rate, the importance of data sharing and accessibility among astronomy archives cannot be overstated. Since the 1990s, an international partnership between the Space Telescope Science Institute (STScI), the European Space Astronomy Centre (ESAC), and the Canadian Astronomy Data Centre (CADC) has been focused on this endeavor, facilitating the exchange of data from the Hubble and James Webb Space Telescopes. We will present how this collaboration has evolved over time, highlighting key milestones and innovations in decision-making, communication, and technology. Additionally, we will discuss some of the challenges we have encountered and the strategies we employed to overcome them, offering insights that could benefit future archive collaborations.

Current systems used by the Tunisian national archives for the automatic transcription of archival documents are hindered by many issues related to the performance of the optical character recognition (OCR) tools. Indeed, using a classical OCR system to transcribe and index ancient Arabic documents is not a straightforward task due to the idiosyncrasies of this category of documents, such as noise and degradation. Thus, applying an enhancement method or a denoising technique remains an essential prerequisite step to ease the archival document image analysis task. The state-of-the-art methods addressing the use of degraded document image enhancement and denoising are mainly based on applying filters. The most common filtering techniques applied to color images in the literature may be categorized into four approaches: scalar, marginal, vector and hybrid. To provide a set of comprehensive guidelines on the strengths and weaknesses of these filtering approaches, a thorough comparative study is proposed in this article. Numerical experiments are carried out in this study on color archival document images to show and quantify the performance of each assessed filtering approach.

The study of immune cellular composition has been of great scientific interest in immunology because of the generation of multiple large-scale data. From the statistical point of view, such immune cellular data should be treated as compositional. In compositional data, each element is positive, and all the elements sum to a constant, which can be set to one in general. Standard statistical methods are not directly applicable for the analysis of compositional data because they do not appropriately handle correlations between the compositional elements. In this paper, we review statistical methods for compositional data analysis and illustrate them in the context of immunology. Specifically, we focus on regression analyses using log-ratio transformations and the generalized linear model with Dirichlet distribution, discuss their theoretical foundations, and illustrate their applications with immune cellular fraction data generated from colorectal cancer patients.

A previous study of symmetric collisions of massive nuclei has shown that current models of multi-nucleon transfer (MNT) reactions do not adequately describe the transfer product yields. To gain further insight into this problem, we have measured the yields of MNT products in the interaction of 977 (E/A = 4.79 MeV) and 1143 MeV (E/A = 5.60 MeV) $^{204}$Hg with $^{208}$Pb. We find that the yield of multi-nucleon transfer products are similar in these two reactions and are substantially lower than those observed in the reaction of 1257 MeV (E/A = 6.16 MeV) $^{204}$Hg + $^{198}$Pt. We compare our measurements with the predictions of the GRAZING-F, di-nuclear systems (DNS) and improved quantum molecular dynamics (ImQMD) models. For the observed isotopes of the elements Au, Hg, Tl, Pb and Bi, the measured values of the MNT cross sections are orders of magnitude larger than the predicted values. Furthermore, the various models predict the formation of nuclides near the N=126 shell, which are not observed.

Optical clocks have improved their frequency stability and estimated accuracy by more than two orders of magnitude over the best caesium microwave clocks that realise the SI second. Accordingly, an optical redefinition of the second has been widely discussed, prompting a need for the consistency of optical clocks to be verified worldwide. While satellite frequency links are sufficient to compare microwave clocks, a suitable method for comparing high-performance optical clocks over intercontinental distances is missing. Furthermore, remote comparisons over frequency links face fractional uncertainties of a few $10^{-18}$ due to imprecise knowledge of each clock's relativistic redshift, which stems from uncertainty in the geopotential determined at each distant location. Here, we report a landmark campaign towards the era of optical clocks, where, for the first time, state-of-the-art transportable optical clocks from Japan and Europe are brought together to demonstrate international comparisons that require neither a high-performance frequency link nor information on the geopotential difference between remote sites. Conversely, the reproducibility of the clocks after being transporte

Archives are facing numerous challenges. On the one hand, archival assets are evolving to encompass digitized documents and increasing quantities of born-digital information in diverse formats. On the other hand, the audience is changing along with how it wishes to access archival material. Moreover, the interoperability requirements of cultural heritage repositories are growing. In this context, the Portuguese Archives started an ambitious program aiming to evolve its data model, migrate existing records, and build a new archival management system appropriate to both archival tasks and public access. The overall goal is to have a fine-grained and flexible description, more machine-actionable than the current one. This work describes ArchOnto, a linked open data model for archives, and rules for its automatic population from existing records. ArchOnto adopts a semantic web approach and encompasses the CIDOC Conceptual Reference Model and additional ontologies, envisioning interoperability with datasets curated by multiple communities of practice. Existing ISAD(G)-conforming descriptions are being migrated to the new model using the direct mappings provided here. We used a sample of