Memorializes Frank John Vattano (1931-2025). Frank Vattano was a great teacher gifted with fresh perspectives and the ability to convey the importance, centrality, and even the fundamentality of the psychological sciences. Beginning in 1964, served as assistant academic vice president for instructional services at Colorado State University. During his tenure at Colorado State, he also served for several years as dean of the College of Arts, Humanities, and Social Sciences. It is astonishing that a newly minted PhD should be placed in administrative positions at the outset of a career, but Frank excelled in each position. In the early 1960s, Colorado State invested heavily in instructional technology with state-of-the-art recording studios and professionals who assisted professors with the art and science of communication. During this period, Vattano recorded 50-min films for each of the major topics covered in introductory psychology courses. These films were available to all faculty who wished to use them. Vattano must have received every award offered by the university in addition to regional and national awards including Colorado Teacher of the Year offered by the Carnegie Foundation in 1999. (PsycInfo Database Record (c) 2026 APA, all rights reserved).
Presents a summary report of journal operations from 2025. (PsycInfo Database Record (c) 2026 APA, all rights reserved).
Bernard "Bernie" Spilka died on Friday, May 23, 2025, in Denver, Colorado. Bernie was born Thursday, August 12, 1926, in New York City, New York. After World War II service in the Army Air Force Medical Corps, he attained a psychology BA (1949) from New York University. Graduate education at Purdue University included both MA (1950; group influence on individual judgment) and PhD (1952; delayed speech feedback) degrees. In 1953, while working for the U.S. Air Force Human Resources Research Center, Combat Crew Laboratory at Randolph Field, Texas, he met and married Ellen Scharlack. He served as president for many psychological associations and in 1985, along with Ralph W. Hood, Jr., and Richard L. Gorsuch summarized the re-emergent psychology of religion. With rotating authorship, that text remains in print today. He was a fierce advocate for the scientific method and never hesitated to chastise "fuzzy" conceptualizations, theories, methods, or overgeneralizations. (PsycInfo Database Record (c) 2026 APA, all rights reserved).
Nursing moral injury research has expanded rapidly since 2020, yet the conceptual foundations and intellectual trajectories of this growth remain unexamined. This bibliometric study analyzed 179 publications retrieved from the Web of Science Core Collection (2018-2025) to map the conceptual evolution and intellectual foundations of nursing moral injury research, addressing two research questions: how have core concepts and thematic clusters evolved over time, and how has the co-citation knowledge base shifted across the study period? Keyword co-occurrence analysis with temporal overlay was performed via VOSviewer, and co-citation network analysis stratified across three pandemic-aligned periods was conducted via CiteSpace. The publication output increased fivefold between 2020 and 2021, which coincided with the COVID-19 pandemic, and it remained stable during the postpandemic period. Conceptual analysis revealed three concept strata distinguishable by the average year of publication: from contextual scaffolding around trauma, ethics, stress, and pandemic through pandemic-driven empirical research on psychological symptomatology and occupational outcomes to an individualized framework centered on moral resilience, compassion fatigue, and moral courage, with spirituality entering the middle stratum but not persisting into the recent vocabulary and with institutional betrayal entirely absent from the network. Co-citation analysis revealed a knowledge base shifting from the dominance of military psychology to nursing-specific specialization. However, the bio-psycho-social-spiritual framework of Carey and Hodgson (2018) never became an established part of the nursing moral injury knowledge base: it surfaced only briefly and peripherally within the military moral injury cluster of 2020-2022, and was absent from the nursing moral injury literature networks thereafter. Taken together, these findings reveal a field that has grown in volume and scope without consolidating around a stable theoretical anchor. Future research may benefit from adopting the bio-psycho-social-spiritual framework as an organizing structure for nursing-specific conceptualization, measurement, and intervention design, building toward a theoretically grounded and disciplinarily coherent nursing moral injury research agenda.
The American Heart Association (AHA) revised the Pediatric Basic and Advanced Life Support guidelines in 2025 to reflect on the current evidence and best practices. The key changes include a special emphasis on post-cardiac arrest care, prognostication, and survivorship. Other major changes include the elimination of 2-finger chest compressions in infants with a recommendation of compressing the chest with the heel-of-1-hand technique or 2-thumb-encircling hands technique; the preferential and immediate use of an automated external defibrillator with a pediatric attenuator, if available, for cardiac arrest; and in children with severe foreign-body airway obstruction repeated cycles of 5 back blows alternating with 5 abdominal thrusts.
Population pharmacokinetic/pharmacodynamic (PPK/PD) modeling is a key component of model-informed drug development and model-informed precision dosing. Regulatory agencies in the United States, Europe, Japan, and China, together with the recently adopted ICH M15 guideline, have established high-level principles for the conduct, evaluation, and reporting of population modeling analyses. However, many practical implementation details are intentionally left to sponsors, investigators, and analysts. Although this flexibility accommodates diverse objectives, data structures, therapeutic areas, and decision contexts, it may also contribute to inter-analyst variability and limit the reproducibility, transparency, and consistency of PPK/PD practice. This review discusses the 2025 Chinese Pharmacological Society group standard for PPK/PD analysis from an international and implementation-oriented perspective. The standard describes a stepwise analytical lifecycle comprising pre-analysis preparation, base model development, final model establishment, model application, and reporting, with model evaluation embedded iteratively throughout the process. It also formalizes operational elements often implicit or under-specified in existing guidance, including a prospective Population Modeling Analysis Plan, distinction between exploratory and confirmatory analyses, prioritization of decision-relevant parameters, staged verification checkpoints, a five-element risk-management cycle, and ethical considerations related to data governance and equitable model application. We position the Chinese group standard as an analyst-level operational reference that complements, rather than replaces or duplicates, the decision-level assessment framework provided by ICH M15. Although developed within the Chinese regulatory and professional context, the structured workflow described in the standard may provide a practical reference for organizations seeking to improve the reproducibility, transparency, and consistency of PPK/PD analyses internationally.
Jobes and Barnett (see record 2024-78987-001) decided to emphasize and recommend only psychological interventions (e.g., dialectical behavior therapy) in the clinical treatment for suicidal risk and behavior. Such interventions have been, in fact, proven effective in research emphasizing randomized controlled trials. Jobes and Barnett, however, decided not to include a section dealing with medications because they concluded that, with some exceptions (e.g., clozapine), the majority of medications have "little to no evidence" in randomized controlled trials. The article by Jobes and Barnett not only appears to be unintentionally biased in favor of only recommending psychological interventions, but it also appears clinically unsound to advise clinicians to de-emphasize medications in the present clinical context. The core message in the article (emphasis on psychological interventions, but not on medications) does not appear in accord with the American Psychological Association RxP Designation Committee with the mission to review and approve programs in prescriptive authority for psychologists nor with the wide range of medications with evidenced clinical benefits derived from randomized controlled trials funded by the National Institutes of Health and approved for marketing by the U.S. Food and Drug Administration. (PsycInfo Database Record (c) 2026 APA, all rights reserved).
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Whether autism is increasing is a subject of growing interest to researchers, health and social care professionals, policymakers, and the general public. We examined trends over time in the proportion of adults in England self-reporting as autistic, utilising data from an annual repeated cross-sectional survey series of adults registered with a General Practice in England. We report annual unweighted frequencies and weighted percentages (with 95% confidence intervals) for survey respondents self-reporting autism for 2018 to 2025, with equivalent data for self-reporting learning disability and a mental health condition. We additionally report the percentage change for 2019 to 2025, compared to a 2018 survey year baseline. Disaggregated data was reported according to age group, gender identity, and ethnicity. The weighted percentage of adults self-reporting as autistic has increased from 0.9% (95% CI 0.9-0.9) in 2018 to 2.6% (95% CI 2.5-2.7) in 2025, representing a 188.9% increase over a 7-year period. More modest percentage increases over this same time period were observed for learning disability (26.7%) and mental health condition (51.6%). The majority of the increase in adults self-reporting as autistic took place between the 2021 and 2025 survey years, over which time there was a 136.4% increase. There has been a substantial increase in adults self-reporting as autistic in England over a relatively short period of time, with an absence of similar increases in self-reporting as having a learning disability or a mental health condition. Further research is required to better understand the factors underpinning this change.
Sarcopenia is a common comorbidity in older adults. This study aimed to clarify the association between preoperative sarcopenia, based on the Asian Working Group 2025 (AWGS2025) criteria, and postoperative outcomes in older patients with early stage non-small cell lung cancer. This retrospective study included patients aged ≥ 75 years who underwent lung resection for clinical stage I lung cancer. Sarcopenia was diagnosed based on grip strength and bioelectrical impedance-derived muscle mass measured according to the AWGS2025 criteria. The primary outcomes were postoperative pulmonary complications (PPCs), defined as Clavien-Dindo classification Grade ≥ 2 within 30 days, and unplanned readmission within 90 days after surgery. A logistic regression analysis was used to identify the factors associated with postoperative outcomes. Among the 107 patients, 28 (26%) were diagnosed with sarcopenia. The incidence of PPCs (32% [9/28] vs. 8% [6/79], P = 0.003) and unplanned readmission (18% [5/28] vs. 3% [2/79], P = 0.013) was higher in the sarcopenia group. Sarcopenia independently predicted PPCs (odds ratio [OR], 5.00; P = 0.020) and unplanned readmissions (OR, 9.17; P = 0.019). Preoperative sarcopenia, diagnosed using the AWGS2025 criteria, is closely associated with PPCs and unplanned readmissions in older patients. Preoperative screening may facilitate risk stratification and improve perioperative care.
Respiratory infections caused by SARS-CoV-2, influenza, and respiratory syncytial virus (RSV) cause pronounced seasonal morbidity and mortality among residents of nursing homes (NHs). To assess the effect of an on-site point-of-care respiratory multiplex polymerase chain reaction (POC-RMPCR) instrument on NH outbreaks. This multicenter, open-label cluster randomized trial was conducted from November 12, 2024, to May 2, 2025, in NHs in Toronto, Ontario, Canada. The data analysis was performed from October 7, 2025, until December 31, 2025. On-site POC-RMPCR by trained NH staff. The primary outcome was jointly SARS-CoV-2, influenza, and RSV outbreak size and number, and secondary outcomes included the rates of resident emergency department (ED) transfer and death. Among 20 participating NHs with a total of 3963 beds, there was median of 5.5 units, with 30 beds per unit and a crowding index score of 1.42. The joint estimate of outbreak number (51 and 62, respectively) and size for the intervention group was no different from controls, with a rate ratio of 1.12 (95% CI, 0.78 to 1.58). ED transfers for confirmed (-3.5%; 95% CI, -7.2 to -0.2%) and confirmed/suspected infection (-11.0%; 95% CI, -20.6% to -2.0%) were lower among intervention NHs without a difference in death. Viral testing rates (3.69 tests/week vs 1.73 tests/week) and ratio of confirmed to suspect cases (4.2 vs 2.0) were higher in intervention homes along with a shorter time to initiation of antiviral therapy from symptom onset (-2.5 days; 95% CI, -3.1 to -1.9). The results of this cluster randomized clinical trial suggests that use of a POC-RMPCR in NHs did not change outbreak number or size but decreased the number of ED transfers in the context of increased viral testing, improved case detection, and faster initiation of antiviral therapy for influenza. Seasonal adoption of POC-RMPCR in NHs would avoid an estimated 4 ED transfers per 100 beds. ClinicalTrials.gov Identifier: NCT06660433.
The American Society of Breast Surgeons (ASBrS) receives an increasing number of abstracts for its annual meeting, resulting in increasing time and effort for peer-review. We aimed to compare artificial intelligence (AI) large language models (LLMs) to human-generated scores to explore if AI-review is a plausible abstract screening process. Abstracts published from the 2025 ASBrS meeting were assessed with three LLMs: OpenAI's GPT4-o (GPT), Meta's Llama-3.1-405b (Llama) and DeepSeek's DeepSeek-V3 (DeepSeek). Abstracts were analyzed using zero shot (ZS), which included the 2025 ASBrS scoring rubric and few shot (FS) with examples of high- and low-scoring abstracts. Large language model scores were compared with the committee's scores. Model inference was evaluated by using Spearman rank correlation, quartile accuracy, and mean absolute error; 95% CIs were calculated by using bootstrap resampling. A total of 378 published accepted abstracts were included. Human-generated median abstract score was 21.2 (rubric ranged 0-35). Median scores were higher amongst all LLMs for both the ZS and FS approaches (27.0-29.7, p < 0.001). Spearman values with the ZS approach for GPT, DeepSeek, and Llama were 0.24, 0.30, and 0.31, respectively, and for the FS approach were 0.37, 0.35, and 0.27, respectively (p < 0.001 for all). DeepSeek ranked the first quartile correctly with 53.5% accuracy while Llama ranked the fourth quartile correctly with 42.9% accuracy. The FS approach modestly improved correlation and first quartile accuracy, with greatest improvement seen in GPT. Large language models showed statistically significant rank correlation with human ASBrS abstract ranking. Large language models may be useful as a preliminary screening tool to prioritize reviewer effort toward higher-quality abstracts.
Pigmentary disorders, particularly hyperpigmentation, disproportionately affect individuals with skin of color and are associated with significant psychosocial burden. Despite their global prevalence, real-time data on public awareness and interest remain limited. Digital tools such as Google Trends offer a novel approach to assessing public interest in dermatologic conditions. Google Trends was used to evaluate public interest in hyperpigmentation-related terms such as "hyperpigmentation", "pigmentation", "skin brightening", "brown spots", and "dark spot treatment" from January 2004 to October 2025. Data were analyzed for the United States (US) and globally using relative search volume (RSV), a normalized scale from 0-100 representing peak popularity within a defined region and time frame. Temporal trends, seasonal variation, and geographical distribution were assessed. Across all terms, RSV demonstrated a sustained increase over time both domestically and globally. "Pigmentation" and "hyperpigmentation" consistently showed the highest search interest, with a marked spike in "hyperpigmentation" in early 2025. "Brown spots" exhibited seasonal peaks during the summer months. In the US, the highest relative search interest for "brown spots" was observed in southern states, including South Carolina, Alabama, and Tennessee. Globally, countries such as Ghana, Nigeria, and Mauritius frequently ranked highly across multiple terms. Public interest in pigmentary disorders has increased significantly over the past two decades. Google Trends provides valuable insight into consumer awareness and information-seeking behavior, highlighting potential gaps in education and access to dermatologic care. These findings may inform targeted public health initiatives and culturally responsive interventions for populations disproportionately affected by pigmentary conditions.  .
To analyze the influencing factors for intraoperative hypothermia in patients undergoing percutaneous nephrolithotomy (PCNL). Prospective observational study. A total of 236 patients undergoing percutaneous nephrolithotomy (PCNL) at a tertiary hospital from January 6 to April 6, 2025, were selected as the subjects of this study. Patients were divided into hypothermia and non-hypothermia groups based on whether they experienced hypothermia during surgery. Univariate and binary logistic regression analysis were used to screen for influencing factors associated with intraoperative hypothermia. 136 patients (57.6%) experienced intraoperative hypothermia, while 100 patients (42.4%) did not. Univariate analysis revealed that there were statistically significant differences between the hypothermia group and non-hypothermia group in terms of gender, BMI, duration of anesthesia, room temperature, number of tracts, preoperative warming measures, and intraoperative warming measures. Binary logistic regression analysis indicated that gender (OR=2.204, 95%CI: 1.164~4.173, P=0.015), BMI (OR=1.202, 95%CI: 1.096~1.317, P<0.001), number of tracts (OR=0.276, 95%CI: 0.123~0.619, P=0.002), and comprehensive preoperative warming measures (OR=3.041, 95%CI: 1.016~9.097, P=0.047) were independent influencing factors for intraoperative hypothermia in patients undergoing percutaneous nephrolithotomy. The incidence of intraoperative hypothermia in patients undergoing percutaneous nephrolithotomy is relatively high, and its occurrence is associated with gender, BMI, the number of surgical tracts, preoperative warming measures and intraoperative warming measures.
Health, immigration status, race, and gender are intersecting concepts that reveal higher rates of acute and chronic mental health concerns among women. This qualitative systematic review aimed to identify, critically appraise, and synthesize qualitative evidence on how women living with diverse immigration statuses experience mental health interventions in Canada. Literature was searched using Medline (Ovid) and then translated into each of the following databases: Cumulative Index for Nursing and Allied Health Literature (CINAHL Ebsco), PsycINFO (Ebsco), Web of Science, CINAHL, Medline and PsycINFO; and Web of Science. Using Joanna Briggs Institute (JBI) methods and Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, studies published between 2003 and 2025 were identified and screened within Covidence for quality using the standard JBI critical appraisal checklist for qualitative research. A total of 107 findings consisting of participants' verbatim quotes were extracted from 18 studies and aggregated into the following synthesized findings: (1) Women's socio-emotional well-being, (2) Culturally misaligned mental health care among racialized women, (3) Women's cultural preferences and access conditions, and (4) Women's recommendations for improving mental health care and support. Implications of the review findings address gaps in equity-informed mental health services tailored to women living at the intersections of racism and diverse immigration status in Canada.
Transarterial chemoembolization (TACE) is the standard treatment for patients with intermediate-stage hepatocellular carcinoma (HCC), but the rate of complete response (CR) after TACE varies widely. Pretreatment identification of patients likely to achieve CR remains clinically challenging. To assess the pretreatment predictive value of liver imaging reporting and data system (LI-RADS) features and clinical features on gadoxetic acid-enhanced MRI (EOB-MRI) for CR after TACE in patients with HCC > 2 cm. From June 2018 to June 2025, 167 patients with unresectable HCC were enrolled in this retrospective single-center study. All patients underwent EOB-MRI within 2 weeks before initial TACE. Treatment response was classified as CR or non-complete response (nCR) using the modified Response Evaluation Criteria in Solid Tumors (mRECIST). Clinical and MRI features associated with CR were identified using univariate and multivariate logistic regression analyses. The area under the receiver operating characteristic curve (AUC) was used to assess the model performance. A total of 61 of the 167 patients (36.5%) achieved CR on follow-up imaging at 3-4 months after TACE. Multivariate analysis revealed that tumor diameter (odds ratio [OR]: 0.965, 95% confidence interval [CI]: 0.943-0.987; p = 0.002), irregular border (OR: 0.404, 95% CI: 0.196-0.832; p = 0.014), and enhancing capsule (OR: 3.006, 95% CI: 1.147-7.877; p = 0.025) were significantly associated with CR. The combined model incorporating these three features yielded an AUC of 0.723 (95% CI: 0.649-0.790, p < 0.0001), outperforming that of each individual predictor (AUC = 0.658, 0.615, and 0.565, respectively). A simple imaging-based model incorporating tumor diameter, irregular border, and enhancing capsule achieved moderate performance for predicting CR after TACE in patients with HCC > 2 cm, and may serve as a practical tool for response stratification and individualized treatment decisions.
This study investigates the relationship between hereditary protein S deficiency (PSD) and cerebral venous sinus thrombosis (CVST) through phenotypic and genetic analyses in a proband and family members with compound heterozygous PROS1 mutations. A retrospective analysis was conducted on the clinical data of one patient diagnosed with CVST treated in The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University in July 2025. Peripheral venous blood samples were collected from the proband and 14 individuals from three generations, and relevant coagulation parameters and thrombin generation and inhibition assays were performed. Plasma protein S activity (PS: A), total protein S antigen (TPS: Ag), and free protein S antigen (FPS: Ag) were quantified. All exons and flanking regions of PROS1 were amplified by polymerase chain reaction (PCR) and analyzed by Sanger sequencing. Bioinformatics tools were used to evaluate mutation conservation, predict pathogenicity, and analyze structural effects on the protein. Thrombin generation and inhibition assays indicated defective anticoagulant function in the proband. The proband was diagnosed with CVST and type Ⅰ PSD (PS: A 39%, TPS: Ag 53 mg/L, FPS: Ag 42 mg/L). Genetic analysis identified a heterozygous missense variant c.1544G > A (p.Arg515His) and a heterozygous synonymous mutation c.2001 A > G (p.Pro667Pro) in the PROS1 gene. Arg515 was highly conserved across nine homologous species. The p.Arg515His mutation was predicted to be pathogenic and associated with reduced protein stability and abnormal folding. Compound heterozygous variants c.1544G > A and c.2001 A > G in the PROS1 gene may be associated with reduced protein S levels in this pedigree. The occurrence of CVST in the proband with PSD patients may also be related to these compound heterozygous variants.
To establish disease-specific therapeutic plasma concentration ranges for quetiapine (QTP) and its active metabolite N-desalkylquetiapine (NDQ) in Chinese patients with schizophrenia, manic episode, depressive episode, and depressive episode with comorbid insomnia, and to evaluate the impact of polypharmacy on drug concentrations. A Retrospective Analysis was conducted from June 2022 to October 2025, enrolling 576 hospitalized patients: 198 with schizophrenia, 186 with manic episode, and 192 with a depressive episode. From the depressive episode group, 35 patients with severe comorbid insomnia as the primary treatment target were analyzed separately. Consequently, the core depressive episode group for efficacy analysis comprised 157 patients, while the depressive episode with comorbid insomnia subgroup (n = 35) was analyzed separately. Detailed administration regimens (dosage frequency) were recorded for all patients. Steady-state concentrations of QTP and NDQ were measured using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Significant differences in optimal QTP concentration ranges were identified across diseases: 150-550 ng/mL for schizophrenia, 180-580 ng/mL for manic episode, 120-480 ng/mL for depressive episode (consistent with both ≥ 30% and ≥ 50% HAMD-17 reduction standards), and 40-120 ng/mL for depressive episode with comorbid insomnia (12 h concentrations). The mean QTP concentration was lower in the depressive episode group (302 ± 276 ng/mL), which showed a high response rate (82.3% for ≥ 30% HAMD-17 reduction). The highest response rate (85.7%) was observed in the depressive episode with comorbid insomnia subgroup. In contrast, schizophrenia patients required higher concentrations (389 ± 286 ng/mL) but had a lower response rate (73.7%). Polypharmacy with CYP3A4 inhibitors/inducers was recorded; co-administration of venlafaxine (mild CYP3A4 inhibitor) significantly increased QTP concentrations in depressive episode patients, while co-administration of valproate or lithium had no significant impact on QTP concentrations in schizophrenia or manic episode patients. This exploratory study proposes disease-specific QTP concentration ranges that show clinical relevance in this Chinese cohort, providing preliminary evidence to guide future research on personalized TDM. The findings should be interpreted cautiously and require validation in subsequent studies before being used to inform clinical practice.
Lethal means safety counseling involves limiting access to lethal means of suicide in times of crisis. The National Institute of Mental Health Emergency Department (ED) Suicide Risk Screening Pathway recommends lethal means safety counseling for patients with suicidal thoughts being discharged from the ED. We sought to understand ideal characteristics of a lethal means safety counseling tool for the ED from the perspective of teens and caregivers with lived experience. This qualitative study was conducted at a tertiary care children's hospital ED from September 2024 to June 2025. Patients ≥10 years are screened for suicide risk using the Ask Suicide-Screening Questions; those with a nonacute positive Ask Suicide-Screening Questions screen and reported firearm access were eligible. We conducted semistructured interviews with teens (13 to17 years) and/or their caregiver participants spoke English. Teens and caregivers were interviewed separately. Interviews were recorded and transcribed. Inductive coding was performed by 2 team members. Themes were identified using content analysis. We completed 33 interviews (19 caregivers, 14 teens, 14 dyads). Participants were mostly women, heterosexual, White, and non-Hispanic. Themes included the following: (1) lethal means safety counseling is beneficial and helps families feel cared for; (2) specific lethal means safety counseling tool elements should utilize technology, consider equity, and include straightforward language and supportive messaging, as well as an actionable plan; and 3) differing family dynamics and balancing teen autonomy and safety remain barriers to lethal means safety counseling. Lethal means safety counseling is an essential, high-yield component of suicide prevention. Our findings will directly inform the development of a brief family-centered lethal means safety counseling intervention for the ED.