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, significantly enhanced their biological activity, and promoted their differentiation toward nucleus pulposus cells. The mechanical and viscoelastic properties of the hydrogel are enhanced by physical and chemical dual cross-linking to adapt to the loading environment of the degenerated disc. A rat IVDD model is used to validate that the SCGP hydrogel can significantly inhibit the progression of IVDD and stimulate the endogenous repair of IVDD. Therefore, the spatiotemporal differential drug delivery system of the SCGP hydrogel holds promise as a convenient and efficacious therapeutic strategy for minimally invasive IVDD treatment.
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Carnitine is a well-known cofactor for the beta-oxidation of long-chain fatty acid. It also plays a role in transport of acetyl moity for fatty acid and cholesterol synthesis, excretion of organic acid and xenobiotic acid as carnitine ester, and control of ratio of acetylCoA to CoA. Therapeutic effect of acetylcarnitine on Alzheimer disease and HIV-infection, and aberrant incorporation acetylcarnitine into brain under chronic fatigue syndrome have been reported. Carnitine deficiency causes hyperammonemia through suppression of gene expression of urea cycle enzymes. On the other hand, a large amount of carnitine has a therapeutic effect on hyperammonemia by still unclear mechanism. These suggest carnitine as a multifunctional biofactor.
A mysterious comet from beyond our solar system is giving astronomers a rare glimpse into alien worlds — and it may have formed in a place far colder and stranger than anything around our Sun。 The interstellar visitor, called 3I/ATLAS, contains an astonishingly high amount of “heavy water,” far exceeding anything seen in our own solar system
Google's AI search will start citing its sources in several new ways
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Quantum physics once shocked scientists by revealing that particles can behave like waves—and now, that strange behavior has been pushed even further。 For the first time, researchers have observed wave-like interference in positronium, an exotic “atom” made of an electron and its antimatter partner, a positron。 This breakthrough not only strengthen
Scientists may have uncovered a surprising secret behind why life exists at all。 A new study suggests that the Universe’s fundamental constants — the deep physical rules that govern everything from atoms to stars — appear to sit within an incredibly narrow “sweet spot” that allows liquids to flow properly inside living cells。 Even tiny shifts in th
A scorching, airless world just 48 light-years away is offering scientists a rare glimpse into the geology of distant planets。 Using the James Webb Space Telescope, researchers studied LHS 3844 b—a tidally locked “super-Earth” with a permanent dayside hot enough to melt metal—and discovered it’s a dark, barren rock with no atmosphere
In a breakthrough experiment, scientists directly imaged how particles pair up in a system that mimics superconductors。 Instead of behaving independently, the pairs moved in a synchronized, dance-like pattern—something never predicted before。 This suggests a major gap in the classic theory of superconductivity
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A group of undergraduate students pulled off something remarkable: they built their own dark matter detector and used it to probe one of physics’ biggest mysteries。 Working with limited resources but plenty of creativity, they designed a stripped-down experiment to hunt for axions — hypothetical particles that could make up dark matter
Testing shows rotor blades won't disintegrate when they spin at supersonic speed
Creating complex molecules usually requires years of experience and countless decisions, but a new AI system is changing that。 Synthegy lets chemists guide synthesis and reaction planning using simple language, while powerful algorithms generate and evaluate possible solutions。 The AI doesn’t just compute—it reasons, scoring pathways and explaining
There are a couple signs of strain beyond the MacBook Neo and the desktops
Astronomers have unleashed a powerful new AI tool called RAVEN to comb through data from NASA’s TESS mission—and it’s paying off in a big way。 By analyzing millions of stars, the system has confirmed over 100 exoplanets, including 31 brand-new worlds, and identified thousands more promising candidates。 What makes this especially exciting is the dis
In a major breakthrough, scientists have experimentally confirmed a universal growth law in two dimensions using a quantum system of fleeting light–matter particles。 The finding strengthens the idea that wildly different processes—from crystals to living systems—may all follow the same hidden rules
For decades, psychologists have debated whether the human mind can be explained by one unified theory or must be broken into separate parts like memory and attention。 A recent AI model called Centaur seemed to offer a breakthrough, claiming it could mimic human thinking across 160 different cognitive tasks。 But new research is challenging that bold
A team at King’s College London has created a powerful new aluminum compound capable of doing the work of expensive rare metals。 Its unique triangular structure gives it remarkable stability and reactivity, allowing it to drive chemical reactions in ways never seen before。 The discovery could lead to greener and far more affordable industrial proce