The Spotlight on Nursing is a recurring column from the University of Hawai'i at Mānoa School of Nursing and Dental Hygiene (SONDH). It is edited by Holly B. Fontenot, PhD, APRN, WHNP-BC, FAAN, FNAP; Associate Dean for Research, Professor, and Frances A. Matsuda Chair in Women's Health for SONDH, and HJH&SW Contributing Editor; and Joanne R. Loos PhD, Science Writer for SONDH. Hawai'i is experiencing the effects of climate change, including increased temperatures, decreased rainfall, and higher frequency of extreme weather. In 2023, the Climate Change and Health Working Group (CCHWG) was formed, bringing together over 250 public health professionals dedicated to catalyzing community action by adopting a health-oriented approach to challenges posed by climate change. To date, members have engaged in crafting public policy initiatives to embed health perspectives into statewide legislation on climate change issues and created community listening sessions aimed at matching resources to the needs of underserved communities. The CCHWG's actions are charting a roadmap to guide collaborative efforts between health professionals and communities aimed at mitigating the health impacts of climate change and bolstering resilience. Future goals include expanding efforts across the state and to other populations across the Pacific to implement similar community-driven transformative change.
The Women in Behavior Analysis Hall of Fame was created to identify and honor outstanding women who have contributed to the field. Six stellar and impactful women were inducted into the 2022 class: Ellen Reese, Barbara Etzel, Beth Sulzer-Azaroff, Frances Horowitz, Julie Vargas, and Gwendolyn Cartledge. This paper provides details on the individual accomplishments, accolades, and impacts of these women, as described during the Hall of Fame induction ceremony.
Preterm infants (PTIs) are exposed to tremendous stressors within the neonatal intensive care unit (NICU), an environment that is supposed to be nurturing rather than disruptive. Toxic stress has yet to be defined as a concept relevant to premature and older infants. The lack of buffering support (a mother or another meaningful adult who provides physical/emotional support to minimize stressful events and promote resilience) triggers adverse childhood experiences leading to unfavorable-neurodevelopmental consequences. This article aims to clarify the concept of toxic stress in premature infants and infants younger than 2 years old. Walker and Avant's approach is the Wilsonian method, which is a systematic approach for clarifying and presenting a concept. The analysis focuses on infants aged 0 to 24 months in the NICU setting. Using the keywords related to toxic stress' physiologic and behavioral responses, databases including PubMed, CINAHL, and Google Scholar were searched to explore the toxic stress concept. Analysis of 33 English articles published in the last 20 years yielded an enhanced definition and empirical referents of toxic stress. The defining attributes, antecedents, consequences, and exemplar cases of the proposed concept were discussed. Clinical concerns are the uncommon use of the toxic stress concept in the NICU and the lack of physiologic and behavioral toxic stress assessment during routine care. Interventional studies are needed to test strategies to minimize/eliminate toxic stress and modify NICU practices. Mitigating the negative impacts of toxic stress often relies on high-quality nursing assessment and family-integrated care models incorporation.
With widespread application of pancreatic stent in managing pancreatic diseases and preventing post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis, incidence of stent-related complications such as proximal migration has substantially increased. This study aimed to provide strategic insights for retrieving proximally migrated pancreatic stents by analyzing a large endoscopy center experience and synthesizing novel techniques. A retrospective analysis was conducted over 10 years, including 43 cases of proximally migrated pancreatic stent among 32,537 ERCP procedures (2014-2024). Patient demographics, stent features, and procedure details were assessed. Literature on advanced retrieval techniques was reviewed. Most patients (67.4%) were asymptomatic; epigastric discomfort occurred in 32.6%. Endoscopic retrieval was successful in 81.4% of cases (35/43), with 58.1% (25/43) achieved using a single accessory. Median operation duration was 35 minutes (interquartile range 24-59). Pancreatic duct pre-dilation significantly shortened the procedure (31 ± 9 vs. 47 ± 13 minutes, P < 0.001). Stent migration duration showed no correlation with procedure difficulty (r = 0.131, P = 0.201). Eight cases (18.6%) met criteria for difficult-to-retrieve stents (DTRSs), mainly due to ductal tortuosity, strictures, or migration into branch pancreatic ducts. All procedures were completed without perioperative complications. Endoscopic retrieval is safe and effective for proximal pancreatic stent migration. Success optimization requires careful preoperative evaluation, ductal preparation, and adoption of advanced techniques for difficult cases. The DTRS concept provides a valuable framework for clinical decision-making when standard retrieval fails.
Bronchoscopic lung volume reduction (BLVR) is a minimally invasive procedure that improves shortness of breath and quality of life in some patients with emphysema. A key indicator of functional capacity for patients with underlying emphysema is a 6-min walk test (6MWD). This study aims to assess outcomes for patients who underwent BLVR stratified by 6MWD. This single center, retrospective study analyzes patients who underwent BLVR. Patients were stratified into groups based on pre-BLVR 6MWD. The low functional capacity group walked between 100 and 250 m, the intermediate functional capacity group walked between 251 and 400 m, and the high functional capacity group walked greater than 400 m. The primary endpoint of this study is the percentage of FEV1 responders in each group based on pre-procedural 6MWD following BLVR. Secondary outcomes included changes in 6MWD and SGRQ for each group based on pre-procedural 6MWD following BLVR. A total of 96 patients were stratified based on pre-BLVR 6MWD. At 12-months, patients in the low functional capacity group demonstrated an FEV1 responder rate of 51.6%, 48.1% in the intermediate functional capacity group, and high functionality group demonstrated an FEV1 responder rate of 30.8%. The average change in 6MWD following BLVR in the low functionality group was an increase by 53.3 m and an increase of 5.2 m in the intermediate functionality group. The average change in 6MWD in the high functionality group demonstrated a decrease by 53.2 m. Finally, the improvement in SGRQ in the low functionality group was 8.0, the improvement in the intermediate functionality group was 10.1, and the high functionality group showed an improvement by 10.1. This study demonstrates that at 12-months there is no statistically significant association between pre-BLVR 6MWD testing and the FEV1 responder rate or the changes in mean SGRQ. Conversely, subjects in the high functional capacity group showed a statistically significant lower mean change in 6MWD compared to patients who walked less than 400 m. The greatest improvement in average 6MWD following BLVR was seen in the low functional capacity group.
The Good Nursing Care Scale for Nurses (GNCS-N) measures nurses' perceptions of nursing care quality, but no validated Indonesian version has been available. This study aimed to translate, adapt, and evaluate the construct validity and reliability of the Indonesian version of the GNCS-N (I-GNCSN). Following COSMIN-informed procedures, the GNCS-N underwent forward-back translation, expert review, and pilot testing. A cross-sectional study using convenience sampling was conducted among inpatient nurses, and 255 complete responses were retained for confirmatory factor analysis (CFA). A second-order CFA was performed in LISREL 8.72 because the GNCS-N has an established theory-based multidimensional structure. Model fit was evaluated using chi-square, RMSEA, SRMR, CFI, NNFI, NFI, GFI, and AGFI. Convergent validity was assessed using average variance extracted (AVE), and internal consistency was assessed using composite reliability and Cronbach's alpha. The final I-GNCSN retained the original seven dimensions and 40 items. The re-estimated second-order CFA showed acceptable-to-good fit: chi-square = 1529.99, df = 708, RMSEA = 0.068 (90% CI 0.063-0.072), SRMR = 0.059, CFI = 0.98, NNFI = 0.98, and NFI = 0.96. GFI (0.77) and AGFI (0.73) remained below ideal thresholds and are therefore interpreted cautiously. Most standardized factor loadings were moderate to high, although one item showed comparatively weak performance and should be re-examined in future studies. Internal consistency remained acceptable, whereas convergent validity was weaker for constructs with AVE values below 0.50. The I-GNCSN demonstrates acceptable structural validity and good internal consistency for use among Indonesian inpatient nurses. However, some fit indices remained suboptimal and convergent validity was mixed for several constructs; therefore, findings should be interpreted cautiously. Further studies should examine temporal stability, test the instrument in broader clinical settings, and re-evaluate weaker items.
The World Health Organization highlights significant disparities in access to palliative care (PC), especially in primary and community care. In France, ASALEE is an innovative national association that brings nurses and general practitioners in primary and community care. Initially created to address the support needs of patients living with chronic diseases, the nurses' roles have expanded to include PC. However, despite the growing role of such interprofessional models, research on PC nurses' activities and skills in primary and community care are underdeveloped. To identify, categorize, compare PC models in primary and community care and analyze them through nursing skills and activities, using the ASALEE PC link-nurses' specific role as a comparator. A narrative literature review on studies published between 2017 and 2024 was performed. PC models were categorized using the Understanding Integrated Care Conceptual Framework. Extracted data on nursing activities and skills in PC were compared with those developed by ASALEE's PC Support Group. This group is working on the integration of PC for patients in primary and community care. Twenty-one studies were selected. Searching on micro, meso, and macro levels, the review identified six key models of PC in primary and community care: integrative PC, health promotion-, community-, professional skills-, patient-centered, and end-of-life process-focused. These models emphasize inter-professional collaboration, informal caregivers' involvement, community engagement, and patient partnership in PC support. The review provides insights into PC nurses' activities and skills in primary and community care, particularly in terms of interpersonal relationships. The review is limited by heterogeneous study designs and contexts, which constrain generalizability, but, while partially transferable to the French healthcare system, these models require adaptations to be fully integrated. This review proposes perspectives for PC integration, future research, and to enhance ASALEE PC link-nurses' practice and strengthen their collaboration with physicians, informal caregivers, and patients, in France and at the international level. This review identifies PC models, core nursing skills and activities, and collaborative practices that can guide future PC nurses in primary and community care, by proposing changes for their implementation. The World Health Organization notes many people lack access to palliative care, especially in community settings. In France, ASALEE is a program where nurses and family doctors work together in local health centers to support patients. While ASALEE nurses now help with palliative care, we need clearer understanding of their specific roles and skills.We reviewed 21 studies (2017-2024) on palliative care nursing models in primary and community care. We found six main approaches, all emphasizing teamwork between healthcare professionals, involving families and communities, and focusing on patients’ individual needs and life goals. These models show how nurses can effectively provide palliative care through activities like symptom management, emotional support, care coordination, and helping patients make informed decisions.While these models offer valuable insights, they need adaptation to fit different healthcare systems like France’s. This research helps identify how programs like ASALEE can better integrate palliative care into everyday community health services by clarifying the essential skills, activities, and collaborative practices nurses need to support patients with serious illnesses near the end of life.
Here, we present updated nationwide epidemiological and economic data on spinal cord injuries (SCIs) in France, based on the most recent reliable data from health insurance providers for 2023. The incidence rate is approximately 1,500 new cases per year, with an estimated 98,800 people currently living with an SCI. The estimated cost per patient is €8,000, potentially reaching €80,000 in the first year, equating to €790 million annually. Although France's healthcare system helps to reduce costs, spending on SCIs still accounts for a significant proportion of the total healthcare budget (0.4%). The harmonization of health data, particularly with the 11th revision of the International Classification of Diseases (ICD-11, WHO, 2019), should enable more accurate data on SCIs to be obtained in future epidemiological and economic studies.
Background/Objectives: Several randomized controlled trials have found that dietary interventions promoting self-guided shifts away from ultra-processed foods (UPFs) and toward minimally processed, nutrient-dense foods may alleviate depressive symptoms. However, translating these interventions into scalable and sustainable real-world approaches remains a key challenge. Adopting a minimally processed dietary pattern requires sustained effort (e.g., meal planning, shopping, and preparation) within environments where UPFs are pervasive and convenient. These demands may be especially burdensome for individuals experiencing depressive symptoms. Consequently, interventions that rely heavily on individual effort may be difficult to maintain. Commercial meal delivery services may offer a structural solution by reducing logistical and cognitive barriers to dietary change, yet little is known about how individuals with depressive symptoms experience this approach. Methods: In a parent study, we conducted a randomized pilot study of a meal delivery service designed to provide minimally processed meals to adults with moderate to moderately severe depressive symptoms; here we report qualitative findings from post-intervention interviews with participants assigned to the meal delivery condition (n = 20). Results: Participants appreciated reductions in preparatory effort and mental load, which supported adherence. Dietary changes were also linked to improved mood through increased energy, mood stability, and more positive self-evaluation. However, social settings were a near-universal barrier, and acceptability depended on palatability, compatibility with personal preferences, and perceived autonomy. Several participants also described a temporal adjustment process (early cravings/withdrawal followed by adaptation). Conclusions: Overall, these findings suggest participant-informed priorities for future testing and refinement of scalable meal delivery interventions for depression, including personalization and choice, quality control, and support for social and withdrawal-related challenges.
Monoclonal antibodies (mAbs) have been the subject of extensive study in recent years due to their recognition as highly promising therapeutic molecules offering high specificity and a low risk of side effects. Monitoring the structure of these molecules is crucial for developing new therapeutics, characterizing interactions with antigens or receptors, and explaining potential changes in activity between antibody production batches. However, commonly used biophysical approaches provide only low-spatial-resolution information, and conventional structural biology techniques such as crystallography and cryo-electron microscopy (cryo-EM) are difficult to apply to these highly dynamic proteins. Solution nuclear magnetic resonance (NMR) spectroscopy is the method of choice for structural studies of flexible proteins at atomic resolution; however, it has traditionally been limited to low-molecular-weight biological systems. In this review, we present recent advances in NMR spectroscopy and advanced isotopic labeling methods that have enabled the atomic-resolution study of both the crystallizable (Fc) and antigen-binding (Fab) fragments of antibodies. We show how NMR is becoming a powerful tool for investigating full-length mAbs at an atomic level, opening up new possibilities for the characterization and in-depth quality control of therapeutic antibodies in solution.
Antibiotic resistance, responsible for 1.14 million deaths worldwide each year, is one of the most urgent threats to public health. This complex phenomenon, driven by the overuse of antibiotics, agricultural practices, and the spread of resistant bacteria, requires a comprehensive global response within the framework of the "One Health" approach. This article provides an overview of European and national initiatives implemented to combat antibiotic resistance within the framework of the "One Health" approach. It highlights European and national efforts aimed at strengthening governance, coordination between countries and within territories, as well as surveillance and research. These efforts demonstrate Europe's and France's commitment to tackling antibiotic resistance and implementing the "One Health" approach. However, these achievements remain fragile in an international and national context where political priorities are rapidly shifting. To preserve health as a common good, it is crucial to maintain political commitment, funding, and international cooperation in order to address this crisis. Antibiotiques : l’ascension de la résistance… la France et l’Union européenne contre-attaquent ! La résistance aux antibiotiques, responsable de 1,14 million de morts chaque année dans le monde, constitue une menace majeure pour la santé publique. Ce phénomène, lié à la surconsommation d’antibiotiques, aux pratiques agricoles et à la propagation des bactéries résistantes exige une réponse globale suivant l’approche « Une seule santé ». Cet article propose un état des lieux des initiatives nationales et européennes mises en œuvre pour lutter contre l’antibiorésistance dans une dynamique « une seule santé ». Il souligne les efforts de structuration en matière de gouvernance, de coordination interétatique ou territoriale, ainsi que de surveillance et de recherche. Ces efforts démontrent l’engagement de l’Union européenne et de la France en matière de lutte contre l’antibiorésistance et de mise en œuvre de l’approche « une seule santé ». Pourtant, les acquis restent fragiles dans un contexte international et national où les priorités politiques évoluent rapidement. Pour préserver ce bien commun qu’est la santé, il est néanmoins crucial de maintenir l’engagement politique, les financements et la coopération internationale face à cette crise sanitaire majeure.
Background: The integration of internationally educated nurses (IENs) into healthcare workforces is expanding globally, yet organization-led support models remain understudied. Successful IEN integration requires ethical recruitment, structured onboarding, workforce support, and stakeholder engagement in policy discussions related to transition and retention. Objective: To examine the conceptualization, implementation, and policy implications of the Philippine Nurses Association of America Cy Pres Task Force's national initiative to support IEN onboarding and transition into U.S. healthcare. Methods: This descriptive program evaluation utilized governance documents, program planning records, policy summit materials, aggregated survey findings, PNAA Human Rights Committee resources, and the Handbook for Filipino Nurses Immigrating to the United States to examine initiative development, implementation processes, and program outputs. A descriptive narrative synthesis was used to characterize program structure, stakeholder engagement, and policy priorities. Findings: The PNAA Cy Pres governance model was built around ethical recruiting, workforce integration, and advocacy. The work began with policy summits with nurse leaders, health care organizations, recruitment agencies, and policy experts, focusing on hiring, onboarding, legal issues, and staff retention. Stakeholder engagement, interdisciplinary collaboration, and appreciative inquiry were used to identify best practices and goals. Key outputs included the establishment of a national governance structure, implementation of national and regional policy summits, and identification of policy priorities related to ethical recruitment, onboarding, workforce integration, and governance. Conclusions: The PNAA Cy Pres initiative provides an implementation-informed approach that may help guide future workforce integration efforts. The study illustrates how ethical recruitment, workforce integration, and stakeholder engagement can help translate workforce policy principles into practice. Policy & Practice Implications: Healthcare institutions, policymakers, and professional organizations need to work together to standardize onboarding, ethical recruitment, and support mechanisms to facilitate the integration and sustainability of the IEN workforce.
This study investigates the impact of nurse practitioner full practice authority on cancer detection rates in the U.S., focusing on 6 high-prevalence cancers: bladder, cervical, lung, lymphoma, melanoma, and prostate cancers. A difference-in-differences analysis was conducted in February 2025 using nationally representative 2010-2019 data from the Medical Expenditure Panel Survey. Difference-in-differences modeling was used to compare changes in cancer detection before and after full practice authority policy implementation, comparing states with and without full practice authority, with additional adjustments for rurality. The implementation of full practice authority was associated with changes in cancer detection patterns. Statistically significant reductions in bladder cancer detection and increases in cervical cancer and melanoma detection were observed after full practice authority implementation. Effects varied by cancer type and were moderated by rural status, with some associations dissipating in rural counties. No significant changes were detected for lung cancer or lymphoma. Nurse practitioner full practice authority may influence early cancer detection, with variable effects across cancer types and geographic settings. Implementing full practice authority for nurse practitioners could enhance access to preventive oncology care, particularly in underserved areas. Further research is needed to assess long-term clinical outcomes and stage at diagnosis.
Photosynthesis, which sustains life on Earth, depends on organized and yet adaptable protein assemblies embedded in specialized membranes known as thylakoids. Understanding how these complexes interact and reorganize within functional photosynthetic membranes is essential to reveal the molecular basis of energy conversion in cells. Here, we present an improved cross-linking mass spectrometry strategy that captures native protein interactions in photosynthetically active thylakoid membranes from Arabidopsis thaliana and Spinacia oleracea. By monitoring photosynthetic performance during cross-linking, we show that electron transport remains active, allowing structural analysis under physiological conditions. Moreover, we show that trimethylphenylammonium chloride as an adjuvant charged compound does not impair physiological activity, while boosting and diversifying cross-link identifications. Mapping cross-links onto known structures confirms the integrity of major photosynthetic complexes and uncovers previously uncharacterized assemblies involving regulatory and structural proteins. Integration with structural modeling and interaction network analysis identifies novel protein players within the photosynthetic machinery, providing molecular insights into their potential roles. This approach offers a broadly applicable framework for studying membrane protein organization and dynamics in functional bioenergetic systems.
暂无摘要（点击查看详情）
Amphibians in agricultural drainage ditches may be exposed to contaminants through runoff and subsurface drainage, which can result in toxicity. Understanding the agroecosystem management activities that can sustain healthy amphibian populations will support biodiversity and ecosystem services within intensive agricultural areas. This study examined how woody vegetation within agricultural areas is associated with water quality and amphibian health metrics. Cages containing northern leopard frog (Lithobates [Rana] pipiens) tadpoles were placed within nine agricultural ditches differing in their riparian vegetation height and percentage of surrounding forest cover for eight weeks (May-July) in an agriculturally dominated watershed in eastern Canada. Physicochemical water quality measurements and pesticide concentrations indicated that sites higher in percent forest cover (within 1 km radius) had lower specific conductance, atrazine, nitrate, and potassium concentrations. Percent forest cover was positively associated with tadpole growth (snout-to-vent length, tail length, mass) and riparian vegetation height positively related to tadpole development. Furthermore, glucose levels increased with forest cover, while corticosterone and hepatosomatic index remained unchanged, suggesting that elevated glucose was not strongly associated with chronic stress in this study. Finally, tested tadpoles were negative for Batrachochytrium dendrobatidis, B. salamandrivorans and Frog Virus 3, suggesting these pathogens are not currently a threat to these organisms at the sites tested. Collectively, our findings suggest forested habitats within intensive agroecosystems are critical landscape elements for reducing agrochemical exposure and improving tadpole health in drainage ditches, whereas woody riparian buffers provide limited additional benefits for aquatic stages, highlighting the importance of considering life-stage-specific responses.
Niemann-Pick disease type C (NPC) is a neurovisceral lysosomal storage disorder comprising two clinically indistinguishable but genetically distinct subtypes caused by mutations in NPC1, or NPC2. The specific impact of each deficiency on cellular homeostasis remains poorly defined due to the phenotypic heterogeneity of patient-derived models and a lack of isogenic platforms for comparative study. Here we established isogenic ARPE19 models of NPC1 and NPC2 deficiency that faithfully recapitulate hallmark pathologies, including homogeneous lysosomal expansion and lipid sequestration. Direct comparison of these isogenic lines revealed a fundamental divergence in organelle crosstalk: while both genotypes exhibit comparable lipid accumulation, expanded mitochondria-lysosome contact sites (MLCs) are observed exclusively in NPC1 -/- cells. Using StARD3-targeted proximity labelling and quantitative proteomics, we identified the mitochondrial protein HKDC1 as an MLC regulator. We demonstrate that HKDC1 is markedly upregulated in NPC1 -/- cells and that its overexpression drives MLC expansion in wild-type cells. Thus our study uncovers a homeostatic role for HKDC1-mediated organelle remodelling and demonstrates the power of isogenic modelling for identifying novel regulators of organelle architecture and potential therapeutic targets.
Since the early 2000s, smoking prevalence has declined overall in France. This study aims to describe the evolution of social inequalities in smoking in relation to anti-smoking policy between 2000 and 2021. This study is a secondary analysis of data from Santé Publique France's Health Barometers, cross-sectional telephone surveys conducted between 2000 and 2021 on random samples of the French population aged 18-75 years (between 9074 and 28224 people were surveyed, depending on the edition). Evolutions in prevalence according to socio-economic status (level of education, income, and occupational status) were modeled using Poisson regression. Overall, social inequalities related to smoking increased between 2000 and 2021, with the prevalence of daily smoking rising among individuals with lower levels of education (from 30% to 32%), lower incomes or unemployed, while declining among more advantaged groups (e.g. from 28% to 17% for individuals with the highest levels of education). The analysis reveals three distinct phases: an increase in inequalities between 2000 and 2016, e.g. the association between smoking and a level of education below high school increased (adjusted interaction term, AIT=1.027; 95% CI: 1.021-1.033, per year) compared to those with a level of education above high school. Disparities then stabilized between 2016 and 2019. Finally, a resumption of the increase in inequalities related to education and income was observed between 2019 and 2021, e.g. over time, the association between smoking and a level of education below high school increased (AIT=1.071; 95% CI: 1.001-1.141). The 2016-2019 period was marked by the first national tobacco control plan, including numerous measures that addressed social inequalities. Over the same period, smoking declined among all socio-economic groups, and differences in smoking prevalence according to socio-economic status have stabilized, bringing an end to 16 years of increase. Unfortunately, inequality began to rise again in 2020-2021, during the COVID-19 pandemic.
BACKGROUND: During the COVID-19 pandemic, prioritization of COVID-19 patients led to delays in oncological surgery, potentially impacting patient outcomes. This analysis examines the effects of surgical delays in various tumor entities on resectability and postoperative mortality. METHODS: Data from the COVIDSurg Cancer Collaborative, an international prospective cohort study with 19,676 patients, collected between March 26, 2020, and September 16, 2020, were analyzed. Postoperative mortality and complete resection (R0) were the outcomes, with tumor entity, stage and delay to surgery as key exposures. RESULTS: 17,486 patients underwent surgery during the study period, at a median time of three weeks after decision to operate (IQR = 4). 172 (1.0%) patients died within 30 days postoperatively. 15,143 (90.5%) patients had an R0 resection, 1352 (8.1%) an R1 resection and 230 (1.4%) had an R2 resection. Postoperative mortality was highest for oesophageal cancer (3.9%) and UICC stage IV (1.5%). For the overall population, there was no association between delay to surgery and resectability. There was an association between delay to surgery and postoperative mortality (p < 0.001), with the highest 30-day postoperative mortality observed for operations within two weeks following surgical decision. CONCLUSION: Tumor resectability and postoperative mortality in oncological surgeries are influenced by various factors. During the COVID-19 pandemic, moderate delays in surgeries were observed, with differences across tumor types, UICC stages and regions. While no tangible effects on resectability were found, postoperative mortality was higher after a shorter delay to surgery.