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Artificial intelligence models have shown strong potential in acute ischemic stroke imaging, particularly for lesion detection and segmentation using computed tomography and magnetic resonance imaging. However, most existing approaches operate as black box predictors, producing deterministic outputs without explicit uncertainty awareness or structured mechanisms to abstain under ambiguous conditions. This limitation raises serious safety and trust concerns in high risk emergency radiology settings. In this paper, we propose an explainable agentic AI framework for uncertainty aware and abstention enabled decision support in acute ischemic stroke imaging. The framework follows a modular agentic pipeline in which a perception agent performs lesion aware image analysis, an uncertainty estimation agent computes slice level predictive reliability, and a decision agent determines whether to issue a prediction or abstain based on predefined uncertainty thresholds. Unlike prior stroke imaging systems that primarily focus on improving segmentation or classification accuracy, the proposed framework explicitly prioritizes clinical safety, transparency, and clinician aligned decision behavior.

Acute Leukemia is the most common hematologic malignancy in children and adolescents. A key methodology in the diagnostic evaluation of this malignancy is immunophenotyping based on Multiparameter Flow Cytometry (FCM). However, this approach is manual, and thus time-consuming and subjective. To alleviate this situation, we propose in this paper the FCM-Former, a machine learning, self-attention based FCM-diagnostic tool, automating the immunophenotyping assessment in Childhood Acute Leukemia. The FCM-Former is trained in a supervised manner, by directly using flow cytometric data. Our FCM-Former achieves an accuracy of 96.5% assigning lineage to each sample among 960 cases of either acute B-cell, T-cell lymphoblastic, and acute myeloid leukemia (B-ALL, T-ALL, AML). To the best of our knowledge, the FCM-Former is the first work that automates the immunophenotyping assessment with FCM data in diagnosing pediatric Acute Leukemia.

Poorly managed postoperative acute pain can have long-lasting negative impacts and pose a major healthcare issue. There is limited investigation to understand and address the unique needs of patients experiencing acute pain. In this paper, we tackle this gap through an interview study with 14 patients who recently underwent postoperative acute pain to understand their challenges in pain self-management and their need for supportive tools. Our analysis identified various factors associated with the major aspects of acute pain self-management. Together, our findings indicated that tools for supporting these patients need to carefully consider information and support delivery to adapt to rapid changes in pain experiences, offer personalized and dynamic assistance that adapts to individual situations in context, and monitor emotion when promoting motivation. Overall, our work provided valuable knowledge to address the less-investigated but highly-needed problem of designing technology for the self-management of acute pain and similar health conditions.

Artificial intelligence (AI) has become increasingly central to precision medicine by enabling the integration and interpretation of multimodal data, yet implementation in clinical settings remains limited. This paper provides a scoping review of literature from 2019-2024 on the implementation of AI in precision medicine, identifying key barriers and enablers across data quality, clinical reliability, workflow integration, and governance. Through an ecosystem-based framework, we highlight the interdependent relationships shaping real-world translation and propose future directions to support trustworthy and sustainable implementation.

With the increasing interest in deploying Artificial Intelligence in medicine, we previously introduced HAIM (Holistic AI in Medicine), a framework that fuses multimodal data to solve downstream clinical tasks. However, HAIM uses data in a task-agnostic manner and lacks explainability. To address these limitations, we introduce xHAIM (Explainable HAIM), a novel framework leveraging Generative AI to enhance both prediction and explainability through four structured steps: (1) automatically identifying task-relevant patient data across modalities, (2) generating comprehensive patient summaries, (3) using these summaries for improved predictive modeling, and (4) providing clinical explanations by linking predictions to patient-specific medical knowledge. Evaluated on the HAIM-MIMIC-MM dataset, xHAIM improves average AUC from 79.9% to 90.3% across chest pathology and operative tasks. Importantly, xHAIM transforms AI from a black-box predictor into an explainable decision support system, enabling clinicians to interactively trace predictions back to relevant patient data, bridging AI advancements with clinical utility.

The revolutionary progress in development of next-generation sequencing (NGS) technologies has made it possible to deliver accurate genomic information in a timely manner. Over the past several years, NGS has transformed biomedical and clinical research and found its application in the field of personalized medicine. Here we discuss the rise of personalized medicine and the history of NGS. We discuss current applications and uses of NGS in medicine, including infectious diseases, oncology, genomic medicine, and dermatology. We provide a brief discussion of selected studies where NGS was used to respond to wide variety of questions in biomedical research and clinical medicine. Finally, we discuss the challenges of implementing NGS into routine clinical use.

We introduce the CPAISD: Core-Penumbra Acute Ischemic Stroke Dataset, aimed at enhancing the early detection and segmentation of ischemic stroke using Non-Contrast Computed Tomography (NCCT) scans. Addressing the challenges in diagnosing acute ischemic stroke during its early stages due to often non-revealing native CT findings, the dataset provides a collection of segmented NCCT images. These include annotations of ischemic core and penumbra regions, critical for developing machine learning models for rapid stroke identification and assessment. By offering a carefully collected and annotated dataset, we aim to facilitate the development of advanced diagnostic tools, contributing to improved patient care and outcomes in stroke management. Our dataset's uniqueness lies in its focus on the acute phase of ischemic stroke, with non-informative native CT scans, and includes a baseline model to demonstrate the dataset's application, encouraging further research and innovation in the field of medical imaging and stroke diagnosis.

What does Artificial Intelligence (AI) have to contribute to health care? And what should we be looking out for if we are worried about its risks? In this paper we offer a survey, and initial evaluation, of hopes and fears about the applications of artificial intelligence in medicine. AI clearly has enormous potential as a research tool, in genomics and public health especially, as well as a diagnostic aid. It's also highly likely to impact on the organisational and business practices of healthcare systems in ways that are perhaps under-appreciated. Enthusiasts for AI have held out the prospect that it will free physicians up to spend more time attending to what really matters to them and their patients. We will argue that this claim depends upon implausible assumptions about the institutional and economic imperatives operating in contemporary healthcare settings. We will also highlight important concerns about privacy, surveillance, and bias in big data, as well as the risks of over trust in machines, the challenges of transparency, the deskilling of healthcare practitioners, the way AI reframes healthcare, and the implications of AI for the distribution of power in healthcare ins

We study the problem of acute triangulations of convex polyhedra and the space R^n. Here an acute triangulation is a triangulation into simplices whose dihedral angles are acute. We prove that acute triangulations of the n-cube do not exist for n>=4. Further, we prove that acute triangulations of the space R^n do not exist for n>= 5. In the opposite direction, in R^3, we present a construction of an acute triangulation of the cube, the regular octahedron and a non-trivial acute triangulation of the regular tetrahedron. We also prove nonexistence of an acute triangulation of R^4 if all dihedral angles are bounded away from pi/2.

The last few years have seen rapid progress in transitioning quantum computing from lab to industry. In healthcare and life sciences, more than 40 proof-of-concept experiments and studies have been conducted; an increasing number of these are even run on real quantum hardware. Major investments have been made with hundreds of millions of dollars already allocated towards quantum applications and hardware in medicine. In addition to pharmaceutical and life sciences uses, clinical and medical applications are now increasingly coming into the picture. This chapter focuses on three key use case areas associated with (precision) medicine, including genomics and clinical research, diagnostics, and treatments and interventions. Examples of organizations and the use cases they have been researching are given; ideas how the development of practical quantum computing applications can be further accelerated are described.

As an introduction to the concept of "moduli space" we consider the moduli space of similarity classes of acute and right triangles in the plane. This has a map to the moduli space of elliptic curves which is onto and generically three-to-one. The reason is that from any acute or right triangle we can construct an elliptic curve, and every elliptic curve is isomorphic to one constructed this way.

The success of precision medicine requires computational models that can effectively process and interpret diverse physiological signals across heterogeneous patient populations. While foundation models have demonstrated remarkable transfer capabilities across various domains, their effectiveness in handling individual-specific physiological signals - crucial for precision medicine - remains largely unexplored. This work introduces a systematic pipeline for rapidly and efficiently evaluating foundation models' transfer capabilities in medical contexts. Our pipeline employs a three-stage approach. First, it leverages physiological simulation software to generate diverse, clinically relevant scenarios, particularly focusing on data-scarce medical conditions. This simulation-based approach enables both targeted capability assessment and subsequent model fine-tuning. Second, the pipeline projects these simulated signals through the foundation model to obtain embeddings, which are then evaluated using linear methods. This evaluation quantifies the model's ability to capture three critical aspects: physiological feature independence, temporal dynamics preservation, and medical scenario d

Augmented reality becomes popular in education gradually, which provides a contextual and adaptive learning experience. Here, we develop a Chinese herb medicine AR platform based the 3dsMax and the Unity that allows users to visualize and interact with the herb model and learn the related information. The users use their mobile camera to scan the 2D herb picture to trigger the presentation of 3D AR model and corresponding text information on the screen in real-time. The system shows good performance and has high accuracy for the identification of herbal medicine after interference test and occlusion test. Users can interact with the herb AR model by rotating, scaling, and viewing transformation, which effectively enhances learners' interest in Chinese herb medicine.

This study examines the clinical decision-making processes in Traditional East Asian Medicine (TEAM) by reinterpreting pattern identification (PI) through the lens of dimensionality reduction. Focusing on the Eight Principle Pattern Identification (EPPI) system and utilizing empirical data from the Shang-Han-Lun, we explore the necessity and significance of prioritizing the Exterior-Interior pattern in diagnosis and treatment selection. We test three hypotheses: whether the Ext-Int pattern contains the most information about patient symptoms, represents the most abstract and generalizable symptom information, and facilitates the selection of appropriate herbal prescriptions. Employing quantitative measures such as the abstraction index, cross-conditional generalization performance, and decision tree regression, our results demonstrate that the Exterior-Interior pattern represents the most abstract and generalizable symptom information, contributing to the efficient mapping between symptom and herbal prescription spaces. This research provides an objective framework for understanding the cognitive processes underlying TEAM, bridging traditional medical practices with modern computat

Recent studies indicate that Generative Pre-trained Transformer 4 with Vision (GPT-4V) outperforms human physicians in medical challenge tasks. However, these evaluations primarily focused on the accuracy of multi-choice questions alone. Our study extends the current scope by conducting a comprehensive analysis of GPT-4V's rationales of image comprehension, recall of medical knowledge, and step-by-step multimodal reasoning when solving New England Journal of Medicine (NEJM) Image Challenges - an imaging quiz designed to test the knowledge and diagnostic capabilities of medical professionals. Evaluation results confirmed that GPT-4V performs comparatively to human physicians regarding multi-choice accuracy (81.6% vs. 77.8%). GPT-4V also performs well in cases where physicians incorrectly answer, with over 78% accuracy. However, we discovered that GPT-4V frequently presents flawed rationales in cases where it makes the correct final choices (35.5%), most prominent in image comprehension (27.2%). Regardless of GPT-4V's high accuracy in multi-choice questions, our findings emphasize the necessity for further in-depth evaluations of its rationales before integrating such multimodal AI m

We introduce a new class of numerical semigroups, which we call the class of {\it acute} semigroups and we prove that they generalize symmetric and pseudo-symmetric numerical semigroups, Arf numerical semigroups and the semigroups generated by an interval. For a numerical semigroup $Λ=\{λ_0<λ_1<\dots\}$ denote $ν_i=\#\{j\midλ_i-λ_j\inΛ\}$. Given an acute numerical semigroup $Λ$ we find the smallest non-negative integer $m$ for which the order bound on the minimum distance of one-point Goppa codes with associated semigroup $Λ$ satisfies $d_{ORD}(C_i)(:=\min\{ν_j\mid j>i\})=ν_{i+1}$ for all $i\geq m$. We prove that the only numerical semigroups for which the sequence $(ν_i)$ is always non-decreasing are ordinary numerical semigroups. Furthermore we show that a semigroup can be uniquely determined by its sequence $(ν_i)$.

Medicine, including fields in healthcare and life sciences, has seen a flurry of quantum-related activities and experiments in the last few years (although biology and quantum theory have arguably been entangled ever since Schrödinger's cat). The initial focus was on biochemical and computational biology problems; recently, however, clinical and medical quantum solutions have drawn increasing interest. The rapid emergence of quantum computing in health and medicine necessitates a mapping of the landscape. In this review, clinical and medical proof-of-concept quantum computing applications are outlined and put into perspective. These consist of over 40 experimental and theoretical studies. The use case areas span genomics, clinical research and discovery, diagnostics, and treatments and interventions. Quantum machine learning (QML) in particular has rapidly evolved and shown to be competitive with classical benchmarks in recent medical research. Near-term QML algorithms have been trained with diverse clinical and real-world data sets. This includes studies in generating new molecular entities as drug candidates, diagnosing based on medical image classification, predicting patient pe

3D data from high-resolution volumetric imaging is a central resource for diagnosis and treatment in modern medicine. While the fast development of AI enhances imaging and analysis, commonly used visualization methods lag far behind. Recent research used extended reality (XR) for perceiving 3D images with visual depth perception and touch but used restrictive haptic devices. While unrestricted touch benefits volumetric data examination, implementing natural haptic interaction with XR is challenging. The research question is whether a multisensory XR application with intuitive haptic interaction adds value and should be pursued. In a study, 24 experts for biomedical images in research and medicine explored 3D medical shapes with 3 applications: a multisensory virtual reality (VR) prototype using haptic gloves, a simple VR prototype using controllers, and a standard PC application. Results of standardized questionnaires showed no significant differences between all application types regarding usability and no significant difference between both VR applications regarding presence. Participants agreed to statements that VR visualizations provide better depth information, using the hand

Acute stroke lesion segmentation tasks are of great clinical interest as they can help doctors make better informed treatment decisions. Magnetic resonance imaging (MRI) is time demanding but can provide images that are considered gold standard for diagnosis. Automated stroke lesion segmentation can provide with an estimate of the location and volume of the lesioned tissue, which can help in the clinical practice to better assess and evaluate the risks of each treatment. We propose a deep learning methodology for acute and sub-acute stroke lesion segmentation using multimodal MR imaging. The proposed method is evaluated using two public datasets from the 2015 Ischemic Stroke Lesion Segmentation challenge (ISLES 2015). These involve the tasks of sub-acute stroke lesion segmentation (SISS) and acute stroke penumbra estimation (SPES) from diffusion, perfusion and anatomical MRI modalities. The performance is compared against state-of-the-art methods with a blind online testing set evaluation on each of the challenges. At the time of submitting this manuscript, our approach is the first method in the online rankings for the SISS (DSC=0.59$\pm$0.31) and SPES sub-tasks (DSC=0.84$\pm$0.10