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Large language models (LLMs) demonstrate significant potential in advancing medical applications, yet their capabilities in addressing medical ethics challenges remain underexplored. This paper introduces MedEthicEval, a novel benchmark designed to systematically evaluate LLMs in the domain of medical ethics. Our framework encompasses two key components: knowledge, assessing the models' grasp of medical ethics principles, and application, focusing on their ability to apply these principles across diverse scenarios. To support this benchmark, we consulted with medical ethics researchers and developed three datasets addressing distinct ethical challenges: blatant violations of medical ethics, priority dilemmas with clear inclinations, and equilibrium dilemmas without obvious resolutions. MedEthicEval serves as a critical tool for understanding LLMs' ethical reasoning in healthcare, paving the way for their responsible and effective use in medical contexts.
Access to diverse, well-annotated medical images with interactive learning tools is fundamental for training practitioners in medicine and related fields to improve their diagnostic skills and understanding of anatomical structures. While medical atlases are valuable, they are often impractical due to their size and lack of interactivity, whereas online image search may provide mislabeled or incomplete material. To address this, we propose MIRAGE, a multimodal medical text and image retrieval and generation system that allows users to find and generate clinically relevant images from trustworthy sources by mapping both text and images to a shared latent space, enabling semantically meaningful queries. The system is based on a fine-tuned medical version of CLIP (MedICaT-ROCO), trained with the ROCO dataset, obtained from PubMed Central. MIRAGE allows users to give prompts to retrieve images, generate synthetic ones through a medical diffusion model (Prompt2MedImage) and receive enriched descriptions from a large language model (Dolly-v2-3b). It also supports a dual search option, enabling the visual comparison of different medical conditions. A key advantage of the system is that it
Acceleration ethics addresses the tension between innovation and safety in artificial intelligence. The acceleration argument is that risks raised by innovation should be answered with still more innovating. This paper summarizes the theoretical position, and then shows how acceleration ethics works in a real case. To begin, the paper summarizes acceleration ethics as composed of five elements: innovation solves innovation problems, innovation is intrinsically valuable, the unknown is encouraging, governance is decentralized, ethics is embedded. Subsequently, the paper illustrates the acceleration framework with a use-case, a generative artificial intelligence language tool developed by the Canadian telecommunications company Telus. While the purity of theoretical positions is blurred by real-world ambiguities, the Telus experience indicates that acceleration AI ethics is a way of maximizing social responsibility through innovation, as opposed to sacrificing social responsibility for innovation, or sacrificing innovation for social responsibility.
The integration of continuous data from built-in sensors and Large Language Models (LLMs) has fueled a surge of "Sensor-Fused LLM agents" for personal health and well-being support. While recent breakthroughs have demonstrated the technical feasibility of this fusion (e.g., Time-LLM, SensorLLM), research primarily focuses on "Ethical Back-End Design for Generative AI", concerns such as sensing accuracy, bias mitigation in training data, and multimodal fusion. This leaves a critical gap at the front end, where invisible biometrics are translated into language directly experienced by users. We argue that the "illusion of objectivity" provided by sensor data amplifies the risks of AI hallucinations, potentially turning errors into harmful medical mandates. This paper shifts the focus to "Ethical Front-End Design for AI", specifically, the ethics of biometric translation. We propose a design space comprising five dimensions: Biometric Disclosure, Monitoring Temporality, Interpretation Framing, AI Stance, and Contestability. We examine how these dimensions interact with context (user- vs. system-initiated) and identify the risk of biofeedback loops. Finally, we propose "Adaptive Disclos
Medical imaging is an essential tool for diagnosing and treating diseases. However, lacking medical images can lead to inaccurate diagnoses and ineffective treatments. Generative models offer a promising solution for addressing medical image shortage problems due to their ability to generate new data from existing datasets and detect anomalies in this data. Data augmentation with position augmentation methods like scaling, cropping, flipping, padding, rotation, and translation could lead to more overfitting in domains with little data, such as medical image data. This paper proposes the GAN-GA, a generative model optimized by embedding a genetic algorithm. The proposed model enhances image fidelity and diversity while preserving distinctive features. The proposed medical image synthesis approach improves the quality and fidelity of medical images, an essential aspect of image interpretation. To evaluate synthesized images: Frechet Inception Distance (FID) is used. The proposed GAN-GA model is tested by generating Acute lymphoblastic leukemia (ALL) medical images, an image dataset, and is the first time to be used in generative models. Our results were compared to those of InfoGAN a
This chapter discusses the ethics of generative AI. It provides a technical primer to show how generative AI affords experiencing technology as if it were human, and this affordance provides a fruitful focus for the philosophical ethics of generative AI. It then shows how generative AI can both aggravate and alleviate familiar ethical concerns in AI ethics, including responsibility, privacy, bias and fairness, and forms of alienation and exploitation. Finally, the chapter examines ethical questions that arise specifically from generative AI's mimetic generativity, such as debates about authorship and credit, the emergence of as-if social relationships with machines, and new forms of influence, persuasion, and manipulation.
We present Ethics Readiness Levels (ERLs), a four-level, iterative method to track how ethical reflection is implemented in the design of AI systems. ERLs bridge high-level ethical principles and everyday engineering by turning ethical values into concrete prompts, checks, and controls within real use cases. The evaluation is conducted using a dynamic, tree-like questionnaire built from context-specific indicators, ensuring relevance to the technology and application domain. Beyond being a managerial tool, ERLs help facilitate a structured dialogue between ethics experts and technical teams, while our scoring system helps track progress over time. We demonstrate the methodology through two case studies: an AI facial sketch generator for law enforcement and a collaborative industrial robot. The ERL tool effectively catalyzes concrete design changes and promotes a shift from narrow technological solutionism to a more reflective, ethics-by-design mindset.
Digital ethics, also known as computer ethics or information ethics, is now a lively field that draws a lot of attention, but how did it come about and what were the developments that lead to its existence? What are the traditions, the concerns, the technological and social developments that pushed digital ethics? How did ethical issues change with digitalisation of human life? How did the traditional discipline of philosophy respond? The article provides an overview, proposing historical epochs: 'pre-modernity' prior to digital computation over data, via the 'modernity' of digital data processing to our present 'post-modernity' when not only the data is digital, but our lives themselves are largely digital. In each section, the situation in technology and society is sketched, and then the developments in digital ethics are explained. Finally, a brief outlook is provided.
There is a significant body of work looking at the ethical considerations of large language models (LLMs): critiquing tools to measure performance and harms; proposing toolkits to aid in ideation; discussing the risks to workers; considering legislation around privacy and security etc. As yet there is no work that integrates these resources into a single practical guide that focuses on LLMs; we attempt this ambitious goal. We introduce 'LLM Ethics Whitepaper', which we provide as an open and living resource for NLP practitioners, and those tasked with evaluating the ethical implications of others' work. Our goal is to translate ethics literature into concrete recommendations and provocations for thinking with clear first steps, aimed at computer scientists. 'LLM Ethics Whitepaper' distils a thorough literature review into clear Do's and Don'ts, which we present also in this paper. We likewise identify useful toolkits to support ethical work. We refer the interested reader to the full LLM Ethics Whitepaper, which provides a succinct discussion of ethical considerations at each stage in a project lifecycle, as well as citations for the hundreds of papers from which we drew our recomm
It is commonly accepted that clinicians are ethically obligated to disclose their use of medical machine learning systems to patients, and that failure to do so would amount to a moral fault for which clinicians ought to be held accountable. Call this "the disclosure thesis." Four main arguments have been, or could be, given to support the disclosure thesis in the ethics literature: the risk-based argument, the rights-based argument, the materiality argument, and the autonomy argument. In this article, I argue that each of these four arguments are unconvincing, and therefore, that the disclosure thesis ought to be rejected. I suggest that mandating disclosure may also even risk harming patients by providing stakeholders with a way to avoid accountability for harm that results from improper applications or uses of these systems.
I give a short introduction to data ethics. I begin with some background information and societal context for data ethics. I then discuss data ethics in mathematical-science education and indicate some available course material. I briefly highlight a few efforts -- at my home institution and elsewhere -- on data ethics, society, and social good. I then discuss open data in research, research replicability and some other ethical issues in research, and the tension between privacy and open data and code, and a few controversial studies and reactions to studies. I then discuss ethical principles, institutional review boards, and a few other considerations in the scientific use of human data. I then briefly survey a variety of research and lay articles that are relevant to data ethics and data privacy. I conclude with a brief summary and some closing remarks. My focal audience is mathematicians, but I hope that this chapter will also be useful to others. I am not an expert about data ethics, and this chapter provides only a starting point on this wide-ranging topic. I encourage you to examine the resources that I discuss and to reflect carefully on data ethics, its role in mathematics
Determining whether two sets of images belong to the same or different distributions or domains is a crucial task in modern medical image analysis and deep learning; for example, to evaluate the output quality of image generative models. Currently, metrics used for this task either rely on the (potentially biased) choice of some downstream task, such as segmentation, or adopt task-independent perceptual metrics (e.g., Fréchet Inception Distance/FID) from natural imaging, which we show insufficiently capture anatomical features. To this end, we introduce a new perceptual metric tailored for medical images, FRD (Fréchet Radiomic Distance), which utilizes standardized, clinically meaningful, and interpretable image features. We show that FRD is superior to other image distribution metrics for a range of medical imaging applications, including out-of-domain (OOD) detection, the evaluation of image-to-image translation (by correlating more with downstream task performance as well as anatomical consistency and realism), and the evaluation of unconditional image generation. Moreover, FRD offers additional benefits such as stability and computational efficiency at low sample sizes, sensiti
The diagnosis and treatment of various diseases had been expedited with the help of medical imaging. Different medical imaging modalities, including X-ray, Computed Tomography (CT), Magnetic Resonance Imaging (MRI), Nuclear Imaging, Ultrasound, Electrical Impedance Tomography (EIT), and Emerging Technologies for in vivo imaging modalities is presented in this chapter, in addition to these modalities, some advanced techniques such as contrast-enhanced MRI, MR approaches for osteoarthritis, Cardiovascular Imaging, and Medical Imaging data mining and search. Despite its important role and potential effectiveness as a diagnostic tool, reading and interpreting medical images by radiologists is often tedious and difficult due to the large heterogeneity of diseases and the limitation of image quality or resolution. Besides the introduction and discussion of the basic principles, typical clinical applications, advantages, and limitations of each modality used in current clinical practice, this chapter also highlights the importance of emerging technologies in medical imaging and the role of data mining and search aiming to support translational clinical research, improve patient care, and
Medical image segmentation is critical for clinical diagnosis, treatment planning, and monitoring, yet segmentation models often struggle with uncertainties stemming from occlusions, ambiguous boundaries, and variations in imaging devices. Traditional test-time augmentation (TTA) techniques typically rely on predefined geometric and photometric transformations, limiting their adaptability and effectiveness in complex medical scenarios. In this study, we introduced Test-Time Generative Augmentation (TTGA), a novel augmentation strategy specifically tailored for medical image segmentation at inference time. Different from conventional augmentation strategies that suffer from excessive randomness or limited flexibility, TTGA leverages a domain-fine-tuned generative model to produce contextually relevant and diverse augmentations tailored to the characteristics of each test image. Built upon diffusion model inversion, a masked null-text inversion method is proposed to enable region-specific augmentations during sampling. Furthermore, a dual denoising pathway is designed to balance precise identity preservation with controlled variability. We demonstrate the efficacy of our TTGA through
Medical image segmentation has been significantly advanced with the rapid development of deep learning (DL) techniques. Existing DL-based segmentation models are typically discriminative; i.e., they aim to learn a mapping from the input image to segmentation masks. However, these discriminative methods neglect the underlying data distribution and intrinsic class characteristics, suffering from unstable feature space. In this work, we propose to complement discriminative segmentation methods with the knowledge of underlying data distribution from generative models. To that end, we propose a novel hybrid diffusion framework for medical image segmentation, termed HiDiff, which can synergize the strengths of existing discriminative segmentation models and new generative diffusion models. HiDiff comprises two key components: discriminative segmentor and diffusion refiner. First, we utilize any conventional trained segmentation models as discriminative segmentor, which can provide a segmentation mask prior for diffusion refiner. Second, we propose a novel binary Bernoulli diffusion model (BBDM) as the diffusion refiner, which can effectively, efficiently, and interactively refine the seg
Recently, the state space model Mamba has demonstrated efficient long-sequence modeling capabilities, particularly for addressing long-sequence visual tasks in 3D medical imaging. However, existing generative self-supervised learning methods have not yet fully unleashed Mamba's potential for handling long-range dependencies because they overlook the inherent causal properties of state space sequences in masked modeling. To address this challenge, we propose a general-purpose pre-training framework called MambaMIM, a masked image modeling method based on a novel TOKen-Interpolation strategy (TOKI) for the selective structure state space sequence, which learns causal relationships of state space within the masked sequence. Further, MambaMIM introduces a bottom-up 3D hybrid masking strategy to maintain a masking consistency across different architectures and can be used on any single or hybrid Mamba architecture to enhance its multi-scale and long-range representation capability. We pre-train MambaMIM on a large-scale dataset of 6.8K CT scans and evaluate its performance across eight public medical segmentation benchmarks. Extensive downstream experiments reveal the feasibility and ad
Artificial intelligence (AI) models trained using medical images for clinical tasks often exhibit bias in the form of disparities in performance between subgroups. Since not all sources of biases in real-world medical imaging data are easily identifiable, it is challenging to comprehensively assess how those biases are encoded in models, and how capable bias mitigation methods are at ameliorating performance disparities. In this article, we introduce a novel analysis framework for systematically and objectively investigating the impact of biases in medical images on AI models. We developed and tested this framework for conducting controlled in silico trials to assess bias in medical imaging AI using a tool for generating synthetic magnetic resonance images with known disease effects and sources of bias. The feasibility is showcased by using three counterfactual bias scenarios to measure the impact of simulated bias effects on a convolutional neural network (CNN) classifier and the efficacy of three bias mitigation strategies. The analysis revealed that the simulated biases resulted in expected subgroup performance disparities when the CNN was trained on the synthetic datasets. More
In this paper, we situate the educational movement of "Ethics in Mathematics," as outlined by the Cambridge University Ethics in Mathematics Project, in the wider area of mathematics ethics education. By focusing on the core message coming out of Ethics in Mathematics, its target group, and educational philosophy, we set it into relation with "Mathematics for Social Justice" and Paul Ernest's recent work on ethics of mathematics. We conclude that, although both Ethics in Mathematics and Mathematics for Social Justice appear antagonistic at first glance, they can be understood as complementary rather than competing educational strategies.
We consider the question of what properties a Machine Ethics system should have. This question is complicated by the existence of ethical dilemmas with no agreed upon solution. We provide an example to motivate why we do not believe falling back on the elicitation of values from stakeholders is sufficient to guarantee correctness of such systems. We go on to define two broad categories of ethical property that have arisen in our own work and present a challenge to the community to approach this question in a more systematic way.
Training segmentation models for medical images continues to be challenging due to the limited availability of data annotations. Segment Anything Model (SAM) is a foundation model that is intended to segment user-defined objects of interest in an interactive manner. While the performance on natural images is impressive, medical image domains pose their own set of challenges. Here, we perform an extensive evaluation of SAM's ability to segment medical images on a collection of 19 medical imaging datasets from various modalities and anatomies. We report the following findings: (1) SAM's performance based on single prompts highly varies depending on the dataset and the task, from IoU=0.1135 for spine MRI to IoU=0.8650 for hip X-ray. (2) Segmentation performance appears to be better for well-circumscribed objects with prompts with less ambiguity and poorer in various other scenarios such as the segmentation of brain tumors. (3) SAM performs notably better with box prompts than with point prompts. (4) SAM outperforms similar methods RITM, SimpleClick, and FocalClick in almost all single-point prompt settings. (5) When multiple-point prompts are provided iteratively, SAM's performance ge