This article is accompanied by the following Invited Commentary: Longrois D, Hoeft A, De Hert S. 2014 European Society of Cardiology/European Society of Anaesthesiology guidelines on non-cardiac surgery: cardiovascular assessment and management. A short explanatory statement from the European Society of Anaesthesiology members who participated in the European Task Force. Eur J Anaesthesiol 2014; 31:513–516. ESC Committee for Practice Guidelines: Jose Luis Zamorano (Chairperson) (Spain), Stephan Achenbach (Germany), Helmut Baumgartner (Germany), Jeroen J. Bax (Netherlands), Héctor Bueno (Spain), Veronica Dean (France), Christi Deaton (UK), Cetin Erol (Turkey), Robert Fagard (Belgium), Roberto Ferrari (Italy), David Hasdai (Israel), Arno W. Hoes (Netherlands), Paulus Kirchhof (Germany/UK), Juhani Knuuti (Finland), Philippe Kolh (Belgium), Patrizio Lancellotti (Belgium), Ales Linhart (Czech Republic), Petros Nihoyannopoulos (UK), Massimo F. Piepoli (Italy), Piotr Ponikowski (Poland), Per Anton Sirnes (Norway), Juan Luis Tamargo (Spain), Michal Tendera (Poland), Adam Torbicki (Poland), William Wijns (Belgium), Stephan Windecker (Switzerland). ESA Clinical Guidelines Committee: Maurizio Solca (Chairperson) (Italy), Jean-François Brichant (Belgium), Stefan De Herta (Belgium), Edoardo de Robertisb (Italy), Dan Longroisc (France), Sibylle Kozek Langenecker (Austria), Josef Wichelewski (Israel). a Scientific Committee Chairperson & ESA Board Representative, πbNASC Chairperson,cEBA/UEMS representative Document Reviewers: Massimo Piepoli (Review coordinator) (Italy), William Wijns (Review coordinator) (Belgium), Stefan Agewall (Denmark), Claudio Ceconi (Italy), Antonio Coca (Spain), Ugo Corrà (Italy), Raffaele De Caterina (Italy), Carlo Di Mario (UK), Thor Edvardsen (Norway), Robert Fagard (Belgium), Giuseppe Germano (Italy), Fabio Guarracino (Italy), Arno Hoes (Netherlands), Torben Joergensen (Denmark), Peter Jüni (Switzerland), Pedro Marques-Vidal (Switzerland), Christian Mueller (Switzerland), Öztekin Oto (Turkey), Philippe Pibarot (Canada), Piotr Ponikowski (Poland), Olav FM Sellevold (Norway), Filippos Triposkiadis (Greece), Stephan Windecker (Switzerland), Patrick Wouters (Belgium). ESC National Cardiac Societies document reviewers listed in appendix The disclosure forms of the authors and reviewers are available on the ESC website www.escardio.org/guidelines Keywords: Guidelines, Non-cardiac surgery, Preoperative cardiac risk assessment, Preoperative cardiac testing, Preoperative coronary artery revascularization, Perioperative cardiac management, Anti-thrombotic therapy, Beta-blockers, Valvular disease, Arrhythmias, Heart failure, Renal disease, Pulmonary disease, Cerebrovascular disease, Anaesthesiology, Postoperative cardiac surveillance Table of Contents Abbreviations and acronyms 520 Preamble 522 Introduction 523 2.1. Magnitude of the problem 523 2.2. Change in population demographics 524 2.3. Purpose and organization 524 Preoperative evaluation 525 3.1. Surgical risk for cardiac events 525 3.2. Type of surgery 526 3.2.1. Endovascular versus open vascular procedures 526 3.2.2. Open versus laparoscopic or thoracoscopic procedures 526 3.3. Functional capacity 527 3.4. Risk indices 528 3.5. Biomarkers 529 3.6. Non-invasive testing 529 3.6.1. Non-invasive testing of cardiac disease 530 3.6.2. Non-invasive testing of ischaemic heart disease 530 3.7. Invasive coronary angiography 532 Risk-reduction strategies 532 4.1. Pharmacological 532 4.1.1. Beta-blockers 532 4.1.2. Statins 535 4.1.3. Nitrates 536 4.1.4. Angiotensin-converting enzyme inhibitors and angiotensin-receptor blockers 536 4.1.5. Calcium channel blockers 537 4.1.6. Alpha2 receptor agonists 537 4.1.7. Diuretics 537 4.2. Perioperative management in patients on antiplatelet agents 538 4.2.1. Aspirin 538 4.2.2. Dual antiplatelet therapy 538 4.2.3. Reversal of antiplatelet therapy 539 4.3. Perioperative management in patients on anticoagulants 539 4.3.1. Vitamin K antagonists 539 4.3.2. Non-vitamin K antagonist oral anticoagulants 540 4.3.3. Reversal of anticoagulant therapy 541 4.4. Revascularization 542 4.4.1. Prophylactic revascularization in patients with asymptomatic or stable ischaemic heart disease 543 4.4.2. Type of prophylactic revascularization in patients with stable ischaemic heart disease 544 4.4.3. Revascularization in patients with NSTE-ACS 544 Specific diseases 545 5.1. Chronic heart failure 545 5.2. Arterial hypertension 547 5.3. Valvular heart disease 548 5.3.1. Patient evaluation 548 5.3.2. Aortic stenosis 548 5.3.3. Mitral stenosis 548 5.3.4. Primary aortic regurgitation and mitral regurgitation 548 5.3.5. Secondary mitral regurgitation 549 5.3.6. Patients with prosthetic valve(s) 549 5.3.7. Prophylaxis of infective endocarditis 549 5.4. Arrhythmias 550 5.4.1. New onset ventricular arrhythmias in the preoperative period 550 5.4.2. Management of supraventricular arrhythmias and atrial fibrillation in the preoperative period 550 5.4.3. Perioperative bradyarrhythmias 550 5.4.4. Perioperative management of patients with pacemaker/implantable cardioverter defibrillator 551 5.5. Renal disease 551 5.6. Cerebrovascular disease 553 5.7. Peripheral artery disease 554 5.8. Pulmonary disease 555 5.9. Congenital heart disease 557 Perioperative monitoring 557 6.1. Electrocardiography 557 6.2. Transoesophageal echocardiography 558 6.3. Right heart catheterization 559 6.4. Disturbed glucose metabolism 559 6.5. Anaemia 560 Anaesthesia 560 7.1. Intraoperative anaesthetic management 560 7.2. Neuraxial techniques 561 7.3. Perioperative goal-directed therapy 561 7.4. Risk stratification after surgery 562 7.5. Early diagnosis of postoperative complications 562 7.6. Postoperative pain management 562 Gaps in evidence 563 Summary 563 Appendix 566 References 566 Abbreviations and acronyms AAA abdominal aortic aneurysm ACEI angiotensin converting enzyme inhibitor ACS acute coronary syndromes AF atrial fibrillation AKI acute kidney injury AKIN Acute Kidney Injury Network ARB angiotensin receptor blocker ASA American Society of Anesthesiologists b.i.d. bis in die (twice daily) BBSA beta-blocker in spinal anaesthesia BMS bare-metal stent BNP B-type natriuretic peptide CABG coronary artery bypass graft CAD coronary artery disease CARP Coronary Artery Revascularization Prophylaxis CAS carotid artery stenting CASS Coronary Artery Surgery Study CEA carotid endarterectomy CHA2DS2-VASc cardiac failure, hypertension, age ≥75 (doubled), diabetes, stroke (doubled)-vascular disease, age 65–74 and sex category (female) CI confidence interval CI-AKI contrast-induced acute kidney injury CKD chronic kidney disease CKD-EPI Chronic Kidney Disease Epidemiology Collaboration Cmax maximum concentration CMR cardiovascular magnetic resonance COPD chronic obstructive pulmonary disease CPG Committee for Practice Guidelines CPX/CPET cardiopulmonary exercise test CRP C-reactive protein CRT cardiac resynchronisation therapy CRT-D cardiac resynchronization therapy defibrillator CT computed tomography cTnI cardiac troponin I cTnT cardiac troponin T CVD cardiovascular disease CYP3a4 cytochrome P3a4 enzyme DECREASE Dutch Echocardiographic Cardiac Risk Evaluation Applying Stress Echocardiography DES drug-eluting stent DIPOM Diabetic Postoperative Mortality and Morbidity DSE dobutamine stress echocardiography ECG electrocardiography/electrocardiographically/electrocardiogram eGFR estimated glomerular filtration rate ESA European Society of Anaesthesiology ESC European Society of Cardiology EVAR endovascular abdominal aortic aneurysm repair FEV1 Forced expiratory volume in 1 second HbA1c glycosylated haemoglobin HF-PEF heart failure with preserved left ventricular ejection fraction HF-REF heart failure with reduced left ventricular ejection fraction ICD implantable cardioverter defibrillator IHD ischaemic heart disease INR international normalized ratio IOMC iso-osmolar contrast medium KDIGO Kidney Disease: Improving Global Outcomes LMWH low-molecular weight heparin LOCM low-osmolar contrast medium LV left ventricular LVEF left ventricular ejection fraction MaVS Metoprolol after Vascular Surgery MDRD Modification of Diet in Renal Disease MET metabolic equivalent MRI magnetic resonance imaging NHS National Health Service NOAC non-vitamin K oral anticoagulant NSQIP National Surgical Quality Improvement Program NSTE-ACS non–ST-elevation acute coronary syndromes NT-proBNP N-terminal pro-brain natriuretic peptide O2 oxygen OHS obesity hypoventilation syndrome OR odds ratio P gp platelet glycoprotein PAC pulmonary artery catheter PAD artery disease pulmonary artery hypertension coronary Evaluation Perioperative evaluation die daily) disease computed tomography supraventricular Coronary with and Cardiac Surgery aortic ischaemic echocardiography echocardiography heparin surgery heart disease Vascular Surgery Patients Evaluation K antagonist ventricular ventricular Guidelines and available evidence the of the on a with the of in the management strategies for with a the on the of or Guidelines and the in the by the in with the and A of Guidelines in by the European Society of Cardiology and the European Society of Anaesthesiology by and of the on for the of guidelines in the The for and Guidelines on the ESC Guidelines the of on and are of Task by the ESC and ESA with the of patients with in the a of the evidence for management and of a the ESC Committee for Practice Guidelines and ESA Guidelines Committee A evaluation of and procedures assessment of the of for The of evidence and the of of management and in 1 and of of of the and in of forms or of of forms and on the ESC in of the period the and The Task from the ESC and ESA from the The ESC CPG and the of Guidelines by Task or The Committee is for the of The ESC and Guidelines by the CPG and Guidelines Committee and is by the in the Task Force. The document is by the for in the European Heart and in the European of after of the and and the evidence available the of The of Guidelines the of the the of and for the the guidelines with for for are are the is available on the ESC and ESA The National Societies of the ESC and of the ESA are and the ESC are the of disease by the of and are is in with is in the the of and Health are the Guidelines in the and the of or the Guidelines in the of and in of and in with and the is the the and and the of 2.1. Magnitude of the problem The guidelines on the cardiovascular management of patients in heart disease is a of complications non-cardiac The risk of complications on the of the surgery, the of and the and of the cardiac complications in patients with or asymptomatic ischaemic heart disease left ventricular heart disease and who procedures are with and cardiac the of are a in the ratio of in metabolic a coronary artery stenosis by and acute coronary syndromes of a in with vascular and LV and arrhythmias for the of IHD and arrhythmias with cardiac and are in the population non-cardiac The of the problem in in the of the non-cardiac and the risk of cardiac complications in on the and of and on are available a in European and A on available in estimated the of rate of with population of a of procedures the of the procedures are in patients with cardiovascular of the patients procedures in the of cardiovascular procedures are in European patients who with risk of cardiovascular non-cardiac surgery is with rate of and and a rate and on of are by cardiac the population in the European cardiac of are non-cardiac procedures 2.2. Change in population demographics the the in of the population a on management. is estimated surgery the of the is estimated the of patients surgery by by the the population by The of procedures of the of with The of the National the of procedures in age and the in the and of patients surgery a of patients and from cardiac disease is in the the of heart failure and cardiovascular risk diabetes, is the in patients for surgery, cardiovascular disease is the for a in the risk of are with and pulmonary and on the evaluation of risk age 2.3. Purpose and organization guidelines are for and in the and postoperative of patients non-cardiac The is a and cardiac management. 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Surgical risk for cardiac events Cardiac complications after non-cardiac surgery on risk on the of surgery and on the Surgical cardiac risk are the and of the the in and a stress This is by injury and by and in the period the This stress oxygen Surgery in the and in coronary The of is the and of the with management, and of anaesthesia and heart and anaesthesia the stress by anaesthetic techniques in patients risk and postoperative are in the cardiac risk for non-cardiac the of surgery cardiac open or endovascular and with estimated cardiac and of and The and preoperative cardiac evaluation on the of the of for abdominal aortic aneurysm or for a cardiac evaluation the and of the the management in the bypass for acute or of the and of the the cardiac risk the evaluation the the cardiac risk the the the cardiac risk the of and the of or of aortic in the in the cardiac evaluation cardiac complications and or This is the in prophylactic the of or asymptomatic carotid stenosis the of the and the risk of the are in the of the 3.2. Type of surgery and endovascular techniques and the rate of laparoscopic with open techniques and and from versus open in of or The of procedures in a of a risk of a cardiac the open surgery are endovascular or the reduced and 3.2.1. Endovascular versus open vascular procedures Vascular are of the risk of cardiac of the risk by in Open aortic and procedures is a revascularization a cardiac risk or of aortic This by the of diabetes, IHD and age in This the risk artery are is Endovascular AAA repair with and open with complications and in patients who in and A of open and for the of disease bypass surgery is with ratio confidence interval and failure endovascular with in and in the bypass of the in patients with a bypass a for patients with a artery stenting carotid endarterectomy CAS the rate of and the rate of stroke or is with in and by a in the risk of The of carotid revascularization is in patients with ischaemic or stroke and a carotid artery asymptomatic carotid revascularization is with therapy, in patients with a carotid stenosis and estimated The CEA and CAS and of the and 3.2.2. 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Risk indices strategies the risk of cardiac complications cardiac evaluation the for patients with cardiac risk after evaluation on is strategies the risk risk by is in patients with a cardiac cardiac imaging techniques are patients imaging techniques for patients in test and management. the of the preoperative cardiac evaluation the and the of the surgery is the evaluation the of a with cardiac risk evaluation is on and of surgery, and and the risk indices on of the and cardiac and The indices by and a the for the for cardiac and assessment of risk for cardiac The or cardiac risk a of the postoperative pulmonary ventricular fibrillation or cardiac and heart This risk is of of surgery, of of heart failure, of disease, preoperative with and preoperative and by and the available in non-cardiac of the risk indices and in the of and in the and management of non-cardiac a the risk of or cardiac the American of National Surgical Quality Improvement Program This NSQIP on from patients from from the and with the patients and The or cardiac after of of surgery, or American Society of Anesthesiologists is disease is disease is a and a who is for with or the and This is risk the risk the or in a and risk the NSQIP a a of the of for The risk the risk with in in vascular the risk cardiac complications of pulmonary and heart in the NSQIP in the NSQIP the of the risk of pulmonary and of heart in and A of patients the patients versus risk for cardiac events after non-cardiac surgery, cardiac events after vascular non-cardiac surgery or the and risk and the in the Risk management of the in with the the 3.5. Biomarkers A or is a and is of the on and and LV Cardiac T and I and are the for the diagnosis of and available The is and cardiac of risk and LV cTnI and cTnT of for risk assessment in ACS in the and of evidence in cTnT in the period injury with cardiac and The of the assessment of assessment of cardiac in and after surgery, troponin in The diagnosis of on the of patients with risk of coronary in the are available on the B-type natriuretic peptide and N-terminal are in cardiac in in This of heart failure, of the or of BNP and NT-proBNP cardiac diseases in Preoperative BNP and NT-proBNP for and for cardiac events after non-cardiac vascular on preoperative from are on the assessment of for patients non-cardiac surgery for in patients or with a cardiac risk for vascular surgery and for Non-invasive testing Preoperative testing on cardiac risk LV and heart of are of postoperative LV is and imaging are of exercise ECG and imaging techniques non-cardiac surgery is The is the for risk stratification of and LV for patients in the with or Non-invasive testing for coronary artery revascularization for of management in of surgery, anaesthetic and 3.6.1. Non-invasive testing of cardiac disease Electrocardiography The ECG is of preoperative cardiovascular risk assessment in patients non-cardiac IHD the preoperative ECG and is of of and the ECG or in patients with or with of left ventricular LV non-cardiac surgery by computed tomography magnetic resonance imaging or computed tomography with Echocardiography is the available and for ventricular echocardiography is for the preoperative evaluation of ventricular in asymptomatic patients with Preoperative LV mitral regurgitation and aortic are with cardiac The of LV assessment for the failure Non-invasive testing of ischaemic heart disease exercise a or of and heart rate and The of exercise ECG Risk stratification with exercise test is for patients with exercise capacity heart in and A of in the test the the onset of a ischaemic exercise is with a risk of and cardiac the onset of is with a risk a Pharmacological stress testing with imaging or echocardiography is in patients with exercise The of imaging for preoperative risk is patients with exercise stress or is are stress and the of ischaemic or or The of the of ischaemic in a in patients vascular Study cardiac and The authors patients vascular surgery, with a in of the LV the of cardiac events with Patients with from A second the of imaging in for vascular surgery a period from The cardiac or in patients with test in patients with and in patients with on of the a of cardiac events in patients with or the of for or in This is in management and of the of imaging for patients with a Stress echocardiography exercise or stress for preoperative cardiac risk The test on LV heart and the and of 530 patients the of dobutamine stress echocardiography for the assessment of cardiac risk of postoperative events in patients with a of heart failure CI and ischaemic of heart rate CI DSE for in patients with hypertension, aortic or stress echocardiography a and a test is with a of cardiac events for patients the is and the of a cardiac is stress A DSE aortic surgery postoperative heart rate is DSE A DSE of the heart rate Patients with are risk for events a of imaging and DSE for risk stratification vascular surgery, the of stress imaging for ischaemic events is with the with IHD patients with a of the is reduced with a of magnetic resonance imaging for of and stress and The for assessment of is with a of and a of is is and in a the and the are of CMR in the preoperative dobutamine stress CMR in patients non-cardiac the of cardiac events and heart are available in the of preoperative risk CT coronary coronary and CT angiography is coronary artery disease in patients who are risk of are available in the of preoperative risk imaging and a management. Patients with a population in therapy a cardiac Preoperative testing is for surgery in patients with capacity and of the risk listed in Table in patients with of risk preoperative testing A is for surgery from are the rate of patients for surgery, is test management in stable cardiac Clinical risk the cardiac risk Invasive coronary angiography Coronary angiography is a is the risk of patients non-cardiac is a of from on in patients for non-cardiac coronary angiography assessment and in risk the the CAD in a of patients non-cardiac surgery, for preoperative coronary angiography and revascularization are angiography in the Preoperative of or with is non-cardiac surgery 4.1. Pharmacological The stress of surgery and anaesthesia in oxygen a in oxygen or strategies and of surgery, preoperative evaluation and the of cardiovascular risk 4.1.1. Beta-blockers a of of the Dutch Echocardiographic Cardiac Risk Evaluation Applying Stress Echocardiography and the of in the The for beta-blocker is oxygen by heart a period and the of cardiovascular the of on in in Summary of the of on postoperative and patients risk for complications of the of surgery, the of IHD or risk for cardiac risk for in The Evaluation a of risk of cardiac patients with IHD risk or with IHD who for non-cardiac surgery for vascular with a in for in the and in the The patients vascular surgery or in a of or stroke and P Patients cardiac risk and with a of the The Metoprolol after Vascular Surgery patients abdominal or vascular surgery or The of heart failure, arrhythmias or stroke and P The cardiac risk in of patients and in The Postoperative Mortality and Morbidity patients with diabetes, age and of surgery of or The of or heart failure and P of patients a of or cardiac risk and or The patients or Patients and or of risk for surgery, or for vascular of surgery, the after surgery, the therapy the of in the in a in the of or cardiac P the in P by a in P and a in stroke P with P the risk for and and on and a in and in patients in in or cardiac in patients the of of and of surgery, of of the DECREASE cardiac risk and of beta-blocker and the the weight in of by in patients Perioperative in patients with and A of disease with risk of is a the DECREASE with a CI in 529 the and the reduced of and of the of on and cardiovascular risk beta-blocker and heart The of in surgery and in heart of and of the DECREASE in the of by in of surgery and the of of and of by the of the on cardiac risk or a beta-blocker anaesthesia after on the of in the in postoperative with patients with risk surgery, and evidence a in cardiac and with Perioperative is in patients with by stress testing are risk of cardiac complications beta-blocker in patients risk and the risk of cardiac complications and A in by a and in patients with and the risk of stroke and beta-blocker postoperative in patients vascular patients in the of The in with or risk following preoperative beta-blocker in Beta-blockers for IHD or are for hypertension, the of evidence for a with a of Beta-blockers in patients