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To explore expectations and experiences with video consultations of people with type 1 diabetes using insulin pump therapy and healthcare professionals (HCPs). An interpretive description approach was used in a longitudinal design. Semi-structured interviews were conducted with people with diabetes and HCPs at two time points (T1 and T2). T1 interviews explored expectations prior to a randomised controlled trial. T2 interviews explored experiences with intervention group participants and HCPs. A reflexive thematic data analysis was employed. In total, 33 interviews were conducted. Two themes for people with diabetes at T1 were: 'Is video inferior?-The fear of missing something' and 'Allows me to stay in my everyday life'. At follow-up interviews (T2): 'It is fine for smaller issues-but not for larger issues' and 'Are video consultations worth it?'. HCPs' themes at T1 were: 'Can video consultations increase empowerment?' and 'What can be done?-Something in-between a phone and an in-person consultation'. At follow-up interviews (T2): 'If carried out right, a lot can be done' and 'Obstacles for moving forward'. Video consultations can potentially be a less disruptive form of consultation, allowing people with diabetes to stay in their everyday lives, especially for minor issues or minor treatment adjustments. Challenges, in terms of pre-visit preparation, might outweigh the benefits. Adjustment of clinical work is required to address people with diabetes' preferences for video consultations, guidance on preparation and requirements for participants.

Power plays an important role in nursing practice, yet there is limited research into how nurses themselves understand and use it. As staffing concerns grow, many nurses report feeling unable to influence change. Existing research often frames power as something that is granted to nurses rather than something they experience internally; this grounded theory study examines how nurses and nurse leaders perceive and enact power in practice. The resulting theory, feeling heard flips the switch, affirms that nurses access power when they feel heard. Feeling heard activates agency, enabling nurses to advocate for patients and themselves and fostering healthier work environments that support recruitment and retention.

Men's support deficits explain gender differences classically associated with parental investment theory. That is, men may have sex on their minds not because the costs are low, but because sex is a primary route for constructing something profound that they lack: an emotionally fulfilling relationship. The breadth of findings consistent with the support-deficit explanation has made it the parsimonious one.

Fetal hydrops, characterized by abnormal fluid accumulation in two or more fetal compartments, is a critical condition with a poor prognosis, often resulting in significant fetal mortality. The condition itself is not a diagnosis but a clinical sign with many underlying causes, ranging from infections and chromosomal abnormalities to rare maternal conditions such as mirror syndrome. This review examines three cases of fetal hydrops, highlighting common etiologies, such as infections and chromosomal disorders, and more unusual causes like maternal complications. The current approach to diagnosing hydrops fetalis relies primarily on ultrasound imaging and Doppler studies to identify abnormal fluid accumulation and pathophysiology. However, advances in genomic testing are rapidly transforming the diagnostic pathway. With increasing accuracy, speed and accessibility of genetic testing, it is likely that these tools will be integrated earlier in the diagnostic process, potentially improving prognostic assessments and treatment outcomes. The importance of early and accurate identification of the cause is essential to inform clinical management, improve fetal survival rates and support parental decision-making. Fetal hydrops is a serious condition during pregnancy. It occurs when much fluid builds up in different parts of an unborn baby. It can build up around the lungs, heart or under the skin. It is not usually a disease by itself but rather it’s a sign that something else is wrong. There are many possible causes. For example, infections passed from the mother, problems with the baby’s chromosomes, heart problems, or other rare conditions.In this article, we describe three pregnancies seen at our hospital where the babies developed fetal hydrops for very different reasons. The first baby had an infection caused by parvovirus B19. The second baby had Down syndrome. The third baby had no clear cause, but the mother developed a rare condition called mirror syndrome. In her case, she became swollen and had high blood pressure as her baby became sicker.Unfortunately, all three babies did not survive. This shows how serious this condition can be. By shedding light on these cases, we hope to help doctors in recognizing fetal hydrops earlier and find the underlying cause.

General practice plays a central role in healthcare delivery and holds significant potential to advance sustainability by reducing its environmental footprint and promoting population health. While Denmark has implemented national and regional strategies to enhance sustainability in hospitals and secondary care, comparable initiatives in primary care remain limited, and little is known about general practitioner (GP) views on sustainability in general practice. The aim of the study was to explore GPs' views on sustainability in general practice. Eleven semi-structured interviews were conducted during November and December 2024 with GPs from all regions of Denmark. A qualitative individual interview design using interpretative reflexive thematic analysis was used. Two main themes were constructed (i) Making sense of sustainability: How GPs perceive sustainability in practice, with the subthemes: Abstract threat, concrete practices, Translating sustainability into clinical language, Financial sustainability as a prerequisite, and When social sustainability feels imposed; and (ii) Between responsibility and reluctance: the GP's role in a sustainable future, with the subthemes: Waiting for direction and delegation, and Forming sustainability as part of the professional identity. While most participants recognised sustainability as an important topic, they described challenges in transforming it into something manageable that could be incorporated into everyday clinical practice. This study underscores the need for more research and policy attention to sustainability in Danish general practice. GPs appear willing to support a sustainability transition in health care, but they require further guidance and knowledge.

This study focused on developing an effective Rheumatoid Arthritis (RA) treatment by creating diacerein-loaded nanoparticles. The goal was to create a more efficient RA treatment with fewer side effects, something conventional treatments fail to achieve. Using the solvent evaporation technique, the researchers produced nanoparticles and formulated them, which they optimized using DOE (Design of Experiments). They also analyzed their nanoparticle formulations through three methods: particle size, entrapment efficiency, and in vitro drug release. Their results indicate controlled drug release and desirable physical-chemical properties that should lead to greater bioavailability, which is a good thing because it leads to less waste. The in-vitro studies show that when using diacerein delivered through nanoparticles, there will be a greater anti-inflammatory response from chondrocytes than if diacerein were administered alone. Therefore, this study provides evidence that nanoparticles can be used to treat RA, improving drug effectiveness, decreasing systemic toxicity, and improving patient compliance. In order to achieve a constant percentage of encapsulation efficiency, regulated particle size, and desired drug release patterns, this work effectively used RSM to optimize diacerein-loaded nanoparticles. The results demonstrate the potential of optimized diacerein nanoparticles for improved therapeutic uses in targeted drug delivery systems and emphasize the value of statistical techniques in pharmaceutical formulation development.

Voxel-based meta-analyses-also known as coordinate-based meta-analyses (CBMAs)-are powerful tools for synthesizing evidence from neuroimaging studies in human neuroscience, including investigations of psychological functions and differences in brain disorders. To achieve their full potential in accurately assessing the evidence, CBMAs should adhere to established best-practicmpe guidelines, such as the "Ten Simple Rules" published in 2018. Yet, even when studies report following these recommendations, the degree to which individual items are applicable or fully addressed is often unclear. To better support the evaluation of methodological rigor-which the 10 rules already promote but are not always consistently applied-, the developers of the most used CBMA methods followed a Delphi-style iterative process to create a reporting checklist focused on the methodological quality of CBMAs (Qual-CBMA). Qual-CBMA comprises criteria (e.g., preregistration, systematic search, homogeneous study characteristics, etc.) that authors should verify and comment on explicitly in the checklist (and, when unmet, also in the manuscript). The checklist encourages rigor and transparency by prompting authors to identify potential methodological limitations and to discuss their relevance-or irrelevance-in the context of their specific study. The checklist is designed as an aid to make reporting clearer and more transparent, not as a tool for evaluating whether authors have done something incorrectly. In this context, a high-quality CBMA is not defined by meeting every criterion, but by clearly commenting on the criteria-and explaining when unmet criteria are appropriately not applicable given the study's objectives. We encourage authors to submit the Qual-CBMA checklist, together with their accompanying comments, when publishing new CBMAs, thereby reinforcing transparency and rigorous methodology and advancing understanding in cognitive neuroscience and clinical conditions.

The prevalence of mental health challenges, such as anxiety and depression, highlights the need for accessible and practical methods to enhance wellbeing as a preventative measure. Over half of the global population (54%) owns a smartphone, and the number of mobile users worldwide was projected to reach 7.49 billion by 2025. With smartphone cameras widely available, individuals can easily document daily moments, potentially benefitting their emotional wellbeing. This qualitative study explored the impact of photo-taking on individual wellbeing through a 3-week intervention grounded in positive psychology principles. Nineteen participants, recruited via social media took a daily photo for 3 weeks, each based on a theme set by the researcher: something they were grateful for (week 1), a selfie or self-portrait highlighting positive traits (week 2) and a picture to share with someone else (week 3). Participants then engaged in online one-on-one interviews with the researcher. Reflexive thematic analysis identified four core themes: (1) appreciation of life's value, (2) shifts in mindset, (3) cultivation of purpose and (4) pursuit of positivity. The findings suggest that this intervention contributes to fostering a positive outlook and enhancing feelings of happiness, contributing to participants' emotional wellbeing. While the study demonstrates a promising link between photo-taking and wellbeing as an accessible and preventative tool, further research is needed to examine additional variables, particularly across diverse age groups and ethnicities. As technology becomes increasingly integrated into daily life, such methods hold the potential for promoting individual and community flourishing with minimal effort.

Despite increasing initiatives in healthcare, it often remains a challenge to effectuate patient participation. A promising space for patient participation is to be found within Moral Case Deliberation, a dialogical form of Clinical Ethics Support. However, presence of patients in these dialogues is still rare. This paper aims to provide a better understanding of moral considerations of participation of patients (and their relatives) in Moral Case Deliberation, by collecting expectations and experiences from patients, relatives, healthcare professionals and facilitators. The study is an explorative interview study in two clinical settings. Interviewees were recruited through purposeful sampling and among all relevant perspectives (i.e. patient, parent, healthcare professional and facilitator). Twelve interviewees were included; most did not yet have actual experiences with patient participation in Moral Case Deliberation. A variety of moral considerations was found. Three overarching themes were identified: 'equality', 'transparency' and 'vulnerability', connected to nine considerations: 'sharing the moral dilemma, engagement/acknowledgement of the patient and parent perspective', 'mutual understanding', 'complexities', 'risk of harm', 'self-censorship', 'safety' and 'power dynamics'. There seems to be - as of yet - no principled reason to adopt an attitude of categorial rejection nor acceptance of inclusion of patients or family in Moral Case Deliberation. This study provides a starting point for further identification of and reflection on such considerations. We think that a careful assessment of various considerations is something that should be done by those directly involved in the moral issue at hand on a case-by-case basis.

This community case study describes the development and implementation of the Gambling Awareness Research Initiative (GARI), a community-academic research partnership in Springfield, Massachusetts, created in response to the expansion of legalized gambling and the need for community-driven research to further understand gambling's impact on youth and young adults. The initiative uses a participatory action research design that positions the Young Adult Action Collective, a group of young adults from the city, as co-researchers and co-leaders, working in partnership with the city's Department of Health & Human Services, a youth-serving community organization, and a university research team. Methodologically, GARI explores the adoption of arts-based research, such as digital storytelling and a creative crowdsourcing contest, as potential approaches to illuminate a stigmatized and often hidden public health issue like gambling. The paper highlights the process elements that make this model effective, including radical love, collective learning and growth, and young-adult-driven research development, as well as the logistical and structural challenges that arise from balancing research priorities and the realities of young-adult participation. Community work is, at its core, about building relationships and doing work that endures past the project at hand. Through this process, something meaningful is created: a kind of knowledge and connection that has the power to transform individuals, groups, and communities over time. As the public health field continues to confront complex health and social issues, GARI exemplifies how community-driven, arts-based methodologies can help engage young adults in shaping both the research questions and the pathways toward change. Such approaches hold the potential to deepen understanding, challenge extractive research norms, and strengthen the connections between the community and academia.

Every day, we are likely to encounter novel words. We might even make those ourselves from familiar parts of words we know, creating something new and understandable, e.g., wordify, grantology. However, some combinations of these familiar parts will yield words we are more likely to use: berater seems better than penciler or plantist. This depends on the productivity of the words' parts and how they combine: some suffixes, like -er in dreamer, are very often used to make a new word, reinforcing their use in more novel words. When encountering a novel word, how does the productivity of its stem-suffix combination affect its processing in the brain? How does its processing differ from the processing of words we know? Alongside productivity, do other properties like semantic ambiguity or the stem's syntactic category affect novel word processing? We investigated the neural dynamics of these properties using a lexical decision task in a MEG setting by contrasting existing and novel Verb-er ('tributer'), Noun-er (N-er 'legender'), and Noun-ist ('collagist') words. Throughout the temporal lobe, orbitofrontal cortex, and ventromedial prefrontal cortex, we found a distinction within novel words, with the most productive form (novel V-er) being processed significantly differently from the other novel word forms. Existing words, on the other hand, did not differ among each other, highlighting the elevated role of productivity in novel words. Importantly, existing-novel counterparts did not differ significantly in their processing. Innovatively investigating plausible novel words of different properties, our findings offer new insight on the role of morphological productivity in the comprehension of new words.

We previously found the glycaemic index (GI) of 3 foods to be similar in subjects aged >40&#x2009;y (mean 49&#x2009;y) versus <40&#x2009;y (mean 29&#x2009;y), but a more recent study reported the GI of 2 foods to be higher in subjects aged >55&#x2009;y (mean 70&#x2009;y) vs. <33&#x2009;y (mean 24&#x2009;y). Here, we compared the GI or relative glycaemic response (RGR, analogous to GI but using a different reference food) of the younger (age <33&#x2009;y) vs. the older (age >55&#x2009;y) subjects who participated in previously published studies that included n&#x2009;&#x2265;&#x2009;9 in each group. Study 1, (GI, 3 foods) had n&#x2009;=&#x2009;19:9 younger:older subjects; Study 2, (GI, 2 foods) n&#x2009;=&#x2009;14:10; Study 3, (RGR, 1 food), n&#x2009;=&#x2009;68:16. The GI or RGR of the 6 foods varied from 36 to 88; none differed significantly in younger vs. older and the overall means were equivalent, 63.2 vs. 63.7, respectively. The GI or RGR values for 5 foods from 3 additional studies not meeting the inclusion criteria above were also similar in younger vs. older subjects. Therefore, we found no evidence from n&#x2009;=&#x2009;11 comparisons that GI values differ in younger vs. older subjects. However, there are insufficient data to determine if GI values are equivalent in older vs. younger subjects, something that requires a different statistical test.