Developmental Dyslexia (DD) has historically been associated with phonological impairments though difficulties may be identified across cognitive and sensorimotor domains. The Temporal Sampling Framework proposed that atypical neural entrainment to temporal structure may underlie difficulties beyond phonological impairments in DD. However, tempo differences are inconsistently reported in the literature, particularly for ecologically valid, spontaneous motor tasks. The present study examined whether university-aged adults with DD differ from skilled readers in spontaneous tempo across speech and gait domains, and whether any observed differences are consistent with domain-general or domain-specific accounts of timing in DD. One-hundred and ten university students (52 with DD, 58 skilled readers) completed four self-paced tempo tasks, including oral diadochokinesis, text reading fluency, natural gait, and tandem gait. Kinematic analysis and audio recording were used to derive cadence and speech rate measures. Adults with DD produced consistently slower spontaneous tempo than skilled readers across all four tasks. These differences persisted when participants with sensorimotor comorbidity (DRSM, N = 14) were excluded from the DD group. Additionally, the DRSM group exhibited lower oral diadochokinetic rate than the DD group but performed similarly across the other tasks. Modest but significant positive correlations between speech and gait tempo were observed across the full cohort. These findings provide evidence for a cross-domain spontaneous tempo deficit in DD that is consistent with a partially domain-general model of timing impairment. The persistence of tempo differences into adulthood suggests that timing differences might reflect stable neurocognitive characteristics of DD.
Impaired inhibitory control is a key factor in drug relapse. Music therapy shows potential for cognitive intervention, but individual differences, particularly in psychological resilience, and the mechanisms underlying tempo effects remain unclear. This study investigated the interactive effects of music tempo and psychological resilience on inhibitory control in male drug addicts, employing a Go/No-go task with drug-related cues. Forty-four male drug addicts were stratified into high and low resilience groups based on the Connor-Davidson Resilience Scale. They performed a Go/No-go task where No-go stimuli were drug-related pictures, under four conditions: fast (160 bpm), medium (105 bpm), and slow (50 bpm) tempo music, and a no-music control. Behavioral data (response time, accuracy) and event-related potentials (ERPs; N2, P3) were recorded. Behaviorally, the high-resilience group exhibited significantly shorter response times than the low-resilience group, an effect modulated by tempo. ERP analyses revealed that the low-resilience group generated larger N2 amplitudes, suggesting greater conflict monitoring demand. Conversely, the high-resilience group exhibited larger P3 amplitudes, indicating more efficient resource allocation for later inhibitory evaluation. A critical interaction was found in the N2 difference wave (N2d): under slow-tempo music, the high-resilience group demonstrated a significantly larger N2d than the low-resilience group, implying enhanced conflict monitoring in a stabilized state. Notably, no significant group differences in N2d were observed at fast tempo, despite persistent behavioral advantages for the high-resilience group. Psychological resilience moderates the impact of music tempo on inhibitory control. High-resilience individuals may optimally mobilize neural resources for conflict monitoring under slow-tempo music, which potentially reduces emotional interference. These findings underscore the importance of considering individual psychological traits in developing personalized, music-based rehabilitation strategies.
This study aimed to investigate the effects of skill level and tempo on coordination variability during consecutive ballet jumps (i.e., temps levé sauté) using continuous relative phase analysis. Eight skilled and eight less-skilled dancers performed the temps levé sauté jumps in first position (a fundamental foot position in ballet, one of the five basic positions in which the heels are together and the toes point outward) at three different tempos: 80 bpm, 100 bpm, and 120 bpm. Hip-knee and knee-ankle coordination was evaluated across three movement sub-phases: propulsion, flight, and landing. Phase deviations were used to quantify inter-joint variability, with larger deviation values indicating greater variability in the relationship between the two joints. The results showed that, during the landing phase, a significant interaction effect between skill level and tempo was observed in hip-knee coordination. Skilled dancers exhibited significantly lower variability in hip-knee coordination during the landing phase. Additionally, both groups showed increased variability at the slowest tempo (i.e., 80 bpm) when compared to the other tempos during the propulsion and landing phases. In the flight phase, however, coordination variability increased with faster tempo. These findings highlight the importance of tailored training strategies based on skill level to enhance ballet jump performance, with more emphasis on developing phase-specific coordination control and adaptability across various tempo conditions.
NaBr-free TEMPO-catalyzed oxidation with sodium dichloroisocyanurate (NaDCC) used as the consumed co-oxidant in water and room temperature was applied to water-insoluble polyglucans, such as a commercial regenerated cellulose (Bemliese), curdlan, α-(1 → 3)-glucan, corn starch, and 20% NaOH-treated/never-dried ramie. Water-soluble oxidized products with degrees of oxidation (DO) of >0.8 were obtained from Bemliese, curdlan, α-(1 → 3)-glucan, and corn starch by the TEMPO/NaDCC system at pH 9. The mass-average degrees of polymerization (DPw) of the oxidized products were higher than those prepared by the conventional TEMPO/NaBr/NaClO system at pH 10. In the case of 20% NaOH-treated and never-dried ramie, DOs were only ~0.6 and water-soluble oxidized products could not be obtained quantitatively. Consequently, the TEMPO/NaDCC system in water at pH 9 is advantageous for preparation of water-soluble oxidized products with higher DPw values from water-insoluble glucans, such as Bemliese, curdlan, α-(1 → 3)-glucan, and corn starch, by suppression of depolymerization probably because of no NaBrO present in the system. The water-soluble oxidized products or sodium polyglucuronates are possible to be used as biodegradable and metabolizable polymeric builders in laundry detergents.
To investigate associations between pubertal timing and tempo and depressive symptoms and clinically diagnosed depression in adolescent boys and girls. Data were obtained from the Danish National Birth Cohort (n = 15,818). Pubertal development was self-reported half-yearly from ages 11-18. Depressive symptoms at age 18 were assessed using the Major Depression Inventory, and clinically diagnosed depression was identified in the Danish National Patient Register. Pubertal timing and tempo were estimated using non-linear mixed-effects growth models. Associations with depressive symptoms were analysed using multinomial logistic regression, and associations with clinically diagnosed depression using binomial logistic regression. In girls, earlier and faster breast development were associated with higher risks of depressive symptoms (RRR = 1.11 (95% CI: 1.00-1.23) and 1.69 (95% CI: 1.08-2.64)), and earlier breast development and menarche were associated with clinically diagnosed depression (RR = 1.27 (95% CI: 1.00-1.60) and 1.36 (95% CI: 1.03-1.79)). In boys, earlier pubic hair development and voice break were associated with depressive symptoms (RRR = 1.32 (95% CI: 1.07-1.63) and 1.35 (95% CI: 1.11-1.63)), while earlier pubic hair development and first ejaculation were associated with clinically diagnosed depression (RR = 1.66 (95% CI: 1.10-2.50) and 1.51 (95% CI: 1.16-1.98)). Earlier pubertal timing was associated with depressive symptoms and clinically diagnosed depression in both boys and girls, while faster breast development was associated with depressive symptoms in girls. Overall, pubertal timing was more strongly associated with adolescent depression than pubertal tempo.
How does the tempo of animal communication signals evolve? This Primer explores two recent reports published in PLOS Biology, identifying a hotspot of signal tempos between 0.5-4 Hz and independently hypothesizing that delta waves in the receivers' brains may drive the evolution of this pattern.
Myocardial infarction (MI) is a leading global cause of death, marked by oxidative stress, electrical dysfunction, and cardiomyocyte loss. Current treatments often cannot simultaneously regulate the pathological microenvironment and restore electrical integrity. Here, we report an injectable "gas-electro" bionic hydrogel (POPHM) for spatiotemporal monitoring and repair of MI. POPHM integrates a dynamic PVA/PEI-PBA/ODex network for mechanical stability and injectability, sustained H2S release via a MeAC-PEG donor for anti-inflammatory, antioxidative, and pro-angiogenic effects, and TEMPO-CNF-modified MXene nanosheets as conductive fillers to form a biomimetic electrical network. The hydrogel shows good biocompatibility, suitable elasticity, and conductivity (1.44 mS·cm-1) matching native myocardium. In vitro, it enables real-time high-fidelity electrophysiological monitoring (e.g., ST-segment elevation) and enhances H9C2 viability and connexin 43 expression. In rat MI models, POPHM reduces infarct size, attenuates fibrosis and inflammation, promotes angiogenesis, and improves cardiac function (EF from 24% to 53.05%). Transcriptomics reveals activated pathways in energy metabolism, antioxidant defense, and cardiac development. By combining H2S gas therapy, MXene-mediated electrical restoration, and real-time ECG monitoring, this theranostic platform offers a promising strategy for comprehensive MI management.
The present investigation sought to conceptualize and fabricate a novel series of azo-oxazine-tetrazole hybrids (C1-C3) and to assess their prospective utility as antibacterial agents by integrating them into pH-responsive nanocomposites derived from TEMPO-oxidized Cellulose Nanocrystals (CNCs). The primary aim was to establish a controlled drug delivery system that demonstrates efficacy against Methicillin-Resistant Staphylococcus aureus (MRSA). The synthesis of azo-oxazine-tetrazole compounds was conducted through a series of multi-step chemical reactions, followed by their conjugation with TEMPO-oxidized CNCs. Structural validation was performed using Fourier-transform infrared (FT-IR) spectroscopy, and surface morphology was characterized by Scanning Electron Microscopy (SEM). Antibacterial activity was assessed employing the disc diffusion method, whereas molecular docking studies against the bacterial 6LXH protein elucidated binding affinities. Additionally, drug loading, release kinetics under variable pH conditions (5.5 and 7.4), and ADME (absorption, distribution, metabolism, excretion) characteristics were examined utilizing SwissADME computational tools. FT-IR spectroscopy corroborated the successful synthesis of the hybrids and their conjugation to CNCs. SEM analysis illustrated uniform CNC fibrils with an average diameter measuring 15 ± 3 nm. The drug-loading efficiencies ranged from 79% to 86%. Among the evaluated compounds, C2 demonstrated the most pronounced antibacterial activity against MRSA, with an inhibition zone of 28 mm at 300 μg/mL. Molecular docking analyses indicated a significant binding affinity for C2, reflected in a MolDock score of -141.428. The drug release exhibited pH sensitivity, achieving 92% release at pH 5.5 and 68% at pH 7.4. Compounds C2 and C3 displayed favorable drug-likeness and low gastrointestinal absorption, coupled with minimal penetration across the blood-brain barrier. This investigation demonstrates the successful formulation of pH-sensitive antibacterial nanocomposites with enhanced drug-delivery properties. The superior performance of C2 can be ascribed to its robust molecular interactions with bacterial proteins and its effective release in acidic environments, which are typically encountered at infection sites. Such findings underscore the hybrid's potential as a targeted therapeutic approach for combating drug-resistant infections. The synthesized azo-oxazine-tetrazole-CNC nanocomposites, particularly C2, exhibit promising antibacterial efficacy, pH-responsive drug release profiles, and advantageous pharmacokinetic properties. These results substantiate their potential for application in the design of nextgeneration nanocarrier systems to address resistant bacterial infections.
Allenes are versatile precursors for constructing complex molecular frameworks, yet oxidative transformations to install C-C or C-heteroatom bonds across the C1-C3 framework rely on inconvenient reagents and yield overoxidized byproducts and unstable intermediates that limit downstream diversification. Herein, we report a general strategy to access multifunctional C(sp2)-TEMPO-acrolein linchpins from simple alkoxyallenes. These TEMPO-acrolein intermediates enable orthogonal transformations of all three carbons of the initial allene framework into heterocyclic scaffolds that include pharmaceutically relevant quinoxalines, imidazoles, oxazoles, and thiazoles. Finally, the utility of this new strategic paradigm is demonstrated through a concise, metal-free synthesis of the natural product clathrodin.
ERPs average neural responses to stimuli across trials. This accentuates consistent activity over time but obscures differences in response strength and phase consistency from trial to trial. The Bipolar-Schizophrenia Network for Intermediate Phenotypes (B-SNIP) identified three transdiagnostic psychosis Biotypes (BT1, BT2, BT3) that differ in cortical excitability and temporal coherence of neural responses. Single-trial power (STP) and inter-trial coherence (ITC) were measured across 3-55 Hz in auditory paired-stimuli and oddball tasks using a large multi-site cohort (n = 2 373). One-way ANOVAs over a continuous time-frequency epoch with FDR and cluster correction identified group differences, resulting in 15 significant STP and ITC features. Linear discriminant analysis of these features identified the dimensions that maximally separated Biotypes. The STP differences covered the entire trial epoch, showing the strongest alterations in the beta band (18-32 Hz), graded BT2 > > BT3 > HC > > BT1. The ITC differences were seen at specific time points primarily in low-frequency bands (3-17 Hz), graded HC > BT3 > BT1 > BT2. These dimensions were orthogonal and did not mirror ERP amplitudes across Biotypes. Biotypes were better distinguished by STP and ITC (Euclidean distances 0.9-2.2) than by DSM diagnosis (0.10-0.45). DSM groups alone did not benefit from this breakdown. Cortical excitability and phase precision are unique neurophysiological targets for the etiological investigation of psychosis Biotypes, which traditional ERP averaging obscures.
The partial sequence of the mitochondrial gene for cytochrome oxidase subunit I (COI) has been analyzed in representatives of the genera Oreoleuciscus, Tribolodon, and Rhynchocypris, using Phoxinus phoxinus as an outgroup. The genus Rhynchocypris includes only freshwater fish (which is typical for cyprinids), while representatives of the genera Tribolodon and Oreoleuciscus have colonized the sea and water bodies of the arid zone (including brackish ones), respectively. The data we obtained suggest that during the colonization of these waters and the formation of these two genera, evolution accelerated, but subsequently, at the stage of adaptive radiation of all three genera, their evolutionary rates no longer differed.
Previous studies on background music and children's creativity have yielded conflicting conclusions, which may be due to the modulation of the effects of background music by task nature, music attributes, broadcast timing, and individual differences. We explored the effects of background music tempo and broadcast timing on prototype-based inventive thinking through two experiments. The results show that slow tempo background music enhances the children's retention of prototype knowledge, while fast tempo background music during the inventive thinking process promotes the fluency and flexibility of scientific inventive thinking but hinders novelty. Playing slow tempo background music during the learning of scientific knowledge can enhance the retention of scientific knowledge and improve scientific inventive thinking. Playing fast tempo background music during the inventive thinking process can change the attention pattern, processing efficiency, and information processing mode, thereby improving the fluency and flexibility of scientific inventive thinking.
Accurately simulating the non-Markovian dynamics of open quantum systems remains a significant challenge. While the recently proposed time-evolving matrix product operator (TEMPO) algorithm based on path integrals successfully circumvents the exponential scaling associated with memory length, its reliance on layer-by-layer tensor contractions and compressions leads to steep scaling with respect to the system Hilbert space dimension. In this work, we introduce the effective Hamiltonian-based TEMPO (EH-TEMPO) algorithm, which reformulates the calculation of the Feynman-Vernon influence functional as an imaginary time evolution governed by an effective Hamiltonian. We demonstrate that this effective Hamiltonian admits a highly compact matrix product operator representation, enabling substantial compression with negligible loss of accuracy. Combining a one-shot global evolution with a backward retrieval approach, EH-TEMPO significantly reduces algorithmic complexity and is naturally suited for GPU acceleration. We benchmark the method by simulating the energy transfer dynamics in the 7-site Fenna-Matthews-Olson complex model and 4-site perylene bisimide model. The results demonstrate that EH-TEMPO achieves numerically exact accuracy with superior efficiency, delivering speedups of up to 17.5× on GPU hardware compared to standard CPU implementations.
Aligning movements with external rhythms depends on temporal adaptation and anticipation, jointly captured by the ADaptation and Anticipation Model (ADAM). Cerebellar pathology disrupts these mechanisms during gradual tempo changes, but its role in synchronization under unpredictable rhythmic structure remains unclear. Sixty-one participants (16 cerebellar, 45 controls) performed a finger-tapping task at 100 beats-per-minute with phase-shifts (±90°) or period-changes (±10%). Synchronization was assessed by quantifying asynchrony (mean, variability) and modeled with ADAM to estimate adaptation (phase, period correction), anticipation (temporal prediction, anticipatory error correction), and noise (timekeeper, motor). Mixed-effects ANOVAs assessed effects of group, stimulus, and perturbation type; regressions identified predictors of synchronization variability. Patients showed higher asynchrony variability. Both groups increased phase and period correction from baseline to perturbation (p < 0.001), with stronger changes for period than phase perturbations (p < 0.006). Controls corrected more to metronomes, yet patients engaged period correction for music (p = 0.009). Temporal prediction relied on weighed averaging of preceding intervals under perturbations (p = 0.008), more with music, and particularly in patients (p = 0.0095). Anticipatory error correction was higher for metronomes than music (p = 0.045) and for period-changes (p < 0.0001), with stimulus effects restricted to controls. Timekeeper and motor noise rose with perturbations (p < 0.0001) and strongly predicted synchronization variability. Period-changes engaged adaptation more than phase-shifts, and music elicited larger corrective responses than metronomes. Patients showed reduced phase correction for metronomes, greater reliance on period correction for music, and elevated timekeeper noise. Findings indicate that the cerebellum contributes to multiple components of adaptation and anticipation, offering insights for designing targeted rehabilitation.
IntroductionGrowth and maturation during adolescence can affect the somatosensory system, potentially impacting coordination and proprioception. Optimal proprioception is important for performance and preventing lower limb injury. This study investigates the relationship between the somatosensory function, biological maturation and growth tempo in youth pathway triathletes to enable coaches and healthcare professionals to optimise training programs for long term injury prevention and enhance subsequent performance through key stages of development.MethodsFifty three pathway triathletes (aged 12-18 years) were assessed over two separate time points during the triathlon season. At each time point data was collected on growth (height and mass) and maturation (bone age and maturity offset), and somatosensory function using the Active movement extent discrimination assessment (AMEDA) assessment.ResultsAMEDA scores improved with increasing maturity offset in both males and females. Females had reduced symmetry in earlier adolescence and a decline in somatosensory function mid-adolescence compared to male triathletes. There was a weak negative association observed between faster growth tempo and lower somatosensory performance.ConclusionThis study supports the need for youth triathletes training programs to account for athletes sex, stage and tempo of biological maturation. Incorporating lower limb focused proprioception training starting pre PHV may support injury prevention and enhance long term performance outcomes as triathletes progress through the athletic pathway.
Improving animal welfare through standardized management protocols remains a key challenge in intensive pig production. Auditory enrichment, such as music, represents a promising non-invasive strategy, yet its application is often empirical, lacking mechanistic understanding and objective assessment tools. This study investigated growing pigs' active preferences for structured musical parameters to establish a precision auditory enrichment framework. Seventy-two crossbred pigs were subjected to a free-choice paradigm under simulated farm conditions, with a 2 × 2 factorial design manipulating musical stimulus type (a guqin string piece vs. a Mozart wind excerpt) and tempo (fast: 200 bpm vs. slow: 65 bpm) was continuously quantified using an enhanced YOLOv11-based automated recognition system (mean average precision mAP50: 90.5% ± 1.5%). Results revealed highly parameter-dependent effects: the slow-tempo GS stimulus and the fast-tempo MF stimulus significantly prolonged occupancy time (p < 0.01) and elicited distinct profiles. The GS stimulus promoted a calm, investigative state, increasing lying, exploration, and drinking time (p < 0.05), while the MF stimulus stimulated an active playful state, characterized by increased walking and playing (p < 0.05). Other musical combinations showed negligible effects, whereas noise exposure consistently triggered stress-related responses. This study establishes an integrated "parametric design → automated assessment → specific output" methodology for precision auditory enrichment, providing an empirical basis for evidence-based acoustic protocols in commercial pig production.
The oligometastatic paradigm has expanded the use of stereotactic ablative radiotherapy (SABR) and local consolidative therapy (LCT) in metastatic non-small cell lung cancer (NSCLC), but accumulating evidence suggests that 'oligometastatic NSCLC' is not a single clinical entity. As systemic therapy has advanced-particularly third-generation EGFR tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors-both the intent and the incremental value of local therapy have diverged by molecular subtype, metastatic tempo and treatment setting. In EGFR-mutated disease, multiple prospective studies now support LCT as a strategy to extend durable benefit from TKIs by ablating limited sites of disease, with contemporary randomised data emerging in the osimertinib era and ongoing trials addressing optimal timing and completeness of consolidation. In driver-negative, immunotherapy-treated NSCLC, early phase and real-world series suggest that carefully selected patients can achieve durable control within multimodality pathways, but the most practice-defining randomised evidence to date has not supported routine consolidation for all non-progressing patients and highlights pneumonitis risk, reinforcing the need for stringent staging and selection. Management of EGFR-mutated small and non-symptomatic brain metastases has similarly evolved towards systemic-first sequencing with selective stereotactic radiosurgery for high-risk lesions or focal central nervous system escape, informed by emerging randomised data. Across settings, lesion count alone is an imperfect surrogate for biology; metastatic tempo, molecular drivers and treatment response patterns are increasingly relevant to deciding when SABR should be comprehensive, selective or deferred. Ongoing trials in targeted and immunotherapy eras will determine when LCT should be integrated as standard care versus an optimisation strategy for a minority. We propose a pragmatic framework centred on treatment intent-comprehensive ablation for potentially curable limited disease versus focal ablation to maintain an effective systemic agent-aimed at supporting multidisciplinary decision-making as the evidence base evolves.
Anxious depression is a prevalent affective disorder characterized by typical depressive symptoms accompanied by persistent anxiety. Increasing evidence suggests that mitochondrial oxidative stress and neuroinflammation contribute to its onset and progression; however, the precise mechanisms linking these processes remain elusive. A rat model of anxious depression was established via chronic restraint stress combined with corticosterone administration. Integrated proteomic and transcriptomic analyses were performed to profile differentially expressed molecules in the hippocampus, with key signaling pathways validated by Western blot and qPCR. A Mito-TEMPO intervention group was introduced to evaluate the role of mitochondrial oxidative stress, involving behavioral tests, mitochondrial ultrastructure and reactive oxygen species (ROS) detection, and analysis of autophagy-, inflammation-, and apoptosis-related markers. Additionally, in vitro experiments were conducted using TXNIP siRNA knockdown in BV2 microglia to further verify the role of TXNIP. Proteomic and transcriptomic profiling identified dysregulation of inflammatory-, synaptic-, and mitophagy-related pathways in the hippocampus of model rats, with prominent upregulation of TXNIP and activation of the NLRP3 inflammasome. Model rats exhibited excessive mitochondrial ROS (mtROS) accumulation, suppressed PINK1/Parkin-mediated mitophagy, neuronal injury, and anxiety- and depression-like behaviors. Mito-TEMPO intervention alleviated these pathological changes by scavenging mtROS, restoring mitophagy, inhibiting TXNIP/NLRP3 inflammasome activation, and reducing neuronal apoptosis. In vitro, TXNIP knockdown in BV2 microglia attenuated LPS-induced NLRP3 inflammasome activation and pro-inflammatory cytokine secretion, thereby protecting HT22 neurons from inflammatory injury. Our findings suggest that the ROS/TXNIP/NLRP3 signaling axis mediates the crosstalk between mitochondrial oxidative stress and neuroinflammation, thereby contributing to the pathogenesis of anxious depression.
A simple and environmentally friendly electrochemical method is reported for accessing polysubstituted pyrimido[4,5-b]indoles via the cyclization of 3-substituted indoles with amidines. By employing tetrabutylammonium iodide (nBu4NI) as the electrolyte and 2,2,6,6-tetramethylpiperidinooxy (TEMPO) as a redox mediator, the target heterocycles were efficiently synthesized in moderate to good yields. Mechanistic studies demonstrated that both TEMPO and nBu4NI are indispensable redox mediators and essential for achieving high selectivity in this transformation.
This paper introduces an updated, publicly accessible version of the Film, Music and Emotion Dataset (FME-24), designed to examine how perceived emotion in film music evolves over time. It provides a comprehensive introduction to the dataset and explores its potential applications across music information retrieval (MIR), psychology, and AI-training contexts. The FME-24 dataset utilises film's immersive qualities to study emotional perception in a naturalistic yet controlled setting. It contains data from 275 film scores spanning the past two decades, including experimental and mainstream works. The dataset integrates high-quality film compositions with time-stamped valence-arousal (V-A) annotations, emotion sentences, familiarity ratings, and detailed metadata. 98 Participants contributed to annotating these temporal emotion features. For each time-stamped point, a two-second audio segment was analysed, and 78 features were extracted, including low-level timbral descriptors (MFCC statistics, spectral centroid), rhythmic descriptors (onset density, tempo), and higher-level psychoacoustic and tonal features (inharmonicity, roughness, chord transitions, tonal entropy). Although full audio files are unavailable due to licensing, reproducibility is ensured via ISRC codes, precise segment timings, and open access to all metadata and feature files in CSV format. The paper details the dataset's structure, annotation, and feature-extraction procedures, highlighting applications in computational and perceptual research and laying a foundation for future studies on emotion, perception, and narrative in film music.