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There is literature review of the acute and chronic pancreatitis experimental models. Patogenetic necrosis mechanisms with fibrosis progress in pancreas were revealed. The stimulation of the proteolytic enzymes synthesis and secretion, that was examined in experiments were compared with clinical examinations. The patients with chronic pancreatitis were investigated in the Central Research Institute of Gastroenterology.
The purpose of the study was to compare the nature of changes in the content of various groups of prostaglandins and cyclic nucleotides in patients with stomach ulcer as well as during the process of development and formation of experimental ulcers.
A measurement of the CKM angle $γ$ and related strong-phase parameters is performed using a novel, model-independent approach in ${B^{\pm}\rightarrow D(\rightarrow K^{0}_{\rm S} h^{\prime+}h^{\prime-}) h^{\pm}}$ decays, where $h^{(\prime)} \equiv π, K$. The analysis uses a joint data sample of electron-positron collisions collected by the BESIII experiment at the Beijing Electron-Positron Collider II during 2010--2011 and 2021--2022, corresponding to an integrated luminosity of 8 fb$^{-1}$, and proton-proton collisions collected by the LHCb experiment at the Large Hadron Collider during 2011--2018, corresponding to an integrated luminosity of 9 fb$^{-1}$. The two datasets are analyzed simultaneously by applying per-event weights based on the amplitude variation over the $D$-decay phase space to enhance the sensitivity to $C\!P$-violating observables. The CKM angle $γ$ is determined to be $γ= (71.3\pm 5.0)^{\circ}$, which constitutes the most precise single measurement to date.
Rotating non-axisymmetric neutron stars (NSs) are promising sources for continuous gravitational waves (CWs). Such CWs can, if detected, inform us about the internal structure and equation of state of NSs. Here, we present a narrowband search for CWs from known pulsars, for which an efficient and sensitive matched-filter search can be applied. Narrowband searches are designed to be robust to mismatches between the electromagnetic (EM) and gravitational emissions, in contrast to fully targeted searches where the CW emission is assumed to be phase-locked to the EM one. In this work, we search for the CW counterparts emitted by 34 pulsars using data from the first and second parts of the fourth LIGO--Virgo--KAGRA observing run. This is the largest number of pulsars so far targeted for narrowband searches in the advanced detector era. We use the 5n-vector narrowband pipeline, which applies frequency-domain matched filtering. In previous searches, it covered a narrow range in the frequency -- frequency time derivative ($f$ -- $\dot{f}$) space. Here, we also explore a range in the second time derivative of the frequency $\ddot{f}$ around the value indicated by EM observations. Additional
We report on a gravitational wave search for compact binary coalescences involving at least one component with mass between $0.2 M_\odot$ to $1 M_\odot$, and ratio of component masses between 0.1 and 1. The analysis uses data collected by the LIGO detectors between May 24 2023 15:00 UTC and January 16 2024 16:00 UTC. No statistically significant sub-solar mass candidates were identified by the participating search algorithms. We report the detection sensitivity of the current searches to the target sub-solar mass black hole population, while also reporting the sensitivity of the search to low-mass neutron star binaries for the first time. With the absence of detections, we place upper limits on the merger rate of sub-solar mass black holes, ranging from $110$ $\mathrm{Gpc^{-3}yr^{-1}}$ to $10000$ $\mathrm{Gpc^{-3}yr^{-1}}$ at 90% confidence. We use the merger rate limits to constrain two illustrative dark matter scenarios that can form sub-solar mass compact objects: primordial black holes, and dark black holes forming in a dissipative dark matter model. For late-forming primordial black hole binaries, our search excludes the fraction of dark matter in primordial black holes to be
We present results from directed searches for continuous gravitational waves from a sample of 15 nearby supernova remnants, likely hosting young neutron star candidates, using data from the first eight months of the fourth observing run (O4) of the LIGO-Virgo-KAGRA Collaboration. The analysis employs five pipelines: four semi-coherent methods -- the Band-Sampled-Data directed pipeline, Weave and two Viterbi pipelines (single- and dual-harmonic) -- and PyStoch, a cross-correlation-based pipeline. These searches cover wide frequency bands and do not assume prior knowledge of the targets' ephemerides. No evidence of a signal is found from any of the 15 sources. We set 95\% confidence-level upper limits on the intrinsic strain amplitude, with the most stringent constraints reaching $\sim 4 \times 10^{-26}$ near 300 Hz for the nearby source G266.2$-$1.2 (Vela Jr.). We also derive limits on neutron star ellipticity and $r$-mode amplitudes for the same source, with the best constraints reaching $\lesssim 10^{-7}$ and $\lesssim 10^{-5}$, respectively, at frequencies above 400 Hz. These results represent the most sensitive wide-band directed searches for continuous gravitational waves from
The worldwide LIGO-Virgo-KAGRA network of gravitational-wave (GW) detectors continues to increase in sensitivity, thus increasing the quantity and quality of the detected GW signals from compact binary coalescences. These signals allow us to perform ever-more sensitive tests of general relativity (GR) in the dynamical and strong-field regime of gravity. This paper is the first of three, where we present the results of a suite of tests of GR using the binary signals included in the fourth GW Transient Catalog (GWTC-4.0), i.e., up to and including the first part of the fourth observing run of the detectors (O4a). We restrict our analysis to the 91 confident signals, henceforth called events, that were measured by at least two detectors, and have false alarm rates $\le 10^{-3} \mathrm{yr}^{-1}$. These include 42 events from O4a. This first paper presents an overview of the methods, selection of events and GR tests, and serves as a guidemap for all three papers. Here we focus on the four general tests of consistency, where we find no evidence for deviations from our models. Specifically, for all the events considered, we find consistency of the residuals with noise. The final mass and
In this second of three papers on tests of general relativity (GR) applied to the compact binary coalescence signals in the fourth Gravitational-Wave Transient Catalog (GWTC-4.0), we present the results of the parameterized tests of GR and constraints on line-of-sight acceleration. We include events up to and including the first part of the fourth observing run (O4a) of the LIGO Virgo KAGRA detectors. As in the other two papers in this series, we restrict our analysis to the 42 confident signals, measured by at least two detectors, that have false alarm rates $\le 10^{-3} \mathrm{yr}^{-1}$ from O4a, in addition to the 49 such events from previous observing runs. This paper focuses on the eight tests that constrain parameterized deviations from the expected GR (or unaccelerated) values. These include modifications of post-Newtonian (PN) parameters, spin-induced quadrupole moments different from those of a binary black hole, and possible dispersive or birefringent propagation effects. Overall, we find no evidence for physics beyond GR, for spin-induced quadrupole moments different from those of a Kerr black hole in GR, or for line of sight acceleration, with more than 90% of the even
The discovery of joint sources of high-energy neutrinos and gravitational waves has been a primary target for the LIGO, Virgo, KAGRA, and IceCube observatories. The joint detection of high-energy neutrinos and gravitational waves would provide insight into cosmic processes, from the dynamics of compact object mergers and stellar collapses to the mechanisms driving relativistic outflows. The joint detection of multiple cosmic messengers can also elevate the significance of the common observation even when some or all of the constituent messengers are sub-threshold, i.e. not significant enough to declare their detection individually. Using data from the LIGO, Virgo, and IceCube observatories, including sub-threshold events, we searched for common sources of gravitational waves and high-energy neutrinos during the third observing run of Advanced LIGO and Advanced Virgo detectors. Our search did not identify significant joint sources. We derive constraints on the rate densities of joint sources. Our results constrain the isotropic neutrino emission from gravitational-wave sources for very high values of the total energy emitted in neutrinos (> $10^{52} - 10^{54}$ erg).
This is the third paper of the set recording the results of the suite of tests of general relativity (GR) performed on the signals from the fourth Gravitational-Wave Transient Catalog (GWTC-4.0), where we focus on the remnants of the binary mergers. We examine for the first time 42 events from the first part of the fourth observing run of the LIGO-Virgo-KAGRA detectors, alongside events from the previous observation runs, restricting our analysis to the confident signals, which were measured in at least two detectors and that have false alarm rates $\le 10^{-3} \mathrm{yr}^{-1}$. This paper focuses on seven tests of the coalescence remnants. Three of these are tests of the ringdown and its consistency with the expected quasinormal mode spectrum of a Kerr black hole. Specifically, two tests analyze just the ringdown in the time domain, and the third test analyzes the entire signal in the frequency domain. Four tests allow for the existence of possible echoes arriving after the end of the ringdown, which are not expected in GR. We find overall consistency of the remnants with GR. When combining events by multiplying likelihoods (hierarchically), one analysis finds that the GR predict
Volume 1 of the FCC Feasibility Report presents an overview of the physics case, experimental programme, and detector concepts for the Future Circular Collider (FCC). This volume outlines how FCC would address some of the most profound open questions in particle physics, from precision studies of the Higgs and EW bosons and of the top quark, to the exploration of physics beyond the Standard Model. The report reviews the experimental opportunities offered by the staged implementation of FCC, beginning with an electron-positron collider (FCC-ee), operating at several centre-of-mass energies, followed by a hadron collider (FCC-hh). Benchmark examples are given of the expected physics performance, in terms of precision and sensitivity to new phenomena, of each collider stage. Detector requirements and conceptual designs for FCC-ee experiments are discussed, as are the specific demands that the physics programme imposes on the accelerator in the domains of the calibration of the collision energy, and the interface region between the accelerator and the detector. The report also highlights advances in detector, software and computing technologies, as well as the theoretical tools /recons
GW240925 and GW250207 are two loud gravitational-wave signals from binary black hole coalescences observed with network signal-to-noise ratios $\sim 32$ and $\sim 69$, respectively, by the LIGO Hanford--LIGO Livingston--Virgo network. Gravitational-wave signals from coalescing binaries have characteristic phase and amplitude evolution predicted by general relativity. These signal waveforms, together with measured instrumental calibration uncertainties, are used to infer source parameters. However, for sufficiently loud detections it is possible to constrain the calibration of the detectors directly using the signals themselves. We present the first informative astrophysical measurements of gravitational-wave detector calibration. For GW240925, we verify the inference of Hanford calibration from the astrophysical signal through cross-checks with known calibration errors obtained from in-situ measurements. At the time of GW250207, the Hanford detector was not fully stabilized, leading to elevated calibration uncertainties; thus, astrophysical calibration is essential to obtain accurate data and to enable source localization. These well-localized, high signal-to-noise observations hav
We present results from an all-sky search for continuous gravitational waves, using three different methods applied to the first eight months of LIGO data from the fourth LIGO-Virgo-KAGRA Collaboration s observing run. We aim at signals potentially emitted by rotating, non-axisymmetric isolated neutron star in the Milky Way. The analysis spans a frequency range from 20 Hz to 2000 Hz and accommodates frequency derivative magnitudes up to $10^{-8}$ Hz/s. No statistically significant periodic gravitational wave signals were detected. We establish 95% confidence-level (CL) frequentist upper limits on the dimensionless strain amplitudes. The most stringent population-averaged strain upper limits reach 9.7 $\times$ $10^{-26}$ near 290 Hz, matching the best previous constraints from 250 to $\sim$1700 Hz while extending coverage to a much broader spin-down range. At higher frequencies, the new limits improve upon previous results by factors of approximately $\sim$1.6. These constraints are applied to three astrophysical scenarios: 1) the distribution of galactic neutron stars as a function of spin frequency and ellipticity; 2) the contribution of millisecond pulsars to the GeV excess near
The Gravitational-Wave Transient Catalog (GWTC) is a collection of short-duration (transient) gravitational-wave signals identified by the LIGO-Virgo-KAGRA Collaboration in gravitational-wave data produced by the eponymous detectors. The catalog provides information about the identified candidates, such as the arrival time and amplitude of the signal and properties of the signal's source as inferred from the observational data. GWTC is the release of this dataset and version 5.0 extends the catalog to include observations made during the second part of the fourth LIGO-Virgo-KAGRA observing run up until 2025 January 28. This paper marks an introduction to a collection of articles related to this version of the catalog, GWTC-5.0. This update significantly increases the number of detected merging binary systems of black holes and neutron stars to over 300, enabling many follow-up studies toward understanding the gravitational-wave universe. The collection of articles accompanying the catalog provides documentation of the methods used to analyze the data, summaries of the catalog of events, observational measurements drawn from the population, and detailed discussions of selected candi
The angular distribution of gravitational-wave power from persistent sources may exhibit anisotropies arising from the large-scale structure of the Universe. This motivates directional searches for astrophysical and cosmological gravitational-wave backgrounds, as well as continuous-wave emitters. We present results of such a search using data from the first observing run through the first portion of the fourth observing run of the LIGO-Virgo-KAGRA Collaborations. We apply gravitational-wave radiometer techniques to generate skymaps and search for both narrowband and broadband persistent gravitational-wave sources. Additionally, we use spherical harmonic decomposition to probe spatially extended sources. No evidence of persistent gravitational-wave signals is found, and we set the most stringent constraints to date on such emissions. For narrowband point sources, our sensitivity estimate to effective strain amplitude lies in the range $(0.03 - 8.4) \times 10^{-24}$ across all sky and frequency range $(20 - 160)$ Hz. For targeted sources -- Scorpius X-1, SN 1987A, the Galactic Center, Terzan 5, and NGC 6397 -- we constrain the strain amplitude with best limits ranging from $\sim 1.1
We search for gravitational-wave background signals produced by various early Universe processes in the Advanced LIGO O4a dataset, combined with the data from the earlier O1, O2, and O3 (LIGO-Virgo) runs. The absence of detectable signals enables powerful constraints on fundamental physics. We derive gravitational-wave background energy density upper limits from the O1-O4a data to constrain parameters associated with various possible processes in the early Universe: first-order phase transitions, cosmic strings, domain walls, stiff equation of state, axion inflation, second-order scalar perturbations, primordial black hole binaries, and parity violation. In our analyses, the presence of an astrophysical background produced by compact (black hole and neutron star) binary coalescences throughout the Universe is also considered. We address the implications for various cosmological and high energy physics models based on the obtained parameter constraints. We conclude that LIGO-Virgo data already yield significant constraints on numerous early Universe scenarios.
The international collaboration designing and constructing the Deep Underground Neutrino Experiment (DUNE) at the Long-Baseline Neutrino Facility (LBNF) has developed a two-phase strategy toward the implementation of this leading-edge, large-scale science project. The ambitious physics program of Phase I and Phase II of DUNE is dependent upon deployment and utilization of significant computing resources, and successful research and development of software (both infrastructure and algorithmic) in order to achieve these scientific goals. This submission discusses the computing resources projections, infrastructure support, and software development needed for DUNE during the coming decades as an input to the European Strategy for Particle Physics Update for 2026. The DUNE collaboration is submitting four main contributions to the 2026 Update of the European Strategy for Particle Physics process. This submission to the 'Computing' stream focuses on DUNE software and computing. Additional inputs related to the DUNE science program, DUNE detector technologies and R&D, and European contributions to Fermilab accelerator upgrades and facilities for the DUNE experiment, are also being su
The Gravitational-Wave Transient Catalog (GWTC) is a collection of candidate gravitational-wave transient signals identified and characterized by the LIGO-Virgo-KAGRA Collaboration. Producing the contents of the GWTC from detector data requires complex analysis methods. These comprise techniques to model the signal; identify the transients in the data; evaluate the quality of the data and mitigate possible instrumental issues; infer the parameters of each transient; compare the data with the waveform models for compact binary coalescences; and handle the large amount of results associated with all these different analyses. In this paper, we describe the methods employed to produce the catalog's fourth release, GWTC-4.0, focusing on the analysis of the first part of the fourth observing run of Advanced LIGO, Advanced Virgo and KAGRA.
We present results from the search for an isotropic gravitational-wave background using Advanced LIGO and Advanced Virgo data from O1 through O4a, the first part of the fourth observing run. This background is the accumulated signal from unresolved sources throughout cosmic history and encodes information about the merger history of compact binaries throughout the Universe, as well as exotic physics and potentially primordial processes from the early cosmos. Our cross-correlation analysis reveals no statistically significant background signal, enabling us to constrain several theoretical scenarios. For compact binary coalescences which approximately follow a 2/3 power-law spectrum, we constrain the fractional energy density to $Ω_{\rm GW}(25{\rm Hz})\leq 2.0\times 10^{-9}$ (95% cred.), a factor of 1.7 improvement over previous results. Scale-invariant backgrounds are constrained to $Ω_{\rm GW}(25{\rm Hz})\leq 2.8\times 10^{-9}$, representing a 2.1x sensitivity gain. We also place new limits on gravity theories predicting non-standard polarization modes and confirm that terrestrial magnetic noise sources remain below detection threshold. Combining these spectral limits with populati
Continuous gravitational waves (CWs) emission from neutron stars carries information about their internal structure and equation of state, and it can provide tests of General Relativity. We present a search for CWs from a set of 45 known pulsars in the first part of the fourth LIGO--Virgo--KAGRA observing run, known as O4a. We conducted a targeted search for each pulsar using three independent analysis methods considering the single-harmonic and the dual-harmonic emission models. We find no evidence of a CW signal in O4a data for both models and set upper limits on the signal amplitude and on the ellipticity, which quantifies the asymmetry in the neutron star mass distribution. For the single-harmonic emission model, 29 targets have the upper limit on the amplitude below the theoretical spin-down limit. The lowest upper limit on the amplitude is $6.4\!\times\!10^{-27}$ for the young energetic pulsar J0537-6910, while the lowest constraint on the ellipticity is $8.8\!\times\!10^{-9}$ for the bright nearby millisecond pulsar J0437-4715. Additionally, for a subset of 16 targets we performed a narrowband search that is more robust regarding the emission model, with no evidence of a sig