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Made available in DSpace on 2021-05-14T23:07:25Z (GMT). No. of bitstreams: 0 Previous issue date: 2003-12-17
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O perfil de um grupo profissional e determinado pelo conjunto de conhecimentos e competencias necessarios para o desempenho da funcao atribuida a profissao. A area de atuacao reivindicada pelos bibliotecarios compreende, basicamente, responsabilidades com a preservacao, tratamento e disseminacao da informacao, mas apresenta, na verdade, muitos aspectos e niveis. E uma area em expansao acelerada, motivada por mudancas sociais e avancos tecnologicos, demandando atualizacao constante e diversidade muito grande de conhecimentos e competencias. A estrutura de formacao profissional legalmente aceita, que permite como porta de entrada apenas o curso de graduacao em biblioteconomia, nao pode, sozinha, preparar profissionais para todas as areas consideradas como de atuacao da classe. A profissao teria mais chances de preencher com eficiencia e relevância seu papel social se ampliasse e diversificasse a estrutura de formacao profissional hoje existente, associando-se a outras profissoes que tambem visam a satisfacao de necessidades individuais de informacao, criando com elas uma classe unica de profissionais.
This paper discusses the State reform issue, new models of public management of sanitation utilities, and the establishment of the regulatory landmark, based upon the author's experience in Rio de Janeiro's State reform programo
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Resumen pt: Este ensaio aborda a importância da lideranca no contexto dos servicos de saude.>>>en: This assay discusses the importance of leadership in the context o...
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This paper analyzes and discusses the inner management of waste produced in surgical centers and their physical characteristics, at two large general hospital plants. A qualitative evaluation was performed through technical inspections, identifying and classifying different types of waste generated in the surgical centers. Wastes observed were basically biological, since they are not separated in the place of origin. In order to classify their quantitative composition, all wastes produced during two periods of fourteen days, each one, were handled. A great amount of paper and plastics (62%), and a direct relationship between the amount of solid wastes and number of surgeries were found. It can be concluded that even in critical areas such as surgical centers, an adequate management of wastes using separation in the place of origin would avoid that the little amount of biological materials (11%) turn all wastes into hazardous material
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A phytochemical study led to the isolation of 25 diterpenoid alkaloids from Aconitum sinomontanum, of which six were described for the first time. Among them compounds 1-3 are anhydrolycoctonine derivatives, rare rearranged aconitine-type C<sub>19</sub>-diterpenoid alkaloids. To our best knowledge, less than ten of this type of alkaloids were isolated just from the genus Aconitum. The structures of these unreported compounds were elucidated by extensive analysis of NMR spectroscopic data and X-ray diffraction. The biological activities of compounds 1-3, 5-9, and 12-25 were evaluated. Among the tested compounds, compounds 2 and 17 showed potent inhibitory effect on the capsaicin (selective TRPV1 agonist) mediated activation of transient receptor potential vanilloid 1 (TRPV1) channels expressed in HEK-293 cells with inhibition rate of 31.78% and 30.94% at the concentration of 10 μM. Compounds 1-3, 5-9, 13, and 18-25 exhibited weak cytotoxic activity against human tumor cell lines NCI-H226 and MDA-MB-231 with inhibition rate over 10% at the concentration of 10 μM. Compound 16 showed most inhibitory effect on the expression of Nrf2 (NF-E2-related factor-2)-regulated gene with inhibition rate of 25% at the concentration of 20 μM.
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