Selected applications of novel techniques in Agricultural Biotechnology, Health Food formulations and Medical Biotechnology are being reviewed with the aim of unraveling future developments and policy changes that are likely to open new niches for Biotechnology and prevent the shrinking or closing the existing ones. Amongst the selected novel techniques with applications to both Agricultural and Medical Biotechnology are: immobilized bacterial cells and enzymes, microencapsulation and liposome production, genetic manipulation of microorganisms, development of novel vaccines from plants, epigenomics of mammalian cells and organisms, as well as biocomputational tools for molecular modeling related to disease and Bioinformatics. Both fundamental and applied aspects of the emerging new techniques are being discussed in relation to their anticipated impact on future biotechnology applications together with policy changes that are needed for continued success in both Agricultural and Medical Biotechnology. Several novel techniques are illustrated in an attempt to convey the most representative and powerful tools that are currently being developed for both immediate and long term applicat
China is the leading crop producer and has successfully implemented sustainable development programs related to agriculture. Sustainable agriculture has been promoted to achieve national food security targets such as food self-sufficiency through the well-facilitated farmland construction (WFFC) approach. The WFFC is introduced in Chinas current national 10-year plan to consolidate farmlands into large and simplified production areas to maximise automation, and improve soil fertility and productivity. However, research suggests that diversified and smaller farms faciliate ecosystem services, can improve yield resilience, defuse human health threats, and increase farm profitability. Currently, WFFC has not considered ecological farmland improvements and it may miss long-term environmental benefits including ecosystem service preservation conducive to yields. Moreover, the nutritional status in China has changed in recent decades with undernutrition being dramatically reduced, but the prevalence of overweight, obesity, and chronic diseases being increased. While a strategic choice and management of crop and livestock species can improve nutrition, the environmental and production ben
Food banks can improve food donation administration, provide real-time inventory tracking, and guarantee compliance with food safety regulations by incorporating blockchain technology. The efficiency, openness, and dependability of food bank supply chains are greatly increased by this integration, leading to more sustainable and successful operations. This study focuses on two primary objectives: identifying key barriers to effective Food bank supply chain (FBSC) operations in blockchain adoption and exploring the interrelationships among these barriers. Barriers were categorized into external and internal frameworks and analyzed using insights from academics and FBs experts. The Decision-Making Trial and Evaluation Laboratory (DEMATEL) methodology was employed to model and quantify the causal relationships among these barriers. DEMATEL's strength lies in its ability to map interdependencies and feedback loops, providing a nuanced understanding of the links between independent and dependent variables in a cause-and-effect network. To address subjectivity and ambiguity in expert opinions during group decision-making, rough theory was integrated with DEMATEL, ensuring a robust approa
Biotechnology Industry 5.0 is advancing with the integration of cutting-edge technologies like Machine Learning (ML), the Internet Of Things (IoT), and cloud computing. It is no surprise that an industry that utilizes data from customers and can alter their lives is a target of a variety of attacks. This chapter provides a perspective of how Machine Learning Security Operations (MLSecOps) can help secure the biotechnology Industry 5.0. The chapter provides an analysis of the threats in the biotechnology Industry 5.0 and how ML algorithms can help secure with industry best practices. This chapter explores the scope of MLSecOps in the biotechnology Industry 5.0, highlighting how crucial it is to comply with current regulatory frameworks. With biotechnology Industry 5.0 developing innovative solutions in healthcare, supply chain management, biomanufacturing, pharmaceuticals sectors, and more, the chapter also discusses the MLSecOps best practices that industry and enterprises should follow while also considering ethical responsibilities. Overall, the chapter provides a discussion of how to integrate MLSecOps into the design, deployment, and regulation of the processes in biotechnology
Food assistance referral requires conversational agents to translate underspecified, often noisy help-seeking dialogues into locally valid resource recommendations. We present Food4All, an agentic food-resource referral framework and benchmark grounded in 686 structured Indiana food resources. Food4All couples a food-specific search tool with 300 multi-turn evaluation tasks spanning single food needs, composite cases with access or document constraints, and five non-ideal user interaction traits: unreasonable demands, rambling responses, impatience, incomplete answers, and inconsistent information. We evaluate six Large Language Models (LLMs) on requirement grounding, resource retrieval, final referral correctness, and interaction efficiency. Although the strongest model achieves 96.33% referral accuracy, our diagnostics reveal persistent failures in grounding schedule, eligibility, intake, and document constraints, as well as failures to preserve valid retrieved resources in the final recommendation. Trait-level analysis further shows that different non-ideal behaviors stress different parts of the referral pipeline. Food4All provides a controlled testbed for studying tool-calling
The dramatic increase in consumption of ultra-processed food has been associated with numerous adverse health effects. Given the public health consequences linked to ultra-processed food consumption, it is highly relevant to build computational models to predict the processing of food products. We created a range of machine learning, deep learning, and NLP models to predict the extent of food processing by integrating the FNDDS dataset of food products and their nutrient profiles with their reported NOVA processing level. Starting with the full nutritional panel of 102 features, we further implemented coarse-graining of features to 65 and 13 nutrients by dropping flavonoids and then by considering the 13-nutrient panel of FDA, respectively. LGBM Classifier and Random Forest emerged as the best model for 102 and 65 nutrients, respectively, with an F1-score of 0.9411 and 0.9345 and MCC of 0.8691 and 0.8543. For the 13-nutrient panel, Gradient Boost achieved the best F1-score of 0.9284 and MCC of 0.8425. We also implemented NLP based models, which exhibited state-of-the-art performance. Besides distilling nutrients critical for model performance, we present a user-friendly web server
Blockchain is an emerging digital technology allowing ubiquitous financial transactions among distributed untrusted parties, without the need of intermediaries such as banks. This article examines the impact of blockchain technology in agriculture and food supply chain, presents existing ongoing projects and initiatives, and discusses overall implications, challenges and potential, with a critical view over the maturity of these projects. Our findings indicate that blockchain is a promising technology towards a transparent supply chain of food, with many ongoing initiatives in various food products and food-related issues, but many barriers and challenges still exist, which hinder its wider popularity among farmers and systems. These challenges involve technical aspects, education, policies and regulatory frameworks.
Web technology is one of the key areas in information and communication technology to be used as a powerful tool in ensuring food security which is one of the main issues in Sri Lanka. Web technology involves in communicating and sharing resources in network of computers all over the world. Main focus of food security is to ensure that all people have fair access to sufficient and quality food without endangering the future supply of the same food. In this context, web sites play a vital and major role in achieving food security in Sri Lanka. In this case study, websites pertaining to Sri Lankan government and link with food security were analyzed to find out their impact in achieving the goals of food security using web technologies and how they are being involved in ensuring food security in Sri Lanka. The other objective of this study is to make the Sri Lankan government aware of present situation of those websites in addressing food security related issues and how modern web technologies could be effectively and efficiently used to address those issues. So, the relevant websites were checked against several criteria and scores were used to assess their capabilities to address t
The global food landscape is rife with scientific, cultural, and commercial claims about what foods are, what they do, what they should not do, or should not do. These range from rigorously studied health benefits (probiotics improve gut health) and misrepresentations (soaked almonds make one smarter) to vague promises (superfoods boost immunity) and culturally rooted beliefs (cold foods cause coughs). Despite their widespread influence, the infrastructure for tracing, verifying, and contextualizing these claims remains fragmented and underdeveloped. In this paper, we propose a Food Claim-Traceability Network (FCN) as an extension of FKG[.]in, a knowledge graph of Indian food that we have been incrementally building. We also present the ontology design and the semi-automated knowledge curation workflow that we used to develop a proof of concept of FKG[.]in-FCN using Reddit data and Large Language Models. FCN integrates curated data inputs, structured schemas, and provenance-aware pipelines for food-related claim extraction and validation. While directly linked to the Indian food knowledge graph as an application, our methodology remains application-agnostic and adaptable to other g
The increasing interest in computer vision applications for nutrition and dietary monitoring has led to the development of advanced 3D reconstruction techniques for food items. However, the scarcity of high-quality data and limited collaboration between industry and academia have constrained progress in this field. Building on recent advancements in 3D reconstruction, we host the MetaFood Workshop and its challenge for Physically Informed 3D Food Reconstruction. This challenge focuses on reconstructing volume-accurate 3D models of food items from 2D images, using a visible checkerboard as a size reference. Participants were tasked with reconstructing 3D models for 20 selected food items of varying difficulty levels: easy, medium, and hard. The easy level provides 200 images, the medium level provides 30 images, and the hard level provides only 1 image for reconstruction. In total, 16 teams submitted results in the final testing phase. The solutions developed in this challenge achieved promising results in 3D food reconstruction, with significant potential for improving portion estimation for dietary assessment and nutritional monitoring. More details about this workshop challenge a
The number of people able to end Earth's technical civilization has heretofore been small. Emerging dual-use technologies, such as biotechnology, may give similar power to thousands or millions of individuals. To quantitatively investigate the ramifications of such a marked shift on the survival of both terrestrial and extraterrestrial technical civilizations, this paper presents a two-parameter model for civilizational lifespans, i.e. the quantity $L$ in Drake's equation for the number of communicating extraterrestrial civilizations. One parameter characterizes the population lethality of a civilization's biotechnology and the other characterizes the civilization's psychosociology. $L$ is demonstrated to be less than the inverse of the product of these two parameters. Using empiric data from Pubmed to inform the biotechnology parameter, the model predicts human civilization's median survival time as decades to centuries, even with optimistic psychosociological parameter values, thereby positioning biotechnology as a proximate threat to human civilization. For an ensemble of civilizations having some median calculated survival time, the model predicts that, after 80 times that dura
We examine the impact of livelihood diversification on food insecurity amid the COVID-19 pandemic. Our analysis uses household panel data from Ethiopia, Malawi, and Nigeria in which the first round was collected immediately prior to the pandemic and extends through multiple rounds of monthly data collection during the pandemic. Using this pre- and post-outbreak data, and guided by a pre-analysis plan, we estimate the causal effect of livelihood diversification on food insecurity. Our results do not support the hypothesis that livelihood diversification boosts household resilience. Though income diversification may serve as an effective coping mechanism for small-scale shocks, we find that for a disaster on the scale of the pandemic this strategy is not effective. Policymakers looking to prepare for the increased occurrence of large-scale disasters will need to grapple with the fact that coping strategies that gave people hope in the past may fail them as they try to cope with the future.
Access to finance is vital for improving food security, particularly in developing nations where agricultural production is crucial. Despite several financial interventions targeted at increasing agricultural production, smallholder farmers continue to lack access to reasonable, timely, and sufficient financing, limiting their ability to invest in improved technology and inputs, lowering productivity and food supply. This study examines the relationship between access to finance and food security among smallholder farmers in Ogun State, employing institutional theory as a theoretical framework. The study takes a quantitative method, with a survey for the research design and a population of 37,200 agricultural smallholder farmers. A sample size of 380 was chosen using probability sampling and simple random techniques. The data were analysed via Partial Least Squares Structural Equation Modelling (PLS-SEM). The findings demonstrate a favourable relationship between access to finance and food security, with an R2-value of 0.615 indicating a robust link. These findings underline the need of improving financial institutions and implementing enabling policies to enable farmers have acces
Driven by advancements in high-throughput biological technologies and the growing number of sequenced genomes, the construction of in silico models at the genome scale has provided powerful tools to investigate a vast array of biological systems and applications. Here, we review comprehensively the uses of such models in industrial and medical biotechnology, including biofuel generation, food production, and drug development. While the use of in silico models is still in its early stages for delivering to industry, significant initial successes have been achieved. For the cases presented here, genome-scale models predict engineering strategies to enhance properties of interest in an organism or to inhibit harmful mechanisms of pathogens. Going forward, genome-scale in silico models promise to extend their application and analysis scope to become a transformative tool in biotechnology.
Half of long-term care (LTC) residents are malnourished increasing hospitalization, mortality, morbidity, with lower quality of life. Current tracking methods are subjective and time consuming. This paper presents the automated food imaging and nutrient intake tracking (AFINI-T) technology designed for LTC. We propose a novel convolutional autoencoder for food classification, trained on an augmented UNIMIB2016 dataset and tested on our simulated LTC food intake dataset (12 meal scenarios; up to 15 classes each; top-1 classification accuracy: 88.9%; mean intake error: -0.4 mL$\pm$36.7 mL). Nutrient intake estimation by volume was strongly linearly correlated with nutrient estimates from mass ($r^2$ 0.92 to 0.99) with good agreement between methods ($σ$= -2.7 to -0.01; zero within each of the limits of agreement). The AFINI-T approach is a deep-learning powered computational nutrient sensing system that may provide a novel means for more accurately and objectively tracking LTC resident food intake to support and prevent malnutrition tracking strategies.
Over time, agriculture is the most consistent activity, and it evolves every day. It contributes to a vast majority of the Gross Domestic Product (GDP) of Nigeria but as ironic as it may be, there is still hunger in significant parts of the country due to low productivity in the agricultural sector and comparison to the geometric population growth. During the first half of 2022, agriculture contributed about 23% of the country's GDP while the industry and services sector had a share of the remaining 77%. This showed that with the high rate of agricultural activities, Nigeria has not achieved food security for the teeming population. and more productivity levels can be attained. Technology can/will assist Nigeria in overcoming global poverty and hunger quicker in both rural and urban areas. Today, there are many types of agricultural technologies available for farmers all over the world to increase productivity. Major technological advancements include indoor vertical farming, automation, robotics, livestock technology, modern greenhouse practices, precision agriculture, artificial intelligence, and blockchain. Mobile phones have one of the highest adoption rates of technologies dev
Food supply chain plays a vital role in human health and food prices. Food supply chain inefficiencies in terms of unfair competition and lack of regulations directly affect the quality of human life and increase food safety risks. This work merges Hyperledger Fabric, an enterprise-ready blockchain platform with existing conventional infrastructure, to trace a food package from farm to fork using an identity unique for each food package while keeping it uncomplicated. It keeps the records of business transactions that are secured and accessible to stakeholders according to the agreed set of policies and rules without involving any centralized authority. This paper focuses on exploring and building an uncomplicated, low-cost solution to quickly link the existing food industry at different geographical locations in a chain to track and trace the food in the market.
In the European Union, official food safety monitoring data collected by member states are submitted to the European Food Safety Authority (EFSA) and published on Zenodo. This data includes 392 million analytical results derived from over 15.2 million samples covering more than 4,000 different types of food products, offering great opportunities for artificial intelligence to analyze trends, predict hazards, and support early warning systems. However, the current format with data distributed across approximately 1000 files totaling several hundred gigabytes hinders accessibility and analysis. To address this, we introduce the CompreHensive European Food Safety (CHEFS) database, which consolidates EFSA monitoring data on pesticide residues, veterinary medicinal product residues, and chemical contaminants into a unified and structured dataset. We describe the creation and structure of the CHEFS database and demonstrate its potential by analyzing trends in European food safety monitoring data from 2000 to 2024. Our analyses explore changes in monitoring activities, the most frequently tested products, which products were most often non-compliant and which contaminants were most often
This paper presents an ontology design along with knowledge engineering, and multilingual semantic reasoning techniques to build an automated system for assimilating culinary information for Indian food in the form of a knowledge graph. The main focus is on designing intelligent methods to derive ontology designs and capture all-encompassing knowledge about food, recipes, ingredients, cooking characteristics, and most importantly, nutrition, at scale. We present our ongoing work in this workshop paper, describe in some detail the relevant challenges in curating knowledge of Indian food, and propose our high-level ontology design. We also present a novel workflow that uses AI, LLM, and language technology to curate information from recipe blog sites in the public domain to build knowledge graphs for Indian food. The methods for knowledge curation proposed in this paper are generic and can be replicated for any domain. The design is application-agnostic and can be used for AI-driven smart analysis, building recommendation systems for Personalized Digital Health, and complementing the knowledge graph for Indian food with contextual information such as user information, food biochemist
In this paper we study the simultaneous problems of food waste and hunger in the context of the possible solution of food (waste) rescue and redistribution. To this end, we develop an empirical model that can be used in Monte Carlo simulations to study the dynamics of the underlying problem. Our model's parameters are derived from a unique data set provided by a large food bank and food rescue organization in north central Colorado. We find that food supply is a non-parametric heavy-tailed process that is well-modeled with an extreme value peaks-over-threshold model. Although the underlying process is stochastic, the basic approach of food rescue and redistribution appears to be feasible both at small and large scales. The ultimate efficacy of this model is intimately tied to the rate at which food expires and hence the ability to preserve and quickly transport and redistribute food. The cost of the redistribution is tied to the number and density of participating suppliers, and costs can be reduced (and supply increased) simply by recruiting additional donors to participate. Our results show that with sufficient funding and manpower, a significant amount of food can be rescued fro