Chinese Spelling Correction (CSC) is gaining increasing attention due to its promise of automatically detecting and correcting spelling errors in Chinese texts. Despite its extensive use in many applications, like search engines and optical character recognition systems, little has been explored in medical scenarios in which complex and uncommon medical entities are easily misspelled. Correcting the misspellings of medical entities is arguably more difficult than those in the open domain due to its requirements of specificdomain knowledge. In this work, we define the task of Medical-domain Chinese Spelling Correction and propose MCSCSet, a large scale specialist-annotated dataset that contains about 200k samples. In contrast to the existing open-domain CSC datasets, MCSCSet involves: i) extensive real-world medical queries collected from Tencent Yidian, ii) corresponding misspelled sentences manually annotated by medical specialists. To ensure automated dataset curation, MCSCSet further offers a medical confusion set consisting of the commonly misspelled characters of given Chinese medical terms. This enables one to create the medical misspelling dataset automatically. Extensive em
Developing intelligent pediatric consultation systems offers promising prospects for improving diagnostic efficiency, especially in China, where healthcare resources are scarce. Despite recent advances in Large Language Models (LLMs) for Chinese medicine, their performance is sub-optimal in pediatric applications due to inadequate instruction data and vulnerable training procedures. To address the above issues, this paper builds PedCorpus, a high-quality dataset of over 300,000 multi-task instructions from pediatric textbooks, guidelines, and knowledge graph resources to fulfil diverse diagnostic demands. Upon well-designed PedCorpus, we propose PediatricsGPT, the first Chinese pediatric LLM assistant built on a systematic and robust training pipeline. In the continuous pre-training phase, we introduce a hybrid instruction pre-training mechanism to mitigate the internal-injected knowledge inconsistency of LLMs for medical domain adaptation. Immediately, the full-parameter Supervised Fine-Tuning (SFT) is utilized to incorporate the general medical knowledge schema into the models. After that, we devise a direct following preference optimization to enhance the generation of pediatric
Large Language Models (LLMs), such as the LLaMA model, have demonstrated their effectiveness in various general-domain natural language processing (NLP) tasks. Nevertheless, LLMs have not yet performed optimally in biomedical domain tasks due to the need for medical expertise in the responses. In response to this challenge, we propose HuaTuo, a LLaMA-based model that has been supervised-fine-tuned with generated QA (Question-Answer) instances. The experimental results demonstrate that HuaTuo generates responses that possess more reliable medical knowledge. Our proposed HuaTuo model is accessible at https://github.com/SCIR-HI/Huatuo-Llama-Med-Chinese.
The Gravitational-Wave Transient Catalog (GWTC) is a collection of candidate gravitational-wave transient signals identified and characterized by the LIGO-Virgo-KAGRA Collaboration. Producing the contents of the GWTC from detector data requires complex analysis methods. These comprise techniques to model the signal; identify the transients in the data; evaluate the quality of the data and mitigate possible instrumental issues; infer the parameters of each transient; compare the data with the waveform models for compact binary coalescences, and handle the large amount of results associated with all these different analyses. In this paper, we describe the methods employed to produce the catalog's fifth release, GWTC-5.0, focusing on the analysis of the second part of the fourth observing run of LIGO, Virgo and KAGRA.
In this second of three papers on tests of general relativity (GR) applied to the compact binary coalescence signals in the 4th Gravitational-Wave Transient Catalog (GWTC-4.0), we present the results of the parameterized tests of GR and constraints on line-of-sight acceleration (LOSA). We include events up to and including the 1st part of the 4th observing run (O4a) of the LIGO-Virgo-KAGRA detectors. As in the other two papers in this series, we restrict our analysis to the 42 confident signals, measured by at least two detectors, that have FAR < 10^{-3}/yr from O4a, in addition to the 49 such events from previous observing runs. This paper focuses on the 8 tests that constrain parameterized deviations from the expected GR (or unaccelerated) values. These include modifications of post-Newtonian (PN) parameters, spin-induced quadrupole moments different from those of a binary black hole (BH), and possible dispersive or birefringent propagation effects. Overall, we find no evidence for physics beyond GR, for spin-induced quadrupole moments different from those of a Kerr BH in GR, or for LOSA, with more than 90% of the events including the null result (no deviation) within their 90
The discovery of joint sources of high-energy neutrinos and gravitational waves has been a primary target for the LIGO, Virgo, KAGRA, and IceCube observatories. The joint detection of high-energy neutrinos and gravitational waves would provide insight into cosmic processes, from the dynamics of compact object mergers and stellar collapses to the mechanisms driving relativistic outflows. The joint detection of multiple cosmic messengers can also elevate the significance of the common observation even when some or all of the constituent messengers are sub-threshold, i.e. not significant enough to declare their detection individually. Using data from the LIGO, Virgo, and IceCube observatories, including sub-threshold events, we searched for common sources of gravitational waves and high-energy neutrinos during the third observing run of Advanced LIGO and Advanced Virgo detectors. Our search did not identify significant joint sources. We derive constraints on the rate densities of joint sources. Our results constrain the isotropic neutrino emission from gravitational-wave sources for very high values of the total energy emitted in neutrinos (> $10^{52} - 10^{54}$ erg).
The Gravitational-Wave Transient Catalog (GWTC) is a collection of short-duration (transient) gravitational-wave signals identified by the LIGO-Virgo-KAGRA Collaboration in gravitational-wave data produced by the eponymous detectors. The catalog provides information about the identified candidates, such as the arrival time and amplitude of the signal and properties of the signal's source as inferred from the observational data. GWTC is the release of this dataset and version 5.0 extends the catalog to include observations made during the second part of the fourth LIGO-Virgo-KAGRA observing run up until 2025 January 28. This paper marks an introduction to a collection of articles related to this version of the catalog, GWTC-5.0. This update significantly increases the number of detected merging binary systems of black holes and neutron stars to over 300, enabling many follow-up studies toward understanding the gravitational-wave universe. The collection of articles accompanying the catalog provides documentation of the methods used to analyze the data, summaries of the catalog of events, observational measurements drawn from the population, and detailed discussions of selected candi
We present results from an all-sky search for continuous gravitational waves, using three different methods applied to the first eight months of LIGO data from the fourth LIGO-Virgo-KAGRA Collaboration s observing run. We aim at signals potentially emitted by rotating, non-axisymmetric isolated neutron star in the Milky Way. The analysis spans a frequency range from 20 Hz to 2000 Hz and accommodates frequency derivative magnitudes up to $10^{-8}$ Hz/s. No statistically significant periodic gravitational wave signals were detected. We establish 95% confidence-level (CL) frequentist upper limits on the dimensionless strain amplitudes. The most stringent population-averaged strain upper limits reach 9.7 $\times$ $10^{-26}$ near 290 Hz, matching the best previous constraints from 250 to $\sim$1700 Hz while extending coverage to a much broader spin-down range. At higher frequencies, the new limits improve upon previous results by factors of approximately $\sim$1.6. These constraints are applied to three astrophysical scenarios: 1) the distribution of galactic neutron stars as a function of spin frequency and ellipticity; 2) the contribution of millisecond pulsars to the GeV excess near
We present results from directed searches for continuous gravitational waves from a sample of 15 nearby supernova remnants, likely hosting young neutron star candidates, using data from the first eight months of the fourth observing run (O4) of the LIGO-Virgo-KAGRA Collaboration. The analysis employs five pipelines: four semi-coherent methods -- the Band-Sampled-Data directed pipeline, Weave and two Viterbi pipelines (single- and dual-harmonic) -- and PyStoch, a cross-correlation-based pipeline. These searches cover wide frequency bands and do not assume prior knowledge of the targets' ephemerides. No evidence of a signal is found from any of the 15 sources. We set 95\% confidence-level upper limits on the intrinsic strain amplitude, with the most stringent constraints reaching $\sim 4 \times 10^{-26}$ near 300 Hz for the nearby source G266.2$-$1.2 (Vela Jr.). We also derive limits on neutron star ellipticity and $r$-mode amplitudes for the same source, with the best constraints reaching $\lesssim 10^{-7}$ and $\lesssim 10^{-5}$, respectively, at frequencies above 400 Hz. These results represent the most sensitive wide-band directed searches for continuous gravitational waves from
The worldwide LIGO-Virgo-KAGRA network of gravitational-wave (GW) detectors continues to increase in sensitivity, thus increasing the quantity and quality of the detected GW signals from compact binary coalescences. These signals allow us to perform ever-more sensitive tests of general relativity (GR) in the dynamical and strong-field regime of gravity. This paper is the first of three, where we present the results of a suite of tests of GR using the binary signals included in the fourth GW Transient Catalog (GWTC-4.0), i.e., up to and including the first part of the fourth observing run of the detectors (O4a). We restrict our analysis to the 91 confident signals, henceforth called events, that were measured by at least two detectors, and have false alarm rates $\le 10^{-3} \mathrm{yr}^{-1}$. These include 42 events from O4a. This first paper presents an overview of the methods, selection of events and GR tests, and serves as a guidemap for all three papers. Here we focus on the four general tests of consistency, where we find no evidence for deviations from our models. Specifically, for all the events considered, we find consistency of the residuals with noise. The final mass and
This is the third paper of the set recording the results of the suite of tests of general relativity (GR) performed on the signals from the fourth Gravitational-Wave Transient Catalog (GWTC-4.0), where we focus on the remnants of the binary mergers. We examine for the first time 42 events from the first part of the fourth observing run of the LIGO-Virgo-KAGRA detectors, alongside events from the previous observation runs, restricting our analysis to the confident signals, which were measured in at least two detectors and that have false alarm rates $\le 10^{-3} \mathrm{yr}^{-1}$. This paper focuses on seven tests of the coalescence remnants. Three of these are tests of the ringdown and its consistency with the expected quasinormal mode spectrum of a Kerr black hole. Specifically, two tests analyze just the ringdown in the time domain, and the third test analyzes the entire signal in the frequency domain. Four tests allow for the existence of possible echoes arriving after the end of the ringdown, which are not expected in GR. We find overall consistency of the remnants with GR. When combining events by multiplying likelihoods (hierarchically), one analysis finds that the GR predict
LIGO, Virgo, KAGRA, and GEO 600 form a network of gravitational-wave observatories. Data and analysis results from this network are made publicly available through the Gravitational Wave Open Science Center (GWOSC). This paper describes open data from this network, including the addition of data from the second part of the fourth observing run (O4b) and selected periods from the preceding engineering run (ER16), which were collected from times spanning April 6th, 2024 to January 28th, 2025. The public data set includes calibrated strain time series for each instrument, data from additional channels used for noise subtraction and detector characterization, and new analysis data products in the online GWOSC release associated with version 5.0 of the Gravitational-Wave Transient Catalog.
GW240925 and GW250207 are two loud gravitational-wave signals from binary black hole coalescences observed with network signal-to-noise ratios $\sim 32$ and $\sim 69$, respectively, by the LIGO Hanford--LIGO Livingston--Virgo network. Gravitational-wave signals from coalescing binaries have characteristic phase and amplitude evolution predicted by general relativity. These signal waveforms, together with measured instrumental calibration uncertainties, are used to infer source parameters. However, for sufficiently loud detections it is possible to constrain the calibration of the detectors directly using the signals themselves. We present the first informative astrophysical measurements of gravitational-wave detector calibration. For GW240925, we verify the inference of Hanford calibration from the astrophysical signal through cross-checks with known calibration errors obtained from in-situ measurements. At the time of GW250207, the Hanford detector was not fully stabilized, leading to elevated calibration uncertainties; thus, astrophysical calibration is essential to obtain accurate data and to enable source localization. These well-localized, high signal-to-noise observations hav
We present the results of a search for continuous gravitational waves from the low-mass X-ray binary Scorpius X-1 using LIGO data from the first part of the fourth LIGO-Virgo-KAGRA observing run. By applying the resampling version of the cross-correlation pipeline to search for signal frequencies $f_0$ between $25$ and $200\un{Hz}$ (corresponding to neutron star spin frequencies of $12.5$ to $100\un{Hz}$ for GW due to triaxiality, or $\sim15-20$ to $\sim120-150\un{Hz}$ for GW due to $r$-modes), we set upper limits below the standard torque balance level, independent of neutron star spin inclination, for $50\un{Hz}\lesssim f_0\lesssim200\un{Hz}$. While uncertainties in the modelling of torque and equation of state limit the strength of our inference, our results nonetheless argue against torque balance in this spin range for a neutron star described by a hadronic equation of state. The most sensitive upper limits on the gravitational wave amplitude $h_0$, at the upper end of the frequency band searched, approach $5\times10^{-26}$ marginalized over inclination angle and $2\times10^{-26}$ assuming the most favorable inclination. The marginalized upper limits correspond to a sensitivit
The signals from the LIGO-Virgo-KAGRA network of gravitational-wave (GW) detectors allow us to perform sensitive tests of general relativity (GR) in the dynamical and strong-field regime of gravity. We present the results of seven tests of GR using the observed binary signals in the fifth GW Transient Catalog (GWTC-5.0), i.e., up to and including the second part of the fourth observing run (O4b). We restrict our analysis to the confident signals, henceforth called events, observed by at least two detectors that have estimated false alarm rates $\le 10^{-3} \ \rm{yr}^{-1}$. These include 72 events from O4b and five events from the first part of the fourth observing run that are now analyzed due to their increased significance from updated search results, bringing the total number of events for tests of GR in the cumulative GWTC to 168. After subtracting the best-fit waveforms, we find the residuals are consistent with detector noise for all events considered. We also find no strong evidence for additional polarizations beyond those predicted by GR. We perform tests of GW generation, improving the constraints on deviations from the GR post-Newtonian coefficients by factors of 1.2-2.6
Version 5.0 of the Gravitational-Wave Transient Catalog (GWTC-5.0) adds new candidates detected by the LIGO Virgo KAGRA network of observatories through the second part of the fourth observing run (O4b: 2024 April 10 15:00:00 to 2025 January 28 17:00:00 UTC) and four days of the preceding engineering run (2024 April 6 to 2024 April 10). We find 161 compact binary coalescence candidates that are identified by at least one of our search algorithms with a probability of astrophysical origin $p_\mathrm{astro} \geq 0.5$ and that are not vetoed during event validation. We also provide detailed source property measurements for 104 candidates that have a false-alarm rate < 1yr$^{-1}$. Based on the inferred component masses, all these candidates are consistent with signals from binary black holes. Median inferred component masses in the new candidates range from 5.14$M_\odot$ (GW241109_115924) to 70$M_\odot$ (GW241116_151753). Improvements in detector sensitivity allow us to observe compact binary coalescences with increasing clarity: 5 binary-black-hole signals have network signal-to-noise ratio exceeding 30, with a maximum to date of 76.9 for GW250114_082203. Such loud signals enable m
Rotating non-axisymmetric neutron stars (NSs) are promising sources for continuous gravitational waves (CWs). Such CWs can, if detected, inform us about the internal structure and equation of state of NSs. Here, we present a narrowband search for CWs from known pulsars, for which an efficient and sensitive matched-filter search can be applied. Narrowband searches are designed to be robust to mismatches between the electromagnetic (EM) and gravitational emissions, in contrast to fully targeted searches where the CW emission is assumed to be phase-locked to the EM one. In this work, we search for the CW counterparts emitted by 34 pulsars using data from the first and second parts of the fourth LIGO--Virgo--KAGRA observing run. This is the largest number of pulsars so far targeted for narrowband searches in the advanced detector era. We use the 5n-vector narrowband pipeline, which applies frequency-domain matched filtering. In previous searches, it covered a narrow range in the frequency -- frequency time derivative ($f$ -- $\dot{f}$) space. Here, we also explore a range in the second time derivative of the frequency $\ddot{f}$ around the value indicated by EM observations. Additional
We report on a gravitational wave search for compact binary coalescences involving at least one component with mass between $0.2\,M_\odot$ to $1\,M_\odot$, and ratio of component masses between 0.1 and 1. The analysis uses data collected by the LIGO detectors between May 24 2023 15:00 UTC and January 16 2024 16:00 UTC. No statistically significant sub-solar mass candidates were identified by the participating search algorithms. We report the detection sensitivity of the current searches to the target sub-solar mass black hole population. With the absence of detections, we place upper limits on the merger rate of sub-solar mass black holes, ranging from 110 ${\rm Gpc^{-3}\,yr^{-1}}$ to 10000 ${\rm Gpc^{-3}\,yr^{-1}}$ at 90\% confidence. We constrain two illustrative dark matter scenarios that can form sub-solar mass compact objects with these searches: primordial black holes, and dark black holes forming in a dissipative dark matter model. For late-forming primordial black hole binaries, our search excludes the fraction of dark matter in primordial black holes to be $\leq 1$ only for masses above $0.9\,M_\odot$. In the early-formation scenario, we limit this fraction to be $\leq 7\%
We search for gravitational-wave background signals produced by various early Universe processes in the Advanced LIGO O4a dataset, combined with the data from the earlier O1, O2, and O3 (LIGO-Virgo) runs. The absence of detectable signals enables powerful constraints on fundamental physics. We derive gravitational-wave background energy density upper limits from the O1-O4a data to constrain parameters associated with various possible processes in the early Universe: first-order phase transitions, cosmic strings, domain walls, stiff equation of state, axion inflation, second-order scalar perturbations, primordial black hole binaries, and parity violation. In our analyses, the presence of an astrophysical background produced by compact (black hole and neutron star) binary coalescences throughout the Universe is also considered. We address the implications for various cosmological and high energy physics models based on the obtained parameter constraints. We conclude that LIGO-Virgo data already yield significant constraints on numerous early Universe scenarios.
The angular distribution of gravitational-wave power from persistent sources may exhibit anisotropies arising from the large-scale structure of the Universe. This motivates directional searches for astrophysical and cosmological gravitational-wave backgrounds, as well as continuous-wave emitters. We present results of such a search using data from the first observing run through the first portion of the fourth observing run of the LIGO-Virgo-KAGRA Collaborations. We apply gravitational-wave radiometer techniques to generate skymaps and search for both narrowband and broadband persistent gravitational-wave sources. Additionally, we use spherical harmonic decomposition to probe spatially extended sources. No evidence of persistent gravitational-wave signals is found, and we set the most stringent constraints to date on such emissions. For narrowband point sources, our sensitivity estimate to effective strain amplitude lies in the range $(0.03 - 8.4) \times 10^{-24}$ across all sky and frequency range $(20 - 160)$ Hz. For targeted sources -- Scorpius X-1, SN 1987A, the Galactic Center, Terzan 5, and NGC 6397 -- we constrain the strain amplitude with best limits ranging from $\sim 1.1