搜索结果：Frontiers in bioscience (Landmark edition)

Landmarks have long played a pivotal role in automated planning, serving as crucial elements for improving the planning algorithms. The main limitation of classical landmark extraction methods is their sensitivity to specific planning tasks. This results in landmarks fully tailored to individual instances, thereby limiting their applicability across other instances of the same planning domain. We propose a novel approach that learns landmark relationships from multiple planning tasks of a planning domain. This leads to the creation of a \textit{probabilistic lifted ordering graph}, as a structure that captures weighted abstractions of relationships between parameterized landmarks. Although these orderings are not 100\% true (they are probabilistic), they can still be very useful in planning. Next, given a new planning task for that domain, we instantiate the relationships from that graph to this particular instance. This instantiation operates in two phases. First, it generates two graphs: the former instantiating information from the initial state and the latter from the goal state. Second, it combines these two graphs into one unified graph by searching equivalences to extract la

Test anxiety is beginning to be recognized as a significant factor affecting student performance in science, technology, engineering, and mathematics (STEM) courses, potentially contributing to gender inequity within these fields. Additionally, the management of test anxiety can improve self-efficacy, which is a construct that has been well studied in the physics context. In this study, we investigated the relationship between self-efficacy, test anxiety, and gender differences in performance in a two-semester-long introductory physics course sequence for bioscience students in which women outnumber men. Using validated survey data and grade information from students in a two-semester introductory physics course sequence, we compared the predictive power of self-efficacy and test anxiety on female and male students' performance on both low- and high-stakes assessments. We found that there were gender differences disadvantaging women in self-efficacy and test anxiety in both Physics 1 and Physics 2, as well as gender differences in high-stakes outcomes in Physics 1. There were no gender differences in low-stakes assessment scores. We also found that self-efficacy and test anxiety pr

In this study, we investigate student performance using grades and grade anomalies across periods before, during, and after COVID-19 remote instruction in courses for bioscience and health-related majors. Additionally, we explore gender equity in these courses using these measures. We define grade anomaly as the difference between a student's grade in a course of interest and their overall grade point average (GPA) across all other courses taken up to that point. If a student's grade in a course is lower than their GPA in all other courses, we refer to this as a grade penalty. Students received grade penalties in all courses studied, consisting of twelve courses taken by the majority of bioscience and health-related majors. Overall, we found that both grades and grade penalties improved during remote instruction but deteriorated after remote instruction. Additionally, we find more pronounced gender differences in grade anomalies than in grades. We hypothesize that women's decisions to pursue STEM careers may be more influenced by the grade penalties they receive in required science courses than men's, as women tend to experience larger penalties across all periods studied. Furtherm

Markerless biomechanics increasingly relies on 3D skeletal keypoints extracted from video, yet downstream biomechanical mappings typically treat these estimates as deterministic, providing no principled mechanism for frame-wise quality control. In this work, we investigate predictive uncertainty as a quantitative measure of confidence for mapping 3D pose keypoints to 3D anatomical landmarks, a critical step preceding inverse kinematics and musculoskeletal analysis. Within a temporal learning framework, we model both uncertainty arising from observation noise and uncertainty related to model limitations. Using synchronized motion capture ground truth on AMASS, we evaluate uncertainty at frame and joint level through error--uncertainty rank correlation, risk--coverage analysis, and catastrophic outlier detection. Across experiments, uncertainty estimates, particularly those associated with model uncertainty, exhibit a strong monotonic association with landmark error (Spearman $ρ\approx 0.63$), enabling selective retention of reliable frames (error reduced to $\approx 16.8$ mm at 10% coverage) and accurate detection of severe failures (ROC-AUC $\approx 0.92$ for errors $>50$ mm). R

Edit distance with moves (EDM) is a string-to-string distance measure that includes substring moves in addition to ordinal editing operations to turn one string to the other. Although optimizing EDM is intractable, it has many applications especially in error detections. Edit sensitive parsing (ESP) is an efficient parsing algorithm that guarantees an upper bound of parsing discrepancies between different appearances of the same substrings in a string. ESP can be used for computing an approximate EDM as the L1 distance between characteristic vectors built by node labels in parsing trees. However, ESP is not applicable to a streaming text data where a whole text is unknown in advance. We present an online ESP (OESP) that enables an online pattern matching for EDM. OESP builds a parse tree for a streaming text and computes the L1 distance between characteristic vectors in an online manner. For the space-efficient computation of EDM, OESP directly encodes the parse tree into a succinct representation by leveraging the idea behind recent results of a dynamic succinct tree. We experimentally test OESP on the ability to compute EDM in an online manner on benchmark datasets, and we show O

In this paper, we have proposed a new strategy of using the landmark anchor node instead of a radio-based anchor node to obtain the virtual coordinates (landmarkID, DISTANCE) of moving troops or defense forces that will help in tracking and maneuvering the troops along a safe path within a GPS-denied battlefield environment. The proposed strategy implements landmark recognition using the Yolov5 model and landmark distance estimation using an efficient Stereo Matching Algorithm. We consider that a moving node carrying a low-power mobile device facilitated with a calibrated stereo vision camera that captures stereo images of a scene containing landmarks within the battlefield region whose locations are stored in an offline server residing within the device itself. We created a custom landmark image dataset called MSTLandmarkv1 with 34 landmark classes and another landmark stereo dataset of those 34 landmark instances called MSTLandmarkStereov1. We trained the YOLOv5 model with MSTLandmarkv1 dataset and achieved 0.95 mAP @ 0.5 IoU and 0.767 mAP @ [0.5: 0.95] IoU. We calculated the distance from a node to the landmark utilizing the bounding box coordinates and the depth map generated b

The increasing diversity and scale of video data demand retrieval systems capable of multimodal understanding, adaptive reasoning, and domain-specific knowledge integration. This paper presents LLandMark, a modular multi-agent framework for landmark-aware multimodal video retrieval to handle real-world complex queries. The framework features specialized agents that collaborate across four stages: query parsing and planning, landmark reasoning, multimodal retrieval, and reranked answer synthesis. A key component, the Landmark Knowledge Agent, detects cultural or spatial landmarks and reformulates them into descriptive visual prompts, enhancing CLIP-based semantic matching for Vietnamese scenes. To expand capabilities, we introduce an LLM-assisted image-to-image pipeline, where a large language model (Gemini 2.5 Flash) autonomously detects landmarks, generates image search queries, retrieves representative images, and performs CLIP-based visual similarity matching, removing the need for manual image input. In addition, an OCR refinement module leveraging Gemini and LlamaIndex improves Vietnamese text recognition. Experimental results show that LLandMark achieves adaptive, culturally

Benchmarking the performance of complex systems such as rail networks, renewable generation assets and national economies is central to transport planning, regulation and macroeconomic analysis. Classical frontier methods, notably Data Envelopment Analysis (DEA) and Stochastic Frontier Analysis (SFA), estimate an efficient frontier in the observed input-output space and define efficiency as distance to this frontier, but rely on restrictive assumptions on the production set and only indirectly address heterogeneity and scale effects. We propose Geometric Manifold Analysis (GeMA), a latent manifold frontier framework implemented via a productivity-manifold variational autoencoder (ProMan-VAE). Instead of specifying a frontier function in the observed space, GeMA represents the production set as the boundary of a low-dimensional manifold embedded in the joint input-output space. A split-head encoder learns latent variables that capture technological structure and operational inefficiency. Efficiency is evaluated with respect to the learned manifold, endogenous peer groups arise as clusters in latent technology space, a quotient construction supports scale-invariant benchmarking, and

Recent multimodal models for instruction-based face editing enable semantic manipulation but still struggle with precise attribute control and identity preservation. Structural facial representations such as landmarks are effective for intermediate supervision, yet most existing methods treat them as rigid geometric constraints, which can degrade identity when conditional landmarks deviate significantly from the source (e.g., large expression or pose changes, inaccurate landmark estimates). To address these limitations, we propose LaTo, a landmark-tokenized diffusion transformer for fine-grained, identity-preserving face editing. Our key innovations include: (1) a landmark tokenizer that directly quantizes raw landmark coordinates into discrete facial tokens, obviating the need for dense pixel-wise correspondence; (2) a location-mapped positional encoding and a landmark-aware classifier-free guidance that jointly facilitate flexible yet decoupled interactions among instruction, geometry, and appearance, enabling strong identity preservation; and (3) a landmark predictor that leverages vision-language models to infer target landmarks from instructions and source images, whose struct

In year 2006 Bio-Linux with the work of Tim Booth and team gives its rising and provide an operating system that was and still specialized in providing a bioinformatic specific software environment for the working needs in this corner of bioscience. It is shown that Bio-Linux is affected by a 2 year release cycle and with this the final releases of Bio-Linux will not have the latest bioinformatic software on board. The paper shows how to get around this huge time gap and bring new software for Bio-Linux on board through a process that is called backporting. A summary of within the work to this paper just backported bioinformatic tools is given. A describtion of a workflow for continuously integration of the newest bioinformatic tools gives an outlook to further concrete planned developments and the influence of speeding up scientific progress.

Recent progress in 4D representations, such as Dynamic NeRF and 4D Gaussian Splatting (4DGS), has enabled dynamic 4D scene reconstruction. However, text-driven 4D scene editing remains under-explored due to the challenge of ensuring both multi-view and temporal consistency across space and time during editing. Existing studies rely on 2D diffusion models that edit frames independently, often causing motion distortion, geometric drift, and incomplete editing. We introduce Dynamic-eDiTor, a training-free text-driven 4D editing framework leveraging Multimodal Diffusion Transformer (MM-DiT) and 4DGS. This mechanism consists of Spatio-Temporal Sub-Grid Attention (STGA) for locally consistent cross-view and temporal fusion, and Context Token Propagation (CTP) for global propagation via token inheritance and optical-flow-guided token replacement. Together, these components allow Dynamic-eDiTor to perform seamless, globally consistent multi-view video without additional training and directly optimize pre-trained source 4DGS. Extensive experiments on multi-view video dataset DyNeRF demonstrate that our method achieves superior editing fidelity and both multi-view and temporal consistency pr

Anatomical landmark localization in 2D/3D images is a critical task in medical imaging. Although many general-purpose tools exist for landmark localization in classical computer vision tasks, such as pose estimation, they lack the specialized features and modularity necessary for anatomical landmark localization applications in the medical domain. Therefore, we introduce landmarker, a Python package built on PyTorch. The package provides a comprehensive, flexible toolkit for developing and evaluating landmark localization algorithms, supporting a range of methodologies, including static and adaptive heatmap regression. landmarker enhances the accuracy of landmark identification, streamlines research and development processes, and supports various image formats and preprocessing pipelines. Its modular design allows users to customize and extend the toolkit for specific datasets and applications, accelerating innovation in medical imaging. landmarker addresses a critical need for precision and customization in landmark localization tasks not adequately met by existing general-purpose pose estimation tools.

In this paper, we examine 3 important issues in the practical use of state-of-the-art facial landmark detectors and show how a combination of specific architectural modifications can directly improve their accuracy and temporal stability. First, many facial landmark detectors require face normalization as a preprocessing step, which is accomplished by a separately-trained neural network that crops and resizes the face in the input image. There is no guarantee that this pre-trained network performs the optimal face normalization for landmark detection. We instead analyze the use of a spatial transformer network that is trained alongside the landmark detector in an unsupervised manner, and jointly learn optimal face normalization and landmark detection. Second, we show that modifying the output head of the landmark predictor to infer landmarks in a canonical 3D space can further improve accuracy. To convert the predicted 3D landmarks into screen-space, we additionally predict the camera intrinsics and head pose from the input image. As a side benefit, this allows to predict the 3D face shape from a given image only using 2D landmarks as supervision, which is useful in determining lan

Learning node representations is a fundamental problem in graph machine learning. While existing embedding methods effectively preserve local similarity measures, they often fail to capture global functions like graph distances. Inspired by Bourgain's seminal work on Hilbert space embeddings of metric spaces (1985), we study the performance of local distance-preserving node embeddings. Known as landmark-based algorithms, these embeddings approximate pairwise distances by computing shortest paths from a small subset of reference nodes called landmarks. Our main theoretical contribution shows that random graphs, such as Erdos-Renyi random graphs, require lower dimensions in landmark-based embeddings compared to worst-case graphs. Empirically, we demonstrate that the GNN-based approximations for the distances to landmarks generalize well to larger real-world networks, offering a scalable and transferable alternative for graph representation learning.

Practical webcam gaze tracking is constrained not only by error, but also by calibration burden, robustness to head motion and session drift, runtime footprint, and browser use. We therefore target a deployment-oriented operating point rather than the image large-backbone regime. We cast landmark-based point-of-regard estimation as session-wise adaptation: a shared geometric encoder produces embeddings that can be aligned to a new session from a small calibration set. We present Equivariant Meta-Calibrated Gaze (EMC-Gaze), a lightweight landmark-only method combining an E(3)-equivariant landmark-graph encoder, local eye geometry, binocular emphasis, auxiliary 3D gaze-direction supervision, and a closed-form ridge calibrator differentiated through episodic meta-training. To reduce pose leakage, we use a two-view canonicalization consistency loss. The deployed predictor uses only facial landmarks and fits a per-session ridge head from brief calibration. In a fixation-style interactive evaluation over 33 sessions at 100 cm, EMC-Gaze achieves 5.79 +/- 1.81 deg RMSE after 9-point calibration versus 6.68 +/- 2.34 deg for Elastic Net; the gain is larger on still-head queries (2.92 +/- 0.7

We present the second edition of the book `CosmoAmautas: Astrophysics in the classroom' which is a text and activity book on selected topics in astrophysics. The content is written in Spanish and intended as the introductory literature and material for high school teachers who want to integrate astronomy to their science and math classes. The book includes an introduction to topics such as planetary science, stellar evolution, exoplanets, galaxies, black holes, and cosmology. In addition to the astronomy content, the book includes didactic notes on general physics of gravity and light, unit conversion, history of science, and tools for the digital classroom (ICT tools), which are compatible with the requirements of the Peruvian high school curriculum. This book is constructed based on the astrophysics curriculum and education model introduced in the online teacher-training workshop CosmoAmautas, which took place in 2021 and 2022. CosmoAmautas (amauta = teacher in the Quechua language) is an astronomy education project in Peru, funded by the IAU Office of Astronomy for Development. For more information, please visit www.cosmoamautas.org.

Facial landmark detection plays an important role for the similarity analysis in artworks to compare portraits of the same or similar artists. With facial landmarks, portraits of different genres, such as paintings and prints, can be automatically aligned using control-point-based image registration. We propose a deep-learning-based method for facial landmark detection in high-resolution images of paintings and prints. It divides the task into a global network for coarse landmark prediction and multiple region networks for precise landmark refinement in regions of the eyes, nose, and mouth that are automatically determined based on the predicted global landmark coordinates. We created a synthetically augmented facial landmark art dataset including artistic style transfer and geometric landmark shifts. Our method demonstrates an accurate detection of the inner facial landmarks for our high-resolution dataset of artworks while being comparable for a public low-resolution artwork dataset in comparison to competing methods.

Recently, heatmap regression methods based on 1D landmark representations have shown prominent performance on locating facial landmarks. However, previous methods ignored to make deep explorations on the good potentials of 1D landmark representations for sequential and structural modeling of multiple landmarks to track facial landmarks. To address this limitation, we propose a Transformer architecture, namely 1DFormer, which learns informative 1D landmark representations by capturing the dynamic and the geometric patterns of landmarks via token communications in both temporal and spatial dimensions for facial landmark tracking. For temporal modeling, we propose a recurrent token mixing mechanism, an axis-landmark-positional embedding mechanism, as well as a confidence-enhanced multi-head attention mechanism to adaptively and robustly embed long-term landmark dynamics into their 1D representations; for structure modeling, we design intra-group and inter-group structure modeling mechanisms to encode the component-level as well as global-level facial structure patterns as a refinement for the 1D representations of landmarks through token communications in the spatial dimension via 1D

Synthesizing second-language (L2) speech is potentially highly valued for L2 language learning experience and feedback. However, due to the lack of L2 speech synthesis datasets, it is difficult to synthesize L2 speech for low-resourced languages. In this paper, we provide a practical solution for editing native speech to approximate L2 speech and present PPG2Speech, a diffusion-based multispeaker Phonetic-Posteriorgrams-to-Speech model that is capable of editing a single phoneme without text alignment. We use Matcha-TTS's flow-matching decoder as the backbone, transforming Phonetic Posteriorgrams (PPGs) to mel-spectrograms conditioned on external speaker embeddings and pitch. PPG2Speech strengthens the Matcha-TTS's flow-matching decoder with Classifier-free Guidance (CFG) and Sway Sampling. We also propose a new task-specific objective evaluation metric, the Phonetic Aligned Consistency (PAC), between the edited PPGs and the PPGs extracted from the synthetic speech for editing effects. We validate the effectiveness of our method on Finnish, a low-resourced, nearly phonetic language, using approximately 60 hours of data. We conduct objective and subjective evaluations of our approac