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Significance Catechol chemistry has emerged as a cornerstone of bioinspired polymers and adhesives due to its versatility in creating diverse covalent and dynamic noncovalent interactions (including metal coordination). The concept initially arose from the discovery that mussels use catechol moieties of 3,4-dihydroxyphenylalanine (DOPA) to mediate robust surface adhesion in seawater and to reinforce tough and self-healing biopolymer fibers. Currently, difficulties controlling DOPA redox chemistry limit its synthetic application; yet, mussels overcome this challenge daily through apparent physical and chemical process control. Here, we reveal that mussels employ several different processing pathways that predetermine the cross-linking fate of DOPA-containing proteins via spatiotemporal control of microenvironments in secretory vesicles and later in mature threads—with key significance for advanced polymer design. Inspired largely by the role of the posttranslationally modified amino acid dopa (DOPA) in mussel adhesion, catechol functional groups have become commonplace in medical adhesives, tissue scaffolds, and advanced smart polymers. Yet, the complex redox chemistry of catechol g

Memory formation enables the retention of life experiences overtime. Based on previously acquired information, organisms can anticipate future events and adjust their behaviors to maximize survival. However, in an ever-changing environment, a memory needs to be malleable to maintain its relevance. In fact, substantial evidence suggests that a consolidated memory can become labile and susceptible to modifications after being reactivated, a process termed reconsolidation. When an extinction process takes place, a memory can also be temporarily inhibited by a second memory that carries information with opposite meaning. In addition, a memory can fade and lose its significance in a process known as forgetting. Thus, following retrieval, new life experiences can be integrated with the original memory trace to maintain its predictive value. In this review, we explore the determining factors that regulate the fate of a memory after its reactivation. We focus on three post-retrieval memory destinies (reconsolidation, extinction, and forgetting) and discuss recent rodent studies investigating the biological functions and neural mechanisms underlying each of these processes.

the exact opposite: racism is in fact so embedded in society that even a black president cannot escape it. Berry details a series of media-led microaggressions and biased framing used around Obama in ways that perpetuate racial stereotyping. The final chapter explores blackness in science fiction and in futuristic and speculative fiction narratives. This is one of the most interesting chapters in the book because it offers a glimpse of creative and imaginative possibilities and ways to reimagine black identity and the place of race (if any) in the future. At the same time, it is attentive to the black past, with storylines often presenting black characters from the future time-traveling back to the time of slavery, segregation and oppressive racism. It is difficult to do justice to the many examples used by Berry in carefully putting together a picture of a media culture that is as disappointing in its repetition of old and dangerous racial stereotypes, as it is promising in developing ways that upend, interrogate and undermine these stereotypes. In this, she shows both the tenacity of racial imaginaries but also the bold, creative and ultimately transformative stories that can ove

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The Anthropocene names the epoch wherein humans have become the main geological agent on the planet’s surface. But which humans, and since when? Dating the onset of the Anthropocene is a political and ontological as much as a scientific act. This essay argues the Anthropocene is inexorably racial because it flows out of a capitalist system which requires racializing populations and environments from early modernity to the present and into the future. The essay contends that racial capitalism should be a central category in explaining the onset of the Anthropocene. The focus will be on investigating whether it makes sense to take the European discovery of the Americas and the genocide against its original inhabitants as threshold of a new geological epoch. Following the radicalization of Marx in the philosophy of Deleuze and Guattari, it will be suggested that though colonization and slavery were essential for modern globalization to emerge, capital embarked on its self-perpetuating destructive trajectory through industrialization. Structural racism was transmuted and continues to characterize the global ecological crisis.

We examine the long-term impacts of drought exposure on women born in 19 countries in sub-Saharan Africa, across four decades. We find that women who were exposed to drought conditions during their early childhood are significantly less wealthy as adults. These effects are confined to women born and raised in rural households, indicating that the impacts of rainfall are felt via changes in agricultural output. In addition to lower levels of wealth, women who experience droughts in infancy also receive fewer years of formal education and, in the case of extreme drought conditions, have reduced adult heights. Our results also suggest that drought exposure in infancy can have long-term, negative impacts on women’s empowerment. Finally, we also show that these impacts may be transmitted to the women’s offspring, with children of affected women more likely to be born at a low birth weight (weighing <2.5 kg). To our knowledge, this represents the largest study to date both geographically and over time showing a strong relationship between early life rainfall conditions and adult outcomes, and the first to show that the impacts could span generations.

The control of gene expression is a multi-layered process occurring at the level of DNA, RNA, and proteins. With the emergence of highly sensitive techniques, new aspects of RNA regulation have been uncovered leading to the emerging field of epitranscriptomics dealing with RNA modifications. Among those post-transcriptional modifications, N6-methyladenosine (m6A) is the most prevalent in messenger RNAs (mRNAs). This mark can either prevent or stimulate the formation of RNA-protein complexes, thereby influencing mRNA-related mechanisms and cellular processes. This review focuses on proteins containing a YTH domain (for YT521-B Homology), a small building block, that selectively detects the m6A nucleotide embedded within a consensus motif. Thereby, it contributes to the recruitment of various effectors involved in the control of mRNA fates through adjacent regions present in the different YTH-containing proteins.