搜索结果：Economics and human biology

This article frames the relation between biology and physics by characterizing the former as a subdiscipline rather than a special case of the latter. To do this, we posit biological physics as the science of living matter in contrast to classic biophysics, the study of organismal properties by physical techniques. At the scale of the individual cell, living matter is nonunitary, i.e., not composed of aggregated subunits, and has features (e.g., intracellular organizational arrangements and biomolecular condensates) that are unlike any materials of the nonliving world. In transiently or constitutively multicellular forms (social microorganisms, animals, plants), living matter sustains physical processes that are generic (shared with nonliving matter, e.g., subunit communication by molecular diffusion in cellular slime molds), biogeneric (analogous to nonliving matter but realized through cellular activities, e.g., subunit demixing in animal embryos) or nongeneric (pertaining to sui generis materials, e.g., budding of active solids in plants). This "forms of matter" perspective is philosophically situated in the dialectical materialism of Engels and Hessen and the multilevel physica

Humans exhibit irrational decision-making patterns in response to environmental triggers, such as experiencing an economic loss or gain. In this paper we investigate whether algorithms exhibit the same behavior by examining the observed decisions and latent risk and rationality parameters estimated by a random utility model with constant relative risk-aversion utility function. We use a dataset consisting of 10,000 hands of poker played by Pluribus, the first algorithm in the world to beat professional human players and find (1) Pluribus does shift its playing style in response to economic losses and gains, ceteris paribus; (2) Pluribus becomes more risk-averse and rational following a trigger but the humans become more risk-seeking and irrational; (3) the difference in playing styles between Pluribus and the humans on the dimensions of risk-aversion and rationality are particularly differentiable when both have experienced a trigger. This provides support that decision-making patterns could be used as "behavioral signatures" to identify human versus algorithmic decision-makers in unlabeled contexts.

We survey and introduce concepts and tools located at the intersection of information theory and network biology. We show that Shannon's information entropy, compressibility and algorithmic complexity quantify different local and global aspects of synthetic and biological data. We show examples such as the emergence of giant components in Erdos-Renyi random graphs, and the recovery of topological properties from numerical kinetic properties simulating gene expression data. We provide exact theoretical calculations, numerical approximations and error estimations of entropy, algorithmic probability and Kolmogorov complexity for different types of graphs, characterizing their variant and invariant properties. We introduce formal definitions of complexity for both labeled and unlabeled graphs and prove that the Kolmogorov complexity of a labeled graph is a good approximation of its unlabeled Kolmogorov complexity and thus a robust definition of graph complexity.

Understanding the biological mechanisms of disease is crucial for medicine, and in particular, for drug discovery. AI-powered analysis of genome-scale biological data holds great potential in this regard. The increasing availability of single-cell RNA sequencing data has enabled the development of large foundation models for disease biology. However, existing foundation models only modestly improve over task-specific models in downstream applications. Here, we explored two avenues for improving single-cell foundation models. First, we scaled the pre-training data to a diverse collection of 116 million cells, which is larger than those used by previous models. Second, we leveraged the availability of large-scale biological annotations as a form of supervision during pre-training. We trained the \model family of models comprising six transformer-based state-of-the-art single-cell foundation models with 70 million, 160 million, and 400 million parameters. We vetted our models on several downstream evaluation tasks, including identifying the underlying disease state of held-out donors not seen during training, distinguishing between diseased and healthy cells for disease conditions and

While generative artificial intelligence (Gen AI) increasingly transforms academic environments, a critical gap exists in understanding and mitigating human biases in AI interactions, such as anchoring and confirmation bias. This position paper advocates for metacognitive AI literacy interventions to help university students critically engage with AI and address biases across the Human-AI interaction workflows. The paper presents the importance of considering (1) metacognitive support with deliberate friction focusing on human bias; (2) bi-directional Human-AI interaction intervention addressing both input formulation and output interpretation; and (3) adaptive scaffolding that responds to diverse user engagement patterns. These frameworks are illustrated through ongoing work on "DeBiasMe," AIED (AI in Education) interventions designed to enhance awareness of cognitive biases while empowering user agency in AI interactions. The paper invites multiple stakeholders to engage in discussions on design and evaluation methods for scaffolding mechanisms, bias visualization, and analysis frameworks. This position contributes to the emerging field of AI-augmented learning by emphasizing the

Financial and economic history is strewn with bubbles and crashes, booms and busts, crises and upheavals of all sorts. Understanding the origin of these events is arguably one of the most important problems in economic theory: are economies intrinsically unstable, and can one ``stabilize unstable economies''? In this review I argue, from a physicist's vantage point, that the concept of equilibrium -- so central to mainstream economic thinking -- is likely to be the exception rather than the rule in large, complex, interacting systems. Drawing on a series of stylized ``toy'' models, I show how excess volatility, endogenous crises and crashes, inflation swells and persistent inequalities can all emerge naturally from genuinely out-of-equilibrium dynamics, without invoking large exogenous shocks. Three generic mechanisms recur throughout: trapping in a multiplicity of history-dependent equilibria; the impossibility of dynamically reaching equilibrium, leading to oscillations and chaos; and the spontaneous evolution towards fragile, marginally stable states -- the self-organized criticality paradigm. I stress that these are phenomenological scenarios rather than calibrated theories: th

As digital social platforms and mobile technologies are becoming more prevalent and robust, the use of Artificial Intelligence (AI) in facilitating human communication will grow. This, in turn, will pave the way for the development of intuitive, adaptive, and effective empathic AI interfaces that better address the needs of socially and culturally diverse communities. I believe such developments must consider a principled framework that includes the human perceptual senses in the digital design process right from the start, for a more accurate, as well as a more aesthetic, memorable, and soothing experience. In this position paper, I suggest features, identify some challenges that need to be addressed in the process, and propose some future research directions that I think should be part of the design and implementation. Such an approach will allow various communities of practice to investigate the areas of intersection between artificial intelligence, on one side, and human communication, perceptual needs and social and cultural values, on the other.

Examining the economic impact of noise pollution from a lens of household is a burgeoning field in the study of environmental sustainability. Economics studies cover the source, measure, consequence of noise pollution, as well as the econometric methods used to identify the causal impact of noise pollution on socioeconomic welfare. There are broadly four major noise origins along with the industrial growth and urban development, which are airport, railway, urban traffic, and neighborhood. Four general kinds of measures or data sources are used in economics studies to capture the noise variations, namely, proximity to noise origins, real-time noise monitor records, household surveys, and administrative records on noise complaints. The socioeconomic consequences of noise pollution span from physical or mental health to happiness, violence and suicide, housing market capitalization, and inequality. In economics studies, generally three types of econometric methods are used to identify causal impact of noise pollution on the household's welfare, which are instrumental variable estimation, difference-in-difference estimation, randomized and quasi-natural experiments. The causal impact o

Integrating Large Language Models (LLMs) into business process management tools promises to democratize Business Process Model and Notation (BPMN) modeling for non-experts. While automated frameworks assess syntactic and semantic quality, they miss human factors like trust, usability, and professional alignment. We conducted a mixed-methods evaluation of our proposed solution, an LLM-powered BPMN copilot, with five process modeling experts using focus groups and standardized questionnaires. Our findings reveal a critical tension between acceptable perceived usability (mean CUQ score: 67.2/100) and notably lower trust (mean score: 48.8\%), with reliability rated as the most critical concern (M=1.8/5). Furthermore, we identified output-quality issues, prompting difficulties, and a need for the LLM to ask more in-depth clarifying questions about the process. We envision five use cases ranging from domain-expert support to enterprise quality assurance. We demonstrate the necessity of human-centered evaluation complementing automated benchmarking for LLM modeling agents.

Heuristic evaluation is a widely used method in Human-Computer Interaction (HCI) to inspect interfaces and identify issues based on heuristics. Recently, Large Language Models (LLMs), such as GPT-4o, have been applied in HCI to assist in persona creation, the ideation process, and the analysis of semi-structured interviews. However, considering the need to understand heuristics and the high degree of abstraction required to evaluate them, LLMs may have difficulty conducting heuristic evaluation. However, prior research has not investigated GPT-4o's performance in heuristic evaluation compared to HCI experts in web-based systems. In this context, this study aims to compare the results of a heuristic evaluation performed by GPT-4o and human experts. To this end, we selected a set of screenshots from a web system and asked GPT-4o to perform a heuristic evaluation based on Nielsen's Heuristics from a literature-grounded prompt. Our results indicate that only 21.2% of the issues identified by human experts were also identified by GPT-4o, despite it found 27 new issues. We also found that GPT-4o performed better for heuristics related to aesthetic and minimalist design and match between

We developed a theory showing that under appropriate normalizations and rescalings, temperature response curves show a remarkably regular behavior and follow a general, universal law. The impressive universality of temperature response curves remained hidden due to various curve-fitting models not well-grounded in first principles. In addition, this framework has the potential to explain the origin of different scaling relationships in thermal performance in biology, from molecules to ecosystems. Here, we summarize the background, principles and assumptions, predictions, implications, and possible extensions of this theory.

We argue that Ulam-Hyers stability concept is quite significant in realistic problems in numerical analysis, biology and economics. A generalization to nonlinear systems is proposed and applied to the logistic equation (both differential and difference), SIS epidemic model, Cournot model in economics and a reaction diffusion equation. To the best of our knowledge this is the first time Ulam-Hyers stability is considered from the applications point of view.

With the reversal of Roe v. Wade in 2022, many U.S. employers announced they would reimburse employees for abortion-related travel expenses. This action complements increasingly common employer policies subsidizing employee access to assisted reproductive technologies such as in-vitro fertilization and egg freezing. This article reflects on why employers offer these benefits and whether they enhance or undermine reproductive justice. From the employer's perspective, abortion and assisted reproductive technologies help women to plan childbearing around the demands of their jobs. Both are associated with delayed childbirth and reduced fertility, which lower the costs of motherhood to employers. However, firm subsidization of these services does not further reproductive justice because it reifies structures which incentivize women to delay childbirth and reduce fertility, and it reinforces economic and reproductive inequalities. We conclude by questioning whether reproductive justice is possible without transforming the economy so that it prioritizes care over profits.

In a recent paper, Wilmes et al. demonstrated a qualitative integration of omics data streams to gain a mechanistic understanding of cyclosporine A toxicity. One of their major conclusions was that cyclosporine A strongly activates the nuclear factor (erythroid-derived 2)-like 2 pathway (Nrf2) in renal proximal tubular epithelial cells exposed in vitro. We pursue here the analysis of those data with a quantitative integration of omics data with a differential equation model of the Nrf2 pathway. That was done in two steps: (i) Modeling the in vitro pharmacokinetics of cyclosporine A (exchange between cells, culture medium and vial walls) with a minimal distribution model. (ii) Modeling the time course of omics markers in response to cyclosporine A exposure at the cell level with a coupled PK-systems biology model. Posterior statistical distributions of the parameter values were obtained by Markov chain Monte Carlo sampling. Data were well simulated, and the known in vitro toxic effect EC50 was well matched by model predictions. The integration of in vitro pharmacokinetics and systems biology modeling gives us a quantitative insight into mechanisms of cyclosporine A oxidative-stress

Human-robot teaming offers great potential because of the opportunities to combine strengths of heterogeneous agents. However, one of the critical challenges in realizing an effective human-robot team is efficient information exchange - both from the human to the robot as well as from the robot to the human. In this work, we present and analyze an augmented reality-enabled, gesture-based system that supports intuitive human-robot teaming through improved information exchange. Our proposed system requires no external instrumentation aside from human-wearable devices and shows promise of real-world applicability for service-oriented missions. Additionally, we present preliminary results from a pilot study with human participants, and highlight lessons learned and open research questions that may help direct future development, fielding, and experimentation of autonomous HRI systems.

While the proliferation of foundation models has significantly boosted individual productivity, it also introduces a potential challenge: the homogenization of creative content. In response, we revisit Design-by-Analogy (DbA), a cognitively grounded approach that fosters novel solutions by mapping inspiration across domains. However, prevailing perspectives often restrict DbA to early ideation or specific data modalities, while reducing AI-driven design to simplified input-output pipelines. Such conceptual limitations inadvertently foster widespread design fixation. To address this, we expand the understanding of DbA by embedding it into the entire creative process, thereby demonstrating its capacity to mitigate such fixation. Through a systematic review of 85 studies, we identify six forms of representation and classify techniques across seven stages of the creative process. We further discuss three major application domains: creative industries, intelligent manufacturing, and education and services, demonstrating DbA's practical relevance. Building on this synthesis, we frame DbA as a mediating technology for human-AI collaboration and outline the potential opportunities and inhe

Rapid increases in food supplies have reduced global hunger, while rising burdens of diet-related disease have made poor diet quality the leading cause of death and disability around the world. Today's "double burden" of undernourishment in utero and early childhood then undesired weight gain and obesity later in life is accompanied by a third less visible burden of micronutrient imbalances. The triple burden of undernutrition, obesity, and unbalanced micronutrients that underlies many diet-related diseases such as diabetes, hypertension and other cardiometabolic disorders often coexist in the same person, household and community. All kinds of deprivation are closely linked to food insecurity and poverty, but income growth does not always improve diet quality in part because consumers cannot directly or immediately observe the health consequences of their food options, especially for newly introduced or reformulated items. Even after direct experience and epidemiological evidence reveals relative risks of dietary patterns and nutritional exposures, many consumers may not consume a healthy diet because food choice is driven by other factors. This chapter reviews the evidence on diet

This paper establishes the theoretical and practical foundations for using Large Language Models (LLMs) as measurement instruments for latent economic variables -- specifically variables that describe the cognitive content of occupational tasks at a level of granularity not achievable with existing survey instruments. I formalize four conditions under which LLM-generated scores constitute valid instruments: semantic exogeneity, construct relevance, monotonicity, and model invariance. I then apply this framework to the Augmented Human Capital Index (AHC_o), constructed from 18,796 O*NET task statements scored by Claude Haiku 4.5, and validated against six existing AI exposure indices. The index shows strong convergent validity (r = 0.85 with Eloundou GPT-gamma, r = 0.79 with Felten AIOE) and discriminant validity. Principal component analysis confirms that AI-related occupational measures span two distinct dimensions -- augmentation and substitution. Inter-rater reliability across two LLM models (n = 3,666 paired scores) yields Pearson r = 0.76 and Krippendorff's alpha = 0.71. Prompt sensitivity analysis across four alternative framings shows that task-level rankings are robust. Obv

This paper presents a novel quantitative approach for comparative economic studies, addressing limitations in current classification methods. Conventional approaches in comparative economics often rely on ad hoc and categorical classifications, leading to subjective judgments and disregarding the continuous nature of the spectrum of economic systems. These can result in subjectivity and significant information loss, particularly for countries with systems near categorical borders. To overcome these shortcomings, the present paper proposes distance-based indices for objective categorization, considering economic foundations and using hard data. Accordingly, the paper introduces institutional similarity indices--Capitalism Similarity Index (CapSI), Communism Similarity Index (ComSI), and Socialism Similarity Index (SocSI)-which reflect countries' positions along the economic system continuum. These indices adhere to mathematical rigor and are grounded in the mathematical fields of real analysis, metric spaces, and distance functions. By classifying 135 countries and creating GIS maps, the practical applicability of the proposed approach is demonstrated. Results show a high explanator