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Following the publication of the above paper, it was drawn to the Editor's attention by a concerned reader that certain of the flow cytometric plots featured in Fig. 4 on p. 3748 were strikingly similar to plots that had appeared in a pair of articles written by different authors at different research institutes that had already been submitted for publication/published in the journal Medical Science Monitor, and a further paper with which the above paper shared flow cytometric data was identified as having been submitted to the journal Oncology Letters. Owing to the fact that the contentious data in the above article had already been published prior to its submission to Molecular Medicine Reports, the Editor has decided that this paper should be retracted from the Journal. The authors were asked for an explanation to account for these concerns, but the Editorial Office did not receive a reply. The Editor apologizes to the readership for any inconvenience caused. [Molecular Medicine Reports 18: 3744‑3750, 2018; DOI: 10.3892/mmr.2018.9358].

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In a critically ill cohort of 1505 patients with acute decompensated heart failure, the BAN-ADHF score was inversely associated with diuretic efficiency (Spearman ρ = -0.518) and discriminated the lowest-efficiency quintile (AUROC 0.780 at 24 h; 0.769 at 72 h), with efficiency falling more than four-fold across risk categories. This first external validation in an intensive-care population extends the evidence for BAN-ADHF to patients excluded from prior cohorts and supports prospective evaluation of score-guided decongestive strategies in critical illness.

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Kultanaruangnonth et al. recently reported a well-conducted double-blind randomized trial comparing intraoperative irrigation with 0.05% aqueous chlorhexidine gluconate (CHG) against normal saline for the prevention of surgical site infection (SSI) in abdominal surgery, concluding that CHG did not significantly reduce SSI. We raise three interpretive points. First, the antimicrobial rationale offered for CHG draws on clean-field trials (arthroplasty, caesarean delivery, breast reconstruction) in which SSI is driven by skin flora, whereas this trial's population was predominantly colorectal and hepatobiliary/contaminated surgery, fields dominated by enteric gram-negative and anaerobic organisms against which chlorhexidine is comparatively less active a plausible explanation for the smaller-than-expected effect. Second, the trial's own 95% confidence interval for the primary risk ratio (0.45-1.25) spans a 55% relative reduction to a 25% relative increase in SSI, and is compounded by a statistically fragile exploratory multivariable model (49 events across eight covariates, several dichotomized); we argue the result is more accurately described as statistically inconclusive than as a negative finding. Third, the Discussion's suggestion of particular benefit 'in high-risk populations' is not supported by any treatment-by-subgroup interaction analysis in the manuscript. We conclude that these findings argue for a larger, stratified, culture-informed confirmatory trial rather than for adopting or abandoning CHG wound irrigation in contaminated abdominal surgery.

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Hereditary angioedema (HAE) is a rare, potentially life-threatening disorder caused by autosomal dominant mutations in the SERPING1 gene, leading to deficiency or dysfunction of C1 esterase inhibitor. Recent estimates of global HAE prevalence are 1.22 per 100,000 individuals. With total fertility rates (TFRs) decreasing worldwide, several developed countries are now well below the population replacement rate in an "ultra-low fertility" group. With the decrease in fertility, how rare diseases are approached should be re-examined. In this letter, we describe how continued and sustained declines in total fertility rate and population may influence the future number of new HAE cases. We also address disease-specific factors that may further influence future case count, including reproductive hesitancy related to autosomal dominant inheritance, estrogen-associated exacerbation of angioedema attacks, and potential fertility effects of complement dysregulation. These demographic considerations are relevant to clinicians, researchers, and pharmaceutical companies involved in HAE care. Better characterizing population changes in the context of reduced fertility rates may help inform long-term clinical planning and the development of novel therapies for HAE and other rare diseases.

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Sight loss will affect an estimated 2.7 million people in the UK by 2030 and is associated with substantial reductions in quality of life, mobility, independence, and poorer mental health. Our own research has demonstrated that depressive symptoms are highly prevalent among blind and partially sighted people yet often remain unrecognised and untreated. To effectively disseminate our research to healthcare professionals, we involved members of the public with lived experience of sight loss in an art installation. The aim of this project is to evaluate the feasibility and value of using such an arts-based approach as a method for involving blind and partially sighted individuals in dissemination, and here we reflect on what all stakeholders learnt from the process. We recruited eight blind and partially sighted storytellers to share themes from our research using narratives of their own lived experience, focusing on the emotional impact of sight loss and professional interactions. Audio-recorded stories and accompanying portraits were developed into Eight Voices in Darkness, a sound installation designed to reflect both the literal and metaphorical darkness associated with vision impairment and depression. The installation was exhibited publicly over three days alongside workshops for eyecare professionals and mental health practitioners. Visitor and participant feedback (n = 92) was analysed using Pendleton's reflective framework to explore what went well, what did not, and what was learned. Visitors consistently reported an enhanced understanding of the mental health consequences of sight loss, valuing the authenticity, emotional resonance, and individuality conveyed through the artistic format. Many indicated intentions to adopt more empathetic, patient centred practices, improve accessibility, and initiate conversations about mental health. Storytellers highlighted the value of being heard and connecting with others' experiences. Researchers and the artist reflected on the strengths of partnership with the charity, the power of the immersive format, and challenges relating to managing expectations. The process generated important insights into involving the public in dissemination through art, including ethical editing, audience preparation, and sustaining involvement. Involving people with lived experience in arts-based dissemination offers a powerful and engaging method for disseminating research findings to professionals to improve healthcare. Future work should refine practical elements and enhance coproduction. Many people in the UK live with sight loss, which can make every aspect of everyday life harder, including tasks like reading and mobility. Our research showed that sight loss can also impact mental health, and that many people with sight loss do not get the emotional support they need, partly because some eyecare professionals do not realise how common mental health problems are among this group. Our aim was to involve patients and the public, specifically blind and partially sighted people, in sharing our research effectively so that vision-related professionals and the public could learn how sight loss affects mental health. We created an art project called Eight Voices in Darkness. Eight individuals talked about the key topics noted in our previous body of research on sight loss and mental health: how their sight loss affects their feelings, challenges faced, and support required. Their stories were recorded, along with a portrait photo of each person. An artist turned these stories into an art installation. In a quiet, dark theatre, visitors could sit and listen to short parts of each person’s story. Over three days, almost 200 people visited. Many said the experience helped them understand sight loss in a new and powerful way and they would try to be more kind, patient, and willing to talk about mental health in the future. The storytellers also said it felt good to be listened to. This project showed that art is a valuable mechanism to involve individuals with lived experience in sharing research with professionals and the public to improve healthcare. Research teams must consider practical and ethical considerations when individuals’ stories are harnessed to share research findings and allow sufficient time and resources.

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