搜索结果：Immunity & ageing : I & A

Immunoglobulin levels in saliva, serum and gastrointestinal perfusates were measured in groups of ageing CDF (F-344)Cr1BR rats. Four age groups were studied, including: (i) weanling (21-35 days), (ii) adult (3-4 months), (iii) midlife (10-12 months), and (iv) senescent (18-20 months). There was no difference in the mean salivary volume and protein levels in the three older groups of rats. Salivary IgA in the weanling rats was significantly lower, having not yet attained adult levels, while salivary IgG was decreased in the senescent group. No IgM was detected in saliva from any of the animals. Serum IgM was elevated in the midlife and senescent rats. In contrast, serum IgG was significantly decreased in the senescent group when compared to the adult or midlife animals. Significant elevations were noted in serum and intestinal perfusate IgA in the senescent rats when compared to the adult group. While salivary IgA from all groups was shown to be greater than 95% polymeric, only the weanling and senescent groups exhibited a tendency toward predominantly polymeric serum IgA (67-70%). The results define altered immunoglobulin profiles in aged rats in both secretory and systemic fluids, which could affect the immunocompetence of these animals.

This is the third paper of the set recording the results of the suite of tests of general relativity (GR) performed on the signals from the fourth Gravitational-Wave Transient Catalog (GWTC-4.0), where we focus on the remnants of the binary mergers. We examine for the first time 42 events from the first part of the fourth observing run of the LIGO-Virgo-KAGRA detectors, alongside events from the previous observation runs, restricting our analysis to the confident signals, which were measured in at least two detectors and that have false alarm rates $\le 10^{-3} \mathrm{yr}^{-1}$. This paper focuses on seven tests of the coalescence remnants. Three of these are tests of the ringdown and its consistency with the expected quasinormal mode spectrum of a Kerr black hole. Specifically, two tests analyze just the ringdown in the time domain, and the third test analyzes the entire signal in the frequency domain. Four tests allow for the existence of possible echoes arriving after the end of the ringdown, which are not expected in GR. We find overall consistency of the remnants with GR. When combining events by multiplying likelihoods (hierarchically), one analysis finds that the GR predict

Version 5.0 of the Gravitational-Wave Transient Catalog (GWTC-5.0) adds new candidates detected by the LIGO Virgo KAGRA network of observatories through the second part of the fourth observing run (O4b: 2024 April 10 15:00:00 to 2025 January 28 17:00:00 UTC) and four days of the preceding engineering run (2024 April 6 to 2024 April 10). We find 161 compact binary coalescence candidates that are identified by at least one of our search algorithms with a probability of astrophysical origin $p_\mathrm{astro} \geq 0.5$ and that are not vetoed during event validation. We also provide detailed source property measurements for 104 candidates that have a false-alarm rate < 1yr$^{-1}$. Based on the inferred component masses, all these candidates are consistent with signals from binary black holes. Median inferred component masses in the new candidates range from 5.14$M_\odot$ (GW241109_115924) to 70$M_\odot$ (GW241116_151753). Improvements in detector sensitivity allow us to observe compact binary coalescences with increasing clarity: 5 binary-black-hole signals have network signal-to-noise ratio exceeding 30, with a maximum to date of 76.9 for GW250114_082203. Such loud signals enable m

LIGO, Virgo, KAGRA, and GEO 600 form a network of gravitational-wave observatories. Data and analysis results from this network are made publicly available through the Gravitational Wave Open Science Center (GWOSC). This paper describes open data from this network, including the addition of data from the second part of the fourth observing run (O4b) and selected periods from the preceding engineering run (ER16), which were collected from times spanning April 6th, 2024 to January 28th, 2025. The public data set includes calibrated strain time series for each instrument, data from additional channels used for noise subtraction and detector characterization, and new analysis data products in the online GWOSC release associated with version 5.0 of the Gravitational-Wave Transient Catalog.

The Gravitational-Wave Transient Catalog (GWTC) is a collection of short-duration (transient) gravitational-wave signals identified by the LIGO-Virgo-KAGRA Collaboration in gravitational-wave data produced by the eponymous detectors. The catalog provides information about the identified candidates, such as the arrival time and amplitude of the signal and properties of the signal's source as inferred from the observational data. GWTC is the release of this dataset and version 5.0 extends the catalog to include observations made during the second part of the fourth LIGO-Virgo-KAGRA observing run up until 2025 January 28. This paper marks an introduction to a collection of articles related to this version of the catalog, GWTC-5.0. This update significantly increases the number of detected merging binary systems of black holes and neutron stars to over 300, enabling many follow-up studies toward understanding the gravitational-wave universe. The collection of articles accompanying the catalog provides documentation of the methods used to analyze the data, summaries of the catalog of events, observational measurements drawn from the population, and detailed discussions of selected candi

In this second of three papers on tests of general relativity (GR) applied to the compact binary coalescence signals in the fourth Gravitational-Wave Transient Catalog (GWTC-4.0), we present the results of the parameterized tests of GR and constraints on line-of-sight acceleration. We include events up to and including the first part of the fourth observing run (O4a) of the LIGO Virgo KAGRA detectors. As in the other two papers in this series, we restrict our analysis to the 42 confident signals, measured by at least two detectors, that have false alarm rates $\le 10^{-3} \mathrm{yr}^{-1}$ from O4a, in addition to the 49 such events from previous observing runs. This paper focuses on the eight tests that constrain parameterized deviations from the expected GR (or unaccelerated) values. These include modifications of post-Newtonian (PN) parameters, spin-induced quadrupole moments different from those of a binary black hole, and possible dispersive or birefringent propagation effects. Overall, we find no evidence for physics beyond GR, for spin-induced quadrupole moments different from those of a Kerr black hole in GR, or for line of sight acceleration, with more than 90% of the even

The Gravitational-Wave Transient Catalog (GWTC) is a collection of candidate gravitational-wave transient signals identified and characterized by the LIGO-Virgo-KAGRA Collaboration. Producing the contents of the GWTC from detector data requires complex analysis methods. These comprise techniques to model the signal; identify the transients in the data; evaluate the quality of the data and mitigate possible instrumental issues; infer the parameters of each transient; compare the data with the waveform models for compact binary coalescences, and handle the large amount of results associated with all these different analyses. In this paper, we describe the methods employed to produce the catalog's fifth release, GWTC-5.0, focusing on the analysis of the second part of the fourth observing run of LIGO, Virgo and KAGRA.

GW240925 and GW250207 are two loud gravitational-wave signals from binary black hole coalescences observed with network signal-to-noise ratios $\sim 32$ and $\sim 69$, respectively, by the LIGO Hanford--LIGO Livingston--Virgo network. Gravitational-wave signals from coalescing binaries have characteristic phase and amplitude evolution predicted by general relativity. These signal waveforms, together with measured instrumental calibration uncertainties, are used to infer source parameters. However, for sufficiently loud detections it is possible to constrain the calibration of the detectors directly using the signals themselves. We present the first informative astrophysical measurements of gravitational-wave detector calibration. For GW240925, we verify the inference of Hanford calibration from the astrophysical signal through cross-checks with known calibration errors obtained from in-situ measurements. At the time of GW250207, the Hanford detector was not fully stabilized, leading to elevated calibration uncertainties; thus, astrophysical calibration is essential to obtain accurate data and to enable source localization. These well-localized, high signal-to-noise observations hav

The worldwide LIGO-Virgo-KAGRA network of gravitational-wave (GW) detectors continues to increase in sensitivity, thus increasing the quantity and quality of the detected GW signals from compact binary coalescences. These signals allow us to perform ever-more sensitive tests of general relativity (GR) in the dynamical and strong-field regime of gravity. This paper is the first of three, where we present the results of a suite of tests of GR using the binary signals included in the fourth GW Transient Catalog (GWTC-4.0), i.e., up to and including the first part of the fourth observing run of the detectors (O4a). We restrict our analysis to the 91 confident signals, henceforth called events, that were measured by at least two detectors, and have false alarm rates $\le 10^{-3} \mathrm{yr}^{-1}$. These include 42 events from O4a. This first paper presents an overview of the methods, selection of events and GR tests, and serves as a guidemap for all three papers. Here we focus on the four general tests of consistency, where we find no evidence for deviations from our models. Specifically, for all the events considered, we find consistency of the residuals with noise. The final mass and

We report on a gravitational wave search for compact binary coalescences involving at least one component with mass between $0.2 M_\odot$ to $1 M_\odot$, and ratio of component masses between 0.1 and 1. The analysis uses data collected by the LIGO detectors between May 24 2023 15:00 UTC and January 16 2024 16:00 UTC. No statistically significant sub-solar mass candidates were identified by the participating search algorithms. We report the detection sensitivity of the current searches to the target sub-solar mass black hole population, while also reporting the sensitivity of the search to low-mass neutron star binaries for the first time. With the absence of detections, we place upper limits on the merger rate of sub-solar mass black holes, ranging from $110$ $\mathrm{Gpc^{-3}yr^{-1}}$ to $10000$ $\mathrm{Gpc^{-3}yr^{-1}}$ at 90% confidence. We use the merger rate limits to constrain two illustrative dark matter scenarios that can form sub-solar mass compact objects: primordial black holes, and dark black holes forming in a dissipative dark matter model. For late-forming primordial black hole binaries, our search excludes the fraction of dark matter in primordial black holes to be

The Gravitational-Wave Transient Catalog (GWTC) is a collection of short-duration (transient) gravitational wave signals identified by the LIGO-Virgo-KAGRA Collaboration in gravitational-wave data produced by the eponymous detectors. The catalog provides information about the identified candidates, such as the arrival time and amplitude of the signal and properties of the signal's source as inferred from the observational data. GWTC is the data release of this dataset and version 4.0 extends the catalog to include observations made during the first part of the fourth LIGO-Virgo-KAGRA observing run up until 2024 January 31. This paper marks an introduction to a collection of articles related to this version of the catalog, GWTC-4.0. The collection of articles accompanying the catalog provides documentation of the methods used to analyze the data, summaries of the catalog of events, observational measurements drawn from the population, and detailed discussions of selected candidates

The Proton Improvement Plan (PIP-II) to the FNAL accelerator chain and the Long-Baseline Neutrino Facility (LBNF) will provide the world's most intense neutrino beam to the Deep Underground Neutrino Experiment (DUNE) enabling a wide-ranging physics program. This document outlines the significant contributions made by European national laboratories and institutes towards realizing the first phase of the project with a 1.2 MW neutrino beam. Construction of this first phase is well underway. For DUNE Phase II, this will be closely followed by an upgrade of the beam power to > 2 MW, for which the European groups again have a key role and which will require the continued support of the European community for machine aspects of neutrino physics. Beyond the neutrino beam aspects, LBNF is also responsible for providing unique infrastructure to install and operate the DUNE neutrino detectors at FNAL and at the Sanford Underground Research Facility (SURF). The cryostats for the first two Liquid Argon Time Projection Chamber detector modules at SURF, a contribution of CERN to LBNF, are central to the success of the ongoing execution of DUNE Phase I. Likewise, successful and timely procurem

The discovery of joint sources of high-energy neutrinos and gravitational waves has been a primary target for the LIGO, Virgo, KAGRA, and IceCube observatories. The joint detection of high-energy neutrinos and gravitational waves would provide insight into cosmic processes, from the dynamics of compact object mergers and stellar collapses to the mechanisms driving relativistic outflows. The joint detection of multiple cosmic messengers can also elevate the significance of the common observation even when some or all of the constituent messengers are sub-threshold, i.e. not significant enough to declare their detection individually. Using data from the LIGO, Virgo, and IceCube observatories, including sub-threshold events, we searched for common sources of gravitational waves and high-energy neutrinos during the third observing run of Advanced LIGO and Advanced Virgo detectors. Our search did not identify significant joint sources. We derive constraints on the rate densities of joint sources. Our results constrain the isotropic neutrino emission from gravitational-wave sources for very high values of the total energy emitted in neutrinos (> $10^{52} - 10^{54}$ erg).

We present results from an all-sky search for continuous gravitational waves, using three different methods applied to the first eight months of LIGO data from the fourth LIGO-Virgo-KAGRA Collaboration s observing run. We aim at signals potentially emitted by rotating, non-axisymmetric isolated neutron star in the Milky Way. The analysis spans a frequency range from 20 Hz to 2000 Hz and accommodates frequency derivative magnitudes up to $10^{-8}$ Hz/s. No statistically significant periodic gravitational wave signals were detected. We establish 95% confidence-level (CL) frequentist upper limits on the dimensionless strain amplitudes. The most stringent population-averaged strain upper limits reach 9.7 $\times$ $10^{-26}$ near 290 Hz, matching the best previous constraints from 250 to $\sim$1700 Hz while extending coverage to a much broader spin-down range. At higher frequencies, the new limits improve upon previous results by factors of approximately $\sim$1.6. These constraints are applied to three astrophysical scenarios: 1) the distribution of galactic neutron stars as a function of spin frequency and ellipticity; 2) the contribution of millisecond pulsars to the GeV excess near

Rotating non-axisymmetric neutron stars (NSs) are promising sources for continuous gravitational waves (CWs). Such CWs can, if detected, inform us about the internal structure and equation of state of NSs. Here, we present a narrowband search for CWs from known pulsars, for which an efficient and sensitive matched-filter search can be applied. Narrowband searches are designed to be robust to mismatches between the electromagnetic (EM) and gravitational emissions, in contrast to fully targeted searches where the CW emission is assumed to be phase-locked to the EM one. In this work, we search for the CW counterparts emitted by 34 pulsars using data from the first and second parts of the fourth LIGO--Virgo--KAGRA observing run. This is the largest number of pulsars so far targeted for narrowband searches in the advanced detector era. We use the 5n-vector narrowband pipeline, which applies frequency-domain matched filtering. In previous searches, it covered a narrow range in the frequency -- frequency time derivative ($f$ -- $\dot{f}$) space. Here, we also explore a range in the second time derivative of the frequency $\ddot{f}$ around the value indicated by EM observations. Additional

We present results from directed searches for continuous gravitational waves from a sample of 15 nearby supernova remnants, likely hosting young neutron star candidates, using data from the first eight months of the fourth observing run (O4) of the LIGO-Virgo-KAGRA Collaboration. The analysis employs five pipelines: four semi-coherent methods -- the Band-Sampled-Data directed pipeline, Weave and two Viterbi pipelines (single- and dual-harmonic) -- and PyStoch, a cross-correlation-based pipeline. These searches cover wide frequency bands and do not assume prior knowledge of the targets' ephemerides. No evidence of a signal is found from any of the 15 sources. We set 95\% confidence-level upper limits on the intrinsic strain amplitude, with the most stringent constraints reaching $\sim 4 \times 10^{-26}$ near 300 Hz for the nearby source G266.2$-$1.2 (Vela Jr.). We also derive limits on neutron star ellipticity and $r$-mode amplitudes for the same source, with the best constraints reaching $\lesssim 10^{-7}$ and $\lesssim 10^{-5}$, respectively, at frequencies above 400 Hz. These results represent the most sensitive wide-band directed searches for continuous gravitational waves from

Volume 3 of the FCC Feasibility Report presents studies related to civil engineering, the development of a project implementation scenario, and environmental and sustainability aspects. The report details the iterative improvements made to the civil engineering concepts since 2018, taking into account subsurface conditions, accelerator and experiment requirements, and territorial considerations. It outlines a technically feasible and economically viable civil engineering configuration that serves as the baseline for detailed subsurface investigations, construction design, cost estimation, and project implementation planning. Additionally, the report highlights ongoing subsurface investigations in key areas to support the development of an improved 3D subsurface model of the region. The report describes development of the project scenario based on the 'avoid-reduce-compensate' iterative optimisation approach. The reference scenario balances optimal physics performance with territorial compatibility, implementation risks, and costs. Environmental field investigations covering almost 600 hectares of terrain - including numerous urban, economic, social, and technical aspects - confirme

We present an all-sky search for long-duration gravitational waves (GWs) from the first part of the LIGO-Virgo-KAGRA fourth observing run (O4), called O4a and comprising data taken between 24 May 2023 and 16 January 2024. The GW signals targeted by this search are the so-called "long-duration" (> 1 s) transients expected from a variety of astrophysical processes, including non-axisymmetric deformations in magnetars or eccentric binary coalescences. We make minimal assumptions on the emitted GW waveforms in terms of morphologies and durations. Overall, our search targets signals with durations ~1-1000 s and frequency content in the range 16-2048 Hz. In the absence of significant detections, we report the sensitivity limits of our search in terms of root-sum-square signal amplitude (hrss) of reference waveforms. These limits improve upon the results from the third LIGO-Virgo-KAGRA observing run (O3) by about 30% on average. Moreover, this analysis demonstrates substantial progress in our ability to search for long-duration GW signals owing to enhancements in pipeline detection efficiencies. As detector sensitivities continue to advance and observational runs grow longer, unmodeled

The Gravitational-Wave Transient Catalog (GWTC) is a collection of candidate gravitational-wave transient signals identified and characterized by the LIGO-Virgo-KAGRA Collaboration. Producing the contents of the GWTC from detector data requires complex analysis methods. These comprise techniques to model the signal; identify the transients in the data; evaluate the quality of the data and mitigate possible instrumental issues; infer the parameters of each transient; compare the data with the waveform models for compact binary coalescences; and handle the large amount of results associated with all these different analyses. In this paper, we describe the methods employed to produce the catalog's fourth release, GWTC-4.0, focusing on the analysis of the first part of the fourth observing run of Advanced LIGO, Advanced Virgo and KAGRA.